Projects
Search from 1164 projects:
1164 Project(s)
Lilly JAHZ A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Phase 3 Study of Baricitinib
Feb 28, 2019A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Phase 3 Study of Baricitinib in Patients with systemic lupus erythematosus (SLE).
Clinical Studies - Feb 28, 2019 - Feb 28, 2022
Completed
Project leader: Rubbert-Roth Andrea
Members: Neumann Thomas, Bartz-Batliner Mira, Hutz Carina Liane, Peischl Riana, Sasselli Clelia
Vergleich der Kinematik von anatomischen und inversen Schulter-Totalprothesen
Feb 28, 2019tbd
Fundamental Research - Feb 28, 2019 - Dec 31, 2020
Automatically Closed
Project leader: Jost Bernhard
Members: Olach Martin, Zdravkovic Vilijam
DPF Coro - Entwicklung einer diagnostischen Probabilitätsfunktion (DPF) bei Patienten mit rezidivierenden Thoraxschmerzen zur Schätzung der Wahrscheinlichkeit einer relevanten koronaren Herzkrankheit
Feb 1, 2019Ziele: Aus den klinischen Daten (Anamnese, körperliche Untersuchung und einem der Ischämietests [Ergometrie, Stress-Echo, Stress MRI) wird mit einer logistischen Regression eine Wahrscheinlichkeits-funktion abgeleitet. Als Referenzuntersuchung gelten...
Clinical Studies - Feb 1, 2019 - Mar 31, 2022
Completed
Project leader: Rickli Hans
Members: Schneider Irene
Antibiotic resistance and antibiotic consumption in Swiss intensive care units between 2005 and 2019
Feb 1, 2019ANRESIS, das Schweizer Zentrum für Antibiotikaresistenzen, sammelt mikrobiologische Proben aus über 25 Laboratorien der Schweiz sowie Antibiotikaverbrauchsdaten aus über 40 Spitalapotheken und wird durch das Bundesamt für Gesundheit finanziert. Das v...
Clinical Studies - Feb 1, 2019 - Nov 30, 2019
Automatically Closed
Members: Barnsteiner Stefanie
iModern
Jan 20, 2019Titel: instantaneous wave-free ratio guided Multivessel revascularizatiOn During percutaneous coronary intervEntion for acute myocaRdial iNfarction Objective: To compare an iFR-guided intervention of noninfarct lesions during the acute interventi...
Clinical Studies - Jan 20, 2019 - Dec 31, 2024
Ongoing
Project leader: Rigger Johannes
Members: Schneider Irene
A phase III trial of marizomib in combination with standard
Jan 14, 2019Phase 1/2 Open-label Trial of Tinostamustine Conditioning and Autologous Stem Cell Transplantation for Salvage Treatment in Relapsed / Refractory Multiple Myeloma (TITANIUM 1)
Clinical Studies - Jan 14, 2019 - Jun 20, 2019
Automatically Closed
Project leader: Hess Dagmar
M14-675
Jan 1, 2019A Multicenter, Randomized, Double-Blind, Placebo-Controlled Induction Study to Evaluate the Efficacy and Safety of Upadacitinib (ABT-494) in Subjects with Moderately to Severely Active Ulcerative Colitis
Clinical Studies - Jan 1, 2019 - Aug 1, 2020
Completed
Project leader: Sulz Michael
Members: Brand Stephan, Krieger-Grübel Claudia, Smolders Jolijn
Stromal Cell Niches at the Nexus of the Innate Lymphoid Cell Interactome
Jan 1, 2019Innate lymphoid cells (ILCs) critically impact a diverse array of diseases. While the main cell-intrinsic molecular pathways and some of the soluble mediators that regulate ILC development and their functional activity have been characterized, the ce...
Fundamental Research - Jan 1, 2019 - Dec 31, 2022
Automatically Closed
Project leader: Ludewig Burkhard
Members: Lütge Mechthild
Transcriptomic analysis of the B and T cell repertoire in Multiple Sclerosis – an exploratory study
Jan 1, 2019Multiple Sclerosis (MS) is an immune-mediated disease of the central nervous system (CNS). While T cells dominate the immune response, both B and T cells contribute to the demyelination and neuronal injury that underlies clinical disease manifestatio...
Fundamental Research - Jan 1, 2019 - Jan 31, 2019
Automatically Closed
Project leader: Pikor Natalia, Ludewig Burkhard
Deciphering the transcriptomic landscape of cancer-associated fibroblasts in pancreatic cancer / Oncological Research
Jan 1, 2019Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancer types with a 5-year survival of only 7% and strongly limited treatment options. A major obstacle for successful treatment is the immunosuppressive nature of the tumor microe...
Fundamental Research - Jan 1, 2019 - Dec 31, 2021
Automatically Closed
Project leader: Ludewig Burkhard, Lütge Mechthild
Inorganic Nanoparticles with Anti-inflammatory and Antimicrobial Activity: New Prospects for Long-term Local Immunoimodulation?
Jan 1, 2019Control and eventual attenuation of inflammation is important in the management of a plethora of diseases. However, suppression of inflammatory responses, e.g. by corticosteroids or systemic blockade of immune effector pathways, is associated with se...
Fundamental Research - Jan 1, 2019 - Dec 31, 2019
Automatically Closed
Project leader: Ludewig Burkhard, Herrmann Inge
A prospective randomized, parallel-group, multicentre, superiority trial of the SUPERA peripheral stent system in patients with femoro-popliteal artery disease
Jan 1, 2019The primary objective of the study is to investigate, if the Supera® Peripheral Stent System has clinical superiority over EverFlex™ Self-Expanding Peripheral Stent System with Entrust™ Delivery System or as Protégé™ EverFlex™, a standard self-expand...
Clinical Studies - Jan 1, 2019 - Dec 31, 2025
Ongoing
Project leader: Hechelhammer Lukas
Members: Dick Florian, von Allmen Regula, Benecke Ulf, Baumer Andrea, Koeger Philipp, Stillhard Roman
I6T-MC-AMAM
Jan 1, 2019A Phase 3, Multicenter, Randomized, Double-Blind, Placebo- and Active- Controlled, Treat-Through Study to Evaluate the Efficacy and Safety of Mirikizumab in Patients with Moderately to Severely Active Crohn's Disease
Clinical Studies - Jan 1, 2019 - Dec 1, 2022
Automatically Closed
Project leader: Brand Stephan
Members: Sulz Michael, Smolders Jolijn, Krieger-Grübel Claudia
The „seed and soil“-based pathogenesis of proteasome inhibitor resistance in multiple myeloma
Jan 1, 2019Using the novel method of single-sell RNA sequencing, recently established by the Institute of Immunobiology at MFZ, KSSG, and our experience and knowledge about proteasome inhibitor resistance of myeloma plasma cells in vitro, we shall use the MFZ s...
Fundamental Research - Jan 1, 2019 - Dec 31, 2019
Automatically Closed
Project leader: Besse Lenka
Members: Besse Andrej, Schwestermann Jonas
Identification and manipulation of immune-stimulating fibroblastic stromal cell niches in the inflamed CNS
Jan 1, 2019The unique anatomy of the central nervous system (CNS) necessitates that inflammation in this organ is limited. However, emerging studies reveal that focal inflammation may be more prominent than previously appreciated. Avenues for immune surveill...
Fundamental Research - Jan 1, 2019 - Jun 30, 2023
Automatically Closed
Project leader: Pikor Natalia, Ludewig Burkhard
Prospective Observational international Registry of Patients with newly diagnosed peripheral T-Cell Lymphoma
Jan 1, 2019
Clinical Studies - Jan 1, 2019 - Dec 31, 2030
Ongoing
Project leader: Hitz Felicitas
Members: Demmer-Steingruber Ruth, Müller Fiona
A phase III trial of marizomib in combination with standard
Dec 13, 2018Marizomib in Glioblastoma
Clinical Studies - Dec 13, 2018 - Nov 13, 2021
Automatically Closed
Project leader: Hundsberger Thomas
MK-3475-495 KeyImPaCT
Dec 12, 2018Open-label randomisierte Phase II Studie, welche in der Erstlinientherapie bei Patienten mit metastasiertem NSCLC die Kombination von Pembrolizumab mit entweder MK-4280 oder lenvatinib untersucht. Ausgenommen sind Patienten für die eine zielgericht...
Clinical Studies - Dec 12, 2018 - Dec 19, 2020
Automatically Closed
Project leader: Schmid Sabine
IBCSG 55-17 “Touch” Phase II open-label, multicenter, randomized trial of neo-adjuvant palbociclib in combination with hormonal therapy and HER2 blockade versus paclitaxel in combination with HER2 blockade for elderly patients with hormone receptor positive/HER2 positive early breast cancer
Dec 4, 2018CDK4/6-Inhibitoren bringen enorme Verbesserungen bei der Behandlung von Patienten mit fortgeschrittenen, HR+ (Hormonrezeptor positiv)/HER2- (human epidermal growth factor receptor 2 negativ) BC (Brustkrebserkrankungen). Palbociclib und andere CDK4/6-...
Clinical Studies - Dec 4, 2018 - Dec 31, 2021
Automatically Closed
Project leader: Weder Patrik
„Comparing Analgesic Efficacy of Systemic Lidocaine against Placebo in General Anesthesia in Bariatric Surgery: prospective, randomized, double-blinded, placebo controlled, monocenter study” (COALAS)
Dec 1, 2018Hintergrund: Die bariatrische Chirurgie hat in den letzten Jahren eine zentrale Bedeutung in der Behandlung der morbiden Adipositas erlangt und wird auch an unserem Spital regelmässig durchgeführt. Anästhesiologisch ist die Betreuung dieser Patienten...
Clinical Studies - Dec 1, 2018 - Dec 31, 2020
Automatically Closed
Project leader: Filipovic Miodrag