Dissecting the association of anti-microbiota antibodies and auto-reactive T-cells in cardiomyopathy– an exploratory research Project

Project

Dissecting the association of anti-microbiota antibodies and auto-reactive T-cells in cardiomyopathy– an exploratory research Project

Completed · 2018 until 2021

Maeder Micha, Vetsch Susanne, Ludewig Burkhard

Type

Clinical Studies

Range

Monocentric project at KSSG

Units

Kardiologie, Medizinisches Forschungszentrum, Institute of Immunobiology

Status

Completed

Start Date

2018

End Date

2021

Financing

Self Financed

Study Design

Sampling of biological material and collection of health-related personal data with single center project set-up. Blood samples will be obtained from patients that fulfill the inclusion criteria, HLA will by typified and antimicrobial crossreactive T and B cell responses will be assessed in the Institute of Immunobiology, Kantonsspital St. Gallen

Partner

Klinik für Kardiologie KSSG

Brief description/objective

Prospective research project in which biological material is sampled from humans and health-related personal data is collected (HFV Art 6).
To generate further scientific evidence for a potential role of crossreactive antimicrobial T and B cell responses in patients with heart failure.
i) Determine the levels of anti-heart proteins - and anti-microbiota specific antibodies in serum of patients with newly diagnosed heart failure of non-ischemic origin, patients with active or recent myocarditits/perimyocarditis and controls.
ii) Determine the abundance of heart-reactive and crossreactive antimicrobial effector T cells in PBMCs from patients with heart failure, myocarditis/perimyocarditis and controls.
iii) Determine if the HLA-DQB1*03:01 molecule is linked to the development of cardiac autoimmunity and heart failure