The primary aim of the present study is to analyze the validity and feasibility of a wearable ECG Acquisition System (EMPA) by comparing standard measures of heart rate variability (Low-frequency power, LF) with those of polysomnography.

Grundlagenforschung - 01.06.2015 - 01.12.2016

Automatisch geschlossen

Projektleitung: Brutsche Martin
Mitarbeiter/innen: Baty Florent, van Gestel Arnoldus, Rossi Rene, Annaheim Simon, Weder Markus, Schoch Otto

Register-Studie Emphysema

Klinische Forschung - 24.03.2015 - 24.03.2017

Abgebrochen

Projektleitung: Schneider Tino
Mitarbeiter/innen: Brutsche Martin, Kapfer Sarah, Schlotter Sandra

A prospective multicenter study to assess the coreelation of LONGterm wrist ACTigraphy recorded physical Performance and 6-minute walk distance in patients with pulmonary arterial Hypertension newly initiating endothelin receptor antagonist therapy

Klinische Forschung - 24.03.2015 - 24.03.2015

Abgebrochen

Projektleitung: Brutsche Martin
Mitarbeiter/innen: Baty Florent, Kapfer Sarah, Schlotter Sandra, Schoch Otto

The objective is to establish telehealthcare as an integrated, web-based treatment network between patient, GP and hospital to optimise care for COPD patients according to the GOLD-guidelines, assisted by simple-to-use, network-based gadgets (via sma...

Klinische Forschung - 01.02.2015 - 01.02.2016

Abgeschlossen

Projektleitung: Brutsche Martin
Mitarbeiter/innen: Baty Florent, Dusemund Frank

Eine randomisierte, doppelblinde, kontinuierlich verabreichte, placebokontrollierte, multizentrische klinische Prüfung der Phase III zur Untersuchung der Wirksamkeit und Sicherheit von 2 Dosierungen Benralizumab (MEDI-563) bei Pat. mit moderater bis...

Klinische Forschung - 01.01.2015 - 01.01.2016

Automatisch geschlossen

Projektleitung: Brutsche Martin
Mitarbeiter/innen: Benz Gabriel

Activating mutations in lung cancer are targeted by a series of molecularly targeted therapies. Patients harboring such mutations can receive significant benefit from these therapies. However a proportion of patients without activating mutations can...

Grundlagenforschung - 01.01.2015 - 31.12.2016

Automatisch geschlossen

Projektleitung: Baty Florent
Mitarbeiter/innen: Franzini Anca, Früh Martin, Jörger Markus, Brutsche Martin

Cystic Fibrosis is a deadly genetic disease mainly due to chronic bacterial colonization and recurrent bacterial infections of the lungs. It has often been documented that once a certain microbial species such as Pseudomonas aeruginosa establishes, t...

Grundlagenforschung - 01.09.2014 - 31.12.2016

Automatisch geschlossen

Projektleitung: Baty Florent
Mitarbeiter/innen: Brutsche Martin, Kahlert Christian, Von Mering Christian, Vyas Rounak

​An open-label, crossover, interventional Phase IV study to compare the ease of use of tobramycin inhalation solution and nebulized colistimethate for the treatment of pulmonary Pseudomonas aeruginosa in patients with CF

Klinische Forschung - 01.07.2014 - 18.03.2015

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Projektleitung: Brutsche Martin
Mitarbeiter/innen: Finger Rebekka

The proposed study will compare vSBP values during physical exercise between patients with COPD and age- and gender-matched controls. We hypothesize that vSBP during the 6MWT is increased in patients with COPD compared to age- and gender matched cont...

Grundlagenforschung - 10.03.2014 - 01.06.2015

Abgeschlossen

Projektleitung: van Gestel Arnoldus J R
Mitarbeiter/innen: Baty Florent, Brutsche Martin, Gajic Andreja

Randomisierte, doppelblinde, placebokontrollierte, multizentrische Phase-II-Studie zur Bestimmung der Wirksamkeit und der Sicherheit von GS-6624 bei Patienten mit idiopathischer Lungenfibrose

Klinische Forschung - 01.08.2013 - 01.08.2015

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Projektleitung: Pellet Sarah
Mitarbeiter/innen: Finger Rebekka, Brutsche Martin, Burger Barbara

Background Patients with severe respiratory failure (SRF) are often in need for rapid ventilatory support. Availability of immediate NIV is often limited to the intensive care unit (ICU). We hypothesized that immediate initiation of NIV in the ED is...

Grundlagenforschung - 01.06.2013 - 01.01.2015

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Projektleitung: Rüdiger Jochen, Brutsche Martin
Mitarbeiter/innen: Kleger Gian-Reto, Diethelm Markus, Osterwalder Joseph

Objective 1) To assess safety and tolerability, clinical effects of riociguat. 2) To provide access to riociguat for patients with in-operable chronic thromboembolic pulmonary hypertension (CTEPH), or recurrent or persisting pulmonary hypertension (P...

Klinische Forschung - 01.06.2013 - 01.06.2015

Abgebrochen

Projektleitung: Brutsche Martin
Mitarbeiter/innen: Pellet Sarah, Finger Rebekka

Genome-wide Gene/Exon expression analysis of late stage NSCLC treated by Erlotinib /Bevacizumab: role of tumor-stroma interactions

Grundlagenforschung - 01.02.2013 - 01.06.2015

Abgeschlossen

Projektleitung: Baty Florent
Mitarbeiter/innen: Brutsche Martin, Oliver Dürr, Franzini Anca

Lung cancer is the most frequent cause of death in cancer patients in industrialized countries. Most patients with advanced nonsmall cell lung cancer (NSCLC) do not respond to the current treatment schemes indicating that the basic mechanisms of tumo...

Grundlagenforschung - 01.01.2013 - 31.12.2014

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Projektleitung: Ludewig Burkhard, Brutsche Martin
Mitarbeiter/innen: Baty Florent, Novkovic Mario, Onder Lucas

Introduction: The acceptance of positive airway pressure therapy (CPAP) within the first month is a critical aspect of successful OSAS therapy. Telemedicine is a novel tool to supervise CPAP use at patient's home. We report 30-day results of a pilot...

Grundlagenforschung - 01.01.2013 - 01.03.2013

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Projektleitung: Schoch Otto, Brutsche Martin
Mitarbeiter/innen: Baty Florent, Niedermann Jolanda, Rüdiger Jochen

We hypothesize that the use of telemedicine combined with support interventions by short messages, telephone calls and ambulatory visits to control CPAP treatment in OSAS patients during the first month improves adherence and reduces unresolved side...

Klinische Forschung - 01.01.2013 - 31.12.2015

Abgeschlossen

Projektleitung: Schoch Otto
Mitarbeiter/innen: Baty Florent, Niedermann Jolanda, Brutsche Martin

Lung cancer remains a health issue with a dismal outcome and evolution in the search of new prognostic markers and therapeutic approaches. To improve research efforts interdisciplinary and multicenter research networks are needed. For competitive tra...

Grundlagenforschung - 01.10.2012 - 31.12.2015

Abgeschlossen

Projektleitung: Brutsche Martin, Putora Paul Martin
Mitarbeiter/innen: Baty Florent

A multicenter, reandomized, double-blind, single-dose study to assess the effect of the combined inhalation of 150 ug indacaterol maleate (QAB149) and 50 ug glycopyrronium bromide (NVA237) versus inhaled 150 ug indacaterol maleate (QAB149) alone on i...

Klinische Forschung - 01.10.2012 - 31.08.2013

Abgeschlossen

Projektleitung: Pellet Sarah
Mitarbeiter/innen: Brutsche Martin, Finger Rebekka, Burger Barbara

The pathophysiology of the adrenal insufficiency of patients with critical diseases remains unclear. In a prior exploratory study investigating patients with exacerbation of chronic obstructive pulmonary disease (COPD), we demonstrated a highly signi...

Grundlagenforschung - 01.09.2012 - 01.09.2013

Abgebrochen

Projektleitung: Rüdiger Jochen
Mitarbeiter/innen: Baty Florent, Bilz Stefan, Lehmann Natalie, Brutsche Martin

Background Only few studies have examined the effect of public smoking bans on respiratory conditions. These showed reduced admission rates for different respiratory diseases. Objective of the present study was to evaluate the effect of the public sm...

Grundlagenforschung - 01.09.2012 - 01.06.2013

Abgeschlossen

Projektleitung: Baty Florent, Brutsche Martin
Mitarbeiter/innen: Dusemund Frank