Projects
Search from 1157 projects:
1157 Project(s)
WIN: Worldwide registry to assess the STENTYS XPOSITION S for revascularization of coronary arteries In routine cliNical practice
Jan 27, 2017To assess the long term safety and efficacy of the XPOSITION S STENT in routine clinical practice. Inclusion of subjects with coronary artery disease, including patients with chronic stable angina, silent ischemia and acute coronary syndrome, who qua...
Clinical Studies - Jan 27, 2017 - Jan 31, 2020
Completed
Project leader: Weilenmann Daniel
Members: Schneider Irene
Dissecting the association of the human palatine tonsil microbiome and HPV-driven oropharyngeal squamous cell carcinoma
Jan 1, 2017Oropharyngeal squamous cell carcinoma (OPSCC) can be caused by viral transformation of epithelial cells in the oropharynx such as high risk-human papilloma virus (HR-HPV). Importantly, the incidence of OPSCC has been increasing during the last decade...
Fundamental Research - Jan 1, 2017 - Dec 31, 2018
Automatically Closed
Project leader: Ludewig Burkhard
Members: Broglie Däppen Martina, Stöckli Sandro, Cupovic Jovana
M14-533
Jan 1, 2017A Phase 3 Multicenter, Long-Term Extension Study to Evaluate the Safety and Efficacy of Upadacitinib (ABT-494) in Subjects with Ulcerative Colitis
Clinical Studies - Jan 1, 2017 - Dec 1, 2022
Automatically Closed
Project leader: Sulz Michael
Members: Smolders Jolijn, Brand Stephan
Amyloidosis Registry
Jan 1, 2017
Clinical Studies - Jan 1, 2017 - Dec 31, 2030
Ongoing
Project leader: Hitz Felicitas
Members: Steiner Marianne
HEMATITE
Dec 16, 2016Quality of Life measurement using wrist actigraph in HCV genotype 1 infected, Treatment naive patients suffering from fatique and receiving Viekirax/Exviera.
Clinical Studies - Dec 16, 2016 - Dec 16, 2018
Completed
Project leader: Semela David
Members: Stillhard Roman
ETNA-AF
Dec 6, 2016Nicht-interventionelle Studie zur Edoxaban-Therapie in der klinischen Routinepraxis bei Patienten mit nicht-valvulärem Vorhofflimmern (Non-interventional study on Edoxaban Treatment in routiNe clinical prActise for patients with non valvular Atrial F...
Clinical Studies - Dec 6, 2016 - Dec 15, 2021
Completed
Project leader: Ammann Peter
Members: Gemperle Michaela, Altmann David
Maximise
Dec 5, 2016MAXIMISE (Managing AXIal Manifestations in PsorIatic Arthritis with SEcukinumab), a randomized, double-blind, placebo-controlled, multicenter, 52-week study to assess the efficacy and safety of secukinumab 150 mg or 300 mg s.c. in patients with activ...
Clinical Studies - Dec 5, 2016 - Sep 13, 2019
Completed
Project leader: Rubbert-Roth Andrea
Members: Bartz-Batliner Mira, Hutz Carina Liane, Forrer Silvia
Mongersen GED-0301
Dec 1, 2016A Phase 3, randomized, double-blind, placebo-controlled, multicenter study to investigate the efficacy and safety of mongersen (GED-0301) for the treatment of subjects with active Crohn’s disease.
Clinical Studies - Dec 1, 2016 - Dec 1, 2018
Completed
Members: Dora Barbara, Knellwolf Christina, Krieger-Grübel Claudia, Sulz Michael
PCG-4/UCR
Dec 1, 2016Randomized, double-blind, double-dummy, placebo-controlled, Phase III clinical trial on the efficacy and safety of a 48-weeks treatment with gastroresistant phosphatidylcholine (LT-02) versus placebo versus mesalamine for maintenance of remission in...
Clinical Studies - Dec 1, 2016 - Dec 1, 2018
Completed
Members: Dora Barbara, Knellwolf Christina, Krieger-Grübel Claudia, Sulz Michael
Abbvie M14-234
Dec 1, 2016A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of ABT-494 for Induction and Maintenance Therapy in Subjects with Moderately to Severely Active Ulcerative Colitis
Clinical Studies - Dec 1, 2016 - Dec 1, 2018
Automatically Closed
Members: Dora Barbara, Knellwolf Christina, Krieger-Grübel Claudia, Sulz Michael
FIDELIO
Dec 1, 2016Wirksamkeit und Sicherheit von Finerenon bei Patienten mit Typ-2-Diabetes mellitus und der klinischen Diagnose einer diabetischen Nephropathie Eine randomisierte, doppelblinde, placebokontrollierte, multizentrische, Ereignis-gesteuerte Parallelgrupp...
Clinical Studies - Dec 1, 2016 - Aug 31, 2020
Completed
Project leader: Bilz Stefan
Members: Dehos Barbara, Jenni Vera, Räss Andrea
A multicenter, randomized, 52-week, double-blind, parallel group, active controlled study to compare the efficacy and safety of QVM149 with QMF149 in patients with asthma
Nov 11, 2016Asthma is a serious global health problem affecting all age groups. Despite existing therapies, there are significant unmet medical needs in treating asthma. Novartis is developing QVM149, a fixed-dose combination (FDC) of indacaterol acetate, an inh...
Clinical Studies - Nov 11, 2016 - Mar 31, 2018
Automatically Closed
Project leader: Brutsche Martin
Members: Baty Florent, Schlotter Sandra
SAKK 24/14: Anti-EGFR-immunoliposomes loaded with doxorubicin in patients with advanced triple negative EGFR positive breast cancer – A multicenter single arm phase II trial
Nov 7, 2016Advanced triple negative breast cancer (TNBC) is a highly chemosensitive disease displaying a dismal short-term prognosis with more than three quarters of patients in pro-gression 12 months after the initiation of conventional chemotherapy. Approxima...
Clinical Studies - Nov 7, 2016 - May 31, 2023
Automatically Closed
Project leader: Weder Patrik
FERINJECT
Nov 1, 2016Ferric carboxymaltose is an effective parenteral therapy for iron deficiency. Because of the limited resorption and side effects of oral iron supplements parenteral iron preparations are preferred in post bariatric surgery patients to maintain normal...
Clinical Studies - Nov 1, 2016 - Jul 1, 2018
Completed
Project leader: Bilz Stefan
Members: Schöb Manuela, Räss Andrea
HIV-Proteaseinhibitoren als Basis für Krebstherapie: Verständnis des Mechanismus, Identifikation der Targets, Entwicklung wirksamerer Substanzen
Nov 1, 2016Proteasominhibitor-Resistenz ist ein wichtiger unmet clinical need beim Multiplen Myelom (MM). Die Aktivität von next generation therapy (Daratumumab, Carfilzomib, Pomalidomid) ist hier bei ca. 30 % Partialremissionen (PR). Wir haben in vitro durch...
Fundamental Research - Nov 1, 2016 - Oct 31, 2018
Automatically Closed
Project leader: Driessen Christoph
Members: Kraus Marianne, Bader Juergen, Besse Lenka, Besse Andrej
SAKK 30/15; HOVON 135: A randomized phase II multicenter study to assess the to erability and efficacy of the addition of ibrutinib to 10-day decitabine in UNFIT (i.e. HCT-CI ≥ 3) AML and high risk myelodysplasia (MDS) (IPSS-R > 4.5) patients aged ≥ 66 years. A study in the frame of the masterprotocol of parallel randomized phase II studies in UNFITolder AML/high-risk MDS patients
Oct 27, 2016This is a prospective, open label, multicenter study that is conducted in the frame of a masterprotocol with multiple parallel randomized phase II arms. The scheme of this design consists of one arm with the standard treatment for AML (the 10-day dec...
Clinical Studies - Oct 27, 2016 - Jul 31, 2018
Automatically Closed
Project leader: Fehr Martin
CA209-577: A Randomized, Multicenter, Double Blind, Phase III Study of Nivolumab or Placebo in Subjects with Resected Lower Esophageal, or Gastroesophageal Junction Cancer (CheckMate 577: CHECKpoint pathway and nivoluMab clinical Trial Evaluation 577)
Oct 21, 2016CA209577 is a phase 3, randomized, double-blind, placebo controlled study of adjuvant nivolumab in subjects with resected esophageal cancer (EC), or gastroesophageal junction (GEJ) cancer who have received chemoradiother-apy(CRT) followed by surgery....
Clinical Studies - Oct 21, 2016 - Nov 30, 2017
Automatically Closed
Project leader: Weisshaupt Christian
BIOSTEMI und BIOSTEMI Ext
Oct 12, 2016Mit dieser Studie wird die Sicherheit und Effektivität von zwei medikamentenbeschichteten Stents bei Patienten, die einen STEMI erlitten haben verglichen. Es wird geprüft, ob der Stent mit einer selbst auflösenden Beschichtung bei Patienten mit einem...
Clinical Studies - Oct 12, 2016 - Dec 30, 2023
Completed
Project leader: Weilenmann Daniel
Members: Schneider Irene
PhenoTox: Hunting the missing heritability of early-onset fluoropyrimdine-related toxicity in cancer patients: an observational multi-center study
Oct 4, 2016In cancer patients receiving fluoropyrimidine-based chemo-therapy, there is extensive inter-individual variability in plasma drug concentrations and the severity of chemo-therapy-related toxicity. A strong association has been shown for plasma concen...
Clinical Studies - Oct 4, 2016 - Feb 27, 2024
Completed
Project leader: Jörger Markus
IDN-6556-14 NASH und Emricasan
Sep 14, 2016A Multicenter, Randomized, Double-Blind, Placebo- Controlled Trial of Emricasan, an Oral Caspase Inhibitor, in Subjects with Non-Alcoholic Steatohepatitis (NASH) Cirrhosis and Severe Portal Hypertension
Clinical Studies - Sep 14, 2016 - Sep 14, 2021
Aborted
Project leader: Semela David
Members: Alfter Christine