Comparison of the effect of outdoor eccentric versus indoor concentric exercise training on physical capacity and qualityof-life in patients with advanced COPD (DOWNHILL-study)

Ongoing - recruitment active · 2021 until 2023

Fundamental Research
Monocentric project at KSSG
Ongoing - recruitment active
Start Date
End Date
Brief description/objective

Patients with chronic obstructive pulmonary disease (COPD) often suffer from cardio-pulmonary limitations, which makes them avoid exercise training. However, exercise training is explicitly recommended for COPD patients as physical activity (PA) is known to positively modulate disease progression and increase the quality of life. Therefore, cleverly devised training modalities that account for cardio-pulmonary limitations are warranted to enable efficient training and increase the PA of patients with COPD. Eccentric exercise training (EET) is a training modality that puts relatively high strain on the muscles while sparing cardio-pulmonary output requirements. Thus, EET allows that patients
with moderate-to-severe COPD can perform exercise training and strengthen their muscles without experiencing exercise-limiting dyspnea. It is therefore reasonable to assume that EET may have high compliance in COPD and that the training effects of EET are at least non-inferior to those of classical concentric exercise training (CET).
In this study, we address this question in a two-arm randomized controlled trial (RCT) of EET vs. CET training interventions. The study is embedded into the existing outpatient pulmonary rehabilitation program (“ambulante pulmonale Rehabilitation”) of the Lung Center, Cantonal
Hospital St.Gallen.