Projekt

Systems biology approach to moleculary characterize the lung cancer microenvironment

Abgeschlossen · 2012 bis 2014

Art
Grundlagenforschung
Reichweite
Monozentrisch am KSSG
Bereiche
Status
Abgeschlossen
Start
2012
Ende
2014
Finanzierungsart
Andere
Schlagwörter (Tags)
lung cancer, microenvironment, stromal cell, tumor
Kurzbeschreibung/Zielsetzung

Tumor cells display distinct genetic alterations that permit their unrestricted growth. In contrast, stromal cells that provide the growth scaffold and nutrients for the tumor, most likely exhibit universal signatures that determine their function. The aim of this project is to gain novel knowledge on stromal cells that determine the growth-supporting micro-environment of lung cancer. Researcher at the Kantonsspital St. Gallen have developed unique tools and methods to label, characterize and molecularly ablate lung cancer stromal cells. We expect that our research will identify critical target structures on lung cancer stromal cells and that this knowledge will foster the development of novel diagnostic and therapeutic avenues.