Prof. Dr. Burkhard Ludewig
Leiter, Medizinisches Forschungszentrum
Leiter, Institut für Immunbiologie
Klinik-/Instituts-/Zentrumsleiter/in
Medizinisches Forschungszentrum, Institut für Immunbiologie · Dept. Direktion
The NFκB-inducing kinase is essential for the developmental programming of skin-resident and IL-17-producing γδ T cells
Mair F, Joller S, Hoeppli R, Onder L, Hahn M, Ludewig B, Waisman A, Becher B. The NFκB-inducing kinase is essential for the developmental programming of skin-resident and IL-17-producing γδ T cells. Elife 2015; 4
05.12.2015The NFκB-inducing kinase is essential for the developmental programming of skin-resident and IL-17-producing γδ T cells
05.12.2015Elife 2015; 4
Mair Florian, Joller Stefanie, Hoeppli Romy, Onder Lucas, Hahn Matthias, Ludewig Burkhard, Waisman Ari, Becher Burkhard
Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage
Bhattacharya A, Arnold I, Flatz L, Xu H, Lang P, Aderem A, Takaoka A, Superti-Furga G, Colinge J, Ludewig B, Löhning M, Baazim H, Khamina K, Panse I, Hegazy A, Deigendesch N, Kosack L, Cupovic J, Kandasamy R, Hildebrandt A, Merkler D, Kühl A, Vilagos B, Schliehe C, Bergthaler A. Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage. Immunity 2015; 43:974-86.
17.11.2015Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage
17.11.2015Immunity 2015; 43:974-86
Bhattacharya Anannya, Arnold Isabelle, Flatz Lukas, Xu Haifeng C, Lang Philipp A, Aderem Alan, Takaoka Akinori, Superti-Furga Giulio, Colinge Jacques, Ludewig Burkhard, Löhning Max, Baazim Hatoon, Khamina Kseniya, Panse Isabel, Hegazy Ahmed N, Deigendesch Nikolaus, Kosack Lindsay, Cupovic Jovana, Kandasamy Richard K, Hildebrandt Andrea, Merkler Doron, Kühl Anja A, Vilagos Bojan, Schliehe Christopher, Bergthaler Andreas
Phenotypic and Morphological Properties of Germinal Center Dark Zone Cxcl12-Expressing Reticular Cells
Rodda L, Bannard O, Ludewig B, Nagasawa T, Cyster J. Phenotypic and Morphological Properties of Germinal Center Dark Zone Cxcl12-Expressing Reticular Cells. J Immunol 2015; 195:4781-91.
09.10.2015Phenotypic and Morphological Properties of Germinal Center Dark Zone Cxcl12-Expressing Reticular Cells
09.10.2015J Immunol 2015; 195:4781-91
Rodda Lauren B, Bannard Oliver, Ludewig Burkhard, Nagasawa Takashi, Cyster Jason G
Tuning up FALCs: immunological shielding in the body cavities
Pérez Shibayama C, Ludewig B. Tuning up FALCs: immunological shielding in the body cavities. Nat Immunol 2015; 16:796-8.
21.07.2015Tuning up FALCs: immunological shielding in the body cavities
21.07.2015Nat Immunol 2015; 16:796-8
Pérez Shibayama Christian Ivan, Ludewig Burkhard
Another TLO in the Wall: Education and Control of T Cells in Atherosclerotic Arteries
Onder L, Ludewig B. Another TLO in the Wall: Education and Control of T Cells in Atherosclerotic Arteries. Immunity 2015; 42:981-3.
16.06.2015Another TLO in the Wall: Education and Control of T Cells in Atherosclerotic Arteries
16.06.2015Immunity 2015; 42:981-3
Onder Lucas, Ludewig Burkhard
Alternative NF-κB signaling regulates mTEC differentiation from podoplanin-expressing presursors in the cortico-medullary junction
Onder L, Waisman A, Becher B, Ledermann B, Mair F, Maier R, Bomze D, Novkovic M, Caviezel-Firner S, Cheng H, Chai Q, Scandella E, Nindl V, Ludewig B. Alternative NF-κB signaling regulates mTEC differentiation from podoplanin-expressing presursors in the cortico-medullary junction. Eur J Immunol 2015
14.05.2015Alternative NF-κB signaling regulates mTEC differentiation from podoplanin-expressing presursors in the cortico-medullary junction
14.05.2015Eur J Immunol 2015
Onder Lucas, Waisman Ari, Becher Burkhard, Ledermann Birgit, Mair Florian, Maier Reinhard, Bomze David, Novkovic Mario, Caviezel-Firner Sonja, Cheng Hung-Wei, Chai Qian, Scandella Elke, Nindl Veronika, Ludewig Burkhard
Thromboxane A2 acts as tonic immunoregulator by preferential disruption of low-avidity CD4+ T cell-dendritic cell interactions
Moalli F, Cupovic J, Thelen F, Halbherr P, Fukui Y, Narumiya S, Ludewig B, Stein J. Thromboxane A2 acts as tonic immunoregulator by preferential disruption of low-avidity CD4+ T cell-dendritic cell interactions. J Exp Med 2014; 211:2507-17.
08.12.2014Thromboxane A2 acts as tonic immunoregulator by preferential disruption of low-avidity CD4+ T cell-dendritic cell interactions
08.12.2014J Exp Med 2014; 211:2507-17
Moalli Federica, Cupovic Jovana, Thelen Flavian, Halbherr Pascal, Fukui Yoshinori, Narumiya Shuh, Ludewig Burkhard, Stein Jens V
The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture
Astarita J, Xia L, Mooney D, Carroll M, Weimer R, Ludewig B, Onder L, Gogineni A, Woodruff M, Kondo Y, Song K, Nieves-Bonilla J, Peck J, Darnell M, Fu J, Cremasco V, Turley S. The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture. Nat Immunol 2014; 16:75-84.
27.10.2014The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture
27.10.2014Nat Immunol 2014; 16:75-84
Astarita Jillian L, Xia Lijun, Mooney David J, Carroll Michael C, Weimer Robby M, Ludewig Burkhard, Onder Lucas, Gogineni Alvin, Woodruff Matthew C, Kondo Yuji, Song Kai, Nieves-Bonilla Janice M, Peck James R, Darnell Max C, Fu Jianxin, Cremasco Viviana, Turley Shannon J
HDAC1 controls CD8+ T cell homeostasis and antiviral response.
Tschismarov R, Firner S, Gil-Cruz C, Göschl L, Boucheron N, Steiner G, Matthias P, Seiser C, Ludewig B, Ellmeier W. HDAC1 controls CD8+ T cell homeostasis and antiviral response. PloS one 2014; 9:e110576.
21.10.2014HDAC1 controls CD8+ T cell homeostasis and antiviral response.
21.10.2014PloS one 2014; 9:e110576
Tschismarov Roland, Firner Sonja, Gil-Cruz Cristina, Göschl Lisa, Boucheron Nicole, Steiner Günter, Matthias Patrick, Seiser Christian, Ludewig Burkhard, Ellmeier Wilfried
Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses
Fasnacht N, Luther S, Ludewig B, Tacchini-Cottier F, MacDonald H, Pinschewer D, Kallert S, Onder L, Chai Q, Auderset F, Favre S, Koch U, Huang H, Radtke F. Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses. J Exp Med 2014; 211:2265-79.
13.10.2014Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses
13.10.2014J Exp Med 2014; 211:2265-79
Fasnacht Nicolas, Luther Sanjiv A, Ludewig Burkhard, Tacchini-Cottier Fabienne, MacDonald H Robson, Pinschewer Daniel D, Kallert Sandra, Onder Lucas, Chai Qian, Auderset Floriane, Favre Stéphanie, Koch Ute, Huang Hsin-Ying, Radtke Freddy
MHC Class II-restricted antigen presentation by plasmacytoid dendritic cells drives proatherogenic T cell immunity
Sage A, Hugues S, Reizis B, Hansson G, Reith W, Ludewig B, Harrison J, Grassia G, Ait-Oufella H, Finigan A, Cambrook H, Baker L, Sabir S, Masters L, Maffia P, Murphy D, Mallat Z. MHC Class II-restricted antigen presentation by plasmacytoid dendritic cells drives proatherogenic T cell immunity. Circulation 2014; 130:1363-73.
15.09.2014MHC Class II-restricted antigen presentation by plasmacytoid dendritic cells drives proatherogenic T cell immunity
15.09.2014Circulation 2014; 130:1363-73
Sage Andrew P, Hugues Stephanie, Reizis Boris, Hansson Göran K, Reith Walter, Ludewig Burkhard, Harrison James E, Grassia Gianluca, Ait-Oufella Hafid, Finigan Alison J, Cambrook Helen, Baker Lauren L, Sabir Suleman R, Masters Leanne M, Maffia Pasquale, Murphy Deirdre, Mallat Ziad
B cell homeostasis and follicle confines are governed by fibroblastic reticular cells
Cremasco V, Carroll M, Ludewig B, Wucherpfennig K, Harvey C, Cremasco F, Chang J, Schildberg F, Nieves-Bonilla J, Cupovic J, Onder L, Woodruff M, Turley S. B cell homeostasis and follicle confines are governed by fibroblastic reticular cells. Nat Immunol 2014; 15:973-81.
24.08.2014B cell homeostasis and follicle confines are governed by fibroblastic reticular cells
24.08.2014Nat Immunol 2014; 15:973-81
Cremasco Viviana, Carroll Michael C, Ludewig Burkhard, Wucherpfennig Kai, Harvey Christopher J, Cremasco Floriana, Chang Jonathan, Schildberg Frank A, Nieves-Bonilla Janice M, Cupovic Jovana, Onder Lucas, Woodruff Matthew C, Turley Shannon J
Plasticity and complexity of B cell responses against persisting pathogens
Pérez Shibayama C, Gil Cruz C, Ludewig B. Plasticity and complexity of B cell responses against persisting pathogens. Immunol Lett 2014; 162:53-8.
25.07.2014Plasticity and complexity of B cell responses against persisting pathogens
25.07.2014Immunol Lett 2014; 162:53-8
Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Ludewig Burkhard
IFN-γ-producing CD4+ T cells promote generation of protective germinal center-derived IgM+ B cell memory against Salmonella Typhi
Pérez Shibayama C, López-Macías C, Isibasi A, Waisman A, Regen T, Scandella E, Onder L, Chai Q, Hisaki E, Cervantes-Barragan L, Pastelin-Palacios R, Gil Cruz C, Ludewig B. IFN-γ-producing CD4+ T cells promote generation of protective germinal center-derived IgM+ B cell memory against Salmonella Typhi. J Immunol 2014; 192:5192-200.
28.04.2014IFN-γ-producing CD4+ T cells promote generation of protective germinal center-derived IgM+ B cell memory against Salmonella Typhi
28.04.2014J Immunol 2014; 192:5192-200
Pérez Shibayama Christian Ivan, López-Macías Constantino, Isibasi Armando, Waisman Ari, Regen Tommy, Scandella Elke, Onder Lucas, Chai Qian, Hisaki Emiliano, Cervantes-Barragan Luisa, Pastelin-Palacios Rodolfo, Gil Cruz Cristina, Ludewig Burkhard
Mathematical models for CFSE labelled lymphocyte dynamics: asymmetry and time-lag in division
Luzyanina T, Cupovic J, Ludewig B, Bocharov G. Mathematical models for CFSE labelled lymphocyte dynamics: asymmetry and time-lag in division. J Math Biol 2013
13.12.2013Mathematical models for CFSE labelled lymphocyte dynamics: asymmetry and time-lag in division
13.12.2013J Math Biol 2013
Luzyanina Tatyana, Cupovic Jovana, Ludewig Burkhard, Bocharov Gennady
Dendritic cell-specific delivery of Flt3L by coronavirus vectors secures induction of therapeutic antitumor immunity
Pérez Shibayama C, Gil Cruz C, Nussbacher M, Allgäuer E, Cervantes-Barragan L, Züst R, Ludewig B. Dendritic cell-specific delivery of Flt3L by coronavirus vectors secures induction of therapeutic antitumor immunity. PloS one 2013; 8:e81442.
28.11.2013Dendritic cell-specific delivery of Flt3L by coronavirus vectors secures induction of therapeutic antitumor immunity
28.11.2013PloS one 2013; 8:e81442
Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Nussbacher Monika, Allgäuer Eva, Cervantes-Barragan Luisa, Züst Roland, Ludewig Burkhard
Systemic minor histocompatibility antigen expression in blood endothelial cells prevents T cell-mediated vascular immunopathology
Caviezel-Firner S, Engeler D, Bolinger B, Onder L, Scandella E, Yu M, Kroczek R, Ludewig B. Systemic minor histocompatibility antigen expression in blood endothelial cells prevents T cell-mediated vascular immunopathology. Eur J Immunol 2013; 43:3233-43.
06.09.2013Systemic minor histocompatibility antigen expression in blood endothelial cells prevents T cell-mediated vascular immunopathology
06.09.2013Eur J Immunol 2013; 43:3233-43
Caviezel-Firner Sonja, Engeler Daniel, Bolinger Beatrice, Onder Lucas, Scandella Elke, Yu Meimei, Kroczek Richard A, Ludewig Burkhard
Asymmetry of Cell Division in CFSE-Based Lymphocyte Proliferation Analysis
Bocharov G, Luzyanina T, Cupovic J, Ludewig B. Asymmetry of Cell Division in CFSE-Based Lymphocyte Proliferation Analysis. Front Immunol 2013; 4:264.
02.09.2013Asymmetry of Cell Division in CFSE-Based Lymphocyte Proliferation Analysis
02.09.2013Front Immunol 2013; 4:264
Bocharov Gennady, Luzyanina Tatyana, Cupovic Jovana, Ludewig Burkhard
Interleukin-7 is produced by afferent lymphatic vessels and supports lymphatic drainage
Iolyeva M, Finke D, Chen L, Boyman O, Santambrogio L, Ludewig B, Onder L, Krieg C, Bouchaud G, Häner S, Ecoiffier T, Willrodt A, Proulx S, Aebischer D, Halin C. Interleukin-7 is produced by afferent lymphatic vessels and supports lymphatic drainage. Blood 2013; 122:2271-81.
20.08.2013Interleukin-7 is produced by afferent lymphatic vessels and supports lymphatic drainage
20.08.2013Blood 2013; 122:2271-81
Iolyeva Maria, Finke Daniela, Chen Lu, Boyman Onur, Santambrogio Laura, Ludewig Burkhard, Onder Lucas, Krieg Carsten, Bouchaud Grégory, Häner Simone, Ecoiffier Tatiana, Willrodt Ann-Helen, Proulx Steven T, Aebischer David, Halin Cornelia
Efficient boosting of the antiviral T cell response in B cell-depleted patients with autoimmune rheumatic diseases following influenza vaccination
Müller R, Maier R, Hoschler K, Zambon M, Ludewig B, Herrmann M, Schulze-Koops H, von Kempis J. Efficient boosting of the antiviral T cell response in B cell-depleted patients with autoimmune rheumatic diseases following influenza vaccination. Clin Exp Rheumatol 2013; 31:723-30.
14.06.2013Efficient boosting of the antiviral T cell response in B cell-depleted patients with autoimmune rheumatic diseases following influenza vaccination
14.06.2013Clin Exp Rheumatol 2013; 31:723-30
Müller Rüdiger, Maier Reinhard, Hoschler Katja, Zambon Maria, Ludewig Burkhard, Herrmann Martin, Schulze-Koops Hendrik, von Kempis Johannes