Unit
Kardiologie
KARDIO · Dept. I
SwissSCAD
Oct 1, 2020The primary aim is to gather observational data from consecutive SCAD patients in Switzerland, in order to establish a National Swiss Registry (SwissSCAD). SCAD is a poorly understood condition, affecting young patients and is associated with major...
Clinical Studies - Oct 1, 2020 - Dec 31, 2030
Ongoing
Project leader: Rickli Hans
Members: Schneider Irene
XATOC – Xarelto + Acetylsalicylic Acid
Jul 14, 2020Treatment patterns and Outcomes across the disease Continuum in patients with CAD and/or PAD The study aims to collect real-world data on treatment patterns and decision points for treatment in patients with coronary artery disease (CAD) or sym...
Clinical Studies - Jul 14, 2020 - Apr 14, 2023
Completed
Project leader: Rickli Hans
Members: Fink Karin
Cruz HBR
Jul 13, 2020Post-market registry to evaluate the safety and efficacy of the Supraflex Cruz™ sirolimus-eluting coronary stent system in the treatment of all-comer patients with coronary artery disease
Clinical Studies - Jul 13, 2020 - Dec 31, 2022
Completed
Project leader: Weilenmann Daniel
Members: Schneider Irene, Fink Karin
SWISS-AF Burden
Apr 6, 2020Health consequences of the Burden of atrial fibrillation The added information of measuring AF burden and measuring cardiac dimensions and function in an AF patient population where brain MRIs are available, could provide further evidence toward...
Clinical Studies - Apr 6, 2020 - Apr 6, 2024
Completed
Project leader: Ammann Peter
Members: Altmann David, Fink Karin
BIOMASTER BIOMONITOR III
Feb 10, 2020This study is a post-market clinical follow-up (PMCF) study to identify and evaluate residual risks associated with the use of the BIOMONITOR III that are discovered or remain even after risk analysis, risk mitigation and successful conformity assess...
Clinical Studies - Feb 10, 2020 - Jan 21, 2022
Completed
Project leader: Ammann Peter
Members: Schneider Irene
PACIFIC AF
Jan 21, 2020Multicenter, randomized, active comparator-controlled, double-blind, double-dummy, parallel group, dose-finding Phase 2 study to compare the safety of the oral FXIa inhibitor BAY 2433334 to apixaban in patients with atrial fibrillation Primary Safet...
Clinical Studies - Jan 21, 2020 - Dec 7, 2021
Completed
Project leader: Rickli Hans
Members: Fink Karin, Vetsch Susanne
XATOA – Xarelto + Acetylsalicylic Acid: Treatment
Nov 19, 2019The study aims to collect real-world data on treatment patterns and decision points for treatment in patients with coronary artery disease (CAD) or symptomatic peripheral artery disease (PAD) treated with rivaroxaban 2.5 mg[BID] for the prevention of...
Clinical Studies - Nov 19, 2019 - Dec 21, 2021
Completed
Project leader: Rickli Hans
Members: Fink Karin
AEGIS II_CSL112_3001
Aug 7, 2019A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Investigate the Efficacy and Safety of CSL112 in Subjects with Acute Coronary Syndrome
Clinical Studies - Aug 7, 2019 - Aug 30, 2020
Aborted
Project leader: Rickli Hans
Members: Vetsch Susanne
OPTIMIZE
Apr 8, 2019Prospektive nicht-interventionelle Studie zur optimierten Behandlung einer therapierefraktären Hypercholesterinämie bei Patienten mit heterozygoter familiärer Hypercholesterinämie oder klinisch manifester atherosklerotischer kardiovaskulärer Erkranku...
Clinical Studies - Apr 8, 2019 - Jan 15, 2021
Completed
Project leader: Rickli Hans
Members: Gemperle Michaela
Flex Nav
Mar 22, 2019This CE Mark study is a prospective, multi-center, single-arm investigational study to support commercialization of the FlexNav™ Delivery System and Loading System in Europe. The design of this clinical investigation is in compliance to ISO standards...
Clinical Studies - Mar 22, 2019 - Mar 30, 2021
Completed
Project leader: Haager Philipp
Members: Vetsch Susanne
DPF Coro - Entwicklung einer diagnostischen Probabilitätsfunktion (DPF) bei Patienten mit rezidivierenden Thoraxschmerzen zur Schätzung der Wahrscheinlichkeit einer relevanten koronaren Herzkrankheit
Feb 1, 2019Ziele: Aus den klinischen Daten (Anamnese, körperliche Untersuchung und einem der Ischämietests [Ergometrie, Stress-Echo, Stress MRI) wird mit einer logistischen Regression eine Wahrscheinlichkeits-funktion abgeleitet. Als Referenzuntersuchung gelten...
Clinical Studies - Feb 1, 2019 - Mar 31, 2022
Completed
Project leader: Rickli Hans
Members: Schneider Irene
iModern
Jan 20, 2019Titel: instantaneous wave-free ratio guided Multivessel revascularizatiOn During percutaneous coronary intervEntion for acute myocaRdial iNfarction Objective: To compare an iFR-guided intervention of noninfarct lesions during the acute interventi...
Clinical Studies - Jan 20, 2019 - Dec 31, 2024
Ongoing
Project leader: Weilenmann Daniel
Members: Schneider Irene
BIOSOLVE IV - Safety and Performance in de Novo Lesions of Native Coronary Arteries with Magmaris
Nov 1, 2018The aim of the BIOSOLVE - IV Swiss Satellite Registry is to investigate the clinical performance and long-term safety of Magmaris in a real world setting and extend clinical practice using the technology in a monitored nationwide registry. Primary En...
Clinical Studies - Nov 1, 2018 - Mar 31, 2022
Aborted
Project leader: Jörg Lucas
Members: Schneider Irene
Takotsubo - Clinical Characteristics of Takotsubo Cardiomyopathy
Apr 1, 2018Takotsubo Cardiomyopathy, or broken heart syndrome, is a recently described acquired form of cardiomyopathy whose pathophysiology is not well understood and particularly affects postmenopausal women. The exact mechanism is still unclear and large p...
Clinical Studies - Apr 1, 2018 - Dec 31, 2030
Ongoing
Project leader: Jörg Lucas
Members: Fink Karin, Schneider Irene
Dissecting the association of anti-microbiota antibodies and auto-reactive T-cells in cardiomyopathy– an exploratory research Project
Jan 25, 2018Prospective research project in which biological material is sampled from humans and health-related personal data is collected (HFV Art 6). To generate further scientific evidence for a potential role of crossreactive antimicrobial T and B cell respo...
Clinical Studies - Jan 25, 2018 - Aug 25, 2021
Completed
Project leader: Ludewig Burkhard
Members: Maeder Micha, Vetsch Susanne
Effect of induction chemotherapy on lung function measured by spiroergometry and 6-Minute walking test in patients affected by non-small cell lung cancer (NSCLC)
Jan 1, 2018Lung cancer is one of the most common cancers in the world and the leading cause of cancer-related mortality. At diagnosis, approximately 40% of patients are already at an advanced stage, and a third have locally advanced disease (stage III). Stage I...
Fundamental Research - Jan 1, 2018 - Dec 31, 2020
Automatically Closed
Members: Baty Florent, Brutsche Martin, Kern Lukas, Maeder Micha, Früh Martin
SERVE - Effect of phosphodiesterase-5 inhibition with Tadalafil on SystEmic Right VEntricular size and function
Oct 1, 2017This study assesses in a pilot trial the effect of PDE-5 inhibition with Tadalafil on RV size and function, exercise capacity and neurohumoral activation in adults with a systemic RV over a 3-year follow-up period. Included patients: Adults (≥18 year...
Clinical Studies - Oct 1, 2017 - Jul 1, 2021
Completed
Project leader: Engel Reto
Members: Gemperle Michaela
LEADERS FREE III
Aug 1, 2017A study evaluating the safety and efficacy of the BioFreedomTM Biolimus A9TM coated Cobalt Chromium coronary stent system in patients at high risk of bleeding. The objective of this study is to evaluate if the BioFreedomTM CoCr Drug Coated stent has...
Clinical Studies - Aug 1, 2017 - Dec 31, 2021
Completed
Project leader: Weilenmann Daniel
Members: Vetsch Susanne
ENTRUST DSE-EDO-01-15-EU
Jul 7, 2017Beurteilung der Sicherheit und Wirksamkeit eines Edoxabanbasierten , verglichen mit einem Vitamin-K-Antagonist-basierten, antithrombotischen Therapieregimes nach einer erfolgreichen perkutanen Koronarintervention (PCI) mit Stent-Implantation, bei Pat...
Clinical Studies - Jul 7, 2017 - Jul 7, 2021
Completed
Project leader: Rickli Hans
Members: Gemperle Michaela
ECARA
Jun 16, 2017Explore Clinical Utility of Evolocumab in Combination with an e-Health System: Swiss Prospective Observational Study in Patients with clinical Atherosclerotic Cardiovascular Disease (ASCVD) (ECARA)
Clinical Studies - Jun 16, 2017 - Dec 1, 2019
Completed
Project leader: Rickli Hans
Members: Gemperle Michaela