Projects
Search from 1157 projects:
1157 Project(s)
ETOP 15-19 ABC Lung A randomised non-comparative open label phase II trial of atezolizumab plus bevacizumab, with carboplatin-paclitaxel or pemetrexed, in EGFR-mutant non-small cell lung carci-noma with acquired resistance ABC-lung:
Jul 22, 2020Activating mutations in the epidermal growth factor recep-tor (EGFR) are identified in 15% of Non-Small Cell Lung Cancer. Despite the success of targeted treatment, ac-quired resistance and disease progression inevitably occur. A number of mechanisms...
Clinical Studies - Jul 22, 2020 - Aug 11, 2025
Ongoing
A PHASE II, MULTICENTRE, OPEN-LABEL STUDY OF CABOZANTINIB AS 2ND LINE TREATMENT IN SUBJECTS WITH UNRESECTABLE, LOCALLY ADVANCED OR METASTATIC RENAL CELL CARCINOMA WITH A CLEAR-CELL COMPONENT WHO PROGRESSED AFTER 1ST LINE TREATMENT WITH CHECKPOINT INHIBITORS
Jul 17, 2020Multizentrische Studie bei Patienten mit metastasiertem Nierenzellkarzinom nach Progredienz unter einer Erstli-nientherapie mit ICI/ICI oder ICI/TKI Kombination zur Eva-luation der Wirksamkeit und Verträglichkeit des Tyrosin-kinase Inhibitors Cabozan...
Clinical Studies - Jul 17, 2020 - Jul 17, 2022
Automatically Closed
Project leader: Rothermundt Christian
Members: Aeppli Stefanie, Fischer Stefanie, Omlin Aurelius
Observational study of the use of venetoclax in patients with chronic lymphocytic leukemia (CLL) under real-life setting in Austria,Germany and Switzerland (VeRVe)
Jul 15, 2020
Clinical Studies - Jul 15, 2020 - Dec 31, 2030
Ongoing
VeRVe: Observational study of the use of venetoclax in patients with chronic lymphocytic leukemia (CLL) under real-life setting in Austria,Germany and Switzerland (Venetoclax Real Value)
Jul 15, 2020
Clinical Studies - Jul 15, 2020 - Sep 27, 2022
Automatically Closed
Project leader: Baumann Michael
XATOC – Xarelto + Acetylsalicylic Acid
Jul 14, 2020Treatment patterns and Outcomes across the disease Continuum in patients with CAD and/or PAD The study aims to collect real-world data on treatment patterns and decision points for treatment in patients with coronary artery disease (CAD) or sym...
Clinical Studies - Jul 14, 2020 - Apr 14, 2023
Completed
Project leader: Rickli Hans
Members: Fink Karin
Cruz HBR
Jul 13, 2020Post-market registry to evaluate the safety and efficacy of the Supraflex Cruz™ sirolimus-eluting coronary stent system in the treatment of all-comer patients with coronary artery disease
Clinical Studies - Jul 13, 2020 - Dec 31, 2022
Completed
Project leader: Weilenmann Daniel
Members: Schneider Irene, Fink Karin
CAIN457Q12301
Jul 13, 2020A two-year, phase III randomized, double-blind, parallel- group, placebo- controlled trial to evaluate the safety, efficacy, and tolerability of 300 mg s.c. secukinumab versus placebo in combination with SoC therapy in patients with active lupus neph...
Clinical Studies - Jul 13, 2020 - Jul 12, 2023
Automatically Closed
Project leader: Rubbert-Roth Andrea
Members: Bartz-Batliner Mira, Hutz Carina Liane, Peischl Riana, Sasselli Clelia
Protocol SAKK 11/16: Personalized and cell-based anti-tumor immunization MVX-ONCO-1 in advanced head and neck squamous cell carcinoma. A single arm, open label, multicenter phase II trial
Jul 10, 2020MVX-ONCO-1 is a form of active specific immunotherapy, a process by which the patient’s immune response to tumor cells is stimulated and/or augmented. MVX-ONCO-1 is a patient specific, cell-based, immunotherapy composed of: a. An immune-modulator (...
Clinical Studies - Jul 10, 2020 - Nov 8, 2023
Completed
Project leader: Rordorf Tamara
A Randomized, Double-blind, Adaptive, Phase II/III Study of GSK3359609 or Placebo in Combination with Pembroli-zumab for First-Line Treatment of PD-L1 Positive Recur-rent/Metastatic Head and Neck Squamous Cell Carcinoma
Jul 10, 2020The study will evaluate the efficacy of GSK3359609 in combination with pembrolizumab compared with pem-brolizumab plus placebo as a standard first-line chemo-therapy-free regimen in HNSCC. All participants will be stratified by 2 factors i) PD-L1 CPS...
Clinical Studies - Jul 10, 2020 - Jul 31, 2021
Automatically Closed
Project leader: Jörger Markus
Characterization of Patients Utilizing Complementary Medicine at a Tertiary Referral Hospital in Eastern Switzerland
Jul 7, 2020Mit der vorliegenden Studie sollen Daten von Patienten, die eine Therapie im ZIM in Anspruch genommen haben, nach demografischen und krankheits-spezifischen Charakteristika ausgewertet werden. Dies ermöglicht die Anpassung des bestehenden Angebotes a...
Clinical Studies - Jul 7, 2020 - Jul 7, 2021
Completed
Project leader: Schlaeppi Marc, Templeton Arnoud
Members: Schlegel Tiffany
Lymphopenie bei myeloproliferativen Neoplasien: Prävalenz und prognostische Bedeutung
Jul 1, 2020Eine Lymphopenie als Ausdruck einer Störung des adaptiven Immunsystems ist ein etablierter Risikofaktor bei verschiedenen Allgemein- und Tumorerkrankungen. Im Hinblick auf myeloische Neoplasien konnte im Rahmen eines Kooperationsprojektes des KSSG m...
Clinical Studies - Jul 1, 2020 - Jun 30, 2022
Automatically Closed
Project leader: Silzle Tobias
Members: Messerich Nora-Medea, Cogliatti Sergio B., Lehmann Thomas, Graf Lukas
SANTORINI
Jul 1, 2020To assess the characteristics and management of very high risk and high risk patients requiring lipid modifying therapies and the use of healthcare resources associated with current patient management strategies, particularly with respect to the prev...
Clinical Studies - Jul 1, 2020 - Jun 30, 2022
Automatically Closed
Project leader: Bilz Stefan
Members: Räss Andrea, Grillmayr Victoria
PHPT/ FHH-Studie
Jul 1, 2020Primary hyperparathyroidism and familial hypocalciuric hypercalcemia: evaluation of calciuria in spot urine and 24-hours urine sample
Clinical Studies - Jul 1, 2020 - Dec 31, 2024
Ongoing
Project leader: Bilz Stefan
Members: Siegenthaler Martin, Koster Markus, Räss Andrea, Grillmayr Victoria
Psychotraumatologie in der somatischen Medizin - Vorsorgesprechstunde Frauenklinik
Jul 1, 2020Traumatisierungen sind klinisch hoch relevant, gerade auch in den medizinisch-somatischen Fachgebieten. Trotz Fortschritten in den letzten Jahrzehnten ist deren klinische Versorgung noch unzureichend – mit ungünstigen gesundheitlichen Auswirkungen fü...
Clinical Studies - Jul 1, 2020 - Dec 31, 2021
Completed
Project leader: Schmid Dagmar
Members: Hornung René, Schmidt Roger, Krolak Monika, Nobel Gloria, Germann Nicolas, Schönenberger Michelle, Hämmerli Keller Katja
The molecular landscape of proteasome inhibitor resistance of multiple myeloma in vivo
Jul 1, 2020We here aim to dissect the molecular landscape of MM that is acquiring resistance to the most active PI, carfilzomib (CFZ) in vivo. We therefore here extend our model to orthotopic growth conditions of MM in murine bone marrow under continuous select...
Fundamental Research - Jul 1, 2020 - Dec 31, 2023
Automatically Closed
Project leader: Driessen Christoph
Members: Besse Andrej, Schwestermann Jonas, Kraus Marianne, Besse Lenka
Transcriptomic analysis of fibroblasts in brain tumors – an exploratory study
Jun 19, 2020The aim of this study was to evaluate to what extent the fibroblastic landscape is remodelled in human brain metastases and to employ high-resolution transcriptomic and histological analyses to characterize cancer-associated fibroblasts in these CNS...
Fundamental Research - Jun 19, 2020 - Aug 2, 2024
Completed
Project leader: Pikor Natalia
Prospective observational cohort study to investigate long-term pulmonary and extrapulmonary effects of COVID-19
Jun 15, 2020
Clinical Studies - Jun 15, 2020 - Dec 15, 2021
Automatically Closed
Project leader: Brutsche Martin
Members: Baty Florent
GO41717: A Phase III, randomized, double-blinded, place-bo-controlled study of Tiragolumab, an Anti-Tigit Antibody, in combination with Atezolizumab compared with placebo in combination with Atezolizumab in patients with previously untreated locally advanced unresectable or metastatic PD-L1 selected Non-Small Cell Lung Cancer
Jun 11, 2020This study will evaluate the efficacy and safety of ti-ragolumab plus atezolizumab compared with placebo plus atezolizumab in patients with previously untreated locally advanced, unresectable or metastatic programmed deathligand 1 (PD-L1)selected n...
Clinical Studies - Jun 11, 2020 - Dec 12, 2024
Scheduled
A3BAD study - Analysis of amyloid aggregates in blood with atomic force microscopy as a biomarker of Alzheimer Dementia
Jun 1, 2020Background: The key neuropathological feature of Alzheimer disease (AD) is the accumulation of extracellular β-amyloid (Aβ) plaques in the brain which begins long before clinical signs of dementia. Immunotherapies targeting Aβ may prevent Aβ accumula...
Fundamental Research - Jun 1, 2020 - May 30, 2022
Automatically Closed
Project leader: Felbecker Ansgar
Members: Schneider Thomas, Nirmjaraj Peter
Nerve ultrasound as a predictive tool of autonomic dysfunction in Guillain-Barré-Syndrom: a pilot study
May 25, 2020Beim Guillain-Barré-Syndrom (GBS) handelt es sich um eine akute immunvermittelte Polyneuropathie (PNP) mit potentiell lebensbedrohlichen Komplikationen wie respiratorischer Insuffizienz und Herzrhythmusstörungen. Ein frühzeitiges Erkennen der Erkrank...
Fundamental Research - May 25, 2020 - May 24, 2022
Automatically Closed