Projects
Search from 1164 projects:
1164 Project(s)
PHPT/ FHH-Studie
Jul 1, 2020Primary hyperparathyroidism and familial hypocalciuric hypercalcemia: evaluation of calciuria in spot urine and 24-hours urine sample
Clinical Studies - Jul 1, 2020 - Dec 31, 2024
Ongoing
Project leader: Bilz Stefan
Members: Siegenthaler Martin, Koster Markus, Räss Andrea, Grillmayr Victoria
Psychotraumatologie in der somatischen Medizin - Vorsorgesprechstunde Frauenklinik
Jul 1, 2020Traumatisierungen sind klinisch hoch relevant, gerade auch in den medizinisch-somatischen Fachgebieten. Trotz Fortschritten in den letzten Jahrzehnten ist deren klinische Versorgung noch unzureichend – mit ungünstigen gesundheitlichen Auswirkungen fü...
Clinical Studies - Jul 1, 2020 - Dec 31, 2021
Completed
Project leader: Schmid Dagmar
Members: Hornung René, Schmidt Roger, Krolak Monika, Nobel Gloria, Germann Nicolas, Schönenberger Michelle, Hämmerli Keller Katja
The molecular landscape of proteasome inhibitor resistance of multiple myeloma in vivo
Jul 1, 2020We here aim to dissect the molecular landscape of MM that is acquiring resistance to the most active PI, carfilzomib (CFZ) in vivo. We therefore here extend our model to orthotopic growth conditions of MM in murine bone marrow under continuous select...
Fundamental Research - Jul 1, 2020 - Dec 31, 2023
Automatically Closed
Project leader: Driessen Christoph
Members: Besse Andrej, Schwestermann Jonas, Kraus Marianne, Besse Lenka
Transcriptomic analysis of fibroblasts in brain tumors – an exploratory study
Jun 19, 2020The aim of this study was to evaluate to what extent the fibroblastic landscape is remodelled in human brain metastases and to employ high-resolution transcriptomic and histological analyses to characterize cancer-associated fibroblasts in these CNS...
Fundamental Research - Jun 19, 2020 - Aug 2, 2024
Completed
Project leader: Pikor Natalia
Prospective observational cohort study to investigate long-term pulmonary and extrapulmonary effects of COVID-19
Jun 15, 2020
Clinical Studies - Jun 15, 2020 - Dec 15, 2021
Automatically Closed
Project leader: Brutsche Martin
Members: Baty Florent
GO41717: A Phase III, randomized, double-blinded, place-bo-controlled study of Tiragolumab, an Anti-Tigit Antibody, in combination with Atezolizumab compared with placebo in combination with Atezolizumab in patients with previously untreated locally advanced unresectable or metastatic PD-L1 selected Non-Small Cell Lung Cancer
Jun 11, 2020This study will evaluate the efficacy and safety of ti-ragolumab plus atezolizumab compared with placebo plus atezolizumab in patients with previously untreated locally advanced, unresectable or metastatic programmed deathligand 1 (PD-L1)selected n...
Clinical Studies - Jun 11, 2020 - Dec 12, 2024
Scheduled
A3BAD study - Analysis of amyloid aggregates in blood with atomic force microscopy as a biomarker of Alzheimer Dementia
Jun 1, 2020Background: The key neuropathological feature of Alzheimer disease (AD) is the accumulation of extracellular β-amyloid (Aβ) plaques in the brain which begins long before clinical signs of dementia. Immunotherapies targeting Aβ may prevent Aβ accumula...
Fundamental Research - Jun 1, 2020 - May 30, 2022
Automatically Closed
Project leader: Felbecker Ansgar
Members: Schneider Thomas, Nirmjaraj Peter
Nerve ultrasound as a predictive tool of autonomic dysfunction in Guillain-Barré-Syndrom: a pilot study
May 25, 2020Beim Guillain-Barré-Syndrom (GBS) handelt es sich um eine akute immunvermittelte Polyneuropathie (PNP) mit potentiell lebensbedrohlichen Komplikationen wie respiratorischer Insuffizienz und Herzrhythmusstörungen. Ein frühzeitiges Erkennen der Erkrank...
Fundamental Research - May 25, 2020 - May 24, 2022
Automatically Closed
Immune-modulatory radiotherapy to enhance the effects of neoadjuvant PD - L1 blockade after neoadjuvant chemotherapy in patients with resectable stage III ( N2) non -small cell lung cacner (NSCLC)
Apr 29, 2020Evaluation einer immunmodulatorischen neoadjuvanten Radiotherapie in verschiedenen Dosen nach neoadjuvanter Chemotherapie mit Cisplatin und Docetaxel bei Patienten mit operablem, lokal fortgeschrittenem (Stadium IIIA) Nicht-Kleinzelligen Bronchialkar...
Clinical Studies - Apr 29, 2020 - Aug 24, 2030
Ongoing
Project leader: Früh Martin
Members: Sakic Miranda, Müller Fiona
Study to Assess the Safety, Tolerability, Pharmacokinetics, and Effect on Disease Progression of BIIB078 Administered to Previously Treated Adults C9ORF72-Associated Amyotrophic Lateral Sclerosis (ALS)
Apr 28, 2020The primary objective is to evaluate the long-term safety and tolerability of BIIB078 in participants with chromosome 9 open reading frame 72-amyotrophic lateral sclerosis (C9ORF72-ALS). The secondary objective is to evaluate the pharmacokinectic (P...
Clinical Studies - Apr 28, 2020 - Jul 28, 2023
Automatically Closed
Project leader: Weber Markus
Members: Neuwirth Christoph, Braun Nathalie
A Phase I/IIA, Multi-Centre, Open-Label, Dose-Escalation Study with Expansion Arms to Assess the Safety, Tolera-bility, Pharmacokinetics and Preliminary Efficacy of CB-103 Administered Orally in Adult Patients with Locally Ad-vanced or Metastatic Solid Tumour Malignancies Charac-terised by Alterations of the NOTCH Signalling Pathway
Apr 17, 2020This study is designed as an open label, non-randomised, uncontrolled Phase I/IIA dose escalation study with expan-sion cohorts of CB-103 administered orally on a once-daily schedule, based on a 28-day treatment cycle. The admin-istration schedule ma...
Clinical Studies - Apr 17, 2020 - May 26, 2030
Ongoing
Project leader: Hess Dagmar
Protocol SAKK 80/20 Outcome and prognostic factors of SARS CoV-2 infection in cancer patients: A corss - sectional study
Apr 14, 2020The COVID-19 pandemic, caused by the SARS-CoV-2 virus, poses a major challenge for global health care systems, as virus spreads fast and recent data point to >10% of severe cases, requiring hospitalization and/or treatment in the intensive care unit....
Clinical Studies - Apr 14, 2020 - Apr 28, 2021
Automatically Closed
SWISS-AF Burden
Apr 6, 2020Health consequences of the Burden of atrial fibrillation The added information of measuring AF burden and measuring cardiac dimensions and function in an AF patient population where brain MRIs are available, could provide further evidence toward...
Clinical Studies - Apr 6, 2020 - Apr 6, 2024
Completed
Project leader: Ammann Peter
Members: Altmann David, Fink Karin
ALXN1210-ALS-308: An Efficacy and Safety Study of Ravulizumab in ALS Patients
Mar 30, 2020The purpose of the study is to assess the efficacy and safety of ravulizumab for the treatment of adult participants with ALS.
Clinical Studies - Mar 30, 2020 - Oct 17, 2021
Aborted
Project leader: Neuwirth Christoph
Members: Weber Markus, Braun Nathalie
A Phase 3, Randomized, Double-blind Trial of Pembrolizumab (MK3475) Plus Enzalutamide Plus ADT Versus Placebo Plus Enzalutamide Plus ADT in Participants With Metastatic HormoneSensitive Prostate Cancer (mHSPC) (KEYNOTE-991)
Mar 3, 2020While many men diagnosed with locally confined disease may be treated definitively with radiation or surgery, ap-proximately 30% of men have recurrent disease and go on to develop metastatic prostate cancer. In addition, 5% to 30% of men with prostat...
Clinical Studies - Mar 3, 2020 - Mar 10, 2030
Ongoing
Project leader: Omlin Aurelius
Members: Rothermundt Christian, Aeppli Stefanie
Phase 3, Randomized, Open Label Study to Compare Nivolumab plus Concurrent Chemoradiotherapy (CCRT) followed by Nivolumab plus Ipilimumab or Nivolumab plus CCRT Followed by Nivolumab vs CCRT followed by Durvalumab in Previously Untreat-ed, Locally Advanced Non-small Cell Lung Cancer (LA NSCLC)
Mar 3, 2020CA20973L is a phase 3, randomized, open label study to compare nivolumab plus concurrent chemoradiotherapy (CCRT) followed by nivolumab plus ipilimumab or nivolumab alone versus CCRT followed by durvalumab in previously untreated locally advanced non...
Clinical Studies - Mar 3, 2020 - Mar 10, 2029
Ongoing
Project leader: Früh Martin
Revealing molecular basis of cardiotoxicity of carfilzomib towards its safer use in the patients with multiple myeloma
Mar 1, 2020
Fundamental Research - Mar 1, 2020 - Feb 28, 2021
Automatically Closed
Project leader: Besse Lenka
Members: Mendez Lopez Max
Swiss Multicenter Randomized Controlled Trial on different Limb Lengths in Gastric Bypass Surgery
Mar 1, 2020Obesity and type 2 diabetes mellitus (T2DM) are reaching epidemic proportions in the developed world. In morbidly obese patients only surgical treatment (bariatric operations) leads to a sustained weight loss and relief of co-morbidities in the major...
Clinical Studies - Mar 1, 2020 - Feb 28, 2027
Ongoing
Project leader: Peterli Ralph, Folie Patrick
Members: Aczel Stefan, Falconnier Claudine, Greifnieder Dietlind, Schmid Mathias, Lisarelli Loriana, Oettli Seraina, Seiler Edith, Bilz Stefan, Sigrist Sarah
A randomized, open-label, phase I/II open platform study evaluating safety and efficacy of novel ruxolitinib combina-tions in myelofibrosis patients
Feb 14, 2020Myelofibrosis (MF) is defined by progressive bone marrow (BM) fibrosis and a consecutive reduction of blood cells. The disrup-tion of the medullary erythropoietic niche is the primary mecha-nism governing the bone marrow failure and anemia, which typ...
Clinical Studies - Feb 14, 2020 - Feb 20, 2024
Automatically Closed
BIOMASTER BIOMONITOR III
Feb 10, 2020This study is a post-market clinical follow-up (PMCF) study to identify and evaluate residual risks associated with the use of the BIOMONITOR III that are discovered or remain even after risk analysis, risk mitigation and successful conformity assess...
Clinical Studies - Feb 10, 2020 - Jan 21, 2022
Completed
Project leader: Ammann Peter
Members: Schneider Irene