Prof. Dr. Christoph Driessen
Chefarzt Klinik für Medizinische Onkologie und Hämatologie, Kantonsspital St.Gallen
Stellvertretender Leiter Comprehensive Cancer Center Kantonsspital St.Gallen
Medizinische Onkologie und Hämatologie · Dept. I
Design of protease-resistant myelin basic protein-derived peptides by cleavage site directed amino acid substitutions
Burster T, Kalbacher H, Verhelst S, Weber E, Falk K, Rotzschke O, Dunn S, Boehm B, Marin-Esteban V, Driessen C. Design of protease-resistant myelin basic protein-derived peptides by cleavage site directed amino acid substitutions. Biochemical pharmacology 2007; 74:1514-23.
15.11.2007Design of protease-resistant myelin basic protein-derived peptides by cleavage site directed amino acid substitutions
15.11.2007Biochemical pharmacology 2007; 74:1514-23
Burster Timo, Kalbacher Hubert, Verhelst Steven H L, Weber Ekkehard, Falk Kirsten, Rotzschke Olaf, Dunn Shannon, Boehm Bernhard O, Marin-Esteban Viviana, Driessen Christoph
A new approach for distinguishing cathepsin E and D activity in antigen-processing organelles
Zaidi N, Herrmann T, Baechle D, Schleicher S, Gogel J, Driessen C, Voelter W, Kalbacher H. A new approach for distinguishing cathepsin E and D activity in antigen-processing organelles. The FEBS journal 2007; 274:3138-49.
01.06.2007A new approach for distinguishing cathepsin E and D activity in antigen-processing organelles
01.06.2007The FEBS journal 2007; 274:3138-49
Zaidi Nousheen, Herrmann Timo, Baechle Daniel, Schleicher Sabine, Gogel Jeannette, Driessen Christoph, Voelter Wolfgang, Kalbacher Hubert
Interferon-gamma regulates cathepsin G activity in microglia-derived lysosomes and controls the proteolytic processing of myelin basic protein in vitro
Burster T, Tolosa E, Overkleeft H, Kalbacher H, Youssef S, Boehm B, Falk K, Roetzschke O, Reich M, Baechle D, Øren A, Poeschel S, Beck A, Driessen C. Interferon-gamma regulates cathepsin G activity in microglia-derived lysosomes and controls the proteolytic processing of myelin basic protein in vitro. Immunology 2007; 121:82-93.
01.05.2007Interferon-gamma regulates cathepsin G activity in microglia-derived lysosomes and controls the proteolytic processing of myelin basic protein in vitro
01.05.2007Immunology 2007; 121:82-93
Burster Timo, Tolosa Eva, Overkleeft Herman, Kalbacher Hubert, Youssef Sawsan, Boehm Bernhard O, Falk Kirsten, Roetzschke Olaf, Reich Michael, Baechle Daniel, Øren Anita, Poeschel Simone, Beck Alexander, Driessen Christoph
The benefit of using whole-body, low-dose, nonenhanced, multidetector computed tomography for follow-up and therapy response monitoring in patients with multiple myeloma.
Horger M, Kanz L, Denecke B, Vonthein R, Pereira P, Claussen C, Driessen C. The benefit of using whole-body, low-dose, nonenhanced, multidetector computed tomography for follow-up and therapy response monitoring in patients with multiple myeloma. Cancer 2007; 109:1617-26.
15.04.2007The benefit of using whole-body, low-dose, nonenhanced, multidetector computed tomography for follow-up and therapy response monitoring in patients with multiple myeloma.
15.04.2007Cancer 2007; 109:1617-26
Horger Marius, Kanz Lothar, Denecke Barbara, Vonthein Reinhard, Pereira Philippe, Claussen Claus Detlef, Driessen Christoph
Endocytosis targets exogenous material selectively to cathepsin S in live human dendritic cells, while cell-penetrating peptides mediate nonselective transport to cysteine cathepsins
Reich M, van Swieten P, Sommandas V, Kraus M, Fischer R, Weber E, Kalbacher H, Overkleeft H, Driessen C. Endocytosis targets exogenous material selectively to cathepsin S in live human dendritic cells, while cell-penetrating peptides mediate nonselective transport to cysteine cathepsins. Journal of leukocyte biology 2007; 81:990-1001.
01.04.2007Endocytosis targets exogenous material selectively to cathepsin S in live human dendritic cells, while cell-penetrating peptides mediate nonselective transport to cysteine cathepsins
01.04.2007Journal of leukocyte biology 2007; 81:990-1001
Reich Michael, van Swieten Paul F, Sommandas Vinod, Kraus Marianne, Fischer Rainer, Weber Ekkehard, Kalbacher Hubert, Overkleeft Herman S, Driessen Christoph
Activity patterns of proteasome subunits reflect bortezomib sensitivity of hematologic malignancies and are variable in primary human leukemia cells
Kraus M, Ovaa H, Overkleeft H, Burg D, Berkers C, Kammer W, Beck A, Gogel J, Reich M, Rückrich T, Driessen C. Activity patterns of proteasome subunits reflect bortezomib sensitivity of hematologic malignancies and are variable in primary human leukemia cells. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2007; 21:84-92.
01.01.2007Activity patterns of proteasome subunits reflect bortezomib sensitivity of hematologic malignancies and are variable in primary human leukemia cells
01.01.2007Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2007; 21:84-92
Kraus Marianne, Ovaa H, Overkleeft H, Burg D, Berkers C R, Kammer W, Beck A, Gogel J, Reich M, Rückrich T, Driessen Christoph
Specificity of human cathepsin S determined by processing of peptide substrates and MHC class II-associated invariant chain
Rückrich T, Driessen C, Reich M, Melms A, Beck A, Wiederanders B, Schilling K, Stevanovic S, Müller M, Cansier A, Brandenburg J, Kalbacher H. Specificity of human cathepsin S determined by processing of peptide substrates and MHC class II-associated invariant chain. Biol Chem 2006; 387:1503-11.
01.10.2006Specificity of human cathepsin S determined by processing of peptide substrates and MHC class II-associated invariant chain
01.10.2006Biol Chem 2006; 387:1503-11
Rückrich Thomas, Driessen Christoph, Reich Michael, Melms Arthur, Beck Alexander, Wiederanders Bernd, Schilling Klaus, Stevanovic Stefan, Müller Margret, Cansier Alexander, Brandenburg Jens, Kalbacher Hubert
[Extramedullary myeloma manifestations: imaging findings]
Horger M, Brodoefel H, Driessen C. [Extramedullary myeloma manifestations: imaging findings]. RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin 2006; 178:747-51.
01.08.2006[Extramedullary myeloma manifestations: imaging findings]
01.08.2006RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin 2006; 178:747-51
Horger M, Brodoefel H, Driessen Christoph
Differential processing of autoantigens in lysosomes from human monocyte-derived and peripheral blood dendritic cells
Burster T, Overkleeft H, Weber E, Häring H, Kalbacher H, Kraus M, Reich M, Weissert R, Schnorrer P, Tolosa E, Beck A, Driessen C. Differential processing of autoantigens in lysosomes from human monocyte-derived and peripheral blood dendritic cells. Journal of immunology (Baltimore, Md. : 1950) 2005; 175:5940-9.
01.11.2005Differential processing of autoantigens in lysosomes from human monocyte-derived and peripheral blood dendritic cells
01.11.2005Journal of immunology (Baltimore, Md. : 1950) 2005; 175:5940-9
Burster Timo, Overkleeft Herman, Weber Ekkehard, Häring Hans-Ulrich, Kalbacher Hubert, Kraus Marianne, Reich Michael, Weissert Robert, Schnorrer Petra, Tolosa Eva, Beck Alexander, Driessen Christoph
Probing the potential of platinum(II) complexes for the inhibition of thiol-dependent enzymatic activity
van Zutphen S, Kraus M, Driessen C, van der Marel G, Overkleeft H, Reedijk J. Probing the potential of platinum(II) complexes for the inhibition of thiol-dependent enzymatic activity. Journal of inorganic biochemistry 2005; 99:1384-9.
01.06.2005Probing the potential of platinum(II) complexes for the inhibition of thiol-dependent enzymatic activity
01.06.2005Journal of inorganic biochemistry 2005; 99:1384-9
van Zutphen Steven, Kraus Marianne, Driessen Christoph, van der Marel Gijs A, Overkleeft Herman S, Reedijk Jan
Autophagy promotes MHC class II presentation of peptides from intracellular source proteins
Dengjel J, Rammensee H, Driessen C, Brock R, Kalbacher H, Brandenburg J, Altenberend F, Kreymborg K, Müller M, Kraus M, Reich M, Fischer R, Schoor O, Stevanovic S. Autophagy promotes MHC class II presentation of peptides from intracellular source proteins. Proceedings of the National Academy of Sciences of the United States of America 2005; 102:7922-7.
31.05.2005Autophagy promotes MHC class II presentation of peptides from intracellular source proteins
31.05.2005Proceedings of the National Academy of Sciences of the United States of America 2005; 102:7922-7
Dengjel Jörn, Rammensee Hans-Georg, Driessen Christoph, Brock Roland, Kalbacher Hubert, Brandenburg Jens, Altenberend Florian, Kreymborg Katharina, Müller Margret, Kraus Marianne, Reich Michael, Fischer Rainer, Schoor Oliver, Stevanovic Stefan
Biotinylated fluorescent peptide substrates for the sensitive and specific determination of cathepsin D activity
Baechle D, Cansier A, Fischer R, Brandenburg J, Burster T, Driessen C, Kalbacher H. Biotinylated fluorescent peptide substrates for the sensitive and specific determination of cathepsin D activity. Journal of peptide science : an official publication of the European Peptide Society 2005; 11:166-74.
01.03.2005Biotinylated fluorescent peptide substrates for the sensitive and specific determination of cathepsin D activity
01.03.2005Journal of peptide science : an official publication of the European Peptide Society 2005; 11:166-74
Baechle D, Cansier A, Fischer R, Brandenburg J, Burster T, Driessen Christoph, Kalbacher H
Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases
van Swieten P, Ploegh H, van der Marel G, Driessen C, Leeuwenburgh M, Kalbacher H, Wong C, Reich M, Kessler B, van den Nieuwendijk A, Maehr R, Overkleeft H. Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases. Bioorganic & medicinal chemistry letters 2004; 14:3131-4.
21.06.2004Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases
21.06.2004Bioorganic & medicinal chemistry letters 2004; 14:3131-4
van Swieten Paul F, Ploegh Hidde L, van der Marel Gijsbert A, Driessen Christoph, Leeuwenburgh Michiel A, Kalbacher Hubert, Wong Chung-Sing, Reich Michael, Kessler Benedikt M, van den Nieuwendijk Adrianus M C H, Maehr Rene, Overkleeft Herman S
Cathepsin G, and not the asparagine-specific endoprotease, controls the processing of myelin basic protein in lysosomes from human B lymphocytes
Burster T, Kalbacher H, Stevanovic S, Lehmann R, Melms A, Wiendl H, Schwarz G, Brandenburg J, Reich M, Lautwein A, Falk K, Rotzschke O, Marin-Esteban V, Tolosa E, Beck A, Driessen C. Cathepsin G, and not the asparagine-specific endoprotease, controls the processing of myelin basic protein in lysosomes from human B lymphocytes. Journal of immunology (Baltimore, Md. : 1950) 2004; 172:5495-503.
01.05.2004Cathepsin G, and not the asparagine-specific endoprotease, controls the processing of myelin basic protein in lysosomes from human B lymphocytes
01.05.2004Journal of immunology (Baltimore, Md. : 1950) 2004; 172:5495-503
Burster Timo, Kalbacher Hubert, Stevanovic Stefan, Lehmann Rainer, Melms Arthur, Wiendl Heinz, Schwarz Gerold, Brandenburg Jens, Reich Michael, Lautwein Alfred, Falk Kirsten, Rotzschke Olaf, Marin-Esteban Viviana, Tolosa Eva, Beck Alexander, Driessen Christoph
Human B lymphoblastoid cells contain distinct patterns of cathepsin activity in endocytic compartments and regulate MHC class II transport in a cathepsin S-independent manner
Lautwein A, Nordheim A, Kalbacher H, Weber E, Kammer W, Schwarz G, Overkleeft H, Brandenburg J, Burster T, Reich M, Kraus M, Driessen C. Human B lymphoblastoid cells contain distinct patterns of cathepsin activity in endocytic compartments and regulate MHC class II transport in a cathepsin S-independent manner. Journal of leukocyte biology 2004; 75:844-55.
01.05.2004Human B lymphoblastoid cells contain distinct patterns of cathepsin activity in endocytic compartments and regulate MHC class II transport in a cathepsin S-independent manner
01.05.2004Journal of leukocyte biology 2004; 75:844-55
Lautwein Alfred, Nordheim Alfred, Kalbacher Hubert, Weber Ekkehard, Kammer Winfried, Schwarz Gerold, Overkleeft Herman S, Brandenburg J, Burster Timo, Reich Michael, Kraus Marianne, Driessen Christoph
Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis
Tolosa E, Melms A, Kurek R, Stevanovic S, Weber E, Schnorrer P, Driessen C, Lautwein A, Denzin L, Wienhold W, Yasuda Y, Li W, Bromme D. Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis. The Journal of clinical investigation 2003; 112:517-26.
01.08.2003Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis
01.08.2003The Journal of clinical investigation 2003; 112:517-26
Tolosa Eva, Melms Arthur, Kurek Raffael, Stevanovic Stefan, Weber Ekkehard, Schnorrer Petra, Driessen Christoph, Lautwein Alfred, Denzin Lisa K, Wienhold Wolfgang, Yasuda Yoshiyuki, Li Weijie, Bromme Dieter
Antigen processing and presentation in human muscle: cathepsin S is critical for MHC class II expression and upregulated in inflammatory myopathies
Wiendl H, Tolosa E, Melms A, Lochmüller H, Overkleeft H, Weber E, Morgalla M, Wienhold W, Erfurth S, Krause S, Mitsdörffer M, Lautwein A, Driessen C. Antigen processing and presentation in human muscle: cathepsin S is critical for MHC class II expression and upregulated in inflammatory myopathies. Journal of neuroimmunology 2003; 138:132-43.
01.05.2003Antigen processing and presentation in human muscle: cathepsin S is critical for MHC class II expression and upregulated in inflammatory myopathies
01.05.2003Journal of neuroimmunology 2003; 138:132-43
Wiendl Heinz, Tolosa Eva, Melms Arthur, Lochmüller Hanns, Overkleeft Herman S, Weber Ekkehard, Morgalla Matthias, Wienhold Wolfgang, Erfurth Stella, Krause Sabine, Mitsdörffer Meike, Lautwein Alfred, Driessen Christoph
Activity and subcellular distribution of cathepsins in primary human monocytes
Greiner A, Lautwein A, Overkleeft H, Weber E, Driessen C. Activity and subcellular distribution of cathepsins in primary human monocytes. Journal of leukocyte biology 2003; 73:235-42.
01.02.2003Activity and subcellular distribution of cathepsins in primary human monocytes
01.02.2003Journal of leukocyte biology 2003; 73:235-42
Greiner Andrea, Lautwein Alfred, Overkleeft Herman S, Weber Ekkehard, Driessen Christoph
Treatment of relapsed CD20+ Hodgkin lymphoma with the monoclonal antibody rituximab is effective and well tolerated: results of a phase 2 trial of the German Hodgkin Lymphoma Study Group
Rehwald U, Engert A, Diehl V, Muller-Hermelink K, Rüdiger T, Driessen C, Morschhauser F, Staak J, Sieber M, Reiser M, Schulz H, German Hodgkin Lymphoma Study Group (GHSG). Treatment of relapsed CD20+ Hodgkin lymphoma with the monoclonal antibody rituximab is effective and well tolerated: results of a phase 2 trial of the German Hodgkin Lymphoma Study Group. Blood 2003; 101:420-4.
15.01.2003Treatment of relapsed CD20+ Hodgkin lymphoma with the monoclonal antibody rituximab is effective and well tolerated: results of a phase 2 trial of the German Hodgkin Lymphoma Study Group
15.01.2003Blood 2003; 101:420-4
Rehwald Ute, Engert Andreas, Diehl Volker, Muller-Hermelink Konrad, Rüdiger Thomas, Driessen Christoph, Morschhauser Franck, Staak Jan Oliver, Sieber Markus, Reiser Marcel, Schulz Holger, German Hodgkin Lymphoma Study Group (GHSG)
Inflammatory stimuli recruit cathepsin activity to late endosomal compartments in human dendritic cells
Lautwein A, Burster T, Lennon-Duménil A, Overkleeft H, Weber E, Kalbacher H, Driessen C. Inflammatory stimuli recruit cathepsin activity to late endosomal compartments in human dendritic cells. European journal of immunology 2002; 32:3348-57.
01.12.2002Inflammatory stimuli recruit cathepsin activity to late endosomal compartments in human dendritic cells
01.12.2002European journal of immunology 2002; 32:3348-57
Lautwein Alfred, Burster Timo, Lennon-Duménil Ana-Maria, Overkleeft Herman S, Weber Ekkehard, Kalbacher Hubert, Driessen Christoph