Atrial fibrillation before and after patent foramen ovale closure study This is a prospective, multicenter, single-arm, observational study assessing the incidence, predictors and prognostic impact of AF occurring before (monitoring phase A) or af...

Clinical Studies - Jun 23, 2021 - Jun 23, 2027

Ongoing

Project leader: Chronis Joannis
Members: Schneider Irene, Vetsch Susanne

Contemporary findings from the ongoing Swiss-AF cohort study (2’415 patients with atrial fibrillation (AF) enrolled, 1’760 patients with available brain imaging) showed that patients with AF have a high burden of cerebral infarcts and other brain les...

Clinical Studies - Jun 17, 2021 - Jun 17, 2025

Ongoing

Project leader: Ammann Peter
Members: Fink Karin

We aim to: 1. Assess preclinical cardiac dysfunction longitudinally using 2-dimensional (2D) and 3-dimensional (3D) conventional and 2D speckle tracking echocardiography. 2. Assess cardiopulmonary fitness using cardiopulmonary exercise testing. 3....

Clinical Studies - Mar 1, 2021 - Dec 31, 2030

Ongoing

Project leader: Scheler Eva
Members: Schneider Irene

To test in a multicenter open-label randomized controlled trial across Switzerland whether a cascade screening programme for FH, in comparison with usual care, will increase the detection rate of FH within families. The primary outcome will be the...

Clinical Studies - Dec 15, 2020 - Mar 31, 2024

Completed

Project leader: Rickli Hans
Members: Vetsch Susanne, Schneider Irene

Incidence of Silent Atrial Fibrillation in Patients With Clinically Silent Brain Ischemic Lesions Arterial Fibrillation (AF) is well-recognized as a cause for cryptogenic Acute Ischemic Stroke (AIS) and is associated with Silent Brain Infarction...

Clinical Studies - Dec 4, 2020 - Dec 4, 2024

Ongoing

Project leader: Ammann Peter, Kägi Georg
Members: Brenner Roman, Vetsch Susanne, Schneider Irene

The primary aim is to gather observational data from consecutive SCAD patients in Switzerland, in order to establish a National Swiss Registry (SwissSCAD). SCAD is a poorly understood condition, affecting young patients and is associated with major...

Clinical Studies - Oct 1, 2020 - Dec 31, 2030

Ongoing

Project leader: Rickli Hans
Members: Schneider Irene

Treatment patterns and Outcomes across the disease Continuum in patients with CAD and/or PAD The study aims to collect real-world data on treatment patterns and decision points for treatment in patients with coronary artery disease (CAD) or sym...

Clinical Studies - Jul 14, 2020 - Apr 14, 2023

Completed

Project leader: Rickli Hans
Members: Fink Karin

Post-market registry to evaluate the safety and efficacy of the Supraflex Cruz™ sirolimus-eluting coronary stent system in the treatment of all-comer patients with coronary artery disease

Clinical Studies - Jul 13, 2020 - Dec 31, 2022

Completed

Project leader: Weilenmann Daniel
Members: Schneider Irene, Fink Karin

Health consequences of the Burden of atrial fibrillation The added information of measuring AF burden and measuring cardiac dimensions and function in an AF patient population where brain MRIs are available, could provide further evidence toward...

Clinical Studies - Apr 6, 2020 - Apr 6, 2024

Completed

Project leader: Ammann Peter
Members: Altmann David, Fink Karin

This study is a post-market clinical follow-up (PMCF) study to identify and evaluate residual risks associated with the use of the BIOMONITOR III that are discovered or remain even after risk analysis, risk mitigation and successful conformity assess...

Clinical Studies - Feb 10, 2020 - Jan 21, 2022

Completed

Project leader: Ammann Peter
Members: Schneider Irene

Multicenter, randomized, active comparator-controlled, double-blind, double-dummy, parallel group, dose-finding Phase 2 study to compare the safety of the oral FXIa inhibitor BAY 2433334 to apixaban in patients with atrial fibrillation Primary Safet...

Clinical Studies - Jan 21, 2020 - Dec 7, 2021

Completed

Project leader: Rickli Hans
Members: Fink Karin, Vetsch Susanne

The study aims to collect real-world data on treatment patterns and decision points for treatment in patients with coronary artery disease (CAD) or symptomatic peripheral artery disease (PAD) treated with rivaroxaban 2.5 mg[BID] for the prevention of...

Clinical Studies - Nov 19, 2019 - Dec 21, 2021

Completed

Project leader: Rickli Hans
Members: Fink Karin

A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Investigate the Efficacy and Safety of CSL112 in Subjects with Acute Coronary Syndrome

Clinical Studies - Aug 7, 2019 - Aug 30, 2020

Aborted

Project leader: Rickli Hans
Members: Vetsch Susanne

Prospektive nicht-interventionelle Studie zur optimierten Behandlung einer therapierefraktären Hypercholesterinämie bei Patienten mit heterozygoter familiärer Hypercholesterinämie oder klinisch manifester atherosklerotischer kardiovaskulärer Erkranku...

Clinical Studies - Apr 8, 2019 - Jan 15, 2021

Completed

Project leader: Rickli Hans
Members: Gemperle Michaela

This CE Mark study is a prospective, multi-center, single-arm investigational study to support commercialization of the FlexNav™ Delivery System and Loading System in Europe. The design of this clinical investigation is in compliance to ISO standards...

Clinical Studies - Mar 22, 2019 - Mar 30, 2021

Completed

Project leader: Haager Philipp
Members: Vetsch Susanne

Ziele: Aus den klinischen Daten (Anamnese, körperliche Untersuchung und einem der Ischämietests [Ergometrie, Stress-Echo, Stress MRI) wird mit einer logistischen Regression eine Wahrscheinlichkeits-funktion abgeleitet. Als Referenzuntersuchung gelten...

Clinical Studies - Feb 1, 2019 - Mar 31, 2022

Completed

Project leader: Rickli Hans
Members: Schneider Irene

Titel: instantaneous wave-free ratio guided Multivessel revascularizatiOn During percutaneous coronary intervEntion for acute myocaRdial iNfarction Objective: To compare an iFR-guided intervention of noninfarct lesions during the acute interventi...

Clinical Studies - Jan 20, 2019 - Dec 31, 2024

Ongoing

Project leader: Rigger Johannes
Members: Schneider Irene

The aim of the BIOSOLVE - IV Swiss Satellite Registry is to investigate the clinical performance and long-term safety of Magmaris in a real world setting and extend clinical practice using the technology in a monitored nationwide registry. Primary En...

Clinical Studies - Nov 1, 2018 - Mar 31, 2022

Aborted

Project leader: Jörg Lucas
Members: Schneider Irene

Takotsubo Cardiomyopathy, or broken heart syndrome, is a recently described acquired form of cardiomyopathy whose pathophysiology is not well understood and particularly affects postmenopausal women. The exact mechanism is still unclear and large p...

Clinical Studies - Apr 1, 2018 - Dec 31, 2030

Ongoing

Project leader: Jörg Lucas
Members: Fink Karin, Schneider Irene

Prospective research project in which biological material is sampled from humans and health-related personal data is collected (HFV Art 6). To generate further scientific evidence for a potential role of crossreactive antimicrobial T and B cell respo...

Clinical Studies - Jan 25, 2018 - Aug 25, 2021

Completed

Project leader: Ludewig Burkhard
Members: Maeder Micha, Vetsch Susanne