Prof. Dr. Burkhard Ludewig
Leiter, Medizinisches Forschungszentrum
Leiter, Institut für Immunbiologie
Klinik-/Instituts-/Zentrumsleiter/in
Medizinisches Forschungszentrum, Institut für Immunbiologie · Dept. Direktion
Myocardial infarction triggers cardioprotective antigen-specific T helper cell responses
Rieckmann M, van der Laan A, Piek J, Koch C, Wester H, Lapa C, Bauer W, Ludewig B, Friedman N, Frantz S, Hofmann U, Krijnen P, Niessen H, Delgobo M, Gaal C, Büchner L, Steinau P, Reshef D, Gil Cruz C, Ter Horst E, Kircher M, Reiter T, Heinze K, Ramos G. Myocardial infarction triggers cardioprotective antigen-specific T helper cell responses. J Clin Invest 2019; 130
13.08.2019Myocardial infarction triggers cardioprotective antigen-specific T helper cell responses
13.08.2019J Clin Invest 2019; 130
Rieckmann Max, van der Laan Anja M, Piek Jan J, Koch Charlotte, Wester Hans-Jürgen, Lapa Constantin, Bauer Wolfgang R, Ludewig Burkhard, Friedman Nir, Frantz Stefan, Hofmann Ulrich, Krijnen Paul Aj, Niessen Hans Wm, Delgobo Murilo, Gaal Chiara, Büchner Lotte, Steinau Philipp, Reshef Dan, Gil Cruz Cristina, Ter Horst Ellis N, Kircher Malte, Reiter Theresa, Heinze Katrin G, Ramos Gustavo Campos
Association of Checkpoint Inhibitor-Induced Toxic Effects With Shared Cancer and Tissue Antigens in Non-Small Cell Lung Cancer
Berner F, Hartmann F, Cheng H, Hönger G, Recher M, Goldman J, Cozzio A, Früh M, Neefjes J, Driessen C, Ludewig B, Hegazy A, Jochum W, Speiser D, Zippelius A, Läubli H, Bomze D, Diem S, Ali O, Fässler M, Ring S, Niederer R, Ackermann C, Baumgaertner P, Pikor N, Cruz C, van de Veen W, Akdis M, Nikolaev S, Flatz L. Association of Checkpoint Inhibitor-Induced Toxic Effects With Shared Cancer and Tissue Antigens in Non-Small Cell Lung Cancer. JAMA Oncol 2019; 5:1043-1047.
01.07.2019Association of Checkpoint Inhibitor-Induced Toxic Effects With Shared Cancer and Tissue Antigens in Non-Small Cell Lung Cancer
01.07.2019JAMA Oncol 2019; 5:1043-1047
Berner Fiamma, Hartmann Fabienne, Cheng Hung-Wei, Hönger Gideon, Recher Mike, Goldman Jonathan, Cozzio Antonio, Früh Martin, Neefjes Jacques, Driessen Christoph, Ludewig Burkhard, Hegazy Ahmed N, Jochum Wolfram, Speiser Daniel E, Zippelius Alfred, Läubli Heinz, Bomze David, Diem Stefan, Ali Omar Hasan, Fässler Mirjam, Ring Sandra, Niederer Rebekka, Ackermann Christoph J, Baumgaertner Petra, Pikor Natalia, Cruz Cristina Gil, van de Veen Willem, Akdis Mübeccel, Nikolaev Sergey, Flatz Lukas
Lymph Node Mesenchymal and Endothelial Stromal Cells Cooperate via the RANK-RANKL Cytokine Axis to Shape the Sinusoidal Macrophage Niche
Camara A, Flacher V, Ludewig B, Yagita H, Tanaka M, Asano K, Onder L, Chypre M, Sponsel J, Alloush F, Cordeiro O, Mueller C. Lymph Node Mesenchymal and Endothelial Stromal Cells Cooperate via the RANK-RANKL Cytokine Axis to Shape the Sinusoidal Macrophage Niche. Immunity 2019; 50:1467-1481.e6.
11.06.2019Lymph Node Mesenchymal and Endothelial Stromal Cells Cooperate via the RANK-RANKL Cytokine Axis to Shape the Sinusoidal Macrophage Niche
11.06.2019Immunity 2019; 50:1467-1481.e6
Camara Abdouramane, Flacher Vincent, Ludewig Burkhard, Yagita Hideo, Tanaka Masato, Asano Kenichi, Onder Lucas, Chypre Mélanie, Sponsel Janina, Alloush Farouk, Cordeiro Olga G, Mueller Christopher G
Systems analysis reveals complex biological processes during virus infection fate decisions
Argilaguet J, Heath S, Ludewig B, Bocharov G, Kaisho T, Andreu D, Casella V, Gil Cruz C, Vidal E, Riera G, Esteve-Codina A, Pedragosa M, Meyerhans A. Systems analysis reveals complex biological processes during virus infection fate decisions. Genome Res 2019; 29:907-919.
28.05.2019Systems analysis reveals complex biological processes during virus infection fate decisions
28.05.2019Genome Res 2019; 29:907-919
Argilaguet Jordi, Heath Simon, Ludewig Burkhard, Bocharov Gennady, Kaisho Tsuneyasu, Andreu David, Casella Valentina, Gil Cruz Cristina, Vidal Enric, Riera Graciela, Esteve-Codina Anna, Pedragosa Mireia, Meyerhans Andreas
IL-4Rα-Expressing B Cells Are Required for CXCL13 Production by Fibroblastic Reticular Cells
Dubey L, Ludewig B, Luther S, Harris N. IL-4Rα-Expressing B Cells Are Required for CXCL13 Production by Fibroblastic Reticular Cells. Cell Rep 2019; 27:2442-2458.e5.
21.05.2019IL-4Rα-Expressing B Cells Are Required for CXCL13 Production by Fibroblastic Reticular Cells
21.05.2019Cell Rep 2019; 27:2442-2458.e5
Dubey Lalit Kumar, Ludewig Burkhard, Luther Sanjiv A, Harris Nicola L
Divergent memory responses driven by adenoviral vectors are impacted by epitope competition
Colston J, Hutchings C, Chinnakannan S, Highton A, Pérez Shibayama C, Ludewig B, Klenerman P. Divergent memory responses driven by adenoviral vectors are impacted by epitope competition. Eur J Immunol 2019
20.05.2019Divergent memory responses driven by adenoviral vectors are impacted by epitope competition
20.05.2019Eur J Immunol 2019
Colston Julia M, Hutchings Claire, Chinnakannan Senthil, Highton Andrew, Pérez Shibayama Christian Ivan, Ludewig Burkhard, Klenerman Paul
Fibroblastic reticular cells at the nexus of innate and adaptive immune responses
Pérez Shibayama C, Gil Cruz C, Ludewig B. Fibroblastic reticular cells at the nexus of innate and adaptive immune responses. Immunol Rev 2019; 289:31-41.
01.05.2019Fibroblastic reticular cells at the nexus of innate and adaptive immune responses
01.05.2019Immunol Rev 2019; 289:31-41
Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Ludewig Burkhard
Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp
Cheng H, Hehlgans T, Rülicke T, Pfeffer K, Sorg U, Tersteegen A, Miyazaki J, Robinson M, Scandella E, Pikor N, Lütge M, Soneson C, Novkovic M, Onder L, Ludewig B. Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp. Nat Commun 2019; 10:1739.
15.04.2019Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp
15.04.2019Nat Commun 2019; 10:1739
Cheng Hung-Wei, Hehlgans Thomas, Rülicke Thomas, Pfeffer Klaus, Sorg Ursula, Tersteegen Anne, Miyazaki Jun-Ichi, Robinson Mark D, Scandella Elke, Pikor Natalia, Lütge Mechthild, Soneson Charlotte, Novkovic Mario, Onder Lucas, Ludewig Burkhard
Rolf Zinkernagel and the co-discovery of MHC restriction together with Peter Doherty
Ludewig B. Rolf Zinkernagel and the co-discovery of MHC restriction together with Peter Doherty. Allergy 2019
27.03.2019Rolf Zinkernagel and the co-discovery of MHC restriction together with Peter Doherty
27.03.2019Allergy 2019
Ludewig Burkhard
TLR7 Controls VSV Replication in CD169 SCS Macrophages and Associated Viral Neuroinvasion
Solmaz G, Lang K, Wagner H, Clausen B, Ludewig B, Kalinke U, Khairnar V, Duhan V, Swallow M, Guderian M, Lindenberg M, Francozo M, Puttur F, Sparwasser T. TLR7 Controls VSV Replication in CD169 SCS Macrophages and Associated Viral Neuroinvasion. Front Immunol 2019; 10:466.
15.03.2019TLR7 Controls VSV Replication in CD169 SCS Macrophages and Associated Viral Neuroinvasion
15.03.2019Front Immunol 2019; 10:466
Solmaz Gülhas, Lang Karl S, Wagner Hermann, Clausen Björn E, Ludewig Burkhard, Kalinke Ulrich, Khairnar Vishal, Duhan Vikas, Swallow Maxine, Guderian Melanie, Lindenberg Marc, Francozo Marcela, Puttur Franz, Sparwasser Tim D
Antibodies as biomarker candidates for response and survival to checkpoint inhibitors in melanoma patients
Fässler M, Jörger M, Recher M, Risch L, Güsewell S, Risch M, Speiser D, Ludewig B, Levesque M, Dummer R, Siano M, Krolik M, Diem S, Mangana J, Hasan Ali O, Berner F, Bomze D, Ring S, Niederer R, Gil Cruz C, Pérez Shibayama C, Flatz L. Antibodies as biomarker candidates for response and survival to checkpoint inhibitors in melanoma patients. J Immunother Cancer 2019; 7:50.
20.02.2019Antibodies as biomarker candidates for response and survival to checkpoint inhibitors in melanoma patients
20.02.2019J Immunother Cancer 2019; 7:50
Fässler Mirjam, Jörger Markus, Recher Mike, Risch Lorenz, Güsewell Sabine, Risch Martin, Speiser Daniel E, Ludewig Burkhard, Levesque Mitchell P, Dummer Reinhard, Siano Marco, Krolik Michal, Diem Stefan, Mangana Joanna, Hasan Ali Omar, Berner Fiamma, Bomze David, Ring Sandra, Niederer Rebekka, Gil Cruz Cristina, Pérez Shibayama Christian Ivan, Flatz Lukas
Type I interferon induces CXCL13 to support ectopic germinal center formation
Denton A, Good-Jacobson K, Groom J, Ludewig B, Mörbe U, Mabbott N, Lafouresse F, Bradford B, Carr E, Innocentin S, Linterman M. Type I interferon induces CXCL13 to support ectopic germinal center formation. J Exp Med 2019
05.02.2019Type I interferon induces CXCL13 to support ectopic germinal center formation
05.02.2019J Exp Med 2019
Denton Alice E, Good-Jacobson Kim L, Groom Joanna R, Ludewig Burkhard, Mörbe Urs, Mabbott Neil A, Lafouresse Fanny, Bradford Barry M, Carr Edward J, Innocentin Silvia, Linterman Michelle A
Myocarditis Elicits Dendritic Cell and Monocyte Infiltration in the Heart and Self-Antigen Presentation by Conventional Type 2 Dendritic Cells
Van der Borght K, Gillebert T, Ludewig B, Boon L, Saeys Y, Nindl V, Van Isterdael G, Sichien D, Martens L, Scott C, Lambrecht B. Myocarditis Elicits Dendritic Cell and Monocyte Infiltration in the Heart and Self-Antigen Presentation by Conventional Type 2 Dendritic Cells. Front Immunol 2018; 9:2714.
21.11.2018Myocarditis Elicits Dendritic Cell and Monocyte Infiltration in the Heart and Self-Antigen Presentation by Conventional Type 2 Dendritic Cells
21.11.2018Front Immunol 2018; 9:2714
Van der Borght Katrien, Gillebert Thierry C, Ludewig Burkhard, Boon Louis, Saeys Yvan, Nindl Veronika, Van Isterdael Gert, Sichien Dorine, Martens Liesbet, Scott Charlotte L, Lambrecht Bart N
Essential Role of Canonical NF-κB Activity in the Development of Stromal Cell Subsets in Secondary Lymphoid Organs
Bogdanova D, Takeuchi A, Ozawa M, Kanda Y, Rahman M, Ludewig B, Kinashi T, Katakai T. Essential Role of Canonical NF-κB Activity in the Development of Stromal Cell Subsets in Secondary Lymphoid Organs. J Immunol 2018; 201:3580-3586.
05.11.2018Essential Role of Canonical NF-κB Activity in the Development of Stromal Cell Subsets in Secondary Lymphoid Organs
05.11.2018J Immunol 2018; 201:3580-3586
Bogdanova Dana, Takeuchi Arata, Ozawa Madoka, Kanda Yasuhiro, Rahman M Azizur, Ludewig Burkhard, Kinashi Tatsuo, Katakai Tomoya
Redefining the Nature of Lymphoid Tissue Organizer Cells: Response to 'Complexity of Lymphoid Tissue Organizers' by Koning and Mebius
Onder L, Ludewig B. Redefining the Nature of Lymphoid Tissue Organizer Cells: Response to 'Complexity of Lymphoid Tissue Organizers' by Koning and Mebius. Trends Immunol 2018; 39:952-953.
02.11.2018Redefining the Nature of Lymphoid Tissue Organizer Cells: Response to 'Complexity of Lymphoid Tissue Organizers' by Koning and Mebius
02.11.2018Trends Immunol 2018; 39:952-953
Onder Lucas, Ludewig Burkhard
Integrative Computational Modeling of the Lymph Node Stromal Cell Landscape
Novkovic M, Onder L, Cheng H, Bocharov G, Ludewig B. Integrative Computational Modeling of the Lymph Node Stromal Cell Landscape. Front Immunol 2018; 9:2428.
23.10.2018Integrative Computational Modeling of the Lymph Node Stromal Cell Landscape
23.10.2018Front Immunol 2018; 9:2428
Novkovic Mario, Onder Lucas, Cheng Hung-Wei, Bocharov Gennady, Ludewig Burkhard
A Distinct Subset of Fibroblastic Stromal Cells Constitutes the Cortex-Medulla Boundary Subcompartment of the Lymph Node
Takeuchi A, Nagasawa T, Takahama Y, Ludewig B, Miyasaka M, Umemoto E, Shichida Y, Kawamura T, Rahman M, Kurosawa Y, Ohigashi I, Kozai M, Kanda Y, Ozawa M, Katakai T. A Distinct Subset of Fibroblastic Stromal Cells Constitutes the Cortex-Medulla Boundary Subcompartment of the Lymph Node. Front Immunol 2018; 9:2196.
02.10.2018A Distinct Subset of Fibroblastic Stromal Cells Constitutes the Cortex-Medulla Boundary Subcompartment of the Lymph Node
02.10.2018Front Immunol 2018; 9:2196
Takeuchi Arata, Nagasawa Takashi, Takahama Yousuke, Ludewig Burkhard, Miyasaka Masayuki, Umemoto Eiji, Shichida Yuto, Kawamura Toshihiko, Rahman Md Azizur, Kurosawa Yoichi, Ohigashi Izumi, Kozai Mina, Kanda Yasuhiro, Ozawa Madoka, Katakai Tomoya
A Fresh View on Lymph Node Organogenesis
Onder L, Ludewig B. A Fresh View on Lymph Node Organogenesis. Trends Immunol 2018; 39:775-787.
24.08.2018A Fresh View on Lymph Node Organogenesis
24.08.2018Trends Immunol 2018; 39:775-787
Onder Lucas, Ludewig Burkhard
Fibroblastic reticular cells initiate immune responses in visceral adipose tissues and secure peritoneal immunity
Pérez Shibayama C, Gommerman J, Scandella E, Robinson M, Soneson C, Mack M, Turley S, Buechler M, López-Macías C, Li C, Novkovic M, Mörbe U, Printz A, Onder L, Cheng H, Gil Cruz C, Ludewig B. Fibroblastic reticular cells initiate immune responses in visceral adipose tissues and secure peritoneal immunity. Sci Immunol 2018; 3
10.08.2018Fibroblastic reticular cells initiate immune responses in visceral adipose tissues and secure peritoneal immunity
10.08.2018Sci Immunol 2018; 3
Pérez Shibayama Christian Ivan, Gommerman Jennifer, Scandella Elke, Robinson Mark D, Soneson Charlotte, Mack Matthias, Turley Shannon J, Buechler Matthew B, López-Macías Constantino, Li Conglei, Novkovic Mario, Mörbe Urs, Printz Andrea, Onder Lucas, Cheng Hung-Wei, Gil Cruz Cristina, Ludewig Burkhard
Tissue maintenance of CMV-specific inflationary memory T cells by IL-15
Baumann N, Ludewig B, Ikuta K, Cicin-Sain L, Oduro J, Pallmer K, Borsa M, Barnstorf I, Welten S, Torti N, Oxenius A. Tissue maintenance of CMV-specific inflationary memory T cells by IL-15. PLoS Pathog 2018; 14:e1006993.
13.04.2018Tissue maintenance of CMV-specific inflationary memory T cells by IL-15
13.04.2018PLoS Pathog 2018; 14:e1006993
Baumann Nicolas S, Ludewig Burkhard, Ikuta Koichi, Cicin-Sain Luka, Oduro Jennifer D, Pallmer Katharina, Borsa Mariana, Barnstorf Isabel, Welten Suzanne P M, Torti Nicole, Oxenius Annette