Prof Martin Brutsche
Chefarzt Pneumologie und interdisziplinäres Schlafzentrum
chief physician
Pneumologie und Schlafmedizin · Dept. I
Systembiologische Untersuchungen zur molekularen Charakterisierung der Mikroumgebung in Lungentumoren
Jul 1, 2012Das Thema des geplanten Forschungsprojekts sind systembiologische Untersuchungen zur molekularen Charakterisierung der Mikroumgebung in Lungentumoren. Lungenkrebs ist eine der häufigsten Todesursachen in den industrialisierten Ländern. Die meisten Pa...
Fundamental Research - Jul 1, 2012 - Jun 30, 2014
Completed
Project leader: Ludewig Burkhard, Brutsche Martin
Members: Franzini Anca, Tarantino Ignazio
Circulating micro-RNA profiling in patients with advanced non-squamous non small-cell lung cancer receiving bevacizumab/erlotinib first-line treatment followed by platinum-based chemotherapy at disease progression (SAKK 19/05)
Apr 1, 2012Background: This study was initiated by the Swiss Group for Clinical Cancer Research (SAKK) 19/05 study to assess the predictive and prognostic value of circulating miRNA profiles from peripheral blood of patients with non-squamous non small-cell lu...
Fundamental Research - Apr 1, 2012 - Sep 1, 2013
Completed
Project leader: Brutsche Martin
Members: Jörger Markus, Zappa Francesco, Gautschi Oliver, Pless Miklos, Ochsenbein Adrian, Bubendorf Lukas, von Moos Roger, Betticher Daniel, Stahel Rolph, Früh Martin, Baty Florent
A 24 week, randomized, double-blind, multicenter, placebo-controlled efficacy, safety, tolerability and PK trial of Nilotinib (AMN107) in pulmonary arterial hypertension (PAH)
Feb 1, 2012
Clinical Studies - Feb 1, 2012 - Apr 1, 2014
Aborted
Project leader: Brutsche Martin
Members: Burger Barbara, Haider Karin
The obstructive pulmonary disease outcomes cohort of Switzerland (TOP DOCS): phenotypes and vascular amage in COPD
Jan 1, 2012Prospective cohort study including COPD patients from 6 study centers in Northern Switzerland
Fundamental Research - Jan 1, 2012 - Dec 31, 2015
Automatically Closed
Project leader: Brutsche Martin
Members: Rüdiger Jochen, Burger Barbara, Haider Karin
Pleural pharmacokinetics of moxifloxacin and amoxicillin-clavulanate in the context of parapneumonic pleural effusions and empyema
Dec 1, 2011The main objective of the study is the characterization of the PK profiles of moxifloxacin and amoxicillin clavulanate in the pleural fluid of patients with parapneumonic effusions using population PK-analysis. Intra- and interpatient variability wil...
Clinical Studies - Dec 1, 2011 - Dec 31, 2012
Completed
Project leader: Brutsche Martin
Members: Boggian Katia, Jörger Markus, Baty Florent, Ruedlinger Luzia
St. Gallen Lung Biopsy Biobank - An interdisciplinary collaboration in pulmonary medicine
Sep 1, 2011The current project proposes to create a tissue and blood sample collection (biobank) of all patients willing to give informed consent, who are undergoing bronchoscopy and/or surgical lug resection in their diagnostic pathway for any pulmonary diseas...
Fundamental Research - Sep 1, 2011 - Dec 31, 2030
Automatically Closed
Project leader: Brutsche Martin
Members: Baty Florent
Comorbidities and burden of COPD: a population based case-control study
Jun 1, 2011COPD is associated with a relevant burden of disease and a high mortality worldwide. Only recently, the importance of comorbidities of COPD has been recognized. Studies postulated an association with inflammatory conditions potentially sharing pathog...
Fundamental Research - Jun 1, 2011 - Jun 1, 2013
Completed
Project leader: Baty Florent, Brutsche Martin
Members: Putora Paul Martin, Isenring Bruno, Blum Torsten
Eine randomisierte, aktiv kontrollierte, doppelblinde, Double-Dummy, multizentrische Parallelgruppen-Studie zum Vergleich der Wirksamkeit und Sicherheit von 2,5µg und 5 µg Tiotropium-Inhalations-Lösung, inhaliert mittels Respimat®-Inhalator gegenüber Tiotropium-Inhalationskapseln 18µg, inhaliert mittels HandiHaler® TIOSPIR-Studie
May 15, 2010A Randomized, Active-controlled, Double-blind, Double-dummy, Parallel Group Design, Multi-center Trial to Compare the Efficacy and Safety of 2.5 µg and 5 µg Tiotropium Inhalation Solution Delivered by the Respimat Inhaler With Tiotropium Inhalation C...
Clinical Studies - May 15, 2010 - Dec 15, 2013
Completed
Project leader: Brutsche Martin
Members: Baty Florent
An extension study to QTI571A2301 to evaluate the longterm safety, tolerability and efficacy of oral QTI571 (imatinib) in the treatment of severe pulmonary arterial hypertension: IMPRESS Extension
Dec 1, 2009
Clinical Studies - Dec 1, 2009 - Dec 1, 2011
Aborted
Project leader: Brutsche Martin
Members: Baty Florent
A multicenter, double-blind, placebo-controlled phase 3 study to demonstrate the efficacy and safety of ACT-293987 in patients with pulmonary arterial hypertension
Oct 1, 2009The primary objective is to demonstrate the effect of ACT-293987 on time to first clinical worsening in patients with pulmonary arterial hypertension (PAH)
Clinical Studies - Oct 1, 2009 - Apr 1, 2013
Aborted
Project leader: Brutsche Martin
Members: Burger Barbara, Haider Karin, Rüdiger Jochen
A phase IIIb multicenter, 52 week treatment, randomized, blinded, double dummy, parallel group efficacy study comparing the effect of inhaled indacaterol 150ug o.d. vs inhaled tiotropium 18ug o.d. on lung function, rate of exacerbations and related outcomes in patients with COPD
Jul 1, 2009
Clinical Studies - Jul 1, 2009 - Jul 1, 2011
Completed
Project leader: Brutsche Martin
Members: Haider Karin, Burger Barbara
Randomized placebo-controled, double-blind exploratory trial of Bosentan for steroid resistant pulmonary sarcoidosis - the BOSSA study
Jul 1, 2007
Clinical Studies - Jul 1, 2007 - Jul 1, 2013
Completed
Project leader: Brutsche Martin
Members: Baty Florent, Burger Barbara