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Brief description/objective

Tumor cells display distinct genetic alterations that permit their unrestricted growth. In contrast, stromal cells that provide the growth scaffold and nutrients for the tumor, most likely exhibit universal signatures that determine their function. The aim of this project is to gain novel knowledge on stromal cells that determine the growth-supporting micro-environment of lung cancer. Researcher at the Kantonsspital St. Gallen have developed unique tools and methods to label, characterize and molecularly ablate lung cancer stromal cells. We expect that our research will identify critical target structures on lung cancer stromal cells and that this knowledge will foster the development of novel diagnostic and therapeutic avenues.