Unit
Neurologie
NL · Dept. III
Cohort Study comparing Corpus Callosum Atrophy as a marker of later development of cognitive impairment in patients with early and remitting relapsing multiple sclerosis
Mar 14, 2011Even in early stages of multiple sclerosis (MS), cognitive dysfunction is a leading cause of disability. It can have profound social and economic consequences for patients and their families. Cognitive impairment is affecting up to 65% of MS patients...
Clinical Studies - Mar 14, 2011 - May 31, 2011
Completed
Project leader: Yildiz Murat
Members: Vehoff Jochen, Müller Stefanie
Neurocognitive changes in patients with remitting relapsing multiple sclerosis treated with Natalizumab
Jan 1, 2011Neurocognitive changes in patients with remitting relapsing multiple sclerosis treated with Natalizumab
Clinical Studies - Jan 1, 2011 - Dec 31, 2012
Completed
Project leader: Yildiz Murat, Müller Stefanie
A multicenter, randomized, double-blind placebo controlled study to assess the effect of rasagiline on sleep-wake disturbance in patients with Parkinson's disease (PD)
Jan 1, 2011A multicenter, randomized, double-blind placebo controlled study to assess the effect of rasagiline on sleep-wake disturbance in patients with Parkinson's disease (PD)
Clinical Studies - Jan 1, 2011 - Mar 31, 2013
Automatically Closed
Project leader: Kägi Georg
A dose blind, multicenter, extension study to determine the safety and efficasy of 2 doses of BG00012 monotherapy with Relapsin Remitting Multiple Sclerosis
Dec 1, 2010A dose blind, multicenter, extension study to determine the safety and efficasy of 2 doses of dimethyl fumarate (BG00012) monotherapy with Relapsin Remitting Multiple Sclerosis
Clinical Studies - Dec 1, 2010 - Dec 8, 2020
Automatically Closed
Project leader: Müller Stefanie
Members: Vehoff Jochen
A 4 Month, open label, multi-center study to explore the tolerability and safety and health outcomes of FTY720 in patients with relapsong forms of multiple sclerosis
Oct 1, 2010A 4 Month, open label, multi-center study to explore the tolerability and safety and health outcomes of FTY720 in patients with relapsong forms of multiple sclerosis Study: FTY720 - 2316
Clinical Studies - Oct 1, 2010 - May 31, 2011
Completed
Project leader: Müller Stefanie
Current Practices of Parenteral Nutrition in incurable cancer patients, having mild to severe intestinal failure: an international, case-vignette based survey of clinical experts
Sep 1, 2010AIM To collect current practises of parenteral nutrition in patients with advanced incurable cancer with mild to severe intestinal failure by a structured international survey of clinical experts, defined as expectance in advanced cancer care and nut...
Clinical Studies - Sep 1, 2010 - Dec 31, 2013
Completed
Project leader: Strasser Florian
Members: Nestor Karen, Simanek Ralf, Wilm Simone
Substudie zu SOLAR: Untersuchung der Wirkung einer Vitamin D-Substitution auf die T-Lymphozyten bei Patienten mit schubförmig-remittierender MS unter Beahndlung mit Rebif®, EMR 200136-532
Jul 1, 2010Substudie zu SOLAR: Untersuchung der Wirkung einer Vitamin D-Substitution auf die T-Lymphozyten bei Patienten mit schubförmig-remittierender MS unter Beahndlung mit Rebif®, EMR 200136-532
Clinical Studies - Jul 1, 2010 - Dec 31, 2013
Completed
Project leader: Müller Stefanie
Tenere: A multi-center, randomized, parallel-group, rater-blinded study comparing the effectiveness and safety of teriflunomide and interferon beta-1a in patients with relapsing multiple sclerosis
May 3, 2010Primary: To assess the effectiveness of 2 doses of teriflunomide in comparison to interferon-beta 1a, evaluated by the time to failure, with failure being defined as either relapse or permanent study treatment discontinuation for any cause whichever...
Clinical Studies - May 3, 2010 - Jun 30, 2011
Completed
Project leader: Putzki Norman
Members: Yildiz Murat, Siebel Philip, Vehoff Jochen, Coco Orazio, Müller Anna, Müller Stefanie
Randomisierte, doppelblinde, placebokontrollierte klinische Prüfung der Phase III mit Parallelgruppen zur Beurteilung der Wirksmkeit und Sicherheit von Desmoteplase bei Patienten mit akuten ischämischem Schlaganfall DIAS III
Mar 12, 2010Multizentrische Therapiestudie zur Anwednung von Desmoteplase
Clinical Studies - Mar 12, 2010 - Dec 31, 2012
Aborted
Project leader: Weder Bruno, Kägi Georg
Members: Hundsberger Thomas, Felbecker Ansgar, Hägele-Link Stefan, Galovic Marian, Leupold Daniela
The ERICA (Echographic Risk Index of Carotid Atherosclerosis) Swiss Study: A novel risk index combining degree of stenosis and plaque morphology of the carotid artery: a multicenter study on asymptomatic 50%-80% or symptomatic 50%-69% carotid stenoses
Mar 1, 2010Asymptomatische mittel- bis hochgradige (50% - 99%) oder symptomatische mittelgradige (50-69%) Stenosen der A. carotis interna sind mit einem 5%-igen jährlichen Risiko eines zerebrovaskuläres Ereignisses assoziiert. Unter Berücksichtigung des 3-6% pe...
Clinical Studies - Mar 1, 2010 - Jan 15, 2017
Completed
Project leader: Kägi Georg
Members: Vehoff Jochen
MAZE - Studie Eine randomisierte, doppelblinde Erweiterungsstudie zur Bewertung der langfristigen Sicherheit und Erforschung der langfristigen Wirksamkeit von Zonisamid als Monotherapie bei neu diagnostizierter partieller Epilepsie
Jan 21, 2010Es handelt sich um eine multizentrische, randomisierte Doppelblindstudie mit Verumkontrolle unter Verwendung eines flexiblem Dosierschemas (wobei die Anfangsdosis der Enddosis entspricht, die in der Studie E2090-E044-310 verabreicht wurde) zur Beurte...
Clinical Studies - Jan 21, 2010 - Jan 1, 2012
Automatically Closed
Project leader: Tettenborn Barbara
Members: Flügel Dominique, Erdelyi Barbara, Siebel Philip, Von Manitius Sigrid
The significance of sensory function for the recovery of hand paresis after ischemic strokeThe significance of sensory function for the recovery of hand paresis after ischemic stroke
Jan 7, 2010Background and Hypotheses Recovery of motor function after cerebral ischemic infarction, occurring over weeks or months, is most probably due to reorganization of the underlying neuronal networks (7). Both common and subject-specific patterns have be...
Clinical Studies - Jan 7, 2010 - Jan 7, 2010
Automatically Closed
Project leader: Weder Bruno
Members: Abela Eugenio
Einfluss von Topiramat auf die kognitiven Funktionen bei Migränepatienten und Patienten mit chronischen Spannungskopfschmerzen
Dec 11, 2009Ziel der Studie ist die Erfassung von kognitiven Funktionen bei der Behandlung von Migränepatienten und Patienten mit chronischen Spannungskopfschmerzen unter Behandlung mit Topiramat. Das aus der Gruppe der Antikonvulsiva kommende Topiramat ist zur...
Clinical Studies - Dec 11, 2009 - Dec 11, 2013
Automatically Closed
Project leader: Flügel Dominique
Fatigue in Multiple Sclerosis now and then: a cross-sectional study
Nov 30, 2009Fatigue is one of the major concerns of MS patients. Disease modifying drugs (DMD) may have an impact on fatigue prevalence and severity. The current study aims to analyze fatigue severity with new disease modifying agents compared to previous invest...
Clinical Studies - Nov 30, 2009 - Apr 30, 2009
Completed
Project leader: Putzki Norman
Members: Yildiz Murat
Selective S1P1 receptor agonist in Patients with Relapsing-Remitting Multiple Sclerosis
Nov 1, 2009Multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-finding phase IIb study to evaluate the efficacy, safety, and tolerability of three doses of an oral S1P1 receptor agonist, administered for twenty-four weks in patients...
Clinical Studies - Nov 1, 2009 - Nov 1, 2010
Completed
Project leader: Putzki Norman
Members: Yildiz Murat, Müller Anna, Siebel Philip, Müller Stefanie
Subkutane Mehrfachdosierungen von LY2127399, einem menschlichen Anti-BAFF-Antikörper, bei Patienten mit schubförmig remittierender multipler Sklerose
Nov 1, 2009Diese Phase II Studie soll Daten zur Dosisfindung zu LY2127399 bei subkutaner (s.c.) Injektion bei Patienten mit schubförmig remittierender multipler Sklerose (relapsing-remitting multiple sclerosis, RRMS) liefern. LY2127399 ist ein auf den Botenstof...
Clinical Studies - Nov 1, 2009 - May 1, 2011
Aborted
Project leader: Putzki Norman
Members: Yildiz Murat, Müller Anna
Telemedizinisches „Stroke Decision Support System“ im Schlaganfallnetzwerk des Kantons St. Gallen
Oct 24, 2009Im Rahmen des Health Management Diplomprogramms der Universität St. Gallen (HSG) und dem Kantonsspital St. Gallen soll als Pilotprojekt ein telemedizinisches Videokonferenzsystem die Kommunikation mit und Untersuchung von Patienten in der Notaufnah...
Clinical Studies - Oct 24, 2009 - Oct 24, 2009
Automatically Closed
Project leader: Siebel Philip
Effect of lenalidomide (Revlimid) in solid tumour patients with inflammatory cancer cachexia syndrome on lean body mass and muscle strength: A multicenter, proof-of-concept study of fixed dose or CRP-response-guided dose of lenalidomide in relation to new standard basic cachexia management (receiving placebo) EKSG 09/40; CTU-11006
Oct 19, 2009Die Studie zielt darauf ab herauszufinden, ob Lenalidomid (Revlimid®), einmal täglich als Kapsel eingenommen auf nüchternen Magen, eine therapeutische Bedeutung beim tumorbedingten Gewichtsverlust bei Patienten mit entzüdlicher Komponente der Tumorer...
Clinical Studies - Oct 19, 2009 - Jun 30, 2012
Aborted
Project leader: Strasser Florian
Members: Gueller Ulrich, Wilm Simone
The Neuroprotective Effect of Lamotrigine and Interferon Beta 1a in Patients With Relapsing-Remitting Multiple Sclerosis
Sep 24, 2009Randomized, Placebo-Controlled Phase II Monocentric Trial for the Neuroprotective Effect of Lamotrigine Plus Interferon Beta 1a 30mcg Once Weekly Intramuscular in Patients With Relapsing-Remitting Multiple Sclerosis. Primary Outcome Measures: N-Ace...
Clinical Studies - Sep 24, 2009 - Sep 24, 2011
Automatically Closed
Project leader: Putzki Norman
Members: Yildiz Murat, Müller Anna, Siebel Philip
Cilengitide for subjects with newly diagnosed glioblastoma multiforme and methylated MGMT gene promotor - a multicenter, open-label, controlled phase III study, testing cilengitide in combination with standard treatment (temozolomide with concomitant radiation therapy, followed by temozolomide maintenance therapy) versus standard treatment (CENTRIC)
Aug 15, 2009A multicenter, open-label, controlled, Phase III study in subjects with newly diagnosed GBM and with methylated MGMT gene promoter, who will be randomized in two groups as follows: • Cilengitide group: cilengitide + radiotherapy (RTX)/temozolomide (T...
Clinical Studies - Aug 15, 2009 - Aug 15, 2013
Completed
Project leader: Hundsberger Thomas