Pleural pharmacokinetics of moxifloxacin and amoxicillin-clavulanate in the context of parapneumonic pleural effusions and empyema

Projekt

Pleural pharmacokinetics of moxifloxacin and amoxicillin-clavulanate in the context of parapneumonic pleural effusions and empyema

Abgeschlossen · 2011 bis 2012

Boggian Katia, Jörger Markus, Baty Florent, Brutsche Martin, Ruedlinger Luzia

Art

Klinische Forschung

Reichweite

Monozentrisch am KSSG

Bereiche

Infektiologie | Infektionsprävention | Reisemedizin, Medizinische Onkologie und Hämatologie, Pneumologie und Schlafmedizin, Clinical Trials Unit

Status

Abgeschlossen

Start

2011

Ende

2012

Finanzierungsart

Industrie

Studiendesign

Within-patient design, clinical pharmacology (PK/PD) phase IV study

Schlagwörter (Tags)

Moxifloxacin, Amoxicillin-Clavulanate, Parapneumonic Pleural Effusion, Pharmacokinetik, PK, PK/PD

Kurzbeschreibung/Zielsetzung

The main objective of the study is the characterization of the PK profiles of moxifloxacin and amoxicillin clavulanate in the pleural fluid of patients with parapneumonic effusions using population PK-analysis. Intra- and interpatient variability will be assessed, and the quantitative influence of various covariates on the PK-profile of both drugs will be assessed.