Projekte
Suche in 1164 Projekten:
1164 Projekt(e)
PHPT/ FHH-Studie
01.07.2020Primary hyperparathyroidism and familial hypocalciuric hypercalcemia: evaluation of calciuria in spot urine and 24-hours urine sample
Klinische Forschung - 01.07.2020 - 31.12.2024
Laufend
Projektleitung: Bilz Stefan
Mitarbeiter/innen: Siegenthaler Martin, Koster Markus, Räss Andrea, Grillmayr Victoria
Psychotraumatologie in der somatischen Medizin - Vorsorgesprechstunde Frauenklinik
01.07.2020Traumatisierungen sind klinisch hoch relevant, gerade auch in den medizinisch-somatischen Fachgebieten. Trotz Fortschritten in den letzten Jahrzehnten ist deren klinische Versorgung noch unzureichend – mit ungünstigen gesundheitlichen Auswirkungen fü...
Klinische Forschung - 01.07.2020 - 31.12.2021
Abgeschlossen
Projektleitung: Schmid Dagmar
Mitarbeiter/innen: Hornung René, Schmidt Roger, Krolak Monika, Nobel Gloria, Germann Nicolas, Schönenberger Michelle, Hämmerli Keller Katja
The molecular landscape of proteasome inhibitor resistance of multiple myeloma in vivo
01.07.2020We here aim to dissect the molecular landscape of MM that is acquiring resistance to the most active PI, carfilzomib (CFZ) in vivo. We therefore here extend our model to orthotopic growth conditions of MM in murine bone marrow under continuous select...
Grundlagenforschung - 01.07.2020 - 31.12.2023
Automatisch geschlossen
Projektleitung: Driessen Christoph
Mitarbeiter/innen: Besse Andrej, Schwestermann Jonas, Kraus Marianne, Besse Lenka
Transcriptomic analysis of fibroblasts in brain tumors – an exploratory study
19.06.2020The aim of this study was to evaluate to what extent the fibroblastic landscape is remodelled in human brain metastases and to employ high-resolution transcriptomic and histological analyses to characterize cancer-associated fibroblasts in these CNS...
Grundlagenforschung - 19.06.2020 - 02.08.2024
Abgeschlossen
Projektleitung: Pikor Natalia
Prospective observational cohort study to investigate long-term pulmonary and extrapulmonary effects of COVID-19
15.06.2020
Klinische Forschung - 15.06.2020 - 15.12.2021
Automatisch geschlossen
Projektleitung: Brutsche Martin
Mitarbeiter/innen: Baty Florent
GO41717: A Phase III, randomized, double-blinded, place-bo-controlled study of Tiragolumab, an Anti-Tigit Antibody, in combination with Atezolizumab compared with placebo in combination with Atezolizumab in patients with previously untreated locally advanced unresectable or metastatic PD-L1 selected Non-Small Cell Lung Cancer
11.06.2020This study will evaluate the efficacy and safety of ti-ragolumab plus atezolizumab compared with placebo plus atezolizumab in patients with previously untreated locally advanced, unresectable or metastatic programmed deathligand 1 (PD-L1)selected n...
Klinische Forschung - 11.06.2020 - 12.12.2024
Geplant
A3BAD study - Analysis of amyloid aggregates in blood with atomic force microscopy as a biomarker of Alzheimer Dementia
01.06.2020Background: The key neuropathological feature of Alzheimer disease (AD) is the accumulation of extracellular β-amyloid (Aβ) plaques in the brain which begins long before clinical signs of dementia. Immunotherapies targeting Aβ may prevent Aβ accumula...
Grundlagenforschung - 01.06.2020 - 30.05.2022
Automatisch geschlossen
Projektleitung: Felbecker Ansgar
Mitarbeiter/innen: Schneider Thomas, Nirmjaraj Peter
Nerve ultrasound as a predictive tool of autonomic dysfunction in Guillain-Barré-Syndrom: a pilot study
25.05.2020Beim Guillain-Barré-Syndrom (GBS) handelt es sich um eine akute immunvermittelte Polyneuropathie (PNP) mit potentiell lebensbedrohlichen Komplikationen wie respiratorischer Insuffizienz und Herzrhythmusstörungen. Ein frühzeitiges Erkennen der Erkrank...
Grundlagenforschung - 25.05.2020 - 24.05.2022
Automatisch geschlossen
SAKK 16/18: Strahlentherapie zur Verstärkung des Effekts einer prä-operativen (vor der Tumor-Operation) Immuntherapie bei Patienten mit lokal fortgeschrittenem nicht-kleinzelligem Bronchuskarzinom (NSCLC). Eine Phase-II-Studie, welche an mehreren Spitälern durchgeführt wird.
29.04.2020Wir wollen mit dieser Studie eine neue Therapieoption bei Patienten mit lokal fortgeschrittenem nicht-kleinzelligem Lungenkrebs (NSCLC) prüfen. Die Frage ist, ob eine zusätzliche Tumorbestrahlung die Wirkung einer Immuntherapie vor der Tumoroperation...
Klinische Forschung - 29.04.2020 - 24.08.2030
Laufend
Projektleitung: Früh Martin
Mitarbeiter/innen: Sakic Miranda, Müller Fiona
Study to Assess the Safety, Tolerability, Pharmacokinetics, and Effect on Disease Progression of BIIB078 Administered to Previously Treated Adults C9ORF72-Associated Amyotrophic Lateral Sclerosis (ALS)
28.04.2020The primary objective is to evaluate the long-term safety and tolerability of BIIB078 in participants with chromosome 9 open reading frame 72-amyotrophic lateral sclerosis (C9ORF72-ALS). The secondary objective is to evaluate the pharmacokinectic (P...
Klinische Forschung - 28.04.2020 - 28.07.2023
Automatisch geschlossen
Projektleitung: Weber Markus
Mitarbeiter/innen: Neuwirth Christoph, Braun Nathalie
A Phase I/IIA, Multi-Centre, Open-Label, Dose-Escalation Study with Expansion Arms to Assess the Safety, Tolera-bility, Pharmacokinetics and Preliminary Efficacy of CB-103 Administered Orally in Adult Patients with Locally Ad-vanced or Metastatic Solid Tumour Malignancies Charac-terised by Alterations of the NOTCH Signalling Pathway
17.04.2020This study is designed as an open label, non-randomised, uncontrolled Phase I/IIA dose escalation study with expan-sion cohorts of CB-103 administered orally on a once-daily schedule, based on a 28-day treatment cycle. The admin-istration schedule ma...
Klinische Forschung - 17.04.2020 - 26.05.2030
Laufend
Projektleitung: Hess Dagmar
Protocol SAKK 80/20 Outcome and prognostic factors of SARS CoV-2 infection in cancer patients: A corss - sectional study
14.04.2020The COVID-19 pandemic, caused by the SARS-CoV-2 virus, poses a major challenge for global health care systems, as virus spreads fast and recent data point to >10% of severe cases, requiring hospitalization and/or treatment in the intensive care unit....
Klinische Forschung - 14.04.2020 - 28.04.2021
Automatisch geschlossen
SWISS-AF Burden
06.04.2020Health consequences of the Burden of atrial fibrillation The added information of measuring AF burden and measuring cardiac dimensions and function in an AF patient population where brain MRIs are available, could provide further evidence toward...
Klinische Forschung - 06.04.2020 - 06.04.2024
Abgeschlossen
Projektleitung: Ammann Peter
Mitarbeiter/innen: Altmann David, Fink Karin
ALXN1210-ALS-308: An Efficacy and Safety Study of Ravulizumab in ALS Patients
30.03.2020The purpose of the study is to assess the efficacy and safety of ravulizumab for the treatment of adult participants with ALS.
Klinische Forschung - 30.03.2020 - 17.10.2021
Abgebrochen
Projektleitung: Neuwirth Christoph
Mitarbeiter/innen: Weber Markus, Braun Nathalie
A Phase 3, Randomized, Double-blind Trial of Pembrolizumab (MK3475) Plus Enzalutamide Plus ADT Versus Placebo Plus Enzalutamide Plus ADT in Participants With Metastatic HormoneSensitive Prostate Cancer (mHSPC) (KEYNOTE-991)
03.03.2020While many men diagnosed with locally confined disease may be treated definitively with radiation or surgery, ap-proximately 30% of men have recurrent disease and go on to develop metastatic prostate cancer. In addition, 5% to 30% of men with prostat...
Klinische Forschung - 03.03.2020 - 10.03.2030
Laufend
Projektleitung: Omlin Aurelius
Mitarbeiter/innen: Rothermundt Christian, Aeppli Stefanie
Phase 3, Randomized, Open Label Study to Compare Nivolumab plus Concurrent Chemoradiotherapy (CCRT) followed by Nivolumab plus Ipilimumab or Nivolumab plus CCRT Followed by Nivolumab vs CCRT followed by Durvalumab in Previously Untreat-ed, Locally Advanced Non-small Cell Lung Cancer (LA NSCLC)
03.03.2020CA20973L is a phase 3, randomized, open label study to compare nivolumab plus concurrent chemoradiotherapy (CCRT) followed by nivolumab plus ipilimumab or nivolumab alone versus CCRT followed by durvalumab in previously untreated locally advanced non...
Klinische Forschung - 03.03.2020 - 10.03.2029
Laufend
Projektleitung: Früh Martin
Revealing molecular basis of cardiotoxicity of carfilzomib towards its safer use in the patients with multiple myeloma
01.03.2020
Grundlagenforschung - 01.03.2020 - 28.02.2021
Automatisch geschlossen
Projektleitung: Besse Lenka
Mitarbeiter/innen: Mendez Lopez Max
Swiss Multicenter Randomized Controlled Trial on different Limb Lengths in Gastric Bypass Surgery
01.03.2020Obesity and type 2 diabetes mellitus (T2DM) are reaching epidemic proportions in the developed world. In morbidly obese patients only surgical treatment (bariatric operations) leads to a sustained weight loss and relief of co-morbidities in the major...
Klinische Forschung - 01.03.2020 - 28.02.2027
Laufend
Projektleitung: Peterli Ralph, Folie Patrick
Mitarbeiter/innen: Aczel Stefan, Falconnier Claudine, Greifnieder Dietlind, Schmid Mathias, Lisarelli Loriana, Oettli Seraina, Seiler Edith, Bilz Stefan, Sigrist Sarah
A randomized, open-label, phase I/II open platform study evaluating safety and efficacy of novel ruxolitinib combina-tions in myelofibrosis patients
14.02.2020Myelofibrosis (MF) is defined by progressive bone marrow (BM) fibrosis and a consecutive reduction of blood cells. The disrup-tion of the medullary erythropoietic niche is the primary mecha-nism governing the bone marrow failure and anemia, which typ...
Klinische Forschung - 14.02.2020 - 20.02.2024
Automatisch geschlossen
BIOMASTER BIOMONITOR III
10.02.2020This study is a post-market clinical follow-up (PMCF) study to identify and evaluate residual risks associated with the use of the BIOMONITOR III that are discovered or remain even after risk analysis, risk mitigation and successful conformity assess...
Klinische Forschung - 10.02.2020 - 21.01.2022
Abgeschlossen
Projektleitung: Ammann Peter
Mitarbeiter/innen: Schneider Irene