Unit
Pneumologie und Schlafmedizin
PNEUMO · Dept. I
Large language models for the identification of etiotypes in Chronic Obstructive Lung Diseases
Mar 1, 2024Recent guidelines proposed new taxonomic classifications for COPD, so-called etiotypes, which have clinical relevance for management and treatment of patients. This project hypothesizes that information extracted from patients' electronic health reco...
Fundamental Research - Mar 1, 2024 - Feb 28, 2025
Ongoing
Project leader: Baty Florent
Members: Brutsche Martin, Albrich Werner, Hastings Janna, Kozu Kei, Toromanovic Tim
Profiling of quitting trajectories during smoking cessation attempt (SMOKEPROFILE-Study)
May 1, 2021The study hypothesis is twofold. First, we hypothesize that investigating daily tobacco consumption of smokers attempting to quit can be used to characterize clinically relevant quitting trajectories which can be used to predict quitting success. Our...
Fundamental Research - May 1, 2021 - Dec 30, 2023
Automatically Closed
Project leader: Baty Florent
Members: Brutsche Martin, Bösch Maximilian, Pohle Susanne
Comparison of the effect of outdoor eccentric versus indoor concentric exercise training on physical capacity and qualityof-life in patients with advanced COPD (DOWNHILL-study)
May 1, 2021Patients with chronic obstructive pulmonary disease (COPD) often suffer from cardio-pulmonary limitations, which makes them avoid exercise training. However, exercise training is explicitly recommended for COPD patients as physical activity (PA) is k...
Fundamental Research - May 1, 2021 - Apr 30, 2025
Ongoing
Project leader: Bösch Maximilian
Members: Baty Florent, Brutsche Martin, Benz Gabriel
Smartphone-Enabled Detection of COugh in COvid-19 (COCO): An Exploratory, Single-Center, Observational Cohort Study
Dec 3, 2020
Clinical Studies - Dec 3, 2020 - Dec 3, 2020
Automatically Closed
Project leader: Rassouli Frank
Members: Bösch Maximilian, Brutsche Martin, Tinschert Peter, Barata Filipe, Shih Iris
COugh During and after acute EXacerbation of chronic obstructive pulmonary disease (CODEX) study
Sep 8, 2020
Clinical Studies - Sep 8, 2020 - Jul 1, 2021
Automatically Closed
Project leader: Rassouli Frank
Members: Brutsche Martin, Barata Filipe, Cleres David
CRiPSI/CRiPSI-X: Covid-19 Risk Prediction in Swiss ICUs-Trial/Extension
Aug 1, 2020Outcome of patients with critical Covid-19 varies. We study risk of and predictors for poor outcome in adult patients with Covid-19 admitted to ICU in a multicenter study. In addition, we assess the prevalence of, risk factors for and mechanisms invo...
Clinical Studies - Aug 1, 2020 - Aug 31, 2022
Automatically Closed
Project leader: Albrich Werner
Members: Von Mering Christian, O'Mahony Liam, Cerny Andreas, Suh Noémie, El Baz Yassir, Dietrich Tobias, Fischer Tim, Felbecker Ansgar, Göhl-Freyn Kristina, Germann Nicolas, Schmid Dagmar, Kahlert Christian, Frischknecht Manuel, Filipovic Miodrag, Brutsche Martin, Pietsch Urs, Kleger Gian-Reto, Bochud Pierre-Yves
Prospective observational cohort study to investigate long-term pulmonary and extrapulmonary effects of COVID-19
Jun 15, 2020
Clinical Studies - Jun 15, 2020 - Dec 15, 2021
Automatically Closed
Project leader: Brutsche Martin
Members: Baty Florent
Predictive markers for checkpoint-based immunotherapy in advanced non-small cell lung cancer
Jan 1, 2020The aim of this study is to elucidate a novel biomarker constellation with superior predictive value for PD-1/PD-L1-targeted immunotherapy in advanced non-small cell lung cancer.
Fundamental Research - Jan 1, 2020 - Dec 31, 2021
Completed
Project leader: Bösch Maximilian
Members: Baty Florent, Brutsche Martin, Früh Martin, Jörger Markus
Swiss Severe Asthma Register
Oct 1, 2019
Clinical Studies - Oct 1, 2019 - Dec 31, 2021
Automatically Closed
Project leader: Kern Lukas
Members: Baty Florent, Widmer Sandra, Brutsche Martin
The role of physical activity, malnutrition and sarcopenia for the prediction of acute exacerbations and the evolution of COPD assessment test (CAT) in patients with COPD
Nov 29, 2018We plan to investigate the association between physical activity, malnutrition and sar-copenia and the occurrence of acute exacerbations of COPD (AECOPD) / the evolution of the COPD assessment test (CAT) over 1 year in a telehealthcare (THC) cohort o...
Clinical Studies - Nov 29, 2018 - Jun 30, 2021
Completed
Project leader: Bösch Maximilian
Members: Baty Florent, Rassouli Frank, Tschirren Ursina, Widmer Sandra, Bilz Stefan, Brutsche Martin
Asthma control Prediction
Feb 1, 2018The project consists of two stages with different objectives. In the first stage, the objective is to investigate whether nocturnal cough occurs in asthmatics more frequently than random (i.e. average nocturnal cough rate significantly greater than z...
Clinical Studies - Feb 1, 2018 - Dec 31, 2018
Automatically Closed
Project leader: Rassouli Frank
Members: Brutsche Martin, Baty Florent, Widmer Sandra, Tschirren Ursina
Effect of induction chemotherapy on lung function measured by spiroergometry and 6-Minute walking test in patients affected by non-small cell lung cancer (NSCLC)
Jan 1, 2018Lung cancer is one of the most common cancers in the world and the leading cause of cancer-related mortality. At diagnosis, approximately 40% of patients are already at an advanced stage, and a third have locally advanced disease (stage III). Stage I...
Fundamental Research - Jan 1, 2018 - Dec 31, 2020
Automatically Closed
Members: Baty Florent, Brutsche Martin, Kern Lukas, Maeder Micha, Früh Martin
Azithromycin for the treatment of cough in idiopathic pulmonary fibrosis
Oct 1, 2017Multi centre, prospective, randomized, double blind, 2 treatment, 2 period crossover study with two 12-week treatment periods separated by a 4 week drug-free washout period and a 4 week follow-up performed at the University Hospital Berne, Basel, Zür...
Clinical Studies - Oct 1, 2017 - Dec 1, 2018
Automatically Closed
Project leader: Brutsche Martin
Members: Finger Rebekka, Tschirren Ursina, Baty Florent, Widmer Sandra
A multicenter, randomized, 52-week, double-blind, parallel group, active controlled study to compare the efficacy and safety of QVM149 with QMF149 in patients with asthma
Nov 11, 2016Asthma is a serious global health problem affecting all age groups. Despite existing therapies, there are significant unmet medical needs in treating asthma. Novartis is developing QVM149, a fixed-dose combination (FDC) of indacaterol acetate, an inh...
Clinical Studies - Nov 11, 2016 - Mar 31, 2018
Automatically Closed
Project leader: Brutsche Martin
Members: Baty Florent, Schlotter Sandra
A 52-week, multicenter, randomized, double-blind, placebocontrolled study to assess the efficacy and safety of QAW039 when added to existing asthma therapy in patients with uncontrolled severe asthma
Sep 11, 2016Das Ziel dieser Studie ist es, die Wirksamkeit und Sicherheit von QAW039 (150 mg und 450 mg einmal täglich) im Vergleich zu Placebo zu bestimmen, wenn es Patienten mit unzureichend kontrolliertem schweren Asthma und hoher Anzahl an Eosinophilen (Eosi...
Clinical Studies - Sep 11, 2016 - Mar 31, 2018
Automatically Closed
Project leader: Brutsche Martin
Members: Baty Florent, Schlotter Sandra
Prevalence and functional role of read-through fusion transcripts in lung cancer
Jun 1, 2016The aim of this exploratory study is to assess the prevalence and the functional role of RTFTs in lung cancer. Total RNA extracted from lung biopsies obtained in 50 p...
Fundamental Research - Jun 1, 2016 - Dec 31, 2018
Automatically Closed
Project leader: Baty Florent
Members: Brutsche Martin
A randomised controlled, international, multicentre crossover trial. We want to test, whether telehealthcare can improve HRQOL and reduce emergency admissions and hospitalisations due to AECOPD
May 11, 2016A randomised controlled, international, multicentre crossover trial. We want to test, whether telehealthcare can improve HRQOL and reduce emergency admissions and hospitalisations due to AECOPD.
Clinical Studies - May 11, 2016 - Dec 31, 2018
Automatically Closed
Project leader: Brutsche Martin
Members: Baty Florent, Rassouli Frank, Schlotter Sandra
Targeting breast cancer through manipulation of IL-7 producing tumor fibroblasts
Jan 1, 2016Breast cancer is by far the most frequent gynaecological cancer. Despite considerable advances in antitumor therapies during the last 15 years, metastatic and recurrent breast cancer is still incurable, indicating that the underlying pathogenesis of...
Fundamental Research - Jan 1, 2016 - Dec 31, 2017
Automatically Closed
Project leader: Ludewig Burkhard
Members: Bösch Maximilian
Cardiopulmonary- and hemodynamic responses during positive and negative airway pressure in patients with chronic obstructive pulmonary disease
Oct 1, 2015The overall aim of the present study is to investigate if positive and negative airway pressure influences cardiopulmonary- and hemodynamic responses by adding resistive loads or/and conducting NPPV throughout the entire breathing cycle in patients w...
Fundamental Research - Oct 1, 2015 - Aug 1, 2016
Automatically Closed
Project leader: Baty Florent, van Gestel Arnoldus, Brutsche Martin
Kalydeco
Sep 1, 2015
Clinical Studies - Sep 1, 2015 - Sep 1, 2017
Automatically Closed
Project leader: Schoch Otto
Members: Finger Rebekka, Brutsche Martin, Kapfer Sarah, Schlotter Sandra