Projects
Search from 1164 projects:
1164 Project(s)
Deciphering the transcriptomic landscape of cancer-associated fibroblasts in pancreatic cancer – an exploratory clinical study
Jul 1, 2018Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancer types with a 5-year survival of only 7% 1. While surgical resection of localized disease offers a moderate increase in survival, patients with metastatic pancreas cancer are...
Fundamental Research - Jul 1, 2018 - Dec 31, 2018
Completed
Project leader: Ludewig Burkhard
Members: Lütge Mechthild
STEP 4
Jun 5, 2018Effect and safety of semaglutide 2.4 mg once-weekly in subjects with overweight or obesity who have reached target dose during run-in period
Clinical Studies - Jun 5, 2018 - May 31, 2020
Completed
Project leader: Bilz Stefan
Members: Sigrist Sarah, Aczel Stefan, Räss Andrea
Randomisierte, offene, multizentrische Phase-2/3-Studie zur Beurteilung der Wirksamkeit und Sicherheit von Ro-garatinib (BAY 1163877) im Vergleich zu Chemotherapie bei Patienten mit FGFR-positivem, lokal fortgeschritte-nem oder metastatischem Urothelkarzinom, die vorher eine platinhaltige Chemotherapie erhalten haben
May 30, 2018Rogaratinib ist ein oraler pan-FGFR inhibitor. Eine FGFR-Überexpression (vorallem FGFR3 isoform) kann in bis zu 40% aller Patienten mit metastasiertem Urothelkarzinom nachgewiesen werden und stellt einen oncogenic driver da. Die Studie untersucht Rog...
Clinical Studies - May 30, 2018 - Dec 31, 2030
Ongoing
Project leader: Schmid Sabine
Patient-needs-based multi-professional delivery of Palliative Interventions by oncologists’ and oncology nurses: a randomized Phase II trial
May 22, 2018Background: Evidence is emerging that early specialist palliative care (SPC) is effective in several defined clinical settings and that it consists of a variety of definable palliative interventions (PCI). PCI encompass pharmacological, procedural, e...
Clinical Studies - May 22, 2018 - May 22, 2018
Automatically Closed
Members: Schmidt Mary Helen, Domeisen Benedetti Franzisca, Attoun-Knobel Suzanne, Behnke Nadine
Multicentre Oberservational Study of MDS Patients in Switzerland- Swiss MDS Registry
May 17, 2018Die Myelodysplastischen Syndrome (MDS) umfassen eine heterogene Gruppe hämatologischer Stammzellerkran-kungen, welche durch Reifungsstörungen des Knochen-markes (Dysplasien) mit Verminderung der Blutzellen (Zy-topenien) charakterisiert sind. Das Spek...
Clinical Studies - May 17, 2018 - Aug 14, 2030
Ongoing
Project leader: Silzle Tobias
Members: Steiner Marianne
Takotsubo - Clinical Characteristics of Takotsubo Cardiomyopathy
Apr 1, 2018Takotsubo Cardiomyopathy, or broken heart syndrome, is a recently described acquired form of cardiomyopathy whose pathophysiology is not well understood and particularly affects postmenopausal women. The exact mechanism is still unclear and large p...
Clinical Studies - Apr 1, 2018 - Dec 31, 2030
Ongoing
Project leader: Jörg Lucas
Members: Fink Karin, Schneider Irene
Evaluation von Superb Microvascular Imaging (SMI) zur Beurteilung von Gallenblasenpolypen
Mar 1, 2018Gallenpolypen stellen eine heterogene Entität dar. Einerseits kann es sich um Cholesterolpolypen ohne weiteren Krankheitswert handeln. Andererseits kann es sich um echte Adenome mit einem mit ihrer Grösse zunehmenden malignen Potential handeln. Zie...
Clinical Studies - Mar 1, 2018 - Dec 31, 2019
Automatically Closed
Project leader: Sawatzki Mikael, Baumeler Stephan
Decision Making in Oncology - Transfer of Competencies between HSG-KSSG
Mar 1, 2018Decision making in medicine is a very complex process and of central importance to the patient and physician in oncology. Our previous work (based at KSSG) has demonstrated a wide variability in expert decision making in oncology (including the use o...
Fundamental Research - Mar 1, 2018 - Dec 31, 2020
Automatically Closed
Project leader: Putora Paul Martin
TRIANGLE: autologous Transplantation after a Rituxi-mab/Ibrutinib/Ara-c containing iNduction in Generalized mantle cell Lymphoma – a randomized European mcl net-work trial
Feb 20, 2018According to current European guidelines (Dreyling, Ann Oncol 2014), the standard of care in younger patients with mantle cell lymphoma (MCL) is a dose-intensified approach with a cytarabine containing immunochemotherapy induction followed by autolog...
Clinical Studies - Feb 20, 2018 - Jan 31, 2028
Ongoing
Project leader: Hitz Felicitas
Asthma control Prediction
Feb 1, 2018The project consists of two stages with different objectives. In the first stage, the objective is to investigate whether nocturnal cough occurs in asthmatics more frequently than random (i.e. average nocturnal cough rate significantly greater than z...
Clinical Studies - Feb 1, 2018 - Dec 31, 2018
Automatically Closed
Project leader: Rassouli Frank
Members: Brutsche Martin, Baty Florent, Widmer Sandra, Tschirren Ursina
Neural Biomarkers of ADHD, and ADD in the Auditory Cortex of Adults – A controlled cross-sectional observational study
Jan 31, 2018Attention deficit (hyperactivity) disorder (AD(H)D) is one of the most common behavioral disorders in children and adolescents, with a worldwide prevalence of about 5% (Polanczyk et al., 2007; American Psychiatric Association, 2013). A substantial p...
Fundamental Research - Jan 31, 2018 - Jul 1, 2019
Automatically Closed
Project leader: Serrallach Bettina
Skippain
Jan 29, 2018SKIPPAIN (Speed of onset of SecuKinumab-Induced relief from Pain in Patients with AxIal SpoNdyloarthritis) A 24-week, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of secukinumab in controlling sp...
Clinical Studies - Jan 29, 2018 - Jun 29, 2019
Completed
Project leader: Rubbert-Roth Andrea
Members: Hutz Carina Liane, Forrer Silvia, Bartz-Batliner Mira
Dissecting the association of anti-microbiota antibodies and auto-reactive T-cells in cardiomyopathy– an exploratory research Project
Jan 25, 2018Prospective research project in which biological material is sampled from humans and health-related personal data is collected (HFV Art 6). To generate further scientific evidence for a potential role of crossreactive antimicrobial T and B cell respo...
Clinical Studies - Jan 25, 2018 - Aug 25, 2021
Completed
Project leader: Ludewig Burkhard
Members: Maeder Micha, Vetsch Susanne
Protocol SAKK 07/17: Nivolumab in combination with I-pilimumab in patients with metastatic renal cell carcinoma: A multicentre single-arm phase lI trial
Jan 4, 2018Superior overall survival of PD-1 blockade with nivolumab compared to everolimus has been shown in the phase III Checkmate-025 trial in metastatic clear cell carcinoma of the kidney in second line after progression under first line therapy with a tyr...
Clinical Studies - Jan 4, 2018 - Oct 31, 2021
Automatically Closed
Project leader: Rothermundt Christian
Effect of induction chemotherapy on lung function measured by spiroergometry and 6-Minute walking test in patients affected by non-small cell lung cancer (NSCLC)
Jan 1, 2018Lung cancer is one of the most common cancers in the world and the leading cause of cancer-related mortality. At diagnosis, approximately 40% of patients are already at an advanced stage, and a third have locally advanced disease (stage III). Stage I...
Fundamental Research - Jan 1, 2018 - Dec 31, 2020
Automatically Closed
Members: Baty Florent, Brutsche Martin, Kern Lukas, Maeder Micha, Früh Martin
Neuropeptide Y NPY-Trial bei Phäochromozytom
Jan 1, 2018Mesure des taux circulants des métabolites du neuropeptide Y chez les volontaires sains, patients hypertendus et patients atteints d’une tumeur neuroendocrine dans le plasma par une nouvelle méthode analytique utilisant la chromatographie liquide cou...
Clinical Studies - Jan 1, 2018 - Jan 1, 2022
Completed
Project leader: Sigrist Sarah
Members: Bilz Stefan, Räss Andrea
Defining the identity and differentiation pathways of the immune-stimulating fibroblastic tumor stroma
Jan 1, 2018Lung cancer is the most frequent cause of death in cancer patients in industrialized countries. A particular property of non-small cell lung cancer is the composition of the tumor microenvironment (TME) with a very high proportion of stromal cells. W...
Fundamental Research - Jan 1, 2018 - Dec 31, 2021
Automatically Closed
Project leader: Ludewig Burkhard
Members: De Martin Angelina
I6T-MC-AMAN
Jan 1, 2018A Phase 3, Multicenter, Randomized, Double-Blind, Parallel, Placebo-Controlled Induction Study of Mirikizumab in Conventional-Failed and Biologic-Failed Patients with Moderately to Severely Active Ulcerative Colitis LUCENT 1
Clinical Studies - Jan 1, 2018 - Feb 1, 2021
Completed
Project leader: Brand Stephan
Members: Krieger-Grübel Claudia, Sulz Michael, Smolders Jolijn
I6T-MC-AMBG
Jan 1, 2018A Phase 3, Multicenter, Randomized, Double-Blind, Parallel-Arm, Placebo-Controlled Maintenance Study of Mirikizumab in Patients with Moderately to Severely Active Ulcerative Colitis LUCENT 2
Clinical Studies - Jan 1, 2018 - Jun 1, 2021
Automatically Closed
Project leader: Brand Stephan
Members: Sulz Michael, Krieger-Grübel Claudia, Smolders Jolijn
ACRE
Jan 1, 2018A MULTICENTER, MULTI-NATIONAL, RANDOMISED, DOUBLE-BLIND, PLACEBO CONTROLLED, PARALLEL GROUP, PHASE IIA STUDY TO EVALUATE THE EFFICACY, SAFETY AND TOLERABILITY OF AN ANTHOCYANIN RICH EXTRACT (ACRE) IN PATIENTS WITH ULCERATIVE COLITIS.
Clinical Studies - Jan 1, 2018 - Jul 1, 2021
Completed
Project leader: Brand Stephan
Members: Stillhard Roman, Sulz Michael, Krieger-Grübel Claudia, Smolders Jolijn