Projects
Search from 1157 projects:
1157 Project(s)
SAKK 17/16: Lurbinectedin Monotherapy in Pa-tients with Progressive Malignant Pleural Mesothelioma. A Multicenter, Single-arm Phase II Trial
Sep 29, 2017Malignant mesothelioma arises from the mesothelial cells of the pleural, peritoneal or pericardial lining and is often associated with asbestos exposition (Robinson, 2005). There is no cure for most malignant mesotheliomas and the scope of all three...
Clinical Studies - Sep 29, 2017 - Sep 29, 2021
Automatically Closed
Project leader: Früh Martin
SAKK 08/15 PROMET
Sep 27, 2017PROMET - Multicenter, Randomized Phase II Trial of Salvage Radiotherapy +/- Metformin for Patients with Prostate Cancer after Prostatectomy The main objective of the trial is to explore the efficacy of SRT plus metformin compared to SRT in the endpo...
Clinical Studies - Sep 27, 2017 - Oct 7, 2030
Ongoing
Project leader: Putora Paul Martin
Members: Panje Cédric
Randomisierte, doppelblinde, placebokontrollierte Pha-se III-Studie zu Rovalpituzumab Tesirin als Erhaltungs-therapie nach einer Erstlinienchemotherapie auf Platin-basis bei Studienteilnehmern mit ausgebreitetem (exten-sive-stage) kleinzelligem Bronchialkarzinom (MERU)
Sep 22, 2017Industrie gesponserte Studie zur Evaluation der Wirksamkeit (hinsichtlich OS und PFS) von Rovalpituzumab Tesirin beim SCLC, eingesetzt als Erhaltungstherapie nach Erstli-nientherapie. Rovalpituzumab Tesirin ist ein Antikörper-Wirkstoff Konju-gat, wob...
Clinical Studies - Sep 22, 2017 - Mar 31, 2019
Automatically Closed
Project leader: Früh Martin
First Experiences with Screening of Anal Intraepithelial Neoplasia (AIN): a Single Center Retrospective Data-Analysis
Sep 1, 2017Hintergrund Zwischen Human Papilloma Virus (HPV) und Analkrebs besteht eine starke Korrelation. Wie beim Cervixkarzinom der Frau sind mehr als 80% der Analkarzinome durch HPV bedingt. Analkrebs geht meist aus Vorläuferläsionen, den analen intraepithe...
Clinical Studies - Sep 1, 2017 - Sep 2, 2018
Automatically Closed
Project leader: Baumeler Stephan
Members: Maurus Christine, Marti Lukas, Borovicka Jan, Bock Susanne, Bischofberger Stephan, Schmid Patrick
ECARA
Sep 1, 2017Beobachtungsstudie Exploration des klinischen Nutzens von Evolocumab in Kombination mit einem e-Health-System: Schweizerische prospektive Beobachtungsstudie an Patienten mit klinisch manifester atherosklerotischer Herz-Kreislauf-Erkrankung (ASCVD) (E...
Clinical Studies - Sep 1, 2017 - Dec 31, 2018
Completed
Project leader: Bilz Stefan
Members: Dehos Barbara, Räss Andrea
Early versus Late initiation of direct oral Anticoagulants in post-ischaemic stroke patients with atrial fibrillatioN (ELAN): an international, multicentre, randomised-controlled, two-arm, assessor-blinded trial
Aug 31, 2017Inhalt und Ziele des Forschungsprojektes Ein Hirnschlag kann durch ein Vorhofflimmern des Herzens (das heisst unregelmässiger Herzrhythmus) ausgelöst werden. Patienten mit einem solchen Hirnschlag sind einem erhöhten Risiko ausgesetzt weitere Hirnsch...
Clinical Studies - Aug 31, 2017 - Jul 31, 2021
Automatically Closed
Project leader: Vehoff Jochen, Kägi Georg
GA29145
Aug 28, 2017AN OPEN-LABEL EXTENSION AND SAFETY MONITORING STUDY OF PATIENTS WITH MODERATELY TO SEVERELY ACTIVE CROHN’S DISEASE PREVIOUSLY ENROLLED IN THE ETROLIZUMAB PHASE III PROTOCOL GA29144
Clinical Studies - Aug 28, 2017 - Aug 28, 2021
Automatically Closed
Project leader: Borovicka Jan
Members: Dora Barbara, Frei Remus, Knellwolf Christina, Semadeni Gian-Marco, Sulz Michael
The MENAC Trial - A randomised, open-label trial of a multimodal intervention (multimodal = exercise, nutrition and anti-inflammatory medication) versus standard care in cancer patients with cachexia
Aug 24, 2017Cachexia is a common detrimental consequence of cancer limiting therapy, quality of life and survival. There is no standard treatment available and its complex multifactorial pathophysiology requires multimodal treatment. Based on promising phase II...
Clinical Studies - Aug 24, 2017 - May 31, 2020
Automatically Closed
Project leader: Strasser Florian, Domeisen Benedetti Franzisca
Members: Attoun-Knobel Suzanne, Behnke Nadine
TICH-NOAC (Treatment of intracerebral hemorrhage in patients on non-vitamin K oral anticoagulants with tranexamic acid
Aug 22, 2017Neue, direkte, nicht Vitamin-K antagonisierende orale Antikoagulantien (NOAC oder DOAC) sind wirksame Medikamente zur Prophylaxe und Behandlung einer Vielzahl von thrombembolischen Erkrankungen wie zum Beispiel der Hirnschlagprophylaxe bei Patienten...
Clinical Studies - Aug 22, 2017 - Dec 31, 2019
Automatically Closed
Project leader: Kägi Georg
Members: Vehoff Jochen
An open-label, single arm study to evaluate the effectiveness and safety of Ocrelizumab in patients with early stage relapsing remitting Multiple Sclerosis
Aug 14, 2017Ziel der Studie ist es herauszufinden, ob Ocrelizumab (das Prüfpräparat) die Verschlechterung der Anzeichen und Symptome Ihrer Multipler Sklerose (MS) im Frühstadium zum Stillstand bringt.
Clinical Studies - Aug 14, 2017 - Dec 31, 2021
Automatically Closed
GA29144/Bergamot
Aug 1, 2017A PHASE III, RANDOMIZED, DOUBLEBLIND, PLACEBOCONTROLLED, MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF ETROLIZUMAB AS AN INDUCTION AND MAINTENANCE TREATMENT FOR PATIENTS WITH MODERATELY TO SEVERELY ACTIVE CROHN’S DISEASE
Clinical Studies - Aug 1, 2017 - Aug 1, 2021
Automatically Closed
Project leader: Borovicka Jan, Brand Stephan
Members: Dora Barbara, Frei Remus, Knellwolf Christina, Semadeni Gian-Marco, Sulz Michael
ICL670, Deferasirox
Aug 1, 2017A phase II, multicenter, open-label, randomized two-year study to evaluate the efficacy and safety of deferasirox film-coated tablet versus phlebotomy in patients with Hereditary Hemochromatosis
Clinical Studies - Aug 1, 2017 - Jan 1, 2020
Completed
Project leader: Semela David
Members: Stillhard Roman
LEADERS FREE III
Aug 1, 2017A study evaluating the safety and efficacy of the BioFreedomTM Biolimus A9TM coated Cobalt Chromium coronary stent system in patients at high risk of bleeding. The objective of this study is to evaluate if the BioFreedomTM CoCr Drug Coated stent has...
Clinical Studies - Aug 1, 2017 - Dec 31, 2021
Completed
Project leader: Weilenmann Daniel
Members: Vetsch Susanne
CLL13-TRIAL OF THE GCLLSG IN COOPERATION WITH HOVON, NORDIC CLL STUDY GROUP AND SAKK (THE GA101 IBRUTINIB ABT101 (GAIA) TRIAL): A PHASE 3 MULTICENTER, RANDOMIZED, PROSPECTIVE, OPEN-LABEL TRIAL OF STANDARD CHEMOIMMUNOTHERAPY (FCR/BR) VERSUS RITUXIMAB PLUS VENETOCLAX (RVE) VERSUS OBINUTUZUMAB (GA101) PLUS VENETOCLAX (GVE) VERSUS OBINUTUZUMAB PLUS IBRUTINIB PLUS VENETOCLAX (GIVE) IN FIT PATIENTS WITH PREVIOUSLY UNTREATED CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) WITHOUT DEL(17P) OR TP53 MUTATION
Jul 17, 2017Chemoimmunotherapy is the standard of care in first-line treatment of CLL patients without del17p or TP 53 mutation; physically fit patients are treated with fludarabine, cyclophosphamide and rituximab (FCR)1. Due to the high risk of severe neutropen...
Clinical Studies - Jul 17, 2017 - Feb 29, 2024
Automatically Closed
Project leader: Baumann Michael
QLQ-CAX24 Phase4
Jul 17, 2017The aim of the present study is to test the scale structure, reliability, responsiveness to change and validity of the EORTC QLQ-CAX24 in conjunction with the EORTC QLQ-C30 in people diagnosed with cancer cachexia with different primary cancer diagno...
Clinical Studies - Jul 17, 2017 - Oct 1, 2017
Automatically Closed
Project leader: Strasser Florian
Members: Domeisen Benedetti Franzisca, Attoun-Knobel Suzanne
TOASST
Jul 8, 2017Die Studie soll die Hypothese prüfen, dass auch nach längerer Behandlungsdauer mit Prednison®, Spiricort® oder einem verwandten Produkt auf ein langsames Ausschleichen der Dosis verzichtet werden darf, ohne dass dadurch ein schlechterer Verlauf resul...
Clinical Studies - Jul 8, 2017 - Jun 8, 2020
Automatically Closed
Project leader: Brändle Michael
Members: Hörburger David, Baerlocher Lorenz
ENTRUST DSE-EDO-01-15-EU
Jul 7, 2017Beurteilung der Sicherheit und Wirksamkeit eines Edoxabanbasierten , verglichen mit einem Vitamin-K-Antagonist-basierten, antithrombotischen Therapieregimes nach einer erfolgreichen perkutanen Koronarintervention (PCI) mit Stent-Implantation, bei Pat...
Clinical Studies - Jul 7, 2017 - Jul 7, 2021
Completed
Project leader: Rickli Hans
Members: Gemperle Michaela
Stressbewältigung und Teamstärkung durch Achtsamkeit: Mindfulness Based Intervention
Jul 3, 2017Background Reforms within the health care system subject the entire working conditions, in particular physician- or nurse-patient relation, to the principles of cost-effectiveness with consecutively increasing time pressure. As consequence, stress re...
Clinical Studies - Jul 3, 2017 - Dec 31, 2020
Completed
Project leader: Müller-Käser Iris
Members: Schlaeppi Marc, Fringer André
TOASST
Jul 1, 2017Die Studie soll die Hypothese prüfen, dass auch nach längerer Behandlungsdauer mit Prednison®, Spiricort® oder einem verwandten Produkt auf ein langsames Ausschleichen der Dosis verzichtet werden darf, ohne dass dadurch ein schlechterer Verlauf resul...
Clinical Studies - Jul 1, 2017 - Dec 31, 2025
Ongoing
Project leader: Brändle Michael
Members: Drescher Tilman, Baerlocher Lorenz, Hörburger David, Räss Andrea, Grillmayr Victoria
Preclinical investigation of cardiotoxicity as a clinically important side effect of proteasome inhibitor-based therapy
Jul 1, 2017Carfilzomib is the recently approved second generation proteasome inhibitor for multiple myeloma therapy. Carfilzomib has superior clinical activity than the first generation drug, bortezomib, putatively due to less off-target activity and an altered...
Fundamental Research - Jul 1, 2017 - Jun 30, 2018
Automatically Closed
Project leader: Besse Lenka
Members: Mendez Lopez Max