Unit
Pneumologie und Schlafmedizin
PNEUMO · Dept. I
Cardiopulmonary- and hemodynamic responses during positive and negative airway pressure in patients with chronic obstructive pulmonary disease (COPD)
Jul 1, 2015The overall aim of the present study is to investigate if positive and negative airway pressure influences cardiopulmonary- and hemodynamic responses by adding resistive loads or/and conducting NPPV throughout the entire breathing cycle in patients w...
Fundamental Research - Jul 1, 2015 - Mar 1, 2016
Automatically Closed
Project leader: van Gestel Arno Jr
Members: Baty Florent, Brutsche Martin
Effect of counselling during pulmonary rehabilitation on self-determined motivation towards physical activity in patients with Chronic Obstructive Pulmonary Disease
Jun 15, 2015The overall aim of the present study is to investigate if a PA counselling program during PR increases PA level in daily life in patients with COPD.
Fundamental Research - Jun 15, 2015 - Jan 31, 2017
Automatically Closed
Project leader: van Gestel Arno Jr
Members: Rausch Osthoff Anne-Kathrin, Baty Florent, Hess Thomas
Characterizing sleep apnea by using a wearable electro EMPA cardiogram device
Jun 1, 2015The primary aim of the present study is to analyze the validity and feasibility of a wearable ECG Acquisition System (EMPA) by comparing standard measures of heart rate variability (Low-frequency power, LF) with those of polysomnography.
Fundamental Research - Jun 1, 2015 - Dec 1, 2016
Automatically Closed
Project leader: Brutsche Martin
Members: Baty Florent, van Gestel Arnoldus, Rossi Rene, Annaheim Simon, Weder Markus, Schoch Otto
LONGACT study
Mar 24, 2015A prospective multicenter study to assess the coreelation of LONGterm wrist ACTigraphy recorded physical Performance and 6-minute walk distance in patients with pulmonary arterial Hypertension newly initiating endothelin receptor antagonist therapy
Clinical Studies - Mar 24, 2015 - Mar 24, 2015
Aborted
Project leader: Brutsche Martin
Members: Baty Florent, Kapfer Sarah, Schlotter Sandra, Schoch Otto
PneumRx CLN0014 - Europäisches RePneu Register
Mar 24, 2015Register-Studie Emphysema
Clinical Studies - Mar 24, 2015 - Mar 24, 2017
Aborted
Project leader: Schneider Tino
Members: Brutsche Martin, Kapfer Sarah, Schlotter Sandra
Telehealthcare in COPD - a Feasibility Trial
Feb 1, 2015The objective is to establish telehealthcare as an integrated, web-based treatment network between patient, GP and hospital to optimise care for COPD patients according to the GOLD-guidelines, assisted by simple-to-use, network-based gadgets (via sma...
Clinical Studies - Feb 1, 2015 - Feb 1, 2016
Completed
Project leader: Brutsche Martin
Members: Baty Florent, Dusemund Frank
Predictive and prognostic value of integrated exon-level expression to approach drug-response and resistance to EGFR-targeted treatment in non-small cell lung cancer
Jan 1, 2015Activating mutations in lung cancer are targeted by a series of molecularly targeted therapies. Patients harboring such mutations can receive significant benefit from these therapies. However a proportion of patients without activating mutations can...
Fundamental Research - Jan 1, 2015 - Dec 31, 2016
Automatically Closed
Project leader: Baty Florent
Members: Franzini Anca, Früh Martin, Jörger Markus, Brutsche Martin
Galathea
Jan 1, 2015Eine randomisierte, doppelblinde, kontinuierlich verabreichte, placebokontrollierte, multizentrische klinische Prüfung der Phase III zur Untersuchung der Wirksamkeit und Sicherheit von 2 Dosierungen Benralizumab (MEDI-563) bei Pat. mit moderater bis...
Clinical Studies - Jan 1, 2015 - Jan 1, 2016
Automatically Closed
Project leader: Brutsche Martin
Members: Benz Gabriel
Clinical impact of multiplex realtime PCR in respiratory tract infections
Nov 15, 2014Pathogen detection in respiratory tract infections is challenging due to lack of diagnostic gold standard with sufficient sensitivity and specificity. Viral infections likely contribute to a considerable portion of respiratory tract infections partic...
Clinical Studies - Nov 15, 2014 - Dec 31, 2015
Automatically Closed
Project leader: Albrich Werner
Members: Kahlert Christian, Rassouli Frank, Mayer Lena
Airway microbiota resistome in CF - impact on clinical management
Sep 1, 2014Cystic Fibrosis is a deadly genetic disease mainly due to chronic bacterial colonization and recurrent bacterial infections of the lungs. It has often been documented that once a certain microbial species such as Pseudomonas aeruginosa establishes, t...
Fundamental Research - Sep 1, 2014 - Dec 31, 2016
Automatically Closed
Project leader: Baty Florent
Members: Brutsche Martin, Kahlert Christian, Von Mering Christian, Vyas Rounak
Tobramycin
Jul 1, 2014An open-label, crossover, interventional Phase IV study to compare the ease of use of tobramycin inhalation solution and nebulized colistimethate for the treatment of pulmonary Pseudomonas aeruginosa in patients with CF
Clinical Studies - Jul 1, 2014 - Mar 18, 2015
Completed
Project leader: Brutsche Martin
Members: Finger Rebekka
Blood pressure variability during the 6-minute walk test in patients with Chronic Obstructive Pulmonary Disease (COPD): A case-control study
Mar 10, 2014The proposed study will compare vSBP values during physical exercise between patients with COPD and age- and gender-matched controls. We hypothesize that vSBP during the 6MWT is increased in patients with COPD compared to age- and gender matched cont...
Fundamental Research - Mar 10, 2014 - Jun 1, 2015
Completed
Project leader: van Gestel Arnoldus J R
Members: Baty Florent, Brutsche Martin, Gajic Andreja
Thorakoskopische Handheld-SPECT gesteuerte Ektomie von radioaktiv-markierten pulmonalen Rundherden
Nov 1, 2013Bei 30-40 Patienten pro Jahr wird im Kantonsspital St.Gallen ein pulmonaler Rundherd entfernt. Deutlich vorteilhafter gegenüber der offenen Operation ist die thorakoskopische Resektion. Einschränkungen sind die Auffindbarkeit und Resezierbarkeit von...
Clinical Studies - Nov 1, 2013 - Oct 31, 2015
Automatically Closed
Project leader: Müller Joachim
Members: Zeisel Christoph, Schneider Tino, Baty Florent, Eberl Andreas
RAINIER
Aug 1, 2013Randomisierte, doppelblinde, placebokontrollierte, multizentrische Phase-II-Studie zur Bestimmung der Wirksamkeit und der Sicherheit von GS-6624 bei Patienten mit idiopathischer Lungenfibrose
Clinical Studies - Aug 1, 2013 - Aug 1, 2015
Completed
Project leader: Pellet Sarah
Members: Finger Rebekka, Brutsche Martin, Burger Barbara
Immediate non-invasive ventilatory (NIV) support in patients with severe respiratory failure on the emergency ward (ED)- Experience of a 6 months pilot
Jun 1, 2013Background Patients with severe respiratory failure (SRF) are often in need for rapid ventilatory support. Availability of immediate NIV is often limited to the intensive care unit (ICU). We hypothesized that immediate initiation of NIV in the ED is...
Fundamental Research - Jun 1, 2013 - Jan 1, 2015
Completed
Project leader: Rüdiger Jochen, Brutsche Martin
Members: Kleger Gian-Reto, Diethelm Markus, Osterwalder Joseph
Offene, nicht kontrollierte, multizentrische Phase IIIb Studie zur Beurteilung von Riociguat (BAY 63-2521) bei Patienten mit Chronisch Thromboembolischer Pulmonaler Hypertonie (CTEPH)
Jun 1, 2013Objective 1) To assess safety and tolerability, clinical effects of riociguat. 2) To provide access to riociguat for patients with in-operable chronic thromboembolic pulmonary hypertension (CTEPH), or recurrent or persisting pulmonary hypertension (P...
Clinical Studies - Jun 1, 2013 - Jun 1, 2015
Aborted
Project leader: Brutsche Martin
Members: Pellet Sarah, Finger Rebekka
Selection and education of heart-specific Th cells by thymic and lymph node stromal cells
Apr 1, 2013Myocarditis is a frequent disease in children and young adults that can precipitate lethal dilated cardiomyopathy (DCM). Since some heart antigens, such as the cardiac myosin heavy chain alpha (myhca) are not represented in the thymus, heart-specific...
Fundamental Research - Apr 1, 2013 - Mar 31, 2016
Completed
Project leader: Ludewig Burkhard
Members: Pérez Shibayama Christian Ivan, Bösch Maximilian, Gil Cruz Cristina
Genome-wide Gene/Exon expression analysis of late stage NSCLC treated by Erlotinib /Bevacizumab: role of tumor-stroma interactions
Feb 1, 2013Genome-wide Gene/Exon expression analysis of late stage NSCLC treated by Erlotinib /Bevacizumab: role of tumor-stroma interactions
Fundamental Research - Feb 1, 2013 - Jun 1, 2015
Completed
Project leader: Baty Florent
Members: Brutsche Martin, Oliver Dürr, Franzini Anca
Systems biology approach to molecularly characterize the lung cancer microenvironment
Jan 1, 2013Lung cancer is the most frequent cause of death in cancer patients in industrialized countries. Most patients with advanced nonsmall cell lung cancer (NSCLC) do not respond to the current treatment schemes indicating that the basic mechanisms of tumo...
Fundamental Research - Jan 1, 2013 - Dec 31, 2014
Completed
Project leader: Ludewig Burkhard, Brutsche Martin
Members: Baty Florent, Novkovic Mario, Onder Lucas
Improved adherence to CPAP by Telemetric Support in Newly diagnosed OSAS Patients
Jan 1, 2013Introduction: The acceptance of positive airway pressure therapy (CPAP) within the first month is a critical aspect of successful OSAS therapy. Telemedicine is a novel tool to supervise CPAP use at patient's home. We report 30-day results of a pilot...
Fundamental Research - Jan 1, 2013 - Mar 1, 2013
Completed
Project leader: Schoch Otto, Brutsche Martin
Members: Baty Florent, Niedermann Jolanda, Rüdiger Jochen