Prof. Dr. Burkhard Ludewig
Leiter, Medizinisches Forschungszentrum
Leiter, Institut für Immunbiologie
Klinik-/Instituts-/Zentrumsleiter/in
Medizinisches Forschungszentrum, Institut für Immunbiologie · Dept. Direktion
Cardiac Fibroblastic Niches in Homeostasis and Inflammation.
Cadosch N, Gil Cruz C, Pérez Shibayama C, Ludewig B. Cardiac Fibroblastic Niches in Homeostasis and Inflammation. Circ Res 2024; 134:1703-1717.
06.06.2024Cardiac Fibroblastic Niches in Homeostasis and Inflammation.
06.06.2024Circ Res 2024; 134:1703-1717
Cadosch Nadine, Gil Cruz Cristina, Pérez Shibayama Christian Ivan, Ludewig Burkhard
Bone morphogenic protein-4 availability in the cardiac microenviroment controls inflammation and fibrosis in autoimmune myocarditis
Pérez Shibayama C, Gil Cruz C, Cadosch N, Lütge M, Cheng H, De Martin A, Frischmann K, Joachimbauer A, Onder L, Papadopoulou I, Papadopoulou C, Ring S, Krebs P, P. Vu V, P. Nägele M, Rosi V, Parianos D, Zsilavecz V, Cooper L, Flammer A, Ruschitzka F, Reiner P, Schmidt D, Ludewig B. Bone morphogenic protein-4 availability in the cardiac microenviroment controls inflammation and fibrosis in autoimmune myocarditis. Nature Cardiovascular Research 2024; volume 3:301-316.
19.04.2024Bone morphogenic protein-4 availability in the cardiac microenviroment controls inflammation and fibrosis in autoimmune myocarditis
19.04.2024Nature Cardiovascular Research 2024; volume 3:301-316
Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Cadosch Nadine, Lütge Mechthild, Cheng Hung-Wei, De Martin Angelina, Frischmann Kira, Joachimbauer Anna, Onder Lucas, Papadopoulou Iliana, Papadopoulou Chrysa, Ring Sandra, Krebs Philippe, P. Vu Vivian, P. Nägele Matthias, Rosi Valentina, Parianos Danae, Zsilavecz Valentin W, Cooper Leslie T., Flammer Andreas, Ruschitzka Frank, Reiner Peter P, Schmidt Dörthe, Ludewig Burkhard
A replicating LCMV-based vaccine for the treatment of solid tumors.
Purde M, Cupovic J, Palmowski Y, Makky A, Schmidt S, Rochwarger A, Hartmann F, Stemeseder F, Lercher A, Abdou M, Bomze D, Besse L, Berner F, Tüting T, Hölzel M, Bergthaler A, Kochanek S, Ludewig B, Lauterbach H, Orlinger K, Bald T, Schietinger A, Schürch C, Ring S, Flatz L. A replicating LCMV-based vaccine for the treatment of solid tumors. Mol Ther 2023
05.12.2023A replicating LCMV-based vaccine for the treatment of solid tumors.
05.12.2023Mol Ther 2023
Purde Mette-Triin, Cupovic Jovana, Palmowski Yannick A, Makky Ahmad, Schmidt Sarah, Rochwarger Alexander, Hartmann Fabienne, Stemeseder Felix, Lercher Alexander, Abdou Marie-Therese, Bomze David, Besse Lenka, Berner Fiamma, Tüting Thomas, Hölzel Michael, Bergthaler Andreas, Kochanek Stefan, Ludewig Burkhard, Lauterbach Henning, Orlinger Klaus K, Bald Tobias, Schietinger Andrea, Schürch Christian M, Ring Sandra Stephanie, Flatz Lukas
Protective fibroblastic niches in secondary lymphoid organs.
De Martin A, Stanossek Y, Pikor N, Ludewig B. Protective fibroblastic niches in secondary lymphoid organs. J Exp Med 2023; 221
01.12.2023Protective fibroblastic niches in secondary lymphoid organs.
01.12.2023J Exp Med 2023; 221
De Martin Angelina, Stanossek Yves, Pikor Natalia Barbara, Ludewig Burkhard
Author Correction: Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network.
Martínez-Riaño A, Wang S, Boeing S, Minoughan S, Casal A, Spillane K, Ludewig B, Tolar P. Author Correction: Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network. Nat Immunol 2023
20.10.2023Author Correction: Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network.
20.10.2023Nat Immunol 2023
Martínez-Riaño Ana, Wang Shenshen, Boeing Stefan, Minoughan Sophie, Casal Antonio, Spillane Katelyn M, Ludewig Burkhard, Tolar Pavel
Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network.
Martínez-Riaño A, Wang S, Boeing S, Minoughan S, Casal A, Spillane K, Ludewig B, Tolar P. Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network. Nat Immunol 2023; 24:1281-1294.
13.07.2023Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network.
13.07.2023Nat Immunol 2023; 24:1281-1294
Martínez-Riaño Ana, Wang Shenshen, Boeing Stefan, Minoughan Sophie, Casal Antonio, Spillane Katelyn M, Ludewig Burkhard, Tolar Pavel
Fibroblastic reticular cells provide a supportive niche for lymph node-resident macrophages.
D'Rozario J, Knoblich K, Lütge M, Pérez Shibayama C, Cheng H, Alexandre Y, Roberts D, Campos J, Dutton E, Suliman M, Denton A, Turley S, Boyd R, Mueller S, Ludewig B, Heng T, Fletcher A. Fibroblastic reticular cells provide a supportive niche for lymph node-resident macrophages. Eur J Immunol 2023; 53:e2250355.
12.07.2023Fibroblastic reticular cells provide a supportive niche for lymph node-resident macrophages.
12.07.2023Eur J Immunol 2023; 53:e2250355
D'Rozario Joshua, Knoblich Konstantin, Lütge Mechthild, Pérez Shibayama Christian Ivan, Cheng Hung-Wei, Alexandre Yannick O, Roberts David J, Campos Joana, Dutton Emma E, Suliman Muath, Denton Alice E, Turley Shannon J, Boyd Richard L, Mueller Scott N, Ludewig Burkhard, Heng Tracy S P, Fletcher Anne L
Cardioimmunology: the new frontier!
Sattler S, Ramos G, Ludewig B, Rainer P. Cardioimmunology: the new frontier!. Eur Heart J 2023; 44:2355-2357.
07.07.2023Cardioimmunology: the new frontier!
07.07.2023Eur Heart J 2023; 44:2355-2357
Sattler Susanne, Ramos Gustavo Campos, Ludewig Burkhard, Rainer Peter P
Notch signaling drives intestinal graft-versus-host disease in mice and nonhuman primates.
Tkachev V, Vanderbeck A, Perkey E, Furlan S, McGuckin C, Gómez Atria D, Gerdemann U, Rui X, Lane J, Hunt D, Zheng H, Colonna L, Hoffman M, Yu A, Outen R, Kelly S, Allman A, Koch U, Radtke F, Ludewig B, Burbach B, Shimizu Y, Panoskaltsis-Mortari A, Chen G, Carpenter S, Harari O, Kuhnert F, Thurston G, Blazar B, Kean L, Maillard I. Notch signaling drives intestinal graft-versus-host disease in mice and nonhuman primates. Sci Transl Med 2023; 15:eadd1175.
28.06.2023Notch signaling drives intestinal graft-versus-host disease in mice and nonhuman primates.
28.06.2023Sci Transl Med 2023; 15:eadd1175
Tkachev Victor, Vanderbeck Ashley, Perkey Eric, Furlan Scott N, McGuckin Connor, Gómez Atria Daniela, Gerdemann Ulrike, Rui Xianliang, Lane Jennifer, Hunt Daniel J, Zheng Hengqi, Colonna Lucrezia, Hoffman Michelle, Yu Alison, Outen Riley, Kelly Samantha, Allman Anneka, Koch Ute, Radtke Freddy, Ludewig Burkhard, Burbach Brandon, Shimizu Yoji, Panoskaltsis-Mortari Angela, Chen Guoying, Carpenter Stephen M, Harari Olivier, Kuhnert Frank, Thurston Gavin, Blazar Bruce R, Kean Leslie S, Maillard Ivan
A novel cryopreservation and biobanking strategy to study lymphoid tissue stromal cells in human disease.
Brandstadter J, De Martin A, Lϋtge M, Ferreira A, Gaudette B, Stanossek Y, Wang S, Gonzalez M, Camiolo E, Wertheim G, Austin B, Allman D, Bagg A, Salim M, Fajgenbaum D, Aster J, Ludewig B, Maillard I. A novel cryopreservation and biobanking strategy to study lymphoid tissue stromal cells in human disease. Eur J Immunol 2023:e2250362.
27.06.2023A novel cryopreservation and biobanking strategy to study lymphoid tissue stromal cells in human disease.
27.06.2023Eur J Immunol 2023:e2250362
Brandstadter Joshua D, De Martin Angelina, Lϋtge Mechthild, Ferreira Antonio, Gaudette Brian T, Stanossek Yves, Wang Shumei, Gonzalez Michael V, Camiolo Edward, Wertheim Gerald, Austin Bridget, Allman David, Bagg Adam, Salim M, Fajgenbaum David C, Aster Jon C, Ludewig Burkhard, Maillard Ivan
Immunomodulation of Myocardial Fibrosis.
Sikking M, van den Worm S, Marelli-Berg F, Heymans S, Ludewig B, Verdonschot J. Immunomodulation of Myocardial Fibrosis. JACC Basic Transl Sci 2023; 8:1477-1488.
14.06.2023Immunomodulation of Myocardial Fibrosis.
14.06.2023JACC Basic Transl Sci 2023; 8:1477-1488
Sikking Maurits A, van den Worm Sjoerd H E, Marelli-Berg Federica, Heymans Stephane R B, Ludewig Burkhard, Verdonschot Job A J
Conserved stromal-immune cell circuits secure B cell homeostasis and function.
Lütge M, De Martin A, Gil Cruz C, Pérez Shibayama C, Stanossek Y, Onder L, Cheng H, Kurz L, Cadosch N, Soneson C, Robinson M, Stöckli S, Ludewig B, Pikor N. Conserved stromal-immune cell circuits secure B cell homeostasis and function. Nat Immunol 2023
18.05.2023Conserved stromal-immune cell circuits secure B cell homeostasis and function.
18.05.2023Nat Immunol 2023
Lütge Mechthild, De Martin Angelina, Gil Cruz Cristina, Pérez Shibayama Christian Ivan, Stanossek Yves, Onder Lucas, Cheng Hung-Wei, Kurz Lisa, Cadosch Nadine, Soneson Charlotte, Robinson Mark D, Stöckli Sandro, Ludewig Burkhard, Pikor Natalia
PI16 reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches.
De Martin A, Stanossek Y, Lütge M, Cadosch N, Onder L, Cheng H, Brandstadter J, Maillard I, Stöckli S, Pikor N, Ludewig B. PI16 reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches. Nat Immunol 2023; 24:1138-1148.
18.05.2023PI16 reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches.
18.05.2023Nat Immunol 2023; 24:1138-1148
De Martin Angelina, Stanossek Yves, Lütge Mechthild, Cadosch Nadine, Onder Lucas, Cheng Hung-Wei, Brandstadter Joshua D, Maillard Ivan, Stöckli Sandro, Pikor Natalia, Ludewig Burkhard
An Innate Checkpoint Determines Immune Dysregulation and Immunopathology during Pulmonary Murine Coronavirus Infection.
Grabherr S, Waltenspühl A, Büchler L, Lütge M, Cheng H, Caviezel-Firner S, Ludewig B, Krebs P, Pikor N. An Innate Checkpoint Determines Immune Dysregulation and Immunopathology during Pulmonary Murine Coronavirus Infection. J Immunol 2023; 210:774-785.
15.03.2023An Innate Checkpoint Determines Immune Dysregulation and Immunopathology during Pulmonary Murine Coronavirus Infection.
15.03.2023J Immunol 2023; 210:774-785
Grabherr Sarah, Waltenspühl Alexandra, Büchler Lorina, Lütge Mechthild, Cheng Hung-Wei, Caviezel-Firner Sonja, Ludewig Burkhard, Krebs Philippe, Pikor Natalia
A novel cryopreservation and biobanking strategy to study lymphoid tissue stromal cells in human disease.
Brandstadter J, De Martin A, Lütge M, Ferreira A, Gaudette B, Stanossek Y, Wang S, Gonzalez M, Camiolo E, Wertheim G, Austin B, Allman D, Salim M, Fajgenbaum D, Aster J, Ludewig B, Maillard I. A novel cryopreservation and biobanking strategy to study lymphoid tissue stromal cells in human disease. bioRxiv 2023
07.02.2023A novel cryopreservation and biobanking strategy to study lymphoid tissue stromal cells in human disease.
07.02.2023bioRxiv 2023
Brandstadter Joshua D, De Martin Angelina, Lütge Mechthild, Ferreira Antonio, Gaudette Brian T, Stanossek Yves, Wang Shumei, Gonzalez Michael V, Camiolo Edward, Wertheim Gerald, Austin Bridget, Allman David, Salim M, Fajgenbaum David C, Aster Jon C, Ludewig Burkhard, Maillard Ivan
Myocardial Milieu Favors Local Differentiation of Regulatory T Cells.
Delgobo M, Weiß E, Ashour D, Richter L, Popiolkowski L, Arampatzi P, Stangl V, Arias-Loza P, Mariotti-Ferrandiz E, Rainer P, Saliba A, Ludewig B, Hofmann U, Frantz S, Ramos G. Myocardial Milieu Favors Local Differentiation of Regulatory T Cells. Circ Res 2023; 132:565-582.
06.02.2023Myocardial Milieu Favors Local Differentiation of Regulatory T Cells.
06.02.2023Circ Res 2023; 132:565-582
Delgobo Murilo, Weiß Emil, Ashour DiyaaElDin, Richter Leon, Popiolkowski Lisa, Arampatzi Panagiota, Stangl Verena, Arias-Loza Paula, Mariotti-Ferrandiz Encarnita, Rainer Peter P, Saliba Antoine-Emmanuel, Ludewig Burkhard, Hofmann Ulrich G, Frantz Stefan, Ramos Gustavo Campos
Fibroblastic reticular cells mitigate acute graft-versus-host disease via MHCII-dependent maintenance of regulatory T cells.
Shaikh H, Pezoldt J, Mokhtari Z, Gamboa Vargas J, Le D, Peña Mosca J, Arellano-Viera E, Kern M, Graff C, Beyersdorf N, Lutz M, Riedel A, Büttner-Herold M, Zernecke A, Einsele H, Saliba A, Ludewig B, Huehn J, Beilhack A. Fibroblastic reticular cells mitigate acute graft-versus-host disease via MHCII-dependent maintenance of regulatory T cells. JCI Insight 2022
13.10.2022Fibroblastic reticular cells mitigate acute graft-versus-host disease via MHCII-dependent maintenance of regulatory T cells.
13.10.2022JCI Insight 2022
Shaikh Haroon, Pezoldt Joern, Mokhtari Zeinab, Gamboa Vargas Juan, Le Duc-Dung, Peña Mosca Josefina, Arellano-Viera Estibaliz, Kern Michael Ag, Graff Caroline, Beyersdorf Niklas, Lutz Manfred, Riedel Angela, Büttner-Herold Maike, Zernecke Alma, Einsele Hermann, Saliba Antoine-Emmanuel, Ludewig Burkhard, Huehn Jochen, Beilhack Andreas
Fibroblasts tune myocardial inflammation and remodeling
Pérez Shibayama C, Gil Cruz C, Ludewig B. Fibroblasts tune myocardial inflammation and remodeling. Nature Cardiovascular Research 2022; 1:694–695.
12.08.2022Fibroblasts tune myocardial inflammation and remodeling
12.08.2022Nature Cardiovascular Research 2022; 1:694–695
Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Ludewig Burkhard
Multitier mechanics control stromal adaptations in the swelling lymph node.
Assen F, Abe J, Hons M, Hauschild R, Shamipour S, Kaufmann W, Costanzo T, Krens G, Brown M, Ludewig B, Hippenmeyer S, Heisenberg C, Weninger W, Hannezo E, Luther S, Stein J, Sixt M. Multitier mechanics control stromal adaptations in the swelling lymph node. Nat Immunol 2022; 23:1246-1255.
11.07.2022Multitier mechanics control stromal adaptations in the swelling lymph node.
11.07.2022Nat Immunol 2022; 23:1246-1255
Assen Frank P, Abe Jun, Hons Miroslav, Hauschild Robert, Shamipour Shayan, Kaufmann Walter A, Costanzo Tommaso, Krens Gabriel, Brown Markus, Ludewig Burkhard, Hippenmeyer Simon, Heisenberg Carl-Philipp, Weninger Wolfgang, Hannezo Edouard, Luther Sanjiv A, Stein Jens V, Sixt Michael
Stromal Notch ligands foster lymphopenia-driven functional plasticity and homeostatic proliferation of naive B cells.
Gómez Atria D, Gaudette B, Londregan J, Kelly S, Perkey E, Allman A, Srivastava B, Koch U, Radtke F, Ludewig B, Siebel C, Ryan R, Robertson T, Burkhardt J, Pear W, Allman D, Maillard I. Stromal Notch ligands foster lymphopenia-driven functional plasticity and homeostatic proliferation of naive B cells. J Clin Invest 2022; 132
01.07.2022Stromal Notch ligands foster lymphopenia-driven functional plasticity and homeostatic proliferation of naive B cells.
01.07.2022J Clin Invest 2022; 132
Gómez Atria Daniela, Gaudette Brian T, Londregan Jennifer, Kelly Samantha, Perkey Eric, Allman Anneka, Srivastava Bhaskar, Koch Ute, Radtke Freddy, Ludewig Burkhard, Siebel Christian W, Ryan Russell Jh, Robertson Tanner F, Burkhardt Janis K, Pear Warren S, Allman David, Maillard Ivan