Projects
Search from 1157 projects:
1157 Project(s)
COVI-PREG - Internationales Register von Patientin, für die eine SARS-CoV-2 Infektion während der Schwangerschaft vermutet wird
Jan 1, 2020
Fundamental Research - Jan 1, 2020 - Dec 31, 2021
Automatically Closed
Project leader: Baud David
Members: Panchaud Alice, Fischer Tina
Potential treatment approach for severe preeclampsia by using nanoparticles
Jan 1, 2020Preeclampsia is a severe pregnancy associated disease. An antiangiogenic environment is created by an excessive production of sFlt-1. The only current therapeutic option is delivery of the child and placenta. First experimental evidence for the thera...
Fundamental Research - Jan 1, 2020 - Dec 31, 2021
Automatically Closed
Project leader: Herrmann Inge
Members: Rduch Thomas, Fischer Tina, Hornung René
Predictive markers for checkpoint-based immunotherapy in advanced non-small cell lung cancer
Jan 1, 2020The aim of this study is to elucidate a novel biomarker constellation with superior predictive value for PD-1/PD-L1-targeted immunotherapy in advanced non-small cell lung cancer.
Fundamental Research - Jan 1, 2020 - Dec 31, 2021
Completed
Project leader: Bösch Maximilian
Members: Baty Florent, Brutsche Martin, Früh Martin, Jörger Markus
Nanopartikel und Fremdstoffe an der menschlichen Plazenta: Transport, Aufnahme und biologische Effekte
Jan 1, 2020Ziel dieser Untersuchungen ist es herauszufinden, wie sich Fremdstoffe oder Nanomaterialien, inklusive endogene Kalkpartikel, an der Plazentaschranke verhalten, z. B. wie rasch und in welcher Konzentration sie vom mütterlichen in das kindliche Blut g...
Fundamental Research - Jan 1, 2020 - Dec 31, 2021
Automatically Closed
Project leader: Bürki Tina, Fischer Tina
Members: Aengenheister Leonie, Dugershaw Battuja, Chortarea Savvina, Hannig Yvette, Rduch Thomas, Herrmann Inge, Hornung René
EMCL-Registry of the European Mantle Cell Lymphoma study group
Dec 20, 2019Klinisches Register des „Europäischen Mantelzelllymphom Netzwerk (EMCL)“. Erfassung von Patienten mit neu diag-nostiziertem oder rezidiviertem Mantelzelllymphom
Clinical Studies - Dec 20, 2019 - Dec 20, 2025
Ongoing
Project leader: Fehr Martin
EMCL-Registry of the European Mantle Cell Lymphoma study group
Dec 20, 2019
Clinical Studies - Dec 20, 2019 - Dec 31, 2030
Ongoing
Project leader: Fehr Martin
Members: Steiner Marianne
A phase 3, multicenter, double-blind, randomized, placebo-controlled study of ivosidenib or enasidenib in combination with induction therapy and consolidation therapy followed by maintenancetherapy in patients with newly diagnosed acute myeloid leukemia or myelodysplastic syndrome with excess blasts-2, with an IDH1 or IDH2 mutation, respectively, eligible for intensive chemotherapy.
Dec 18, 2019IDH1 or IDH2 mutations are each found in about 10% of AML – and specific inhibitors are approved or in development in this indication. The primary objective of this study is to compare event-free survival (EFS) between ivosidenib/enasidenib and pl...
Clinical Studies - Dec 18, 2019 - Jan 31, 2027
Ongoing
Project leader: Schittenhelm Marcus
Members: Kehl Jeanine, Quinter Janine
A PHASE 3, MULTICENTER, RANDOMIZED, OPEN-LABEL,
Dec 15, 2019Palliative systemic treatment option in Her2 low patients after one, max. 2 chemotherapy lines
Clinical Studies - Dec 15, 2019 - Dec 10, 2022
Automatically Closed
SMArtCare: Longitudinal data assessment from patients with spinal muscular atrophy
Dec 9, 2019Erfassung klinischer Barameter bei Patienten mit SPinaler Muskelatrophie mit und ohne krankheitsmodifizeirende Therapie. Registerstudie.
Clinical Studies - Dec 9, 2019 - Dec 31, 2030
Ongoing
Project leader: Neuwirth Christoph
A Phase 1b/2 Multicenter, Open-label, Expansion Study to As-sess the Safety and Efficacy of AMG 420 as Monotherapy in Subjects With Relapsed and/or Refractory Multiple Myeloma
Dec 5, 2019Bispezifische, T-Zell-aktivierende Antikörper (BITE) sind eine vielversprechende Option, um eine zellvermittelte Immuntherapie von Tumoren zu erreichen. In der vorlie-genden Studie wird die Wirksamkeit und Sicherheit eines gegen das Oberflächenantige...
Clinical Studies - Dec 5, 2019 - Dec 23, 2020
Automatically Closed
Project leader: Driessen Christoph
Members: Silzle Tobias
Six-Minute Walking Test (6WT) as a measure of objective functional impairment in lumbar spinal stenosis. Validation and realtionship to subjective measure of pain, function and quality of life
Dec 1, 2019Background: Lumbar spinal stenosis (LSS) is a progressive, degenerative disorder of the aging spine presenting with lower back pain, which commonly progresses into neurogenic claudication which impedes walking. The precise measurement of symptom seve...
Clinical Studies - Dec 1, 2019 - May 1, 2022
Automatically Closed
Project leader: Maldaner Nicolai
XATOA – Xarelto + Acetylsalicylic Acid: Treatment
Nov 19, 2019The study aims to collect real-world data on treatment patterns and decision points for treatment in patients with coronary artery disease (CAD) or symptomatic peripheral artery disease (PAD) treated with rivaroxaban 2.5 mg[BID] for the prevention of...
Clinical Studies - Nov 19, 2019 - Dec 21, 2021
Completed
Project leader: Rickli Hans
Members: Fink Karin
Developing an EEG-based approach to DBS-frequency modulation in Parkinson’s disease
Nov 1, 2019
Clinical Studies - Nov 1, 2019 - Dec 31, 2021
Automatically Closed
Project leader: Brugger Florian
Members: Dorin Patrick
Regionale Netzwerke für die fachärztliche Weiterbildung
Nov 1, 2019Netzwerke sind modern und gelten auch als Hoffnungsträger für die fachärztliche Weiterbildung. Inwieweit vermeintliche Vorteile vom ärztlichen Nachwuchs tatsächlich als solche wahrgenommen werden, ist jedoch unklar. Das Forschungsprojekt sollte kläre...
Healthcare Research - Nov 1, 2019 - Jan 31, 2022
Completed
Project leader: Thanner Mirjam
Members: Winder Franziska, Schlegel A, Von Szadkowski C, Hornung René
RA Bridge
Oct 3, 2019A Randomized, Active-Controlled, Parallel-Group, Phase 3b/4 Study of Baricitinib in Patients with Rheumatoid Arthritis
Clinical Studies - Oct 3, 2019 - Jul 30, 2023
Automatically Closed
Project leader: Rubbert-Roth Andrea
Members: Bartz-Batliner Mira, Neumann Thomas, Sasselli Clelia, Peischl Riana
Swiss Severe Asthma Register
Oct 1, 2019
Clinical Studies - Oct 1, 2019 - Dec 31, 2021
Automatically Closed
Project leader: Kern Lukas
Members: Baty Florent, Widmer Sandra, Brutsche Martin
STOP FLU
Oct 1, 2019Die jährliche Impfung ist die vorrangige Strategie zur Grippevorbeugung und wird für Transplantationspatienten dringend empfohlen. Leider ist die Wirksamkeit des Standardimpfstoffes bei Patienten, welche eine Organtransplantation hatten, im Vergleich...
Clinical Studies - Oct 1, 2019 - Jul 1, 2020
Completed
Project leader: Binet Françoise-Isabelle
Arimoclomol in Amyotropic Lateral Sclerosis - Open Label Extension Trial
Sep 19, 2019A multicenter, non-randomized, open label trial, to assess long term safety and efficacy of Arimoclomol in subjects with Amyotrophic Lateral Sclerosis (ALS)who have completed the ORARIALS-01 trial.
Clinical Studies - Sep 19, 2019 - Jul 2, 2021
Aborted
Project leader: Neuwirth Christoph
SAKK 66/18: A phase Ib trial of copanlisib in combina-tion with venetoclax in patients with relapsed or refrac-tory lymphoma
Sep 13, 2019A significant number of patients with non-Hodgkin lym-phoma (NHL) are not cured with available treatments and will eventually relapse. Those patients might not be able to tolerate more bone marrow toxicity, limiting their treatment options. Preclinic...
Clinical Studies - Sep 13, 2019 - Dec 31, 2022
Automatically Closed
Project leader: Hess Dagmar
A phase I/Ib, open-label, multi-center dose escalation study of NIS793 in combination with PDR001 in adult patients with advanced malignancies (CNIS793X2101)
Sep 9, 2019This is a first-in-human (FIH), open label, phase I/Ib, multi-center study which consists of: - a dose escalation part of NIS793 as single agent and in combination with PDR001. Patients treated with NIS793 single agent will switch to NIS793 in combin...
Clinical Studies - Sep 9, 2019 - Jul 1, 2021
Automatically Closed
Project leader: Jörger Markus