Prof Martin Brutsche
Chefarzt Pneumologie und interdisziplinäres Schlafzentrum
Chefarzt/Chefärztin
Pneumologie und Schlafmedizin · Dept. I
Nutzung von Large Language Models zur Identifikation von Etiotypen der Chronisch-obstruktiven Lungenerkrankung
01.03.2024Kürzlich veröffentlichte Guidelines haben neue taxonomische Klassifikationen der COPD vorgeschlagen, sogenannte Etiotypen. Diese Etiotypen haben klinische Relevanz für Management und Behandlung von COPD-Patient:innen. Dieses Projekt untersucht wie I...
Grundlagenforschung - 01.03.2024 - 28.02.2025
Laufend
Projektleitung: Baty Florent
Mitarbeiter/innen: Brutsche Martin, Albrich Werner, Hastings Janna, Kozu Kei, Toromanovic Tim
Profiling of quitting trajectories during smoking cessation attempt (SMOKEPROFILE-Study)
01.05.2021The study hypothesis is twofold. First, we hypothesize that investigating daily tobacco consumption of smokers attempting to quit can be used to characterize clinically relevant quitting trajectories which can be used to predict quitting success. Our...
Grundlagenforschung - 01.05.2021 - 30.12.2023
Automatisch geschlossen
Projektleitung: Baty Florent
Mitarbeiter/innen: Brutsche Martin, Bösch Maximilian, Pohle Susanne
Comparison of the effect of outdoor eccentric versus indoor concentric exercise training on physical capacity and qualityof-life in patients with advanced COPD (DOWNHILL-study)
01.05.2021Patients with chronic obstructive pulmonary disease (COPD) often suffer from cardio-pulmonary limitations, which makes them avoid exercise training. However, exercise training is explicitly recommended for COPD patients as physical activity (PA) is k...
Grundlagenforschung - 01.05.2021 - 30.04.2025
Laufend
Projektleitung: Bösch Maximilian
Mitarbeiter/innen: Baty Florent, Brutsche Martin, Benz Gabriel
Smartphone-Enabled Detection of COugh in COvid-19 (COCO): An Exploratory, Single-Center, Observational Cohort Study
03.12.2020
Klinische Forschung - 03.12.2020 - 03.12.2020
Automatisch geschlossen
Projektleitung: Rassouli Frank
Mitarbeiter/innen: Bösch Maximilian, Brutsche Martin, Tinschert Peter, Barata Filipe, Shih Iris
COugh During and after acute EXacerbation of chronic obstructive pulmonary disease (CODEX) study
08.09.2020
Klinische Forschung - 08.09.2020 - 01.07.2021
Automatisch geschlossen
Projektleitung: Rassouli Frank
Mitarbeiter/innen: Brutsche Martin, Barata Filipe, Cleres David
CRiPSI/CRiPSI-X: Covid-19 Risk Prediction in Swiss ICUs-Trial/Extension
01.08.2020Outcome of patients with critical Covid-19 varies. We study risk of and predictors for poor outcome in adult patients with Covid-19 admitted to ICU in a multicenter study. In addition, we assess the prevalence of, risk factors for and mechanisms invo...
Klinische Forschung - 01.08.2020 - 31.08.2022
Automatisch geschlossen
Projektleitung: Albrich Werner
Mitarbeiter/innen: Von Mering Christian, O'Mahony Liam, Cerny Andreas, Suh Noémie, El Baz Yassir, Dietrich Tobias, Fischer Tim, Felbecker Ansgar, Göhl-Freyn Kristina, Germann Nicolas, Schmid Dagmar, Kahlert Christian, Frischknecht Manuel, Filipovic Miodrag, Brutsche Martin, Pietsch Urs, Kleger Gian-Reto, Bochud Pierre-Yves
Prospective observational cohort study to investigate long-term pulmonary and extrapulmonary effects of COVID-19
15.06.2020
Klinische Forschung - 15.06.2020 - 15.12.2021
Automatisch geschlossen
Projektleitung: Brutsche Martin
Mitarbeiter/innen: Baty Florent
Predictive markers for checkpoint-based immunotherapy in advanced non-small cell lung cancer
01.01.2020The aim of this study is to elucidate a novel biomarker constellation with superior predictive value for PD-1/PD-L1-targeted immunotherapy in advanced non-small cell lung cancer.
Grundlagenforschung - 01.01.2020 - 31.12.2021
Abgeschlossen
Projektleitung: Bösch Maximilian
Mitarbeiter/innen: Baty Florent, Brutsche Martin, Früh Martin, Jörger Markus
Swiss Severe Asthma Register
01.10.2019
Klinische Forschung - 01.10.2019 - 31.12.2021
Automatisch geschlossen
Projektleitung: Kern Lukas
Mitarbeiter/innen: Baty Florent, Widmer Sandra, Brutsche Martin
The role of physical activity, malnutrition and sarcopenia for the prediction of acute exacerbations and the evolution of COPD assessment test (CAT) in patients with COPD
29.11.2018We plan to investigate the association between physical activity, malnutrition and sar-copenia and the occurrence of acute exacerbations of COPD (AECOPD) / the evolution of the COPD assessment test (CAT) over 1 year in a telehealthcare (THC) cohort o...
Klinische Forschung - 29.11.2018 - 30.06.2021
Abgeschlossen
Projektleitung: Bösch Maximilian
Mitarbeiter/innen: Baty Florent, Rassouli Frank, Tschirren Ursina, Widmer Sandra, Bilz Stefan, Brutsche Martin
Asthma control Prediction
01.02.2018The project consists of two stages with different objectives. In the first stage, the objective is to investigate whether nocturnal cough occurs in asthmatics more frequently than random (i.e. average nocturnal cough rate significantly greater than z...
Klinische Forschung - 01.02.2018 - 31.12.2018
Automatisch geschlossen
Projektleitung: Rassouli Frank
Mitarbeiter/innen: Brutsche Martin, Baty Florent, Widmer Sandra, Tschirren Ursina
Effect of induction chemotherapy on lung function measured by spiroergometry and 6-Minute walking test in patients affected by non-small cell lung cancer (NSCLC)
01.01.2018Lung cancer is one of the most common cancers in the world and the leading cause of cancer-related mortality. At diagnosis, approximately 40% of patients are already at an advanced stage, and a third have locally advanced disease (stage III). Stage I...
Grundlagenforschung - 01.01.2018 - 31.12.2020
Automatisch geschlossen
Mitarbeiter/innen: Baty Florent, Brutsche Martin, Kern Lukas, Maeder Micha, Früh Martin
Azithromycin for the treatment of cough in idiopathic pulmonary fibrosis
01.10.2017Multi centre, prospective, randomized, double blind, 2 treatment, 2 period crossover study with two 12-week treatment periods separated by a 4 week drug-free washout period and a 4 week follow-up performed at the University Hospital Berne, Basel, Zür...
Klinische Forschung - 01.10.2017 - 01.12.2018
Automatisch geschlossen
Projektleitung: Brutsche Martin
Mitarbeiter/innen: Finger Rebekka, Tschirren Ursina, Baty Florent, Widmer Sandra
A multicenter, randomized, 52-week, double-blind, parallel group, active controlled study to compare the efficacy and safety of QVM149 with QMF149 in patients with asthma
11.11.2016Asthma is a serious global health problem affecting all age groups. Despite existing therapies, there are significant unmet medical needs in treating asthma. Novartis is developing QVM149, a fixed-dose combination (FDC) of indacaterol acetate, an inh...
Klinische Forschung - 11.11.2016 - 31.03.2018
Automatisch geschlossen
Projektleitung: Brutsche Martin
Mitarbeiter/innen: Baty Florent, Schlotter Sandra
A 52-week, multicenter, randomized, double-blind, placebocontrolled study to assess the efficacy and safety of QAW039 when added to existing asthma therapy in patients with uncontrolled severe asthma
11.09.2016Das Ziel dieser Studie ist es, die Wirksamkeit und Sicherheit von QAW039 (150 mg und 450 mg einmal täglich) im Vergleich zu Placebo zu bestimmen, wenn es Patienten mit unzureichend kontrolliertem schweren Asthma und hoher Anzahl an Eosinophilen (Eosi...
Klinische Forschung - 11.09.2016 - 31.03.2018
Automatisch geschlossen
Projektleitung: Brutsche Martin
Mitarbeiter/innen: Baty Florent, Schlotter Sandra
Prevalence and functional role of read-through fusion transcripts in lung cancer
01.06.2016The aim of this exploratory study is to assess the prevalence and the functional role of RTFTs in lung cancer. Total RNA extracted from lung biopsies obtained in 50 p...
Grundlagenforschung - 01.06.2016 - 31.12.2018
Automatisch geschlossen
Projektleitung: Baty Florent
Mitarbeiter/innen: Brutsche Martin
A randomised controlled, international, multicentre crossover trial. We want to test, whether telehealthcare can improve HRQOL and reduce emergency admissions and hospitalisations due to AECOPD
11.05.2016A randomised controlled, international, multicentre crossover trial. We want to test, whether telehealthcare can improve HRQOL and reduce emergency admissions and hospitalisations due to AECOPD.
Klinische Forschung - 11.05.2016 - 31.12.2018
Automatisch geschlossen
Projektleitung: Brutsche Martin
Mitarbeiter/innen: Baty Florent, Rassouli Frank, Schlotter Sandra
Cardiopulmonary- and hemodynamic responses during positive and negative airway pressure in patients with chronic obstructive pulmonary disease
01.10.2015The overall aim of the present study is to investigate if positive and negative airway pressure influences cardiopulmonary- and hemodynamic responses by adding resistive loads or/and conducting NPPV throughout the entire breathing cycle in patients w...
Grundlagenforschung - 01.10.2015 - 01.08.2016
Automatisch geschlossen
Projektleitung: Baty Florent, van Gestel Arnoldus, Brutsche Martin
Kalydeco
01.09.2015
Klinische Forschung - 01.09.2015 - 01.09.2017
Automatisch geschlossen
Projektleitung: Schoch Otto
Mitarbeiter/innen: Finger Rebekka, Brutsche Martin, Kapfer Sarah, Schlotter Sandra
Cardiopulmonary- and hemodynamic responses during positive and negative airway pressure in patients with chronic obstructive pulmonary disease (COPD)
01.07.2015The overall aim of the present study is to investigate if positive and negative airway pressure influences cardiopulmonary- and hemodynamic responses by adding resistive loads or/and conducting NPPV throughout the entire breathing cycle in patients w...
Grundlagenforschung - 01.07.2015 - 01.03.2016
Automatisch geschlossen
Projektleitung: van Gestel Arno Jr
Mitarbeiter/innen: Baty Florent, Brutsche Martin