David Leppert
Contrast-Enhancing Lesion Segmentation in Multiple Sclerosis: A Deep Learning Approach Validated in a Multicentric Cohort.
Greselin M, Lu P, Melie-Garcia L, Ocampo-Pineda M, Galbusera R, Cagol A, Weigel M, de Oliveira Siebenborn N, Ruberte E, Benkert P, Müller S, Finkener S, Vehoff J, Giulio D, Findling O, Chan A, Salmen A, Pot C, Bridel C, Zecca C, Derfuss T, Lieb J, Diepers M, Wagner F, Vargas M, Du Pasquier R, Lalive P, Pravatà E, Weber J, Gobbi C, Leppert D, Kim O, Cattin P, Hoepner R, Roth P, Kappos L, Kuhle J, Granziera C. Contrast-Enhancing Lesion Segmentation in Multiple Sclerosis: A Deep Learning Approach Validated in a Multicentric Cohort. Bioengineering (Basel) 2024; 11
22.08.2024Contrast-Enhancing Lesion Segmentation in Multiple Sclerosis: A Deep Learning Approach Validated in a Multicentric Cohort.
22.08.2024Bioengineering (Basel) 2024; 11
Greselin Martina, Lu Po-Jui, Melie-Garcia Lester, Ocampo-Pineda Mario, Galbusera Riccardo, Cagol Alessandro, Weigel Matthias, de Oliveira Siebenborn Nina, Ruberte Esther, Benkert Pascal, Müller Stefanie, Finkener Sebastian, Vehoff Jochen, Giulio Disanto, Findling Oliver, Chan Andrew T, Salmen Anke, Pot Caroline, Bridel Claire, Zecca Chiara, Derfuss Tobias, Lieb Johanna Maria, Diepers Michael, Wagner Franca, Vargas Maria Isabel, Du Pasquier Renaud A, Lalive Patrice H, Pravatà Emanuele, Weber Johannes, Gobbi Claudio, Leppert David, Kim Olaf Chan-Hi, Cattin Philippe C, Hoepner Robert, Roth Patrick, Kappos Ludwig, Kuhle Jens, Granziera Cristina
Association of Spinal Cord Atrophy and Brain Paramagnetic Rim Lesions With Progression Independent of Relapse Activity in People With MS.
Cagol A, Benkert P, Melie-Garcia L, Schaedelin S, Leber S, Tsagkas C, Barakovic M, Galbusera R, Lu P, Weigel M, Ruberte E, Radue E, Yaldizli O, Oechtering J, Lorscheider J, D'Souza M, Fischer-Barnicol B, Müller S, Achtnichts L, Vehoff J, Giulio D, Findling O, Chan A, Salmen A, Pot C, Bridel C, Zecca C, Derfuss T, Lieb J, Remonda L, Wagner F, Vargas M, Du Pasquier R, Lalive P, Pravatà E, Weber J, Cattin P, Absinta M, Gobbi C, Leppert D, Kappos L, Kuhle J, Granziera C. Association of Spinal Cord Atrophy and Brain Paramagnetic Rim Lesions With Progression Independent of Relapse Activity in People With MS. Neurology 2023; 102:e207768.
13.12.2023Association of Spinal Cord Atrophy and Brain Paramagnetic Rim Lesions With Progression Independent of Relapse Activity in People With MS.
13.12.2023Neurology 2023; 102:e207768
Cagol Alessandro, Benkert Pascal, Melie-Garcia Lester, Schaedelin Sabine A, Leber Selina, Tsagkas Charidimos, Barakovic Muhamed, Galbusera Riccardo, Lu Po-Jui, Weigel Matthias, Ruberte Esther, Radue Ernst-Wilhelm, Yaldizli Ozgür, Oechtering Johanna, Lorscheider Johannes, D'Souza Marcus, Fischer-Barnicol Bettina, Müller Stefanie, Achtnichts Lutz, Vehoff Jochen, Giulio Disanto, Findling Oliver, Chan Andrew T, Salmen Anke, Pot Caroline, Bridel Claire, Zecca Chiara, Derfuss Tobias, Lieb Johanna Maria, Remonda Luca, Wagner Franca, Vargas Maria Isabel, Du Pasquier Renaud A, Lalive Patrice H, Pravatà Emanuele, Weber Johannes, Cattin Philippe C, Absinta Martina, Gobbi Claudio, Leppert David, Kappos Ludwig, Kuhle Jens, Granziera Cristina
Neurofilament Light Chain Elevation and Disability Progression in Multiple Sclerosis.
Abdelhak A, Benkert P, Schaedelin S, Boscardin W, Cordano C, Oechtering J, Ananth K, Granziera C, Melie-Garcia L, Montes S, Beaudry-Richard A, Achtnichts L, Oertel F, Lalive P, Leppert D, Müller S, Henry R, Pot C, Matthias A, Salmen A, Oksenberg J, Giulio D, Zecca C, D'Souza M, Du Pasquier R, Bridel C, Gobbi C, Kappos L, Hauser S, Cree B, Kuhle J, Green A, UCSF, MS EPIC, and the SMSC Study Teams. Neurofilament Light Chain Elevation and Disability Progression in Multiple Sclerosis. JAMA Neurol 2023
06.11.2023Neurofilament Light Chain Elevation and Disability Progression in Multiple Sclerosis.
06.11.2023JAMA Neurol 2023
Abdelhak Ahmed, Benkert Pascal, Schaedelin Sabine A, Boscardin W John, Cordano Christian, Oechtering Johanna, Ananth Kirtana, Granziera Cristina, Melie-Garcia Lester, Montes Shivany Condor, Beaudry-Richard Alexandra, Achtnichts Lutz, Oertel Frederike C, Lalive Patrice H, Leppert David, Müller Stefanie, Henry Roland G, Pot Caroline, Matthias Amandine, Salmen Anke, Oksenberg Jorge R, Giulio Disanto, Zecca Chiara, D'Souza Marcus, Du Pasquier Renaud A, Bridel Claire, Gobbi Claudio, Kappos Ludwig, Hauser Stephen L, Cree Bruce A C, Kuhle Jens, Green Ari J, UCSF, MS EPIC, and the SMSC Study Teams
Serum Glial Fibrillary Acidic Protein Compared With Neurofilament Light Chain as a Biomarker for Disease Progression in Multiple Sclerosis.
Meier S, Willemse E, Schaedelin S, Oechtering J, Lorscheider J, Melie-Garcia L, Cagol A, Barakovic M, Galbusera R, Subramaniam S, Barro C, Abdelhak A, Thebault S, Achtnichts L, Lalive P, Müller S, Pot C, Salmen A, Giulio D, Zecca C, D'Souza M, Orleth A, Khalil M, Buchmann A, Du Pasquier R, Yaldizli O, Derfuss T, Berger K, Hermesdorf M, Wiendl H, Piehl F, Battaglini M, Fischer U, Kappos L, Gobbi C, Granziera C, Bridel C, Leppert D, Maceski A, Benkert P, Kuhle J. Serum Glial Fibrillary Acidic Protein Compared With Neurofilament Light Chain as a Biomarker for Disease Progression in Multiple Sclerosis. JAMA Neurol 2023; 80:287-297.
01.03.2023Serum Glial Fibrillary Acidic Protein Compared With Neurofilament Light Chain as a Biomarker for Disease Progression in Multiple Sclerosis.
01.03.2023JAMA Neurol 2023; 80:287-297
Meier Stephanie, Willemse Eline A J, Schaedelin Sabine A, Oechtering Johanna, Lorscheider Johannes, Melie-Garcia Lester, Cagol Alessandro, Barakovic Muhamed, Galbusera Riccardo, Subramaniam Suvitha, Barro Christian, Abdelhak Ahmed, Thebault Simon, Achtnichts Lutz, Lalive Patrice H, Müller Stefanie, Pot Caroline, Salmen Anke, Giulio Disanto, Zecca Chiara, D'Souza Marcus, Orleth Annette, Khalil Michael, Buchmann Arabella, Du Pasquier Renaud A, Yaldizli Ozgür, Derfuss Tobias, Berger Klaus, Hermesdorf Marco, Wiendl Heinz, Piehl Fredrik, Battaglini Marco, Fischer Urs, Kappos Ludwig, Gobbi Claudio, Granziera Cristina, Bridel Claire, Leppert David, Maceski Aleksandra Maleska, Benkert Pascal, Kuhle Jens
A Multicenter Longitudinal MRI Study Assessing LeMan-PV Software Accuracy in the Detection of White Matter Lesions in Multiple Sclerosis Patients.
Todea A, Melie-Garcia L, Barakovic M, Cagol A, Rahmanzadeh R, Galbusera R, Lu P, Weigel M, Ruberte E, Radue E, Schaedelin S, Benkert P, Oezguer Y, Sinnecker T, Müller S, Achtnichts L, Vehoff J, Disanto G, Findling O, Chan A, Salmen A, Pot C, Lalive P, Bridel C, Zecca C, Derfuss T, Remonda L, Wagner F, Vargas M, Du Pasquier R, Pravatà E, Weber J, Gobbi C, Leppert D, Wuerfel J, Kober T, Marechal B, Corredor-Jerez R, Psychogios M, Lieb J, Kappos L, Cuadra M, Kuhle J, Granziera C. A Multicenter Longitudinal MRI Study Assessing LeMan-PV Software Accuracy in the Detection of White Matter Lesions in Multiple Sclerosis Patients. J Magn Reson Imaging 2023
28.01.2023A Multicenter Longitudinal MRI Study Assessing LeMan-PV Software Accuracy in the Detection of White Matter Lesions in Multiple Sclerosis Patients.
28.01.2023J Magn Reson Imaging 2023
Todea Alexandra Ramona, Melie-Garcia Lester, Barakovic Muhamed, Cagol Alessandro, Rahmanzadeh Reza, Galbusera Riccardo, Lu Po-Jui, Weigel Matthias, Ruberte Esther, Radue Ernst-Wilhelm, Schaedelin Sabine, Benkert Pascal, Oezguer Yaldizli, Sinnecker Tim, Müller Stefanie, Achtnichts Lutz, Vehoff Jochen, Disanto Giulio, Findling Oliver, Chan Andrew, Salmen Anke, Pot Caroline, Lalive Patrice, Bridel Claire, Zecca Chiara, Derfuss Tobias, Remonda Luca, Wagner Franca, Vargas Maria I, Du Pasquier Renaud, Pravatà Emanuele, Weber Johannes, Gobbi Claudio, Leppert David, Wuerfel Jens, Kober Tobias, Marechal Benedicte, Corredor-Jerez Ricardo, Psychogios Marios, Lieb Johanna, Kappos Ludwig, Cuadra Meritxell Bach, Kuhle Jens, Granziera Cristina
Association of Brain Atrophy With Disease Progression Independent of Relapse Activity in Patients With Relapsing Multiple Sclerosis.
Cagol A, Schaedelin S, Barakovic M, Benkert P, Todea R, Rahmanzadeh R, Galbusera R, Lu P, Weigel M, Melie-Garcia L, Ruberte E, Siebenborn N, Battaglini M, Radue E, Yaldizli O, Oechtering J, Sinnecker T, Lorscheider J, Fischer-Barnicol B, Müller S, Achtnichts L, Vehoff J, Giulio D, Findling O, Chan A, Salmen A, Pot C, Bridel C, Zecca C, Derfuss T, Lieb J, Remonda L, Wagner F, Vargas M, Du Pasquier R, Lalive P, Pravatà E, Weber J, Cattin P, Gobbi C, Leppert D, Kappos L, Kuhle J, Granziera C. Association of Brain Atrophy With Disease Progression Independent of Relapse Activity in Patients With Relapsing Multiple Sclerosis. JAMA Neurol 2022; 79:682-692.
01.07.2022Association of Brain Atrophy With Disease Progression Independent of Relapse Activity in Patients With Relapsing Multiple Sclerosis.
01.07.2022JAMA Neurol 2022; 79:682-692
Cagol Alessandro, Schaedelin Sabine A, Barakovic Muhamed, Benkert Pascal, Todea Ramona-Alexandra, Rahmanzadeh Reza, Galbusera Riccardo, Lu Po-Jui, Weigel Matthias, Melie-Garcia Lester, Ruberte Esther, Siebenborn Nina, Battaglini Marco, Radue Ernst-Wilhelm, Yaldizli Ozgür, Oechtering Johanna, Sinnecker Tim, Lorscheider Johannes, Fischer-Barnicol Bettina, Müller Stefanie, Achtnichts Lutz, Vehoff Jochen, Giulio Disanto, Findling Oliver, Chan Andrew T, Salmen Anke, Pot Caroline, Bridel Claire, Zecca Chiara, Derfuss Tobias, Lieb Johanna Maria, Remonda Luca, Wagner Franca, Vargas Maria I, Du Pasquier Renaud A, Lalive Patrice H, Pravatà Emanuele, Weber Johannes, Cattin Philippe C, Gobbi Claudio, Leppert David, Kappos Ludwig, Kuhle Jens, Granziera Cristina
Renal Function and Body Mass Index Contribute to Serum Neurofilament Light Chain Levels in Elderly Patients With Atrial Fibrillation.
Polymeris A, Helfenstein F, Benkert P, Aeschbacher S, Leppert D, Coslovsky M, Willemse E, Schaedelin S, Blum M, Rodondi N, Reichlin T, Moschovitis G, Wuerfel J, De Marchis G, Engelter S, Lyrer P, Conen D, Kühne M, Osswald S, Bonati L, Kuhle J, Swiss-AF investigators. Renal Function and Body Mass Index Contribute to Serum Neurofilament Light Chain Levels in Elderly Patients With Atrial Fibrillation. Front Neurosci 2022; 16:819010.
14.04.2022Renal Function and Body Mass Index Contribute to Serum Neurofilament Light Chain Levels in Elderly Patients With Atrial Fibrillation.
14.04.2022Front Neurosci 2022; 16:819010
Polymeris Alexandros A, Helfenstein Fabrice, Benkert Pascal, Aeschbacher Stefanie, Leppert David, Coslovsky Michael, Willemse Eline, Schaedelin Sabine A, Blum Manuel R, Rodondi Nicolas, Reichlin Tobias, Moschovitis Giorgio, Wuerfel Jens, De Marchis Gian Marco, Engelter Stefan T, Lyrer Philippe A, Conen David, Kühne Michael, Osswald Stefan, Bonati Leo H, Kuhle Jens, Swiss-AF investigators
Intrathecal IgM Synthesis Is Associated with Spinal Cord Manifestation and Neuronal Injury in Early MS.
Oechtering J, Lincke T, Schaedelin S, Décard B, Maceski A, Orleth A, Meier S, Willemse E, Buchmann A, Khalil M, Derfuss T, Benkert P, Heijnen I, Regeniter A, Müller S, Achtnichts L, Lalive P, Salmen A, Pot C, Gobbi C, Kappos L, Granziera C, Leppert D, Schlaeger R, Lieb J, Kuhle J, Swiss MS Cohort Study. Intrathecal IgM Synthesis Is Associated with Spinal Cord Manifestation and Neuronal Injury in Early MS. Ann Neurol 2022; 91:814-820.
09.04.2022Intrathecal IgM Synthesis Is Associated with Spinal Cord Manifestation and Neuronal Injury in Early MS.
09.04.2022Ann Neurol 2022; 91:814-820
Oechtering Johanna, Lincke Therese, Schaedelin Sabine A, Décard Bernhard Friedrich, Maceski Aleksandra Maleska, Orleth Annette, Meier Stephanie, Willemse Eline A J, Buchmann Arabella, Khalil Michael, Derfuss Tobias, Benkert Pascal, Heijnen Ingmar A F M, Regeniter Axel, Müller Stefanie, Achtnichts Lutz, Lalive Patrice H, Salmen Anke, Pot Caroline, Gobbi Claudio, Kappos Ludwig, Granziera Cristina, Leppert David, Schlaeger Regina, Lieb Johanna Maria, Kuhle Jens, Swiss MS Cohort Study
Serum neurofilament light chain for individual prognostication of disease activity in people with multiple sclerosis: a retrospective modelling and validation study.
Benkert P, Meier S, Schaedelin S, Manouchehrinia A, Yaldizli O, Maceski A, Oechtering J, Achtnichts L, Conen D, Derfuss T, Lalive P, Mueller C, Müller S, Naegelin Y, Oksenberg J, Pot C, Salmen A, Willemse E, Kockum I, Blennow K, Zetterberg H, Gobbi C, Kappos L, Wiendl H, Berger K, Sormani M, Granziera C, Piehl F, Leppert D, Kuhle J. Serum neurofilament light chain for individual prognostication of disease activity in people with multiple sclerosis: a retrospective modelling and validation study. Lancet Neurol 2022; 21:246-257.
01.03.2022Serum neurofilament light chain for individual prognostication of disease activity in people with multiple sclerosis: a retrospective modelling and validation study.
01.03.2022Lancet Neurol 2022; 21:246-257
Benkert Pascal, Meier Stephanie, Schaedelin Sabine, Manouchehrinia Ali, Yaldizli Ozgür, Maceski Aleksandra, Oechtering Johanna, Achtnichts Lutz, Conen David, Derfuss Tobias, Lalive Patrice H, Mueller Christian, Müller Stefanie, Naegelin Yvonne, Oksenberg Jorge R, Pot Caroline, Salmen Anke, Willemse Eline, Kockum Ingrid, Blennow Kaj, Zetterberg Henrik, Gobbi Claudio, Kappos Ludwig, Wiendl Heinz, Berger Klaus, Sormani Maria Pia, Granziera Cristina, Piehl Fredrik, Leppert David, Kuhle Jens
Intrathecal Immunoglobulin M Synthesis is an Independent Biomarker for Higher Disease Activity and Severity in Multiple Sclerosis
Oechtering J, Naegelin Y, Maceski A, Meier S, Berger K, Wiendl H, Lincke T, Lieb J, Yaldizli O, Sinnecker T, Derfuss T, Regeniter A, Zecca C, Gobbi C, Kappos L, Granziera C, Leppert D, Kuhle J, Conen D, Aeschbacher S, Subramaniam S, Schaedelin S, Benkert P, Müller S, Achtnichts L, Vehoff J, Giulio D, Findling O, Fischer-Barnicol B, Orleth A, Chan A, Pot C, Barakovic M, Rahmanzadeh R, Galbusera R, Heijnen I, Lalive P, Wuerfel J, Swiss Multiple Sclerosis Cohort Study. Intrathecal Immunoglobulin M Synthesis is an Independent Biomarker for Higher Disease Activity and Severity in Multiple Sclerosis. Ann Neurol 2021; 90:477-489.
22.06.2021Intrathecal Immunoglobulin M Synthesis is an Independent Biomarker for Higher Disease Activity and Severity in Multiple Sclerosis
22.06.2021Ann Neurol 2021; 90:477-489
Oechtering Johanna, Naegelin Yvonne, Maceski Aleksandra, Meier Stephanie, Berger Klaus, Wiendl Heinz, Lincke Therese, Lieb Johanna, Yaldizli Ozgür, Sinnecker Tim, Derfuss Tobias, Regeniter Axel, Zecca Chiara, Gobbi Claudio, Kappos Ludwig, Granziera Cristina, Leppert David, Kuhle Jens, Conen David, Aeschbacher Stefanie, Subramaniam Suvitha, Schaedelin Sabine, Benkert Pascal, Müller Stefanie, Achtnichts Lutz, Vehoff Jochen, Giulio Disanto, Findling Oliver, Fischer-Barnicol Bettina, Orleth Annette, Chan Andrew, Pot Caroline, Barakovic Muhamed, Rahmanzadeh Reza, Galbusera Riccardo, Heijnen Ingmar, Lalive Patrice H, Wuerfel Jens, Swiss Multiple Sclerosis Cohort Study
Serum Neurofilament Light Chain Levels in the Intensive Care Unit: Comparison between Severely Ill Patients with and without Coronavirus Disease 2019.
Sutter R, Hert L, De Marchis G, Twerenbold R, Kappos L, Naegelin Y, Kuster G, Benkert P, Jost J, Maceski A, Rüegg S, Siegemund M, Leppert D, Tschudin-Sutter S, Kuhle J. Serum Neurofilament Light Chain Levels in the Intensive Care Unit: Comparison between Severely Ill Patients with and without Coronavirus Disease 2019. Ann Neurol 2021; 89:610-616.
11.01.2021Serum Neurofilament Light Chain Levels in the Intensive Care Unit: Comparison between Severely Ill Patients with and without Coronavirus Disease 2019.
11.01.2021Ann Neurol 2021; 89:610-616
Sutter Raoul, Hert Lisa, De Marchis Gian Marco, Twerenbold Raphael, Kappos Ludwig, Naegelin Yvonne, Kuster Gabriela M, Benkert Pascal, Jost Jasmine, Maceski Aleksandra Maleska, Rüegg Stephan, Siegemund Martin, Leppert David, Tschudin-Sutter Sarah, Kuhle Jens
Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis.
Disanto G, Barro C, Benkert P, Naegelin Y, Schädelin S, Giardiello A, Zecca C, Blennow K, Zetterberg H, Leppert D, Kappos L, Gobbi C, Kuhle J, Swiss Multiple Sclerosis Cohort Study Group. Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis. Ann Neurol 2017; 81:857-870.
01.06.2017Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis.
01.06.2017Ann Neurol 2017; 81:857-870
Disanto Giulio, Barro Christian, Benkert Pascal, Naegelin Yvonne, Schädelin Sabine, Giardiello Antonella, Zecca Chiara, Blennow Kaj, Zetterberg Henrik, Leppert David, Kappos Ludwig, Gobbi Claudio, Kuhle Jens, Swiss Multiple Sclerosis Cohort Study Group