Project
Selective S1P1 receptor agonist in Patients with Relapsing-Remitting Multiple Sclerosis
Completed · 2009 until 2010
Putzki Norman, Yildiz Murat, Müller Anna, Siebel Philip, Müller Stefanie
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Brief description/objective
Multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-finding phase IIb study to evaluate the efficacy, safety, and tolerability of three doses of an oral S1P1 receptor agonist, administered for twenty-four weks in patients with relapsing-remitting multiple sclerosis
Primary Outcome meassures:
culmulative number of new gadolinium lesions T1-weighted MRI at weeks 12/16/20/24
Secondary objectives:
- annualized confirmed relapse rate
- time to first confirmed relapse
- safety and tolarability