Unit
Neurologie
NL · Dept. III
CELIA (Phase 2)
Mar 1, 2024A Study to Learn About the Safety of BIIB080 and Whether it Can Improve Symptoms of Participants With Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD Dementia Between 50 to 80 Years of Age
Clinical Studies - Mar 1, 2024 - Dec 31, 2026
Ongoing
Project leader: Felbecker Ansgar
Members: Göhl-Freyn Kristina
Memory Clinic Cohort Study
Mar 1, 2024Dementia is a clinical syndrome defined by a progressive cognitive decline interfering with a person's daily life and activities which is caused by a group of heterogenous neurodegenerative and neurovascular diseases which often overlap. Since patho...
Clinical Studies - Mar 1, 2024 - Dec 31, 2040
Ongoing
Project leader: Schneider Thomas, Felbecker Ansgar
Members: Göhl-Freyn Kristina, Schilg-Hafer Lenka
Comparison of discordant baseline imaging findings, reassessment of binary ischemic core evaluation and hypodensity mapping for functional outcome prediction in middle cerebral artery ischemic stroke using ASPECTS
Jan 1, 2024All subprojects focus on expanding the understanding of the emerging trend towards ubiquitously accessible and technically simpler imaging selection criteria for endovascular treatment based on native CT brainimaging in patients with acute ischemic s...
Clinical Studies - Jan 1, 2024 - Jan 1, 2026
Scheduled
Project leader: Dittrich Tolga
Cryptogenic Etiology in Young Adults with Stroke or Transient Ischemic Attack
Oct 2, 2023Explorierung der Charakteristika und klinischen Outcomes «junger» (18-55 J.) Patient:innen mit akutem ischämischen Schlaganfall (inkl. transient ischämischer Attacke) mit fehlender fassbarer Schöaganfallätiologie (trotz erfolgter Basisabklärung; Pati...
Clinical Studies - Oct 2, 2023 - Dec 31, 2024
Ongoing
Project leader: Dittrich Tolga, De Marchis Gian Marco
Members: Schneider Thomas
Leptomeningeal Collaterals in INtracErebral Hemorrhage: Association with Hematoma Size and Expansion
Jul 3, 2023Die intrazerebrale Blutung (ICB) ist eine verheerende Form des Schlaganfalls, die mit einer hohen Morbidität und Mortalität einhergeht. Die Ausdehnung des Hämatoms trägt wesentlich zu den schlechten Ergebnissen bei ICB-Patienten bei und gilt als beei...
Clinical Studies - Jul 3, 2023 - Jan 1, 2025
Ongoing
Project leader: Dittrich Tolga, De Marchis Gian Marco
Members: Zell Daniel
A PHASE IB/II RANDOMIZED, OPEN LABEL DRUG REPURPOSING TRIAL OF GLUTAMATE SIGNALING INHIBITORS IN COMBINATION WITH CHEMORADIOTHERAPY IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA (GLUGLIO)
May 10, 2023Die Studie untersucht die Wirksamkeit einer Kombination der Studienmedikamente Gabapentin, Sulfasalazin und Memantin zusammen mit der Standardtherapie (Strahlentherapie und Chemotherapie mit Temozolomid). Alle drei Studienmedikamente hemmen an unters...
Clinical Studies - May 10, 2023 - Dec 31, 2030
Ongoing
Project leader: Hundsberger Thomas
Members: Harder Anja, Müller Fiona
The motor side of neglect
Apr 1, 2023Motor neglect (MN), which denotes an underutilization of the contralesional limbs not explained by sensorimotor deficits, and premotor neglect (PMN), a directional disorder of movements towards or in the contralateral hemispace, are functionally disa...
Clinical Studies - Apr 1, 2023 - Dec 31, 2025
Ongoing
Project leader: Kägi Georg
Members: Schneider Thomas
A Phase 1 Study to Investigate the Safety, Pharmacokinetics, and Efficacy of Tinostamustine, a Novel Alkylating and Deacetylase Inhibiting Molecule, as Adjuvant Treatment in Patients with Newly Diagnosed Unmethylated MGMT-promoter Glioblastoma
Oct 10, 2022Diese Studie untersucht, wie sicher, verträglich und wirksam Tinostamustin (EDO-S101) für die Behandlung Ihrer Krebserkrankung ist. Tinostamustin ist ein neues Molekül, dass für die Behandlung verschiedener Krebsarten untersucht wird, darunter Blutkr...
Clinical Studies - Oct 10, 2022 - Jun 30, 2024
Completed
Project leader: Hundsberger Thomas
Members: Aeschbacher Anette
Inflammatory Neuropathy Consortium Base (INCbase
Dec 15, 2021The Inflammatory Neuropathy Consortium Base (INCbase) is an international registry for CIDP patients led by an international collaboration of CIDP experts. INCbase provides a state of the art modular research database that members may use to collect...
Fundamental Research - Dec 15, 2021 - Dec 15, 2025
Ongoing
Members: Felbecker Ansgar, Leupold Daniela
Cognitive Outcome 1 year after COVID-19 – A Pilot Study (CogCOVID)
Oct 19, 2021This prospective observational pilot study examines cognitive function 1 year after SARS-Cov-2 disease. Study population consists of formerly hospitalized non-ventilated COVID-19 patients (nvCOVID) and ventilated patients with COVID-19-ARDS (cARDS) t...
Clinical Studies - Oct 19, 2021 - Dec 31, 2022
Automatically Closed
Project leader: Göhl-Freyn Kristina, Felbecker Ansgar
Members: Albrich Werner, Schmid Dagmar, Kleger Gian-Reto, Schrag Claudia, Pietsch Urs
Wirksamkeit von Gruppenpsychotherapie bei Narkolepsie Typ 1
Oct 1, 2021Narkolepsie ist eine seltene schwere chronische neurologische Erkrankung des Schlaf-Wach-Systems, die meist junge Menschen betrifft. Klinisch werden zwei Formen unterschieden: Narkolepsie mit/ohne Kataplexien, bzw. Narkolepsie Typ 1 (mit Kataplexien;...
Clinical Studies - Oct 1, 2021 - Oct 31, 2022
Completed
Project leader: Schmid Dagmar
Members: Reiss Verena, Gehrig Cornelius, Germann Nicolas, Von Manitius Sigrid
EVOKE
Sep 30, 2021A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE) This study is done to find out whether semaglutide has a positive effect on early Alzheimer's disease. Participants will either get semaglutide or placebo - w...
Clinical Studies - Sep 30, 2021 - Dec 31, 2025
Ongoing
Project leader: Felbecker Ansgar
Pilot study on cognitive and social function measures for early detection of progressive neurocognitive disorders in Switzerland
May 12, 2021
Clinical Studies - May 12, 2021 - Sep 15, 2022
Completed
Project leader: Felbecker Ansgar
An open-label Phase 1/2a study of oral BAL101553
Mar 8, 2021Frühe Phase-II Studie zur Behandlung von IDH-Wildtyp Glioblastomen oder IDH-mutierten Astrozytomen WHO Grad IV nach Progression (jede Linie) mit Lisavanbulin als orale Monotherapie mit geringen Nebenwirkungen. Die Wirksamkeit der Behandlung mit Lisav...
Clinical Studies - Mar 8, 2021 - Feb 16, 2030
Completed
Project leader: Hundsberger Thomas
Swiss Primary Hypersomnolence and Narcolepsy Cohort Study
Jan 1, 2021
Clinical Studies - Jan 1, 2021 - Dec 31, 2023
Completed
Project leader: Von Manitius Sigrid
Members: Zieglgänsberger Dominik, Gievers-Steinlein Bettina
SILENT 2
Dec 4, 2020Incidence of Silent Atrial Fibrillation in Patients With Clinically Silent Brain Ischemic Lesions Arterial Fibrillation (AF) is well-recognized as a cause for cryptogenic Acute Ischemic Stroke (AIS) and is associated with Silent Brain Infarction...
Clinical Studies - Dec 4, 2020 - Dec 4, 2024
Ongoing
Project leader: Ammann Peter, Kägi Georg
Members: Brenner Roman, Vetsch Susanne, Schneider Irene
Development of a non-invasive screening system for the early detection of mild cognitive impairments in older adults
Nov 1, 2020In dem geförderten Kooperationsprojekt “Development of a non-invasive screening system for the early detection of mild cognitive impairments in older adults” wird untersucht, ob ein multimodales nicht-invasives Testsystem geeignet ist, um frühe Stadi...
Clinical Studies - Nov 1, 2020 - Jul 1, 2021
Automatically Closed
Project leader: Felbecker Ansgar
Members: Schneider Thomas
CRiPSI/CRiPSI-X: Covid-19 Risk Prediction in Swiss ICUs-Trial/Extension
Aug 1, 2020Outcome of patients with critical Covid-19 varies. We study risk of and predictors for poor outcome in adult patients with Covid-19 admitted to ICU in a multicenter study. In addition, we assess the prevalence of, risk factors for and mechanisms invo...
Clinical Studies - Aug 1, 2020 - Aug 31, 2022
Automatically Closed
Project leader: Albrich Werner
Members: Von Mering Christian, O'Mahony Liam, Cerny Andreas, Suh Noémie, El Baz Yassir, Dietrich Tobias, Fischer Tim, Felbecker Ansgar, Göhl-Freyn Kristina, Germann Nicolas, Schmid Dagmar, Kahlert Christian, Frischknecht Manuel, Filipovic Miodrag, Brutsche Martin, Pietsch Urs, Kleger Gian-Reto, Bochud Pierre-Yves
A3BAD study - Analysis of amyloid aggregates in blood with atomic force microscopy as a biomarker of Alzheimer Dementia
Jun 1, 2020Background: The key neuropathological feature of Alzheimer disease (AD) is the accumulation of extracellular β-amyloid (Aβ) plaques in the brain which begins long before clinical signs of dementia. Immunotherapies targeting Aβ may prevent Aβ accumula...
Fundamental Research - Jun 1, 2020 - May 30, 2022
Automatically Closed
Project leader: Felbecker Ansgar
Members: Schneider Thomas, Nirmjaraj Peter
KSSG Collaborative Brain Tumour Registry
Jan 16, 2020Primary brain tumours remain an important burden of disease in Switzerland. Between 2010 – 2014, there were 1570 incident cases and about 580 deaths attributed to brain tumours each year. Although tumours of the central nervous system (CNS) represent...
Clinical Studies - Jan 16, 2020 - Jan 16, 2025
Ongoing
Project leader: Zeitlberger Anna, Hundsberger Thomas