Lung cancer is one of the most common cancers in the world and the leading cause of cancer-related mortality. At diagnosis, approximately 40% of patients are already at an advanced stage, and a third have locally advanced disease (stage III). Stage I...

Fundamental Research - Jan 1, 2018 - Dec 31, 2020

Automatically Closed

Members: Baty Florent, Brutsche Martin, Kern Lukas, Maeder Micha, Früh Martin

This study assesses in a pilot trial the effect of PDE-5 inhibition with Tadalafil on RV size and function, exercise capacity and neurohumoral activation in adults with a systemic RV over a 3-year follow-up period. Included patients: Adults (≥18 year...

Clinical Studies - Oct 1, 2017 - Jul 1, 2021

Completed

Project leader: Engel Reto
Members: Gemperle Michaela

A study evaluating the safety and efficacy of the BioFreedomTM Biolimus A9TM coated Cobalt Chromium coronary stent system in patients at high risk of bleeding. The objective of this study is to evaluate if the BioFreedomTM CoCr Drug Coated stent has...

Clinical Studies - Aug 1, 2017 - Dec 31, 2021

Completed

Project leader: Weilenmann Daniel
Members: Vetsch Susanne

Beurteilung der Sicherheit und Wirksamkeit eines Edoxabanbasierten , verglichen mit einem Vitamin-K-Antagonist-basierten, antithrombotischen Therapieregimes nach einer erfolgreichen perkutanen Koronarintervention (PCI) mit Stent-Implantation, bei Pat...

Clinical Studies - Jul 7, 2017 - Jul 7, 2021

Completed

Project leader: Rickli Hans
Members: Gemperle Michaela

Explore Clinical Utility of Evolocumab in Combination with an e-Health System: Swiss Prospective Observational Study in Patients with clinical Atherosclerotic Cardiovascular Disease (ASCVD) (ECARA)

Clinical Studies - Jun 16, 2017 - Dec 1, 2019

Completed

Project leader: Rickli Hans
Members: Gemperle Michaela

A multi-center, randomized, double-blind, active-controlled, parallelgroup Phase 3 study to evaluate the efficacy and safety of LCZ696 compared to ramipril on morbidity and mortality in high risk patients following an acute myocardial infarction The...

Clinical Studies - May 31, 2017 - Mar 1, 2021

Completed

Project leader: Maeder Micha
Members: Gemperle Michaela

To assess the long term safety and efficacy of the XPOSITION S STENT in routine clinical practice. Inclusion of subjects with coronary artery disease, including patients with chronic stable angina, silent ischemia and acute coronary syndrome, who qua...

Clinical Studies - Jan 27, 2017 - Jan 31, 2020

Completed

Project leader: Weilenmann Daniel
Members: Schneider Irene

Nicht-interventionelle Studie zur Edoxaban-Therapie in der klinischen Routinepraxis bei Patienten mit nicht-valvulärem Vorhofflimmern (Non-interventional study on Edoxaban Treatment in routiNe clinical prActise for patients with non valvular Atrial F...

Clinical Studies - Dec 6, 2016 - Dec 15, 2021

Completed

Project leader: Ammann Peter
Members: Gemperle Michaela, Altmann David

Mit dieser Studie wird die Sicherheit und Effektivität von zwei medikamentenbeschichteten Stents bei Patienten, die einen STEMI erlitten haben verglichen. Es wird geprüft, ob der Stent mit einer selbst auflösenden Beschichtung bei Patienten mit einem...

Clinical Studies - Oct 12, 2016 - Dec 30, 2023

Completed

Project leader: Weilenmann Daniel
Members: Schneider Irene

Studie mit einem System für die kardiale Resynchronisationstherapie (CRT - Cardiac Resynchronization Therapy) mit der aCRT-Funktion zur optimierten Behandlung von Herzinsuffizie

Clinical Studies - Jun 17, 2016 - Dec 31, 2022

Completed

Project leader: Ammann Peter
Members: Vetsch Susanne

The AdaptResponse study is a prospective, randomized, controlled, interventional, single-blinded, multi-center, post-market, global Cardiac Resynchronization Therapy (CRT) in heart failure (HF) clinical study. The purpose of this clinical study is...

Clinical Studies - May 30, 2016 - Dec 31, 2022

Completed

Project leader: Ammann Peter
Members: Vetsch Susanne

The aim of the retrospective research project is to analyze hardware characteristics (impulse generator and lead manufacturer, battery technology, lead design), implantation techniques and clinical factors associated with reoperations. Primary endpo...

Clinical Studies - May 9, 2016 - May 31, 2018

Completed

Project leader: Ammann Peter
Members: Schneider Irene

To assess the long-term safety and efficacy of the Xposition S stent (self-expanding sirolimus-eluting stent with a durable polymer coating) in the treatment of unprotected left main coronary artery disease. Primary clinical endpoint: Target Lesion...

Clinical Studies - May 2, 2016 - Dec 31, 2019

Completed

Project leader: Weilenmann Daniel
Members: Schneider Irene

Study Hypothesis: In patients with evidence of device-detected sub-clinical atrial fibrillation (SCAF) and additional risk factors for stroke, treatment with apixaban compared with aspirin will reduce the risk of the composite of stroke and systemic...

Clinical Studies - Apr 1, 2016 - Jan 1, 2026

Completed

Project leader: Ammann Peter
Members: Gemperle Michaela, Brenner Roman, Fink Karin, Vetsch Susanne

Hypothesis: In patients undergoing coronary intervention who are receiving oral anticoagulation, Cobra PzF stents with 14 days of DAPT after stenting provide superior outcomes versus Xience/Promus or Resolute drug-eluting stents with 6 months of DAPT...

Clinical Studies - Jan 1, 2016 - Mar 31, 2019

Completed

Project leader: Weilenmann Daniel
Members: Schneider Irene

Wirksamkeit der TYRX-Hülle hinsichtlich des Infektionsrisikos im Zusammenhang mit Herzrhythmusimplantaten innerhalb 12 Monaten nach dem Eingriff

Clinical Studies - Dec 15, 2015 - Aug 31, 2018

Completed

Project leader: Ammann Peter
Members: Vetsch Susanne

The objective of this non-mandated, prospective, multicenter, global post-market study is to assess the battery and device longevity of Boston Scientific’s (BSC) market-released Implantable Cardioverter Defibrillators (ICD) and CRT-D devices. The stu...

Clinical Studies - Dec 14, 2015 - Nov 30, 2021

Completed

Project leader: Ammann Peter
Members: Schneider Irene

It`s a snapshot survey initiated by the European Heart Rhythm Association and the Heart Failure Association, which is designed to describe clinical practice regarding implantation of CRT devices in a broad sample of hospitals. The clinical and demog...

Clinical Studies - Oct 1, 2015 - Dec 31, 2016

Completed

Project leader: Ammann Peter
Members: Schneider Irene

Kurzzeitige duale Thrombozytenaggregationshemmer-Therapie mit Everolimus freisetzenden Stents Synergy® II bei Patienten über 75 Jahren, die eine perkutane Koronarrevaskularisierung erhalten. Ziele: Nachweis der Wirksamkeit und Sicherheit der Everol...

Clinical Studies - Mar 26, 2015 - Nov 30, 2018

Completed

Project leader: Weilenmann Daniel
Members: Schneider Irene

The aim of this registry is to prolong the patient observation period and recruit new patients to gain further insights into the long-term use of NOACs, including switching from Vitamin K antagonists (VKAs), to NOACs in a real life setting. This will...

Clinical Studies - Jan 15, 2015 - Mar 31, 2016

Completed

Project leader: Ammann Peter
Members: Gemperle Michaela