Prof. Dr. Christoph Driessen
Chefarzt Klinik für Medizinische Onkologie und Hämatologie, Kantonsspital St.Gallen
Stellvertretender Leiter Comprehensive Cancer Center Kantonsspital St.Gallen
Medizinische Onkologie und Hämatologie · Dept. I
Spectrum and functional validation of PSMB5 mutations in multiple myeloma
Barrio S, Martinez-Lopez J, Rosenwald A, Beckmann R, Bargou R, Braggio E, Stewart A, Raab M, Einsele H, Driessen C, Chatterjee M, Leich E, Stühmer T, Da-Viá M, Barrio-Garcia C, Lehners N, Besse A, Cuenca I, Garitano-Trojaola A, Fink S, Kortüm K. Spectrum and functional validation of PSMB5 mutations in multiple myeloma. Leukemia 2018
19.07.2018Spectrum and functional validation of PSMB5 mutations in multiple myeloma
19.07.2018Leukemia 2018
Barrio Santiago, Martinez-Lopez Joaquin, Rosenwald Andreas, Beckmann Roland, Bargou Ralf C, Braggio Esteban, Stewart A Keith, Raab Marc S, Einsele Hermann, Driessen Christoph, Chatterjee Manik, Leich Ellen, Stühmer Thorsten, Da-Viá Matteo, Barrio-Garcia Clara, Lehners Nicola, Besse Andrej, Cuenca Isabel, Garitano-Trojaola Andoni, Fink Severin, Kortüm K Martin
Prevention and management of adverse events of novel agents in multiple myeloma: a consensus of the European Myeloma Network
Ludwig H, Cook G, Leleu X, Goldschmidt H, Jackson G, Kaiser M, Weisel K, van de Donk N, Waage A, Beksac M, Mellqvist U, Engelhardt M, Caers J, Driessen C, Bladé J, Mateos M, Garderet L, Delforge M, Facon T, Einsele H, Gay F, Moreau P, Avet-Loiseau H, Boccadoro M, Hájek R, Mohty M, Cavo M, Dimopoulos M, San-Miguel J, Terpos E, Zweegman S, Sonneveld P. Prevention and management of adverse events of novel agents in multiple myeloma: a consensus of the European Myeloma Network. Leukemia 2018
02.05.2018Prevention and management of adverse events of novel agents in multiple myeloma: a consensus of the European Myeloma Network
02.05.2018Leukemia 2018
Ludwig Heinz, Cook Gordon, Leleu Xavier, Goldschmidt Hartmut, Jackson Graham, Kaiser Martin, Weisel Katja, van de Donk Niels W C J, Waage Anders, Beksac Meral, Mellqvist Ulf H, Engelhardt Monika, Caers Jo, Driessen Christoph, Bladé Joan, Mateos Maria-Victoria, Garderet Laurent, Delforge Michel, Facon Thierry, Einsele Hermann, Gay Francesca, Moreau Philippe, Avet-Loiseau Hervé, Boccadoro Mario, Hájek Roman, Mohty Mohamad, Cavo Michele, Dimopoulos Meletios A, San-Miguel Jesús F, Terpos Evangelos, Zweegman Sonja, Sonneveld Pieter
Verbesserte Wirksamkeit von Proteasom-Inhibitoren in der Behandlung des Nierenzellkarzinoms durch die Kombination mit den HIV-Protease-Inhibitoren Lopinavir und Nelfinavir
Abt D, Driessen C, Engeler D, Schmid H, Slaby O, Vodinska M, Silzle T, Bader J, Kraus M, Sedlarikova L, Besse A, Besse L. Verbesserte Wirksamkeit von Proteasom-Inhibitoren in der Behandlung des Nierenzellkarzinoms durch die Kombination mit den HIV-Protease-Inhibitoren Lopinavir und Nelfinavir. German Medicale Science, www.egms.de 2018
01.01.2018Verbesserte Wirksamkeit von Proteasom-Inhibitoren in der Behandlung des Nierenzellkarzinoms durch die Kombination mit den HIV-Protease-Inhibitoren Lopinavir und Nelfinavir
01.01.2018German Medicale Science, www.egms.de 2018
Abt Dominik, Driessen Christoph, Engeler Daniel, Schmid Hans-Peter, Slaby O, Vodinska M, Silzle T, Bader J, Kraus M, Sedlarikova L, Besse A, Besse L
Improving the efficacy of proteasome inhibitors in the treatment of renal cell carcinoma by combination with the human immunodeficiency virus (HIV)-protease inhibitors lopinavir or nelfinavir
Abt D, Driessen C, Engeler D, Schmid H, Slaby O, Vodinska M, Silzle T, Bader J, Kraus M, Sedlarikova L, Besse A, Besse L. Improving the efficacy of proteasome inhibitors in the treatment of renal cell carcinoma by combination with the human immunodeficiency virus (HIV)-protease inhibitors lopinavir or nelfinavir. BJU Int 2018; 121:600-9.
01.01.2018Improving the efficacy of proteasome inhibitors in the treatment of renal cell carcinoma by combination with the human immunodeficiency virus (HIV)-protease inhibitors lopinavir or nelfinavir
01.01.2018BJU Int 2018; 121:600-9
Abt Dominik, Driessen Christoph, Engeler Daniel, Schmid Hans-Peter, Slaby O, Vodinska M, Silzle T, Bader J, Kraus M, Sedlarikova L, Besse A, Besse L
Prevention and management of adverse events of Novel agents in multiple myeloma: A consensus of the european myeloma network
Ludwig H, Cook G, Leleu X, Goldschmidt H, Jackson G, Kaiser M, Weisel K, van de Donk N, Waage A, Beksac M, Mellqvist U, Engelhardt M, Caers J, Driessen C, Mateos M, Garderet L, Zweegman S, Delforge M, Facon T, Einsele H, Gay F, Moreau P, Avet-Loiseau H, Boccadoro M, Hajek R, Mohty M, Cavo M, Dimopoulos M, San-Miguel J, Terpos E, Sonneveld P. Prevention and management of adverse events of Novel agents in multiple myeloma: A consensus of the european myeloma network. Leukemia 2017
18.12.2017Prevention and management of adverse events of Novel agents in multiple myeloma: A consensus of the european myeloma network
18.12.2017Leukemia 2017
Ludwig H, Cook G, Leleu X, Goldschmidt H, Jackson G, Kaiser M, Weisel K, van de Donk N W C J, Waage A, Beksac M, Mellqvist U H, Engelhardt M, Caers J, Driessen Christoph, Mateos M-V, Garderet L, Zweegman S, Delforge M, Facon T, Einsele H, Gay F, Moreau P, Avet-Loiseau H, Boccadoro M, Hajek R, Mohty M, Cavo M, Dimopoulos M A, San-Miguel J F, Terpos E, Sonneveld P
Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4
Skrott Z, Pouckova P, Sedlacek J, Miklovicova A, Kutt A, Li J, Mattova J, Driessen C, Dou Q, Olsen J, Hajduch M, Cvek B, Deshaies R, Vrobel I, Dzubak P, Mistrik M, Andersen K, Friis S, Majera D, Gursky J, Ozdian T, Bartkova J, Turi Z, Moudry P, Kraus M, Michalova M, Vaclavkova J, Bartek J. Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4. Nature 2017; 552:194-199.
06.12.2017Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4
06.12.2017Nature 2017; 552:194-199
Skrott Zdenek, Pouckova Pavla, Sedlacek Jindrich, Miklovicova Andrea, Kutt Anne, Li Jing, Mattova Jana, Driessen Christoph, Dou Q Ping, Olsen Jørgen, Hajduch Marian, Cvek Boris, Deshaies Raymond J, Vrobel Ivo, Dzubak Petr, Mistrik Martin, Andersen Klaus Kaae, Friis Søren, Majera Dusana, Gursky Jan, Ozdian Tomas, Bartkova Jirina, Turi Zsofia, Moudry Pavel, Kraus Marianne, Michalova Martina, Vaclavkova Jana, Bartek Jiri
Improving the efficacy of proteasome inhibitors in the treatment of renal cell carcinoma by combination with the human immunodeficiency virus (HIV)-protease inhibitors lopinavir or nelfinavir
Abt D, Driessen C, Engeler D, Schmid H, Slaby O, Vodinska M, Silzle T, Bader J, Kraus M, Sedlarikova L, Besse A, Besse L. Improving the efficacy of proteasome inhibitors in the treatment of renal cell carcinoma by combination with the human immunodeficiency virus (HIV)-protease inhibitors lopinavir or nelfinavir. BJU Int 2017
21.11.2017Improving the efficacy of proteasome inhibitors in the treatment of renal cell carcinoma by combination with the human immunodeficiency virus (HIV)-protease inhibitors lopinavir or nelfinavir
21.11.2017BJU Int 2017
Abt Dominik, Driessen Christoph, Engeler Daniel, Schmid Hans-Peter, Slaby Ondrej, Vodinska Martina, Silzle Tobias, Bader Juergen, Kraus Marianne, Sedlarikova Lenka, Besse Andrej, Besse Lenka
The p97 Inhibitor CB-5083 Is a Unique Disrupter of Protein Homeostasis in Models of Multiple Myeloma
Le Moigne R, Chesi M, Bergsagel P, Kraus M, Driessen C, Kiss von Soly S, Yakes F, Wustrow D, Shawver L, Zhou H, Martin T, Wolf J, Mitsiades C, Anderson D, Wang J, Rice J, Lam C, Aftab B, Djakovic S, Dhimolea E, Valle E, Murnane M, King E, Soriano F, Menon M, Wu Z, Wong S, Lee G, Yao B, Wiita A, Rolfe M. The p97 Inhibitor CB-5083 Is a Unique Disrupter of Protein Homeostasis in Models of Multiple Myeloma. Mol Cancer Ther 2017; 16:2375-2386.
06.09.2017The p97 Inhibitor CB-5083 Is a Unique Disrupter of Protein Homeostasis in Models of Multiple Myeloma
06.09.2017Mol Cancer Ther 2017; 16:2375-2386
Le Moigne Ronan, Chesi Marta, Bergsagel P Leif, Kraus Marianne, Driessen Christoph, Kiss von Soly Szerenke, Yakes F Michael, Wustrow David, Shawver Laura, Zhou Han-Jie, Martin Thomas G, Wolf Jeffrey L, Mitsiades Constantine S, Anderson Daniel J, Wang Jinhai, Rice Julie, Lam Christine, Aftab Blake T, Djakovic Stevan, Dhimolea Eugen, Valle Eduardo, Murnane Megan, King Emily M, Soriano Ferdie, Menon Mary-Kamala, Wu Zhi Yong, Wong Stephen T, Lee Grace J, Yao Bing, Wiita Arun P, Rolfe Mark
The first-in-class alkylating HDAC inhibitor EDO-S101 is highly synergistic with proteasome inhibition against multiple myeloma through activation of multiple pathways
Besse L, Kraus M, Besse A, Bader J, Silzle T, Mehrling T, Driessen C. The first-in-class alkylating HDAC inhibitor EDO-S101 is highly synergistic with proteasome inhibition against multiple myeloma through activation of multiple pathways. Blood Cancer J 2017; 7:e589.
28.07.2017The first-in-class alkylating HDAC inhibitor EDO-S101 is highly synergistic with proteasome inhibition against multiple myeloma through activation of multiple pathways
28.07.2017Blood Cancer J 2017; 7:e589
Besse Lenka, Kraus Marianne, Besse Andrej, Bader J, Silzle Tobias, Mehrling T, Driessen Christoph
Carfilzomib resistance due to ABCB1/MDR1 overexpression is overcome by nelfinavir and lopinavir in multiple myeloma
Besse A, Besse L, Overkleeft H, Bader J, Kraus M, Morgan G, Weinhold N, Rasche L, Stolze S, Driessen C. Carfilzomib resistance due to ABCB1/MDR1 overexpression is overcome by nelfinavir and lopinavir in multiple myeloma. Leukemia 2017; 32:391-401.
05.07.2017Carfilzomib resistance due to ABCB1/MDR1 overexpression is overcome by nelfinavir and lopinavir in multiple myeloma
05.07.2017Leukemia 2017; 32:391-401
Besse Andrej, Besse Lenka, Overkleeft H S, Bader J, Kraus Marianne, Morgan G J, Weinhold N, Rasche L, Stolze S C, Driessen Christoph
Spotlight on pomalidomide: could less be more?
Zander T, Aebi S, Pabst T, Renner C, Driessen C. Spotlight on pomalidomide: could less be more?. Leukemia 2017; 31:1987-1989.
22.05.2017Spotlight on pomalidomide: could less be more?
22.05.2017Leukemia 2017; 31:1987-1989
Zander T, Aebi S, Pabst T, Renner C, Driessen Christoph
Improving the efficacy of proteasome inhibitors in the treatment of renal cell carcinoma
Abt D, Kraus M, Bader J, Besse A, Schmid H, Engeler D, Driessen C, Besse L (2016). Improving the efficacy of proteasome inhibitors in the treatment of renal cell carcinoma. Präsentiert bei: -, -
01.01.2017Improving the efficacy of proteasome inhibitors in the treatment of renal cell carcinoma
01.01.2017-
Abt Dominik, Kraus M, Bader J, Besse A, Schmid Hans-Peter, Engeler Daniel, Driessen Christoph, Besse L
Verbesserung der Wirksamkeit von Proteasom-Inhibitoren in der Behandlung des Nierenzell-Carcinoms
Abt D, Kraus M, Bader J, Besse A, Schmid H, Engeler D, Driessen C, Besse L (2016). Verbesserung der Wirksamkeit von Proteasom-Inhibitoren in der Behandlung des Nierenzell-Carcinoms. Präsentiert bei: -, -
01.01.2017Verbesserung der Wirksamkeit von Proteasom-Inhibitoren in der Behandlung des Nierenzell-Carcinoms
01.01.2017-
Abt Dominik, Kraus M, Bader J, Besse A, Schmid Hans-Peter, Engeler Daniel, Driessen Christoph, Besse L
Verbesserung der Wirksamkeit von Proteasom-Inhibitoren in der Behandlung des Nierenzell-Carcinoms
Abt D, Kraus M, Bader J, Besse A, Schmid H, Engeler D, Driessen C, Besse L (2016). Verbesserung der Wirksamkeit von Proteasom-Inhibitoren in der Behandlung des Nierenzell-Carcinoms. Präsentiert bei: -, -
01.01.2017Verbesserung der Wirksamkeit von Proteasom-Inhibitoren in der Behandlung des Nierenzell-Carcinoms
01.01.2017-
Abt Dominik, Kraus M, Bader J, Besse A, Schmid Hans-Peter, Engeler Daniel, Driessen Christoph, Besse L
Bendamustine, lenalidomide and dexamethasone (BRd) has high activity as 2(nd) -line therapy for relapsed and refractory multiple myeloma - a phase II trial
Mey U, Ruefer A, Ziske C, Knauf W, Cathomas R, von Moos R, Hitz F, Sauter R, Hiendlmeyer E, Cantoni N, Bargetzi M, Fischer N, Doerfel S, Brugger W, Schwarb H, Pederiva S, Schwarzer A, Dechow T, Jehner P, Rauh J, Taverna C, Schmid M, Schmidt-Hieber M, Driessen C. Bendamustine, lenalidomide and dexamethasone (BRd) has high activity as 2(nd) -line therapy for relapsed and refractory multiple myeloma - a phase II trial. Br J Haematol 2016
16.12.2016Bendamustine, lenalidomide and dexamethasone (BRd) has high activity as 2(nd) -line therapy for relapsed and refractory multiple myeloma - a phase II trial
16.12.2016Br J Haematol 2016
Mey Ulrich J M, Ruefer Axel, Ziske Carsten, Knauf Wolfgang, Cathomas Richard, von Moos Roger, Hitz Felicitas, Sauter Rafael, Hiendlmeyer Elke, Cantoni Nathan, Bargetzi Mario, Fischer Natalie, Doerfel Steffen, Brugger Wolfram, Schwarb Heike, Pederiva Stefanie, Schwarzer Andreas, Dechow Tobias, Jehner Paul, Rauh Jacqueline, Taverna Christian J, Schmid Mathias, Schmidt-Hieber Martin, Driessen Christoph
Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes
Xin B, Groll M, Driessen C, van der Stelt M, Kisselev A, van der Marel G, Filippov D, Florea B, Besse A, Huber E, de Bruin G, Overkleeft H. Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes. J Med Chem 2016; 59:7177-87.
01.08.2016Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes
01.08.2016J Med Chem 2016; 59:7177-87
Xin Bo-Tao, Groll Michael, Driessen Christoph, van der Stelt Mario, Kisselev Alexei F, van der Marel Gijsbert A, Filippov Dmitri V, Florea Bogdan I, Besse Andrej, Huber Eva M, de Bruin Gerjan, Overkleeft Herman S
Multiple myeloma: patient outcomes in real-world practice
Yong K, Schoen P, Raab M, Mateos M, Karlin L, Safaei R, Gonzalez-McQuire S, Flinois A, Fink L, Driessen C, Delforge M, Cavo M. Multiple myeloma: patient outcomes in real-world practice. Br J Haematol 2016; 175:252-264.
13.07.2016Multiple myeloma: patient outcomes in real-world practice
13.07.2016Br J Haematol 2016; 175:252-264
Yong Kwee, Schoen Paul, Raab Marc S, Mateos Maria-Victoria, Karlin Lionel, Safaei Reza, Gonzalez-McQuire Sebastian, Flinois Alain, Fink Leah, Driessen Christoph, Delforge Michel, Cavo Michele
Multiple myeloma: practice patterns across Europe
Raab M, Schoen P, Mateos M, Karlin L, Safaei R, Gonzalez-McQuire S, Flinois A, Fink L, Driessen C, Delforge M, Cavo M, Yong K. Multiple myeloma: practice patterns across Europe. Br J Haematol 2016; 175:66-76.
13.06.2016Multiple myeloma: practice patterns across Europe
13.06.2016Br J Haematol 2016; 175:66-76
Raab Marc S, Schoen Paul, Mateos Maria-Victoria, Karlin Lionel, Safaei Reza, Gonzalez-McQuire Sebastian, Flinois Alain, Fink Leah, Driessen Christoph, Delforge Michel, Cavo Michele, Yong Kwee
Erratum to: Practical Considerations for the Use of Daratumumab, a Novel CD38 Monoclonal Antibody, in Myeloma
Moreau P, Ludwig H, Driessen C, Palumbo A, Facon T, Plesner T, Dimopoulos M, Sondergeld P, Sonneveld P, Zweegman S, Einsele H, van de Donk N, Miguel J, Lokhorst H, Nahi H, Ben-Yehuda D, Cavo M, Cook G, Delforge M, Mateos M. Erratum to: Practical Considerations for the Use of Daratumumab, a Novel CD38 Monoclonal Antibody, in Myeloma. Drugs 2016; 76:989-990.
01.06.2016Erratum to: Practical Considerations for the Use of Daratumumab, a Novel CD38 Monoclonal Antibody, in Myeloma
01.06.2016Drugs 2016; 76:989-990
Moreau Philippe, Ludwig Heinz, Driessen Christoph, Palumbo Antonio, Facon Thierry, Plesner Torben, Dimopoulos Meletios, Sondergeld Pia, Sonneveld Pieter, Zweegman Sonja, Einsele Hermann, van de Donk Niels W C J, Miguel Jesus San, Lokhorst Henk, Nahi Hareth, Ben-Yehuda Dina, Cavo Michele, Cook Gordon, Delforge Michel, Mateos Maria-Victoria
Practical Considerations for the Use of Daratumumab, a Novel CD38 Monoclonal Antibody, in Myeloma
Moreau P, Ludwig H, Driessen C, Palumbo A, Facon T, Plesner T, Dimopoulos M, Sondergeld P, Sonneveld P, Zweegman S, Einsele H, van de Donk N, San Miguel J, Lokhorst H, Nahi H, Ben-Yehuda D, Cavo M, Cook G, Delforge M, Mateos M. Practical Considerations for the Use of Daratumumab, a Novel CD38 Monoclonal Antibody, in Myeloma. Drugs 2016; 76:853-67.
01.05.2016Practical Considerations for the Use of Daratumumab, a Novel CD38 Monoclonal Antibody, in Myeloma
01.05.2016Drugs 2016; 76:853-67
Moreau Philippe, Ludwig Heinz, Driessen Christoph, Palumbo Antonio, Facon Thierry, Plesner Torben, Dimopoulos Meletios, Sondergeld Pia, Sonneveld Pieter, Zweegman Sonja, Einsele Hermann, van de Donk Niels W C J, San Miguel Jesús, Lokhorst Henk, Nahi Hareth, Ben-Yehuda Dina, Cavo Michele, Cook Gordon, Delforge Michel, Mateos Maria-Victoria