The primary aim of the present study is to analyze the validity and feasibility of a wearable ECG Acquisition System (EMPA) by comparing standard measures of heart rate variability (Low-frequency power, LF) with those of polysomnography.

Fundamental Research - Jun 1, 2015 - Dec 1, 2016

Automatically Closed

Project leader: Brutsche Martin
Members: Baty Florent, van Gestel Arnoldus, Rossi Rene, Annaheim Simon, Weder Markus, Schoch Otto

Register-Studie Emphysema

Clinical Studies - Mar 24, 2015 - Mar 24, 2017

Aborted

Project leader: Schneider Tino
Members: Brutsche Martin, Kapfer Sarah, Schlotter Sandra

A prospective multicenter study to assess the coreelation of LONGterm wrist ACTigraphy recorded physical Performance and 6-minute walk distance in patients with pulmonary arterial Hypertension newly initiating endothelin receptor antagonist therapy

Clinical Studies - Mar 24, 2015 - Mar 24, 2015

Aborted

Project leader: Brutsche Martin
Members: Baty Florent, Kapfer Sarah, Schlotter Sandra, Schoch Otto

The objective is to establish telehealthcare as an integrated, web-based treatment network between patient, GP and hospital to optimise care for COPD patients according to the GOLD-guidelines, assisted by simple-to-use, network-based gadgets (via sma...

Clinical Studies - Feb 1, 2015 - Feb 1, 2016

Completed

Project leader: Brutsche Martin
Members: Baty Florent, Dusemund Frank

Eine randomisierte, doppelblinde, kontinuierlich verabreichte, placebokontrollierte, multizentrische klinische Prüfung der Phase III zur Untersuchung der Wirksamkeit und Sicherheit von 2 Dosierungen Benralizumab (MEDI-563) bei Pat. mit moderater bis...

Clinical Studies - Jan 1, 2015 - Jan 1, 2016

Automatically Closed

Project leader: Brutsche Martin
Members: Benz Gabriel

Activating mutations in lung cancer are targeted by a series of molecularly targeted therapies. Patients harboring such mutations can receive significant benefit from these therapies. However a proportion of patients without activating mutations can...

Fundamental Research - Jan 1, 2015 - Dec 31, 2016

Automatically Closed

Project leader: Baty Florent
Members: Franzini Anca, Früh Martin, Jörger Markus, Brutsche Martin

Cystic Fibrosis is a deadly genetic disease mainly due to chronic bacterial colonization and recurrent bacterial infections of the lungs. It has often been documented that once a certain microbial species such as Pseudomonas aeruginosa establishes, t...

Fundamental Research - Sep 1, 2014 - Dec 31, 2016

Automatically Closed

Project leader: Baty Florent
Members: Brutsche Martin, Kahlert Christian, Von Mering Christian, Vyas Rounak

​An open-label, crossover, interventional Phase IV study to compare the ease of use of tobramycin inhalation solution and nebulized colistimethate for the treatment of pulmonary Pseudomonas aeruginosa in patients with CF

Clinical Studies - Jul 1, 2014 - Mar 18, 2015

Completed

Project leader: Brutsche Martin
Members: Finger Rebekka

The proposed study will compare vSBP values during physical exercise between patients with COPD and age- and gender-matched controls. We hypothesize that vSBP during the 6MWT is increased in patients with COPD compared to age- and gender matched cont...

Fundamental Research - Mar 10, 2014 - Jun 1, 2015

Completed

Project leader: van Gestel Arnoldus J R
Members: Baty Florent, Brutsche Martin, Gajic Andreja

Randomisierte, doppelblinde, placebokontrollierte, multizentrische Phase-II-Studie zur Bestimmung der Wirksamkeit und der Sicherheit von GS-6624 bei Patienten mit idiopathischer Lungenfibrose

Clinical Studies - Aug 1, 2013 - Aug 1, 2015

Completed

Project leader: Pellet Sarah
Members: Finger Rebekka, Brutsche Martin, Burger Barbara

Background Patients with severe respiratory failure (SRF) are often in need for rapid ventilatory support. Availability of immediate NIV is often limited to the intensive care unit (ICU). We hypothesized that immediate initiation of NIV in the ED is...

Fundamental Research - Jun 1, 2013 - Jan 1, 2015

Completed

Project leader: Rüdiger Jochen, Brutsche Martin
Members: Kleger Gian-Reto, Diethelm Markus, Osterwalder Joseph

Objective 1) To assess safety and tolerability, clinical effects of riociguat. 2) To provide access to riociguat for patients with in-operable chronic thromboembolic pulmonary hypertension (CTEPH), or recurrent or persisting pulmonary hypertension (P...

Clinical Studies - Jun 1, 2013 - Jun 1, 2015

Aborted

Project leader: Brutsche Martin
Members: Pellet Sarah, Finger Rebekka

Genome-wide Gene/Exon expression analysis of late stage NSCLC treated by Erlotinib /Bevacizumab: role of tumor-stroma interactions

Fundamental Research - Feb 1, 2013 - Jun 1, 2015

Completed

Project leader: Baty Florent
Members: Brutsche Martin, Oliver Dürr, Franzini Anca

Lung cancer is the most frequent cause of death in cancer patients in industrialized countries. Most patients with advanced nonsmall cell lung cancer (NSCLC) do not respond to the current treatment schemes indicating that the basic mechanisms of tumo...

Fundamental Research - Jan 1, 2013 - Dec 31, 2014

Completed

Project leader: Ludewig Burkhard, Brutsche Martin
Members: Baty Florent, Novkovic Mario, Onder Lucas

Introduction: The acceptance of positive airway pressure therapy (CPAP) within the first month is a critical aspect of successful OSAS therapy. Telemedicine is a novel tool to supervise CPAP use at patient's home. We report 30-day results of a pilot...

Fundamental Research - Jan 1, 2013 - Mar 1, 2013

Completed

Project leader: Schoch Otto, Brutsche Martin
Members: Baty Florent, Niedermann Jolanda, Rüdiger Jochen

We hypothesize that the use of telemedicine combined with support interventions by short messages, telephone calls and ambulatory visits to control CPAP treatment in OSAS patients during the first month improves adherence and reduces unresolved side...

Clinical Studies - Jan 1, 2013 - Dec 31, 2015

Completed

Project leader: Schoch Otto
Members: Baty Florent, Niedermann Jolanda, Brutsche Martin

Lung cancer remains a health issue with a dismal outcome and evolution in the search of new prognostic markers and therapeutic approaches. To improve research efforts interdisciplinary and multicenter research networks are needed. For competitive tra...

Fundamental Research - Oct 1, 2012 - Dec 31, 2015

Completed

Project leader: Brutsche Martin, Putora Paul Martin
Members: Baty Florent

A multicenter, reandomized, double-blind, single-dose study to assess the effect of the combined inhalation of 150 ug indacaterol maleate (QAB149) and 50 ug glycopyrronium bromide (NVA237) versus inhaled 150 ug indacaterol maleate (QAB149) alone on i...

Clinical Studies - Oct 1, 2012 - Aug 31, 2013

Completed

Project leader: Pellet Sarah
Members: Brutsche Martin, Finger Rebekka, Burger Barbara

The pathophysiology of the adrenal insufficiency of patients with critical diseases remains unclear. In a prior exploratory study investigating patients with exacerbation of chronic obstructive pulmonary disease (COPD), we demonstrated a highly signi...

Fundamental Research - Sep 1, 2012 - Sep 1, 2013

Aborted

Project leader: Rüdiger Jochen
Members: Baty Florent, Bilz Stefan, Lehmann Natalie, Brutsche Martin

Background Only few studies have examined the effect of public smoking bans on respiratory conditions. These showed reduced admission rates for different respiratory diseases. Objective of the present study was to evaluate the effect of the public sm...

Fundamental Research - Sep 1, 2012 - Jun 1, 2013

Completed

Project leader: Baty Florent, Brutsche Martin
Members: Dusemund Frank