Projects
Search from 1164 projects:
1164 Project(s)
The role of physical activity, malnutrition and sarcopenia for the prediction of acute exacerbations and the evolution of COPD assessment test (CAT) in patients with COPD
Nov 29, 2018We plan to investigate the association between physical activity, malnutrition and sar-copenia and the occurrence of acute exacerbations of COPD (AECOPD) / the evolution of the COPD assessment test (CAT) over 1 year in a telehealthcare (THC) cohort o...
Clinical Studies - Nov 29, 2018 - Jun 30, 2021
Completed
Project leader: Bösch Maximilian
Members: Baty Florent, Rassouli Frank, Tschirren Ursina, Widmer Sandra, Bilz Stefan, Brutsche Martin
Does custom-made total knee arthroplasty better restore normal gait than conventional total knee arthroplasty?
Nov 21, 2018tbd
Fundamental Research - Nov 21, 2018 - Dec 31, 2020
Automatically Closed
Project leader: Behrend Henrik
Members: Zdravkovic Vilijam
Differences in adherence to national target criteria for good disease management in tertiary diabetes care: Challenges and/or unmet needs?
Nov 1, 2018Earlier this year we published the first evaluation, to our knowledge, of adherence to the national target criteria for good disease management in diabetes in tertiary diabetes care. The study was based on the Swiss Diabetes Registry (SwissDiab), an...
Clinical Studies - Nov 1, 2018 - Oct 31, 2019
Automatically Closed
Project leader: Brändle Michael
Members: Renström Frida
BIOSOLVE IV - Safety and Performance in de Novo Lesions of Native Coronary Arteries with Magmaris
Nov 1, 2018The aim of the BIOSOLVE - IV Swiss Satellite Registry is to investigate the clinical performance and long-term safety of Magmaris in a real world setting and extend clinical practice using the technology in a monitored nationwide registry. Primary En...
Clinical Studies - Nov 1, 2018 - Mar 31, 2022
Aborted
Project leader: Jörg Lucas
Members: Schneider Irene
TLD-1, a novel Liposomal Doxorubicin, in Patients with Advanced Solid Tumors; a multicenter open-label single-arm phase I trial.
Oct 26, 2018In dieser Studie wird zum ersten Mal die Sicherheit und Wirksamkeit eines neuen Medikaments (Talidox) bei Menschen untersucht. Bei dem neuen Medikament handelt es sich um einen bekannten Wirkstoff, das Chemotherapeutikum Doxorubicin, welches in einer...
Clinical Studies - Oct 26, 2018 - Dec 31, 2026
Ongoing
Project leader: Hess Dagmar
Members: Harder Anja, Quinter Janine
Trial SAKK 19/17: First line durvalumab in patients with PD-L1 positve, advanced NSCLC with performance status 2 unsuitable for combination chemotherapy. A multicenter, single-arm phase II trial
Oct 23, 2018Lung cancer is the leading cause of cancer deaths. An estimated 30 to 40% of patients diagnosed with NSCLC have a poor PS defined as a score of 2 or higher on the ECOG scale. PS 2 patients are often underrepresented in clinical trials despite represe...
Clinical Studies - Oct 23, 2018 - Nov 23, 2021
Automatically Closed
Project leader: Früh Martin
SAKK 57/16. NAPAGE NAb-PAclitaxel and GEmcita-bine in advanced soft tissue sarcoma. A multicenter open-label single arm phase Ib/IIa trial
Oct 2, 2018Multizentrische Phase Ib/IIa Studie für Patientinnen und Patienten mit metastasiertem Weichteilsarkom, welche bereits eine oder zwei palliative Chemothera-pien erhalten haben. Zunächst erfolgt eine Dosisfin-dung mit Nab-Paclitaxel and Gemcitabine un...
Clinical Studies - Oct 2, 2018 - Oct 9, 2021
Automatically Closed
Project leader: Rothermundt Christian
Exploring indirect embryo-fetal risks of nanomaterials: Interference with inflammatory, vascular and endocrine signaling from human placental tissue
Oct 1, 2018Nanomaterialien können Gewebebarrieren wie Lunge und Darm durchdringen und im Körper zu Schädigungen in Zellen und Geweben führen. Während der Schwangerschaft ist ein Kontakt mit Nanomaterialien besonders problematisch, da der Fötus sehr empfindlich...
Fundamental Research - Oct 1, 2018 - Sep 30, 2021
Automatically Closed
Project leader: Buerki-Thurnherr Tina
Members: Hornung René, Jochum Wolfram, Patrycja Nowak-Sliwinska
Effectiveness of a multidimensional mobile app intervention "WOMAN-PRO III" to reduce postsurgical symptom induced distress in patients with vulvar neoplasia: A mixed methods project
Oct 1, 2018This mixed methods project aims to examine the effectiveness of a multidimensional mobile app intervention (“WOMAN-PRO III”) focusing on possible improvements with the use of the new mobile app intervention (intervention group) compared to standardiz...
Fundamental Research - Oct 1, 2018 - Dec 31, 2020
Automatically Closed
Project leader: Senn B, Hornung René, Kipp B, Gyr T
Members: Ott S, Lux W
Identifying and targeting the “Achilles’ heel” in proteasome inhibitor-resistant multiple myeloma
Oct 1, 2018The proposal aims at understanding the biology of proteasome inhibitor (PI)-refractory multiple myeloma (MM), in particular the specific vulnerabilities of PI-refractory MM, or so called “Achilles’ heel”, towards development of novel treatment option...
Fundamental Research - Oct 1, 2018 - Dec 31, 2021
Automatically Closed
Project leader: Driessen Christoph
Members: Besse Andrej, Kraus Marianne, Besse Lenka, Mendez Lopez Max
CORBUS: Lenabasum bei diffuser systemischer Sklerose
Sep 25, 2018A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial to Evaluate Efficacy and Safety of Lenabasum in Diffuse Cutaneous Systemic Sclerosis
Clinical Studies - Sep 25, 2018 - Sep 27, 2021
Aborted
Project leader: Rubbert-Roth Andrea
Members: Hutz Carina Liane, Bartz-Batliner Mira, Neumann Thomas
Randomisierte klinische Studie zum Vergleich der Vollständigkeit der adjuvanten Chemotherapie nach früher vs. später Stomarückverlagerung bei Patienten mit Rektumkarzinom nach tiefer anteriorer Resektion
Sep 24, 2018Ziel der CoCStom-Studie ist es, den optimalen Zeitpunkt der Rückverlagerung eines künstlichen Darmausgangs (Stoma) zu ermitteln, der im Rahmen der chirurgischen Entfernung des Mastdarms beim lokal fortgeschrittenen Enddarmkrebs (Rektumkarzinom) vorüb...
Clinical Studies - Sep 24, 2018 - Nov 30, 2020
Completed
Project leader: Marti Lukas, Kienle P, Hofheinz R
Members: Beutner Ulrich, Gueller Ulrich, Brunner Walter, Bischofberger Stephan
A Phase 1 Multiple-Ascending-Dose Study to Assess the Safety, Tolerability, and Pharmacokinetics of BIIB078 Administered Intrathecally to Adults with C9ORF72-Associated Amyotrophic Lateral Sclerosis
Sep 10, 2018The primary objective of this study is to evaluate the safety and tolerability of BIIB078 in adults with C9ORF72-Amyotrophic Lateral Sclerosis (ALS). The secondary objectives of this study are to evaluate the pharmacokinetic profile of BIIB078 and to...
Clinical Studies - Sep 10, 2018 - Nov 17, 2021
Completed
Project leader: Weber Markus
Members: Neuwirth Christoph, Braun Nathalie
International Randomised Controlled Trial for the Treatment of Newly Diagnosed Ewing’s Sarcoma Family of Tumours
Aug 30, 2018The objective of the induction/consolidation chemotherapy randomisation (R1) is to compare the VIDE strategy (VIDE induction and VAI/VAC/BuMel consolidation) with the VDC/IE strategy (compressed VDC/IE induction and IE/VC/Bu-Mel consolidation). The e...
Clinical Studies - Aug 30, 2018 - Aug 14, 2014
Automatically Closed
Project leader: Appenzeller Christina
Alternate day dosing of Pomalidomide in patients with re-fractory Multiple
Aug 17, 2018Multiple myeloma (MM) accounts for 1% of all cancers and ∼10% of all hematological malignancies. Despite recent advances in myeloma treatment, including the introduction of proteasome inhibitors, immunomodulatory drugs (IMiDs) and stem cell transplan...
Clinical Studies - Aug 17, 2018 - Apr 23, 2023
Automatically Closed
Project leader: Silzle Tobias
The role of the sensory trick in gating multimodal afferents in adult-onset idiopathic cervical dystonia
Aug 15, 2018The ‘sensory trick’ (ST) refers to a particular manoeuver e.g. slightly touching the face, which is capable of significantly ameliorating the abnormal head posture in patients with cervical dystonia (CD) (synonym: torticollis). The benefit is sometim...
Fundamental Research - Aug 15, 2018 - Jul 31, 2020
Automatically Closed
Project leader: Brugger Florian
Members: Kägi Georg
Abbvie M15-925: A Phase 3, Randomized, Active-Controlled,
Aug 15, 2018
Clinical Studies - Aug 15, 2018 - Aug 16, 2024
Completed
Project leader: Hutz Carina Liane, Rubbert-Roth Andrea
Members: Bartz-Batliner Mira, Neumann Thomas
Arimoclomol in Amyotropic Lateral Sclerosis
Jul 31, 2018A multicenter, randomized, double-blind, placebo-controlled, parallel group trial to evaluate the efficacy and safety of arimoclomol in amyotropic lateral sclerosis (ALS)
Clinical Studies - Jul 31, 2018 - Dec 18, 2020
Aborted
Project leader: Neuwirth Christoph
Tailored AXILLary Surgery with or without axillary lymph node dissection followed by radotherapy in patients with clinically node-positive breast cancer (TAXIS)
Jul 30, 2018The removal of all lymph nodes in the armpit through con-ventional axillary dissection has been standard care for all patients with breast cancer for almost a century. In the nineties, the sentinel lymph node (SLN) procedure, which involves the selec...
Clinical Studies - Jul 30, 2018 - Dec 12, 2030
Ongoing
Project leader: Bekes Inga
Members: Sennhauser Andrina, Müller Fiona
An Observatinal Study of Blinatumomab Safety and Effec-tiveness, Utillisation, and Treatment Practice
Jul 11, 2018Study Background and Rationale As a new treatment for acute lymphoblastic leukaemia (ALL), it is important tounderstand the safety and effective-ness of Blincyto (blinatumomab) as it isadministered in routine clinical practice. This study, developed...
Clinical Studies - Jul 11, 2018 - Feb 22, 2022
Automatically Closed
Project leader: Silzle Tobias