Atrial fibrillation before and after patent foramen ovale closure study This is a prospective, multicenter, single-arm, observational study assessing the incidence, predictors and prognostic impact of AF occurring before (monitoring phase A) or af...

Klinische Forschung - 23.06.2021 - 23.06.2027

Laufend

Projektleitung: Chronis Joannis
Mitarbeiter/innen: Schneider Irene, Vetsch Susanne

Contemporary findings from the ongoing Swiss-AF cohort study (2’415 patients with atrial fibrillation (AF) enrolled, 1’760 patients with available brain imaging) showed that patients with AF have a high burden of cerebral infarcts and other brain les...

Klinische Forschung - 17.06.2021 - 17.06.2025

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Projektleitung: Ammann Peter
Mitarbeiter/innen: Fink Karin

We aim to: 1. Assess preclinical cardiac dysfunction longitudinally using 2-dimensional (2D) and 3-dimensional (3D) conventional and 2D speckle tracking echocardiography. 2. Assess cardiopulmonary fitness using cardiopulmonary exercise testing. 3....

Klinische Forschung - 01.03.2021 - 31.12.2030

Laufend

Projektleitung: Scheler Eva
Mitarbeiter/innen: Schneider Irene

To test in a multicenter open-label randomized controlled trial across Switzerland whether a cascade screening programme for FH, in comparison with usual care, will increase the detection rate of FH within families. The primary outcome will be the...

Klinische Forschung - 15.12.2020 - 31.03.2024

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Projektleitung: Rickli Hans
Mitarbeiter/innen: Vetsch Susanne, Schneider Irene

Incidence of Silent Atrial Fibrillation in Patients With Clinically Silent Brain Ischemic Lesions Arterial Fibrillation (AF) is well-recognized as a cause for cryptogenic Acute Ischemic Stroke (AIS) and is associated with Silent Brain Infarction...

Klinische Forschung - 04.12.2020 - 04.12.2024

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Projektleitung: Ammann Peter, Kägi Georg
Mitarbeiter/innen: Brenner Roman, Vetsch Susanne, Schneider Irene

The primary aim is to gather observational data from consecutive SCAD patients in Switzerland, in order to establish a National Swiss Registry (SwissSCAD). SCAD is a poorly understood condition, affecting young patients and is associated with major...

Klinische Forschung - 01.10.2020 - 31.12.2030

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Projektleitung: Rickli Hans
Mitarbeiter/innen: Schneider Irene

Treatment patterns and Outcomes across the disease Continuum in patients with CAD and/or PAD The study aims to collect real-world data on treatment patterns and decision points for treatment in patients with coronary artery disease (CAD) or sym...

Klinische Forschung - 14.07.2020 - 14.04.2023

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Projektleitung: Rickli Hans
Mitarbeiter/innen: Fink Karin

Post-market registry to evaluate the safety and efficacy of the Supraflex Cruz™ sirolimus-eluting coronary stent system in the treatment of all-comer patients with coronary artery disease

Klinische Forschung - 13.07.2020 - 31.12.2022

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Projektleitung: Weilenmann Daniel
Mitarbeiter/innen: Schneider Irene, Fink Karin

Health consequences of the Burden of atrial fibrillation The added information of measuring AF burden and measuring cardiac dimensions and function in an AF patient population where brain MRIs are available, could provide further evidence toward...

Klinische Forschung - 06.04.2020 - 06.04.2024

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Projektleitung: Ammann Peter
Mitarbeiter/innen: Altmann David, Fink Karin

This study is a post-market clinical follow-up (PMCF) study to identify and evaluate residual risks associated with the use of the BIOMONITOR III that are discovered or remain even after risk analysis, risk mitigation and successful conformity assess...

Klinische Forschung - 10.02.2020 - 21.01.2022

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Projektleitung: Ammann Peter
Mitarbeiter/innen: Schneider Irene

Multicenter, randomized, active comparator-controlled, double-blind, double-dummy, parallel group, dose-finding Phase 2 study to compare the safety of the oral FXIa inhibitor BAY 2433334 to apixaban in patients with atrial fibrillation Primary Safet...

Klinische Forschung - 21.01.2020 - 07.12.2021

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Projektleitung: Rickli Hans
Mitarbeiter/innen: Fink Karin, Vetsch Susanne

The study aims to collect real-world data on treatment patterns and decision points for treatment in patients with coronary artery disease (CAD) or symptomatic peripheral artery disease (PAD) treated with rivaroxaban 2.5 mg[BID] for the prevention of...

Klinische Forschung - 19.11.2019 - 21.12.2021

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Projektleitung: Rickli Hans
Mitarbeiter/innen: Fink Karin

A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Investigate the Efficacy and Safety of CSL112 in Subjects with Acute Coronary Syndrome

Klinische Forschung - 07.08.2019 - 30.08.2020

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Projektleitung: Rickli Hans
Mitarbeiter/innen: Vetsch Susanne

Prospektive nicht-interventionelle Studie zur optimierten Behandlung einer therapierefraktären Hypercholesterinämie bei Patienten mit heterozygoter familiärer Hypercholesterinämie oder klinisch manifester atherosklerotischer kardiovaskulärer Erkranku...

Klinische Forschung - 08.04.2019 - 15.01.2021

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Projektleitung: Rickli Hans
Mitarbeiter/innen: Gemperle Michaela

This CE Mark study is a prospective, multi-center, single-arm investigational study to support commercialization of the FlexNav™ Delivery System and Loading System in Europe. The design of this clinical investigation is in compliance to ISO standards...

Klinische Forschung - 22.03.2019 - 30.03.2021

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Projektleitung: Haager Philipp
Mitarbeiter/innen: Vetsch Susanne

Ziele: Aus den klinischen Daten (Anamnese, körperliche Untersuchung und einem der Ischämietests [Ergometrie, Stress-Echo, Stress MRI) wird mit einer logistischen Regression eine Wahrscheinlichkeits-funktion abgeleitet. Als Referenzuntersuchung gelten...

Klinische Forschung - 01.02.2019 - 31.03.2022

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Projektleitung: Rickli Hans
Mitarbeiter/innen: Schneider Irene

Titel: instantaneous wave-free ratio guided Multivessel revascularizatiOn During percutaneous coronary intervEntion for acute myocaRdial iNfarction Objective: To compare an iFR-guided intervention of noninfarct lesions during the acute interventi...

Klinische Forschung - 20.01.2019 - 31.12.2024

Laufend

Projektleitung: Rigger Johannes
Mitarbeiter/innen: Schneider Irene

The aim of the BIOSOLVE - IV Swiss Satellite Registry is to investigate the clinical performance and long-term safety of Magmaris in a real world setting and extend clinical practice using the technology in a monitored nationwide registry. Primary En...

Klinische Forschung - 01.11.2018 - 31.03.2022

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Projektleitung: Jörg Lucas
Mitarbeiter/innen: Schneider Irene

Takotsubo Cardiomyopathy, or broken heart syndrome, is a recently described acquired form of cardiomyopathy whose pathophysiology is not well understood and particularly affects postmenopausal women. The exact mechanism is still unclear and large p...

Klinische Forschung - 01.04.2018 - 31.12.2030

Laufend

Projektleitung: Jörg Lucas
Mitarbeiter/innen: Fink Karin, Schneider Irene

Prospective research project in which biological material is sampled from humans and health-related personal data is collected (HFV Art 6). To generate further scientific evidence for a potential role of crossreactive antimicrobial T and B cell respo...

Klinische Forschung - 25.01.2018 - 25.08.2021

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Projektleitung: Ludewig Burkhard
Mitarbeiter/innen: Maeder Micha, Vetsch Susanne