Pleural pharmacokinetics of moxifloxacin and amoxicillin-clavulanate in the context of parapneumonic pleural effusions and empyema
Completed · 2011 until 2012
Boggian Katia, Joerger Markus, Baty Florent, Brutsche Martin, Ruedlinger Luzia
The main objective of the study is the characterization of the PK profiles of moxifloxacin and amoxicillin clavulanate in the pleural fluid of patients with parapneumonic effusions using population PK-analysis. Intra- and interpatient variability will be assessed, and the quantitative influence of various covariates on the PK-profile of both drugs will be assessed.