Projects
Search from 1157 projects:
1157 Project(s)
Immune-modulatory radiotherapy to enhance the effects of neoadjuvant PD - L1 blockade after neoadjuvant chemotherapy in patients with resectable stage III ( N2) non -small cell lung cacner (NSCLC)
Apr 29, 2020Evaluation einer immunmodulatorischen neoadjuvanten Radiotherapie in verschiedenen Dosen nach neoadjuvanter Chemotherapie mit Cisplatin und Docetaxel bei Patienten mit operablem, lokal fortgeschrittenem (Stadium IIIA) Nicht-Kleinzelligen Bronchialkar...
Clinical Studies - Apr 29, 2020 - Aug 24, 2030
Ongoing
Project leader: Früh Martin
Members: Sakic Miranda, Müller Fiona
Study to Assess the Safety, Tolerability, Pharmacokinetics, and Effect on Disease Progression of BIIB078 Administered to Previously Treated Adults C9ORF72-Associated Amyotrophic Lateral Sclerosis (ALS)
Apr 28, 2020The primary objective is to evaluate the long-term safety and tolerability of BIIB078 in participants with chromosome 9 open reading frame 72-amyotrophic lateral sclerosis (C9ORF72-ALS). The secondary objective is to evaluate the pharmacokinectic (P...
Clinical Studies - Apr 28, 2020 - Jul 28, 2023
Automatically Closed
Project leader: Weber Markus
Members: Neuwirth Christoph, Braun Nathalie
A Phase I/IIA, Multi-Centre, Open-Label, Dose-Escalation Study with Expansion Arms to Assess the Safety, Tolera-bility, Pharmacokinetics and Preliminary Efficacy of CB-103 Administered Orally in Adult Patients with Locally Ad-vanced or Metastatic Solid Tumour Malignancies Charac-terised by Alterations of the NOTCH Signalling Pathway
Apr 17, 2020This study is designed as an open label, non-randomised, uncontrolled Phase I/IIA dose escalation study with expan-sion cohorts of CB-103 administered orally on a once-daily schedule, based on a 28-day treatment cycle. The admin-istration schedule ma...
Clinical Studies - Apr 17, 2020 - May 26, 2030
Ongoing
Project leader: Hess Dagmar
Protocol SAKK 80/20 Outcome and prognostic factors of SARS CoV-2 infection in cancer patients: A corss - sectional study
Apr 14, 2020The COVID-19 pandemic, caused by the SARS-CoV-2 virus, poses a major challenge for global health care systems, as virus spreads fast and recent data point to >10% of severe cases, requiring hospitalization and/or treatment in the intensive care unit....
Clinical Studies - Apr 14, 2020 - Apr 28, 2021
Automatically Closed
SWISS-AF Burden
Apr 6, 2020Health consequences of the Burden of atrial fibrillation The added information of measuring AF burden and measuring cardiac dimensions and function in an AF patient population where brain MRIs are available, could provide further evidence toward...
Clinical Studies - Apr 6, 2020 - Apr 6, 2024
Completed
Project leader: Ammann Peter
Members: Altmann David, Fink Karin
ALXN1210-ALS-308: An Efficacy and Safety Study of Ravulizumab in ALS Patients
Mar 30, 2020The purpose of the study is to assess the efficacy and safety of ravulizumab for the treatment of adult participants with ALS.
Clinical Studies - Mar 30, 2020 - Oct 17, 2021
Aborted
Project leader: Neuwirth Christoph
Members: Weber Markus, Braun Nathalie
A Phase 3, Randomized, Double-blind Trial of Pembrolizumab (MK3475) Plus Enzalutamide Plus ADT Versus Placebo Plus Enzalutamide Plus ADT in Participants With Metastatic HormoneSensitive Prostate Cancer (mHSPC) (KEYNOTE-991)
Mar 3, 2020While many men diagnosed with locally confined disease may be treated definitively with radiation or surgery, ap-proximately 30% of men have recurrent disease and go on to develop metastatic prostate cancer. In addition, 5% to 30% of men with prostat...
Clinical Studies - Mar 3, 2020 - Mar 10, 2030
Ongoing
Project leader: Omlin Aurelius
Members: Rothermundt Christian, Aeppli Stefanie
Phase 3, Randomized, Open Label Study to Compare Nivolumab plus Concurrent Chemoradiotherapy (CCRT) followed by Nivolumab plus Ipilimumab or Nivolumab plus CCRT Followed by Nivolumab vs CCRT followed by Durvalumab in Previously Untreat-ed, Locally Advanced Non-small Cell Lung Cancer (LA NSCLC)
Mar 3, 2020CA20973L is a phase 3, randomized, open label study to compare nivolumab plus concurrent chemoradiotherapy (CCRT) followed by nivolumab plus ipilimumab or nivolumab alone versus CCRT followed by durvalumab in previously untreated locally advanced non...
Clinical Studies - Mar 3, 2020 - Mar 10, 2029
Ongoing
Project leader: Früh Martin
Revealing molecular basis of cardiotoxicity of carfilzomib towards its safer use in the patients with multiple myeloma
Mar 1, 2020
Fundamental Research - Mar 1, 2020 - Feb 28, 2021
Automatically Closed
Project leader: Besse Lenka
Members: Mendez Lopez Max
Swiss Multicenter Randomized Controlled Trial on different Limb Lengths in Gastric Bypass Surgery
Mar 1, 2020Obesity and type 2 diabetes mellitus (T2DM) are reaching epidemic proportions in the developed world. In morbidly obese patients only surgical treatment (bariatric operations) leads to a sustained weight loss and relief of co-morbidities in the major...
Clinical Studies - Mar 1, 2020 - Feb 28, 2027
Ongoing
Project leader: Peterli Ralph, Folie Patrick
Members: Aczel Stefan, Falconnier Claudine, Greifnieder Dietlind, Schmid Mathias, Lisarelli Loriana, Oettli Seraina, Seiler Edith, Bilz Stefan, Sigrist Sarah
A randomized, open-label, phase I/II open platform study evaluating safety and efficacy of novel ruxolitinib combina-tions in myelofibrosis patients
Feb 14, 2020Myelofibrosis (MF) is defined by progressive bone marrow (BM) fibrosis and a consecutive reduction of blood cells. The disrup-tion of the medullary erythropoietic niche is the primary mecha-nism governing the bone marrow failure and anemia, which typ...
Clinical Studies - Feb 14, 2020 - Feb 20, 2024
Automatically Closed
BIOMASTER BIOMONITOR III
Feb 10, 2020This study is a post-market clinical follow-up (PMCF) study to identify and evaluate residual risks associated with the use of the BIOMONITOR III that are discovered or remain even after risk analysis, risk mitigation and successful conformity assess...
Clinical Studies - Feb 10, 2020 - Jan 21, 2022
Completed
Project leader: Ammann Peter
Members: Schneider Irene
IgPro20_3007: RECLAIM
Feb 5, 2020A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of IgPro20 (Subcutaneous Immunoglobulin, Hizentra®) in Adults with Dermatomyositis (DM)
Clinical Studies - Feb 5, 2020 - Dec 30, 2025
Ongoing
Project leader: Rubbert-Roth Andrea
Members: Hutz Carina Liane, Bartz-Batliner Mira, Peischl Riana, Sasselli Clelia
PACIFIC AF
Jan 21, 2020Multicenter, randomized, active comparator-controlled, double-blind, double-dummy, parallel group, dose-finding Phase 2 study to compare the safety of the oral FXIa inhibitor BAY 2433334 to apixaban in patients with atrial fibrillation Primary Safet...
Clinical Studies - Jan 21, 2020 - Dec 7, 2021
Completed
Project leader: Rickli Hans
Members: Fink Karin, Vetsch Susanne
KSSG Collaborative Brain Tumour Registry
Jan 16, 2020Primary brain tumours remain an important burden of disease in Switzerland. Between 2010 – 2014, there were 1570 incident cases and about 580 deaths attributed to brain tumours each year. Although tumours of the central nervous system (CNS) represent...
Clinical Studies - Jan 16, 2020 - Jan 16, 2025
Ongoing
Project leader: Zeitlberger Anna, Hundsberger Thomas
Geringfügig induzierte Wehen bei einem geplanten Kaiserschnitt sollen das Befinden beim Neugeborenen und der Mutter verbessern – eine randomisierte Studie
Jan 1, 2020
Clinical Studies - Jan 1, 2020 - Dec 31, 2021
Automatically Closed
Project leader: Burkhardt T
Members: Fischer Tina
Metabolism of antiretroviral drugs in HIV infected patients with toxicity – a pilot study
Jan 1, 2020Antiretroviral drugs can be responsible for a wide range of toxic side effects ranging from acute events to long-term toxicity. We hypothesize that the microbiome-mediated metabolism plays a substantial role in antiretroviral drug toxicity through se...
Clinical Studies - Jan 1, 2020 - Dec 31, 2020
Automatically Closed
Project leader: Notter Julia, Zimmermann Michael, Kahlert Christian
Checkmate 73L (CA20973L)
Jan 1, 2020A Phase 3, Randomized, Open Label Study to Compare Nivolumab plus Concurrent Chemoradiotherapy (CCRT) followed by Nivolumab plus Ipilimumab or Nivolumab plus CCRT Followed by Nivolumab vs CCRT followed by Durvalumab in Previously Untreated, Locally A...
Clinical Studies - Jan 1, 2020 - Dec 11, 2023
Automatically Closed
Members: Glatzer Markus
Evaluation of the route of delivery after cesarean birth
Jan 1, 2020Diese single-center, retrospektive Studie beschäftigt sich mit der Entbindungsmethode von Frauen mit Status nach Sectio caesarea. Mit Hilfe der geburtshilflichen Datenbank Peridata analysieren wir die Entbindungsmethode (vaginale Entbindung vs. Re-Se...
Clinical Studies - Jan 1, 2020 - Dec 14, 2020
Automatically Closed
Project leader: Winder Franziska
Members: Tschenett Romina, Fischer Tina
Patienten Charakteristika und Outcome in Frauen mit klinischer Diagnose einer intrauterinen Infektion oder Inflammation oder beides (Triple I)
Jan 1, 2020Diese single-center, retrospektive Studie beschäftigt sich mit der Definition und klinischen Umsetzung von Triple I (intrauterine Infektion oder Inflammation oder beides) im Kantonsspital St. Gallen. Mit Hilfe der geburtshilflichen Datenbank Peridata...
Clinical Studies - Jan 1, 2020 - Dec 31, 2020
Automatically Closed
Project leader: Winder Franziska
Members: Becker Claudia, Fischer Tina