Projects
Search from 1157 projects:
1157 Project(s)
Resistance Development in Escherichia coli at different pH following Delafloxacin and Ciprofloxacin Challenge
Jan 1, 2021Delafloxacin , a novel dual-targeting non-zwitterionic fluoroquinolone, has received approval by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for the treatment of acute bacterial skin and skin structure infectio...
Fundamental Research - Jan 1, 2021 - Jan 1, 2023
Automatically Closed
Project leader: Babouee Flury Baharak
Translation of pre-treatment tumor kinetics and clinical and serological markers of the immune system in the treatment of advanced melanoma
Jan 1, 2021Bei diesem Projekt geht es um die Charakterisierung des Therapieansprechens von Melanommetastasen unter Systemtherapie mit anti-PD-1 Antikörpern, kombinierter Immuntherapie mit dem anti-PD-1 Antikörper Nivolumab und dem anti-CTLA-4 Antikörper Ipilimu...
Clinical Studies - Jan 1, 2021 - Dec 31, 2021
Completed
Project leader: Wagner Nikolaus
Decision-Making Analysis of next generation sequencing in glioblastoma in Switzerland
Jan 1, 2021Glioblastoma is the most frequent and most malignant primary brain tumour with an annual incidence of 3.2/100’000 1,2. The combination of histopathological features (nuclear atypia, mitosis, neoangiogenesis and/or necrosis) and molecular aberrations...
Clinical Studies - Jan 1, 2021 - Dec 1, 2021
Automatically Closed
Members: Putora Paul Martin
Towards identification of novel therapeutic targets: Assessment of proteasome-related alterations in MM patients’ datasets
Jan 1, 2021
Fundamental Research - Jan 1, 2021 - Dec 31, 2021
Automatically Closed
Project leader: Besse Lenka, Buljan Marija
Members: Besse Andrej
Clinical evaluation of a standard treatment algorithm for midshaft clavicle fractures
Jan 1, 2021The aim of this research project is to evaluate the evidence-based treatment standard for patients with midshaft clavicle fractures using an algorithmic approach in a Swiss multi-centre, prospective data collection. This algorithm includes not only t...
Register - Jan 1, 2021 - Dec 31, 2025
Ongoing
Project leader: Spross Christian
Members: Jost Bernhard, Zdravkovic Vilijam, Schöfl Thomas, Farei-Campagna Jan M
Diagnostic role of the "white test" with lipidic solution in the early intraoperative identification of open bile ducts for the prevention of bile leakage after liver resection - A randomized controlled multicentric superiority trial.
Jan 1, 2021Bile leakage (BL) is the most frequent complication after liver resection leading to the need of interventional drainage, ERCP or even reoperation. Strategies leading to a reduction of the rate of this complication are valuable. SMOFlipid 20% is a fa...
Clinical Studies - Jan 1, 2021 - Dec 31, 2024
Ongoing
Project leader: Tarantino Ignazio
Swiss Soliris® and Ultomiris® Reimbursement Registry SSURR: An observational registry for capturing data of patients suffering from paroxysmal nocturnal hemoglobinuria (PNH) who are treated with Soliris® (eculizumab) or Ultomiris® (ravulizumab)
Jan 1, 2021
Clinical Studies - Jan 1, 2021 - Dec 31, 2030
Ongoing
Project leader: Silzle Tobias
Members: Demmer-Steingruber Ruth, Müller Fiona
Swiss Primary Hypersomnolence and Narcolepsy Cohort Study
Jan 1, 2021
Clinical Studies - Jan 1, 2021 - Dec 31, 2023
Completed
Project leader: Von Manitius Sigrid
Members: Zieglgänsberger Dominik, Gievers-Steinlein Bettina
CATCH - Cascade genetic testing of familial hypercholesterolemia: the CATCH multicenter randomized controlled trial
Dec 15, 2020To test in a multicenter open-label randomized controlled trial across Switzerland whether a cascade screening programme for FH, in comparison with usual care, will increase the detection rate of FH within families. The primary outcome will be the...
Clinical Studies - Dec 15, 2020 - Mar 31, 2024
Completed
Project leader: Rickli Hans
Members: Vetsch Susanne, Schneider Irene
SILENT 2
Dec 4, 2020Incidence of Silent Atrial Fibrillation in Patients With Clinically Silent Brain Ischemic Lesions Arterial Fibrillation (AF) is well-recognized as a cause for cryptogenic Acute Ischemic Stroke (AIS) and is associated with Silent Brain Infarction...
Clinical Studies - Dec 4, 2020 - Dec 4, 2024
Ongoing
Project leader: Ammann Peter, Kägi Georg
Members: Brenner Roman, Vetsch Susanne, Schneider Irene
Smartphone-Enabled Detection of COugh in COvid-19 (COCO): An Exploratory, Single-Center, Observational Cohort Study
Dec 3, 2020
Clinical Studies - Dec 3, 2020 - Dec 3, 2020
Automatically Closed
Project leader: Rassouli Frank
Members: Bösch Maximilian, Brutsche Martin, Tinschert Peter, Barata Filipe, Shih Iris
Validation of a textile-based monitoring device for the continuous surveillance of respiratory activity in patients during sedation
Dec 1, 2020
Clinical Studies - Dec 1, 2020 - Nov 30, 2021
Automatically Closed
ASSESS
Dec 1, 2020A randomized, double-blind, placebo-controlled, multi-Center Phase 2 study to assess the efficacy and safety of oral BAY 2327949 in patients with clinical diagnosis of chronic kidney disease due to diabetes or hypertension and at least one cardiovasc...
Clinical Studies - Dec 1, 2020 - Dec 31, 2021
Aborted
Project leader: Bilz Stefan
Members: Räss Andrea, Grillmayr Victoria
COMET-T
Dec 1, 2020Nicht-interventionelle, multizentrische, prospektive Studie zur Erfassung der glykämischen Variabilität in Diabetes mellitus Typ 1 Patienten nach Umstellung auf Insulin glargin 300 E/ml (Gla-300) (wegen unzureichender glykämischer Kontrolle) in Kom...
Clinical Studies - Dec 1, 2020 - Mar 1, 2022
Automatically Closed
Project leader: Bilz Stefan
Members: Räss Andrea, Grillmayr Victoria
XLH-Register
Dec 1, 2020An international, multicenter, prospective, non-interventional registry for patients with X-linked hypophosphatemia (XLH)
Clinical Studies - Dec 1, 2020 - Dec 31, 2030
Ongoing
Project leader: Bilz Stefan
Members: Räss Andrea, Grillmayr Victoria
Validation of COVID-19 risk stratification algorithms based on sTREM-1 and IL-6 in Emergency Departments: a retrospective multicenter cohort study
Dec 1, 2020We will retrospectively select SARS-CoV-2 infected adults who attended the ED of St.Gallen and Bellinzona. We want to measure the concentrations from stored blood samples of: Biomarkers of immune dysfunction: e.g., C reactive protein, procalciton...
Clinical Studies - Dec 1, 2020 - Apr 28, 2023
Completed
Project leader: Albrich Werner
The Role of the Inorganics in Preeclampsia Assessed by Multiscale Characterization of Placentae
Nov 1, 2020
Fundamental Research - Nov 1, 2020 - Dec 30, 2021
Automatically Closed
Project leader: Herrmann Inge
Members: Rduch Thomas, Gogos Alexander, Tsolaki Elena, Leschka Sebastian, Born Diana, Fischer Tina, Hornung René
Development of a non-invasive screening system for the early detection of mild cognitive impairments in older adults
Nov 1, 2020In dem geförderten Kooperationsprojekt “Development of a non-invasive screening system for the early detection of mild cognitive impairments in older adults” wird untersucht, ob ein multimodales nicht-invasives Testsystem geeignet ist, um frühe Stadi...
Clinical Studies - Nov 1, 2020 - Jul 1, 2021
Automatically Closed
Project leader: Felbecker Ansgar
Members: Schneider Thomas
IFX-1-P2.5
Nov 1, 2020a randomized, double-blind, double-dummy, active-controlled, multicenter, 2-part Phase 2 study on replacement of steroids by IFX-1 in active granulomatosis with polyangiitis (GPA) and microscopic polyangitis (MPA)
Clinical Studies - Nov 1, 2020 - Nov 1, 2021
Completed
Project leader: Neumann Thomas
Members: Peischl Riana, Rubbert-Roth Andrea
BMS CA209-914 (Checkmate 914)A Phase 3 Randomized, Double-Blind Study of Nivolumab Monotherapy
Oct 29, 2020The current standard treatment for early stage (l-lll) renal cell cancer (RCC) is surgery. While the prognosis of stage I tumors is excellent, stage II and particularly stage III have a high risk of relapse and represent a high unmet medical need. Th...
Clinical Studies - Oct 29, 2020 - Sep 30, 2030
Ongoing
Project leader: Rothermundt Christian