Projects
Search from 1157 projects:
1157 Project(s)
Exploring indirect embryo-fetal risks of nanomaterials: Interference with inflammatory, vascular and endocrine signaling from human placental tissue
Oct 1, 2018Nanomaterialien können Gewebebarrieren wie Lunge und Darm durchdringen und im Körper zu Schädigungen in Zellen und Geweben führen. Während der Schwangerschaft ist ein Kontakt mit Nanomaterialien besonders problematisch, da der Fötus sehr empfindlich...
Fundamental Research - Oct 1, 2018 - Sep 30, 2021
Automatically Closed
Project leader: Buerki-Thurnherr Tina
Members: Hornung René, Jochum Wolfram, Patrycja Nowak-Sliwinska
Effectiveness of a multidimensional mobile app intervention "WOMAN-PRO III" to reduce postsurgical symptom induced distress in patients with vulvar neoplasia: A mixed methods project
Oct 1, 2018This mixed methods project aims to examine the effectiveness of a multidimensional mobile app intervention (“WOMAN-PRO III”) focusing on possible improvements with the use of the new mobile app intervention (intervention group) compared to standardiz...
Fundamental Research - Oct 1, 2018 - Dec 31, 2020
Automatically Closed
Project leader: Senn B, Hornung René, Kipp B, Gyr T
Members: Ott S, Lux W
Identifying and targeting the “Achilles’ heel” in proteasome inhibitor-resistant multiple myeloma
Oct 1, 2018The proposal aims at understanding the biology of proteasome inhibitor (PI)-refractory multiple myeloma (MM), in particular the specific vulnerabilities of PI-refractory MM, or so called “Achilles’ heel”, towards development of novel treatment option...
Fundamental Research - Oct 1, 2018 - Dec 31, 2021
Automatically Closed
Project leader: Driessen Christoph
Members: Besse Andrej, Kraus Marianne, Besse Lenka, Mendez Lopez Max
CORBUS: Lenabasum bei diffuser systemischer Sklerose
Sep 25, 2018A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial to Evaluate Efficacy and Safety of Lenabasum in Diffuse Cutaneous Systemic Sclerosis
Clinical Studies - Sep 25, 2018 - Sep 27, 2021
Aborted
Project leader: Rubbert-Roth Andrea
Members: Hutz Carina Liane, Bartz-Batliner Mira, Neumann Thomas
Randomisierte klinische Studie zum Vergleich der Vollständigkeit der adjuvanten Chemotherapie nach früher vs. später Stomarückverlagerung bei Patienten mit Rektumkarzinom nach tiefer anteriorer Resektion
Sep 24, 2018Ziel der CoCStom-Studie ist es, den optimalen Zeitpunkt der Rückverlagerung eines künstlichen Darmausgangs (Stoma) zu ermitteln, der im Rahmen der chirurgischen Entfernung des Mastdarms beim lokal fortgeschrittenen Enddarmkrebs (Rektumkarzinom) vorüb...
Clinical Studies - Sep 24, 2018 - Nov 30, 2020
Completed
Project leader: Marti Lukas, Kienle P, Hofheinz R
Members: Beutner Ulrich, Gueller Ulrich, Brunner Walter, Bischofberger Stephan
A Phase 1 Multiple-Ascending-Dose Study to Assess the Safety, Tolerability, and Pharmacokinetics of BIIB078 Administered Intrathecally to Adults with C9ORF72-Associated Amyotrophic Lateral Sclerosis
Sep 10, 2018The primary objective of this study is to evaluate the safety and tolerability of BIIB078 in adults with C9ORF72-Amyotrophic Lateral Sclerosis (ALS). The secondary objectives of this study are to evaluate the pharmacokinetic profile of BIIB078 and to...
Clinical Studies - Sep 10, 2018 - Nov 17, 2021
Completed
Project leader: Weber Markus
Members: Neuwirth Christoph, Braun Nathalie
International Randomised Controlled Trial for the Treatment of Newly Diagnosed Ewing’s Sarcoma Family of Tumours
Aug 30, 2018The objective of the induction/consolidation chemotherapy randomisation (R1) is to compare the VIDE strategy (VIDE induction and VAI/VAC/BuMel consolidation) with the VDC/IE strategy (compressed VDC/IE induction and IE/VC/Bu-Mel consolidation). The e...
Clinical Studies - Aug 30, 2018 - Aug 14, 2014
Automatically Closed
Project leader: Appenzeller Christina
Alternate day dosing of Pomalidomide in patients with re-fractory Multiple
Aug 17, 2018Multiple myeloma (MM) accounts for 1% of all cancers and ∼10% of all hematological malignancies. Despite recent advances in myeloma treatment, including the introduction of proteasome inhibitors, immunomodulatory drugs (IMiDs) and stem cell transplan...
Clinical Studies - Aug 17, 2018 - Apr 23, 2023
Automatically Closed
Project leader: Silzle Tobias
The role of the sensory trick in gating multimodal afferents in adult-onset idiopathic cervical dystonia
Aug 15, 2018The ‘sensory trick’ (ST) refers to a particular manoeuver e.g. slightly touching the face, which is capable of significantly ameliorating the abnormal head posture in patients with cervical dystonia (CD) (synonym: torticollis). The benefit is sometim...
Fundamental Research - Aug 15, 2018 - Jul 31, 2020
Automatically Closed
Project leader: Brugger Florian
Members: Kägi Georg
Abbvie M15-925: A Phase 3, Randomized, Active-Controlled,
Aug 15, 2018
Clinical Studies - Aug 15, 2018 - Aug 16, 2024
Completed
Project leader: Hutz Carina Liane, Rubbert-Roth Andrea
Members: Bartz-Batliner Mira, Neumann Thomas
Arimoclomol in Amyotropic Lateral Sclerosis
Jul 31, 2018A multicenter, randomized, double-blind, placebo-controlled, parallel group trial to evaluate the efficacy and safety of arimoclomol in amyotropic lateral sclerosis (ALS)
Clinical Studies - Jul 31, 2018 - Dec 18, 2020
Aborted
Project leader: Neuwirth Christoph
Tailored AXILLary Surgery with or without axillary lymph node dissection followed by radotherapy in patients with clinically node-positive breast cancer (TAXIS)
Jul 30, 2018The removal of all lymph nodes in the armpit through con-ventional axillary dissection has been standard care for all patients with breast cancer for almost a century. In the nineties, the sentinel lymph node (SLN) procedure, which involves the selec...
Clinical Studies - Jul 30, 2018 - Dec 12, 2030
Ongoing
Project leader: Bekes Inga
Members: Sennhauser Andrina, Müller Fiona
An Observatinal Study of Blinatumomab Safety and Effec-tiveness, Utillisation, and Treatment Practice
Jul 11, 2018Study Background and Rationale As a new treatment for acute lymphoblastic leukaemia (ALL), it is important tounderstand the safety and effective-ness of Blincyto (blinatumomab) as it isadministered in routine clinical practice. This study, developed...
Clinical Studies - Jul 11, 2018 - Feb 22, 2022
Automatically Closed
Project leader: Silzle Tobias
Deciphering the transcriptomic landscape of cancer-associated fibroblasts in pancreatic cancer – an exploratory clinical study
Jul 1, 2018Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancer types with a 5-year survival of only 7% 1. While surgical resection of localized disease offers a moderate increase in survival, patients with metastatic pancreas cancer are...
Fundamental Research - Jul 1, 2018 - Dec 31, 2018
Completed
Project leader: Ludewig Burkhard
Members: Lütge Mechthild
STEP 4
Jun 5, 2018Effect and safety of semaglutide 2.4 mg once-weekly in subjects with overweight or obesity who have reached target dose during run-in period
Clinical Studies - Jun 5, 2018 - May 31, 2020
Completed
Project leader: Bilz Stefan
Members: Sigrist Sarah, Aczel Stefan, Räss Andrea
Randomisierte, offene, multizentrische Phase-2/3-Studie zur Beurteilung der Wirksamkeit und Sicherheit von Ro-garatinib (BAY 1163877) im Vergleich zu Chemotherapie bei Patienten mit FGFR-positivem, lokal fortgeschritte-nem oder metastatischem Urothelkarzinom, die vorher eine platinhaltige Chemotherapie erhalten haben
May 30, 2018Rogaratinib ist ein oraler pan-FGFR inhibitor. Eine FGFR-Überexpression (vorallem FGFR3 isoform) kann in bis zu 40% aller Patienten mit metastasiertem Urothelkarzinom nachgewiesen werden und stellt einen oncogenic driver da. Die Studie untersucht Rog...
Clinical Studies - May 30, 2018 - Dec 31, 2030
Ongoing
Project leader: Schmid Sabine
Patient-needs-based multi-professional delivery of Palliative Interventions by oncologists’ and oncology nurses: a randomized Phase II trial
May 22, 2018Background: Evidence is emerging that early specialist palliative care (SPC) is effective in several defined clinical settings and that it consists of a variety of definable palliative interventions (PCI). PCI encompass pharmacological, procedural, e...
Clinical Studies - May 22, 2018 - May 22, 2018
Automatically Closed
Members: Schmidt Mary Helen, Domeisen Benedetti Franzisca, Attoun-Knobel Suzanne, Behnke Nadine
Multicentre Oberservational Study of MDS Patients in Switzerland- Swiss MDS Registry
May 17, 2018Die Myelodysplastischen Syndrome (MDS) umfassen eine heterogene Gruppe hämatologischer Stammzellerkran-kungen, welche durch Reifungsstörungen des Knochen-markes (Dysplasien) mit Verminderung der Blutzellen (Zy-topenien) charakterisiert sind. Das Spek...
Clinical Studies - May 17, 2018 - Aug 14, 2030
Ongoing
Project leader: Silzle Tobias
Members: Steiner Marianne
Takotsubo - Clinical Characteristics of Takotsubo Cardiomyopathy
Apr 1, 2018Takotsubo Cardiomyopathy, or broken heart syndrome, is a recently described acquired form of cardiomyopathy whose pathophysiology is not well understood and particularly affects postmenopausal women. The exact mechanism is still unclear and large p...
Clinical Studies - Apr 1, 2018 - Dec 31, 2030
Ongoing
Project leader: Jörg Lucas
Members: Fink Karin, Schneider Irene
Evaluation von Superb Microvascular Imaging (SMI) zur Beurteilung von Gallenblasenpolypen
Mar 1, 2018Gallenpolypen stellen eine heterogene Entität dar. Einerseits kann es sich um Cholesterolpolypen ohne weiteren Krankheitswert handeln. Andererseits kann es sich um echte Adenome mit einem mit ihrer Grösse zunehmenden malignen Potential handeln. Zie...
Clinical Studies - Mar 1, 2018 - Dec 31, 2019
Automatically Closed
Project leader: Sawatzki Mikael, Baumeler Stephan