Intrathecal IgM Synthesis Is Associated with Spinal Cord Manifestation and Neuronal Injury in Early MS.

Publikation

Intrathecal IgM Synthesis Is Associated with Spinal Cord Manifestation and Neuronal Injury in Early MS.

Wissenschaftlicher Artikel/Review - 09.04.2022

Oechtering Johanna, Lincke Therese, Schaedelin Sabine A, Décard Bernhard Friedrich, Maceski Aleksandra Maleska, Orleth Annette, Meier Stephanie, Willemse Eline A J, Buchmann Arabella, Khalil Michael, Derfuss Tobias, Benkert Pascal, Heijnen Ingmar A F M, Regeniter Axel, Müller Stefanie, Achtnichts Lutz, Lalive Patrice H, Salmen Anke, Pot Caroline, Gobbi Claudio, Kappos Ludwig, Granziera Cristina, Leppert David, Schlaeger Regina, Lieb Johanna Maria, Kuhle Jens, Swiss MS Cohort Study

Zitation

Oechtering J, Lincke T, Schaedelin S, Décard B, Maceski A, Orleth A, Meier S, Willemse E, Buchmann A, Khalil M, Derfuss T, Benkert P, Heijnen I, Regeniter A, Müller S, Achtnichts L, Lalive P, Salmen A, Pot C, Gobbi C, Kappos L, Granziera C, Leppert D, Schlaeger R, Lieb J, Kuhle J, Swiss MS Cohort Study. Intrathecal IgM Synthesis Is Associated with Spinal Cord Manifestation and Neuronal Injury in Early MS. Ann Neurol 2022; 91:814-820.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Ann Neurol 2022; 91

Veröffentlichungsdatum

09.04.2022

eISSN (Online)

1531-8249

Seiten

814-820

Kurzbeschreibung/Zielsetzung

Intrathecal Immunoglobulin M synthesis (IgM ) and spinal MRI lesions are both strong independent predictors of higher disease activity and severity in multiple sclerosis (MS). We investigated whether IgM is associated with spinal cord manifestation and higher neuroaxonal damage in early MS.