Unit
Institute of Immunobiology
IMMBIO · Management
Immunopathological pathways underlying myocarditis and inflammatory cardiomyopathy – an exploratory study
Jul 24, 2023Primary objective: Analysis of cardiac antigen- and microbiota-reactive CD4+ T cell and B cell response during development of cardiac inflammation. Secondary objectives: Analysis of clinical data, cardiac imaging and immunological parameters (HLA de...
Clinical Studies - Jul 24, 2023 - Jul 24, 2024
Ongoing
Project leader: Ludewig Burkhard
Members: Rickli Hans, Maeder Micha, Vetsch Susanne
T cell responses in myocarditis, inflammatory cardiomyopathy and heart failure
Jun 22, 2023
Fundamental Research - Jun 22, 2023 - Dec 31, 2023
Automatically Closed
Project leader: Ludewig Burkhard
Regulation of lymphoid organ fibroblast differentiation and function by bone morphogenic proteins
Jan 1, 2023
Fundamental Research - Jan 1, 2023 - Dec 31, 2026
Ongoing
Project leader: Ludewig Burkhard
Entschlüsselung der krebsassoziierten Fibroblastenlandschaft bei malignen Erkrankungen des ZNS
Jan 1, 2023
Fundamental Research - Jan 1, 2023 - Dec 31, 2023
Automatically Closed
Project leader: Pikor Natalia
Deep immune cell phenotyping in patients suffering from HPV-positive tonsillar squamous cell carcinoma
Nov 4, 2022
Fundamental Research - Nov 4, 2022 - Dec 31, 2023
Automatically Closed
Project leader: Ludewig Burkhard
Members: Stanossek Yves
Fibroblastendifferenzierung und -funktion im Tonsillenkarzinom
Jun 24, 2022
Fundamental Research - Jun 24, 2022 - Dec 31, 2023
Automatically Closed
Project leader: Ludewig Burkhard
Members: Meili Samuel
Tissue Cytokines at the Nexus of Immune Cell-Cardiac Stromal Cell Interaction-CardiacStroma
Jan 1, 2022
Fundamental Research - Jan 1, 2022 - Dec 30, 2026
Ongoing
Project leader: Ludewig Burkhard
Elucidating mechanisms of disease pathogenesis in a coronavirus-induced model of Multiple Sclerosis
Nov 1, 2021
Fundamental Research - Nov 1, 2021 - Dec 31, 2022
Automatically Closed
Project leader: Pikor Natalia
Deciphering the molecular landscape of the stromal cells in human lymph nodes at the single-cell level
Mar 1, 2019Secondary lymphoid organs are strategically positioned at routes of pathogen invasion and thereby increase the likelihood of lymphocytes to encounter their cognate antigens at a particular location and during a certain time window. Lymph nodes are fo...
Fundamental Research - Mar 1, 2019 - Dec 31, 2019
Automatically Closed
Project leader: Ludewig Burkhard
Stromal Cell Niches at the Nexus of the Innate Lymphoid Cell Interactome
Jan 1, 2019Innate lymphoid cells (ILCs) critically impact a diverse array of diseases. While the main cell-intrinsic molecular pathways and some of the soluble mediators that regulate ILC development and their functional activity have been characterized, the ce...
Fundamental Research - Jan 1, 2019 - Dec 31, 2022
Automatically Closed
Project leader: Ludewig Burkhard
Members: Lütge Mechthild
Identification and manipulation of immune-stimulating fibroblastic stromal cell niches in the
Jan 1, 2019The unique anatomy of the central nervous system (CNS) necessitates that inflammation in this organ is limited. However, emerging studies reveal that focal inflammation may be more prominent than previously appreciated. Avenues for immune surveillanc...
Fundamental Research - Jan 1, 2019 - Dec 31, 2022
Automatically Closed
Project leader: Pikor Natalia, Ludewig Burkhard
Transcriptomic analysis of the B and T cell repertoire in Multiple Sclerosis – an exploratory study
Jan 1, 2019Multiple Sclerosis (MS) is an immune-mediated disease of the central nervous system (CNS). While T cells dominate the immune response, both B and T cells contribute to the demyelination and neuronal injury that underlies clinical disease manifestatio...
Fundamental Research - Jan 1, 2019 - Jan 31, 2019
Automatically Closed
Project leader: Pikor Natalia, Ludewig Burkhard
Deciphering the transcriptomic landscape of cancer-associated fibroblasts in pancreatic cancer / Oncological Research
Jan 1, 2019Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancer types with a 5-year survival of only 7% and strongly limited treatment options. A major obstacle for successful treatment is the immunosuppressive nature of the tumor microe...
Fundamental Research - Jan 1, 2019 - Dec 31, 2021
Automatically Closed
Project leader: Ludewig Burkhard, Lütge Mechthild
Inorganic Nanoparticles with Anti-inflammatory and Antimicrobial Activity: New Prospects for Long-term Local Immunoimodulation?
Jan 1, 2019Control and eventual attenuation of inflammation is important in the management of a plethora of diseases. However, suppression of inflammatory responses, e.g. by corticosteroids or systemic blockade of immune effector pathways, is associated with se...
Fundamental Research - Jan 1, 2019 - Dec 31, 2019
Automatically Closed
Project leader: Ludewig Burkhard, Herrmann Inge
Identification and manipulation of immune-stimulating fibroblastic stromal cell niches in the inflamed CNS
Jan 1, 2019The unique anatomy of the central nervous system (CNS) necessitates that inflammation in this organ is limited. However, emerging studies reveal that focal inflammation may be more prominent than previously appreciated. Avenues for immune surveill...
Fundamental Research - Jan 1, 2019 - Jun 30, 2023
Automatically Closed
Project leader: Pikor Natalia, Ludewig Burkhard
Deciphering the transcriptomic landscape of cancer-associated fibroblasts in pancreatic cancer – an exploratory clinical study
Jul 1, 2018Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancer types with a 5-year survival of only 7% 1. While surgical resection of localized disease offers a moderate increase in survival, patients with metastatic pancreas cancer are...
Fundamental Research - Jul 1, 2018 - Dec 31, 2018
Completed
Project leader: Ludewig Burkhard
Members: Lütge Mechthild
Dissecting the association of anti-microbiota antibodies and auto-reactive T-cells in cardiomyopathy– an exploratory research Project
Jan 25, 2018Prospective research project in which biological material is sampled from humans and health-related personal data is collected (HFV Art 6). To generate further scientific evidence for a potential role of crossreactive antimicrobial T and B cell respo...
Clinical Studies - Jan 25, 2018 - Aug 25, 2021
Completed
Project leader: Ludewig Burkhard
Members: Maeder Micha, Vetsch Susanne
Defining the identity and differentiation pathways of the immune-stimulating fibroblastic tumor stroma
Jan 1, 2018Lung cancer is the most frequent cause of death in cancer patients in industrialized countries. A particular property of non-small cell lung cancer is the composition of the tumor microenvironment (TME) with a very high proportion of stromal cells. W...
Fundamental Research - Jan 1, 2018 - Dec 31, 2021
Automatically Closed
Project leader: Ludewig Burkhard
Members: De Martin Angelina
Dissecting the association of the human palatine tonsil microbiome and HPV-driven oropharyngeal squamous cell carcinoma
Jan 1, 2017Oropharyngeal squamous cell carcinoma (OPSCC) can be caused by viral transformation of epithelial cells in the oropharynx such as high risk-human papilloma virus (HR-HPV). Importantly, the incidence of OPSCC has been increasing during the last decade...
Fundamental Research - Jan 1, 2017 - Dec 31, 2018
Automatically Closed
Project leader: Ludewig Burkhard
Members: Broglie Däppen Martina, Stöckli Sandro, Cupovic Jovana
Constructing accessory lymph nodes in situ for control of mammary carcinoma
Jul 1, 2016Lymph nodes (LNs) are situated at junctures of the blood vascular and the lymphatic system where antigens drain from peripheral tissues via afferent lymphatics. The decision whether and how immune responses against tumors are initiated and maintained...
Fundamental Research - Jul 1, 2016 - Jun 30, 2019
Automatically Closed
Project leader: Ludewig Burkhard
Members: Cupovic Jovana