Unit
Pneumologie und Schlafmedizin
PNEUMO · Dept. I
Telemedicine to enhance CPAP adherence in OSAS - A randomized placebo-controlled prospective study
Jan 1, 2013We hypothesize that the use of telemedicine combined with support interventions by short messages, telephone calls and ambulatory visits to control CPAP treatment in OSAS patients during the first month improves adherence and reduces unresolved side...
Clinical Studies - Jan 1, 2013 - Dec 31, 2015
Completed
Project leader: Schoch Otto
Members: Baty Florent, Niedermann Jolanda, Brutsche Martin
Integrative Translational Research Network for Lung Cancer (ITRNLC)
Oct 1, 2012Lung cancer remains a health issue with a dismal outcome and evolution in the search of new prognostic markers and therapeutic approaches. To improve research efforts interdisciplinary and multicenter research networks are needed. For competitive tra...
Fundamental Research - Oct 1, 2012 - Dec 31, 2015
Completed
Project leader: Brutsche Martin, Putora Paul Martin
Members: Baty Florent
A multicenter, reandomized, double-blind, single-dose study to assess the effect of the combined inhalation of 150 ug indacaterol maleate (QAB149) and 50 ug glycopyrronium bromide (NVA237) versus inhaled 150 ug indacaterol maleate (QAB149) alone on inspiratory capacity in patients with moderate or severe COPD
Oct 1, 2012A multicenter, reandomized, double-blind, single-dose study to assess the effect of the combined inhalation of 150 ug indacaterol maleate (QAB149) and 50 ug glycopyrronium bromide (NVA237) versus inhaled 150 ug indacaterol maleate (QAB149) alone on i...
Clinical Studies - Oct 1, 2012 - Aug 31, 2013
Completed
Project leader: Pellet Sarah
Members: Brutsche Martin, Finger Rebekka, Burger Barbara
The significance of Defensin alpha 4 in the pathophysiology of the adrenal insufficiency in inflammatory lung diseases
Sep 1, 2012The pathophysiology of the adrenal insufficiency of patients with critical diseases remains unclear. In a prior exploratory study investigating patients with exacerbation of chronic obstructive pulmonary disease (COPD), we demonstrated a highly signi...
Fundamental Research - Sep 1, 2012 - Sep 1, 2013
Aborted
Project leader: Rüdiger Jochen
Members: Baty Florent, Bilz Stefan, Lehmann Natalie, Brutsche Martin
Significant reduction of AECOPD hospitalizations after implementation of a public smoking ban in Graubünden, Switzerland
Sep 1, 2012Background Only few studies have examined the effect of public smoking bans on respiratory conditions. These showed reduced admission rates for different respiratory diseases. Objective of the present study was to evaluate the effect of the public sm...
Fundamental Research - Sep 1, 2012 - Jun 1, 2013
Completed
Project leader: Baty Florent, Brutsche Martin
Members: Dusemund Frank
Systembiologische Untersuchungen zur molekularen Charakterisierung der Mikroumgebung in Lungentumoren
Jul 1, 2012Das Thema des geplanten Forschungsprojekts sind systembiologische Untersuchungen zur molekularen Charakterisierung der Mikroumgebung in Lungentumoren. Lungenkrebs ist eine der häufigsten Todesursachen in den industrialisierten Ländern. Die meisten Pa...
Fundamental Research - Jul 1, 2012 - Jun 30, 2014
Completed
Project leader: Ludewig Burkhard, Brutsche Martin
Members: Franzini Anca, Tarantino Ignazio
Systems biology approach to moleculary characterize the lung cancer microenvironment
Jul 1, 2012Tumor cells display distinct genetic alterations that permit their unrestricted growth. In contrast, stromal cells that provide the growth scaffold and nutrients for the tumor, most likely exhibit universal signatures that determine their function. T...
Fundamental Research - Jul 1, 2012 - Jun 30, 2014
Completed
Project leader: Ludewig Burkhard
Members: Franzini Anca, Bocharov Gennady
Circulating micro-RNA profiling in patients with advanced non-squamous non small-cell lung cancer receiving bevacizumab/erlotinib first-line treatment followed by platinum-based chemotherapy at disease progression (SAKK 19/05)
Apr 1, 2012Background: This study was initiated by the Swiss Group for Clinical Cancer Research (SAKK) 19/05 study to assess the predictive and prognostic value of circulating miRNA profiles from peripheral blood of patients with non-squamous non small-cell lu...
Fundamental Research - Apr 1, 2012 - Sep 1, 2013
Completed
Project leader: Brutsche Martin
Members: Jörger Markus, Zappa Francesco, Gautschi Oliver, Pless Miklos, Ochsenbein Adrian, Bubendorf Lukas, von Moos Roger, Betticher Daniel, Stahel Rolph, Früh Martin, Baty Florent
A 24 week, randomized, double-blind, multicenter, placebo-controlled efficacy, safety, tolerability and PK trial of Nilotinib (AMN107) in pulmonary arterial hypertension (PAH)
Feb 1, 2012
Clinical Studies - Feb 1, 2012 - Apr 1, 2014
Aborted
Project leader: Brutsche Martin
Members: Burger Barbara, Haider Karin
The obstructive pulmonary disease outcomes cohort of Switzerland (TOP DOCS): phenotypes and vascular amage in COPD
Jan 1, 2012Prospective cohort study including COPD patients from 6 study centers in Northern Switzerland
Fundamental Research - Jan 1, 2012 - Dec 31, 2015
Automatically Closed
Project leader: Brutsche Martin
Members: Rüdiger Jochen, Burger Barbara, Haider Karin
Pleural pharmacokinetics of moxifloxacin and amoxicillin-clavulanate in the context of parapneumonic pleural effusions and empyema
Dec 1, 2011The main objective of the study is the characterization of the PK profiles of moxifloxacin and amoxicillin clavulanate in the pleural fluid of patients with parapneumonic effusions using population PK-analysis. Intra- and interpatient variability wil...
Clinical Studies - Dec 1, 2011 - Dec 31, 2012
Completed
Project leader: Brutsche Martin
Members: Boggian Katia, Jörger Markus, Baty Florent, Ruedlinger Luzia
St. Gallen Lung Biopsy Biobank - An interdisciplinary collaboration in pulmonary medicine
Sep 1, 2011The current project proposes to create a tissue and blood sample collection (biobank) of all patients willing to give informed consent, who are undergoing bronchoscopy and/or surgical lug resection in their diagnostic pathway for any pulmonary diseas...
Fundamental Research - Sep 1, 2011 - Dec 31, 2030
Automatically Closed
Project leader: Brutsche Martin
Members: Baty Florent
Comorbidities and burden of COPD: a population based case-control study
Jun 1, 2011COPD is associated with a relevant burden of disease and a high mortality worldwide. Only recently, the importance of comorbidities of COPD has been recognized. Studies postulated an association with inflammatory conditions potentially sharing pathog...
Fundamental Research - Jun 1, 2011 - Jun 1, 2013
Completed
Project leader: Baty Florent, Brutsche Martin
Members: Putora Paul Martin, Isenring Bruno, Blum Torsten
Does hyper-thermal incubation and blockage of T-cell inhibitory pathways improve current and future T-cell based diagnostic test systems?
Feb 1, 2011Background: Cell mediated immune (CMI) assays are important research tools to monitor T-cell dependent immune responses towards specific antigens. Recently CMI assays were introduced for the diagnosis of latent tuberculosis infection (LTBI). In these...
Fundamental Research - Feb 1, 2011 - Dec 31, 2014
Completed
Project leader: Ruhwald Morten, Schoch Otto, Hoffmann Matthias
Eine randomisierte, aktiv kontrollierte, doppelblinde, Double-Dummy, multizentrische Parallelgruppen-Studie zum Vergleich der Wirksamkeit und Sicherheit von 2,5µg und 5 µg Tiotropium-Inhalations-Lösung, inhaliert mittels Respimat®-Inhalator gegenüber Tiotropium-Inhalationskapseln 18µg, inhaliert mittels HandiHaler® TIOSPIR-Studie
May 15, 2010A Randomized, Active-controlled, Double-blind, Double-dummy, Parallel Group Design, Multi-center Trial to Compare the Efficacy and Safety of 2.5 µg and 5 µg Tiotropium Inhalation Solution Delivered by the Respimat Inhaler With Tiotropium Inhalation C...
Clinical Studies - May 15, 2010 - Dec 15, 2013
Completed
Project leader: Brutsche Martin
Members: Baty Florent
An extension study to QTI571A2301 to evaluate the longterm safety, tolerability and efficacy of oral QTI571 (imatinib) in the treatment of severe pulmonary arterial hypertension: IMPRESS Extension
Dec 1, 2009
Clinical Studies - Dec 1, 2009 - Dec 1, 2011
Aborted
Project leader: Brutsche Martin
Members: Baty Florent
A multicenter, double-blind, placebo-controlled phase 3 study to demonstrate the efficacy and safety of ACT-293987 in patients with pulmonary arterial hypertension
Oct 1, 2009The primary objective is to demonstrate the effect of ACT-293987 on time to first clinical worsening in patients with pulmonary arterial hypertension (PAH)
Clinical Studies - Oct 1, 2009 - Apr 1, 2013
Aborted
Project leader: Brutsche Martin
Members: Burger Barbara, Haider Karin, Rüdiger Jochen
A phase IIIb multicenter, 52 week treatment, randomized, blinded, double dummy, parallel group efficacy study comparing the effect of inhaled indacaterol 150ug o.d. vs inhaled tiotropium 18ug o.d. on lung function, rate of exacerbations and related outcomes in patients with COPD
Jul 1, 2009
Clinical Studies - Jul 1, 2009 - Jul 1, 2011
Completed
Project leader: Brutsche Martin
Members: Haider Karin, Burger Barbara
Randomized placebo-controled, double-blind exploratory trial of Bosentan for steroid resistant pulmonary sarcoidosis - the BOSSA study
Jul 1, 2007
Clinical Studies - Jul 1, 2007 - Jul 1, 2013
Completed
Project leader: Brutsche Martin
Members: Baty Florent, Burger Barbara