Pleural pharmacokinetics of moxifloxacin and amoxicillin-clavulanate in the context of parapneumonic pleural effusions and empyema

Project

Pleural pharmacokinetics of moxifloxacin and amoxicillin-clavulanate in the context of parapneumonic pleural effusions and empyema

Completed · 2011 until 2012

Boggian Katia, Jörger Markus, Baty Florent, Brutsche Martin, Ruedlinger Luzia

Type

Clinical Studies

Range

Monocentric project at KSSG

Units

Division of Infectious Diseases, Infection Prevention and Travel Medicine, Medizinische Onkologie und Hämatologie, Pneumologie und Schlafmedizin, Clinical Trials Unit

Status

Completed

Start Date

2011

End Date

2012

Financing

Industry

Study Design

Within-patient design, clinical pharmacology (PK/PD) phase IV study

Keywords

Moxifloxacin, Amoxicillin-Clavulanate, Parapneumonic Pleural Effusion, Pharmacokinetik, PK, PK/PD

Brief description/objective

The main objective of the study is the characterization of the PK profiles of moxifloxacin and amoxicillin clavulanate in the pleural fluid of patients with parapneumonic effusions using population PK-analysis. Intra- and interpatient variability will be assessed, and the quantitative influence of various covariates on the PK-profile of both drugs will be assessed.