Unit
Institute of Immunobiology
IMMBIO · Management
Dissecting the association of the human palatine tonsil microbiome and HPV-driven oropharyngeal squamous cell carcinoma
Jan 1, 2017Oropharyngeal squamous cell carcinoma (OPSCC) can be caused by viral transformation of epithelial cells in the oropharynx such as high risk-human papilloma virus (HR-HPV). Importantly, the incidence of OPSCC has been increasing during the last decade...
Fundamental Research - Jan 1, 2017 - Dec 31, 2018
Automatically Closed
Project leader: Ludewig Burkhard
Members: Broglie Däppen Martina, Stöckli Sandro, Cupovic Jovana
Constructing accessory lymph nodes in situ for control of mammary carcinoma
Jul 1, 2016Lymph nodes (LNs) are situated at junctures of the blood vascular and the lymphatic system where antigens drain from peripheral tissues via afferent lymphatics. The decision whether and how immune responses against tumors are initiated and maintained...
Fundamental Research - Jul 1, 2016 - Jun 30, 2019
Automatically Closed
Project leader: Ludewig Burkhard
Members: Cupovic Jovana
Defining the origin of lymph node and Peyer's patch fibroblastic reticular cells at single cell resolution
Apr 1, 2016Secondary lymphoid organs such as lymph nodes (LNs) and Peyer’s patches (PPs) sample antigens from the body’s inner and outer surfaces and mediate optimal interaction of immune cells. These functions rely on the presence of specialized microenvironme...
Fundamental Research - Apr 1, 2016 - Mar 31, 2019
Automatically Closed
Project leader: Ludewig Burkhard
Members: Mörbe Urs, Pérez Shibayama Christian Ivan
Targeting breast cancer through manipulation of IL-7 producing tumor fibroblasts
Jan 1, 2016Breast cancer is by far the most frequent gynaecological cancer. Despite considerable advances in antitumor therapies during the last 15 years, metastatic and recurrent breast cancer is still incurable, indicating that the underlying pathogenesis of...
Fundamental Research - Jan 1, 2016 - Dec 31, 2017
Automatically Closed
Project leader: Ludewig Burkhard
Members: Bösch Maximilian
Vaccine and immunotherapy induced CD8+ T cell responses against auto-, neo- and foreign antigens
Jan 1, 2016The growing incidence of melanoma is an increasing threat, and effective treatment options for advanced forms of melanoma are scarce. Although recently approved targeted- and immunotherapies have shown objective beneficial effects in metastatic melan...
Fundamental Research - Jan 1, 2016 - Dec 31, 2019
Automatically Closed
Project leader: Flatz Lukas
Members: Ring Sandra, Królik Michał Wojciech, Berner Fiamma
Role of activated fibroblastic stromal cells in relapsing-remitting experimental autoimmune encephalomyelitis
Oct 1, 2015Multiple Sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) resulting in demyelination, axonal loss and consequential clinical impairment. In addition, the presence of meningeal inflammatory infiltrates in the progressive M...
Fundamental Research - Oct 1, 2015 - Nov 1, 2016
Automatically Closed
Project leader: Ludewig Burkhard
Members: Pikor Natalia
Blockade der Fibroblastenreifung zum Schutz vor autoimmuner Sehnerventzündung
Oct 1, 2015Optikusneuritis (Neuritis nervi optici, NNO) ist eine akute Entzündung des Sehnervs, die mit Symptomen wie Augenschmerzen und partiellem oder komplettem Sehverlust einhergeht. Die meisten Fälle der NNO sind auf multiple Sklerose (MS) als Grunderkrank...
Fundamental Research - Oct 1, 2015 - Sep 30, 2016
Automatically Closed
Project leader: Ludewig Burkhard
Members: Cupovic Jovana
Impact of omental fibroblastic stromal cells on the induction of anti-bacterial immunity
Oct 1, 2015Adaptive immune responses are induced within secondary lymphoid organs (SLOs) such as lymph nodes, spleen and Peyer’s patches. Structure and compartmentalization of SLOs is determined by fibroblastic stromal cells which built and maintain specialized...
Fundamental Research - Oct 1, 2015 - Sep 30, 2016
Automatically Closed
Project leader: Ludewig Burkhard
Members: Pérez Shibayama Christian Ivan, Mörbe Urs
Ontogeny and functional characterization of splenic fibroblastic reticular cells (FRCs) and their mesenchymal precursors during homeostasis, immune-activation and infection
Sep 1, 2015Secondary lymphatic organs (SLOs) such as the spleen provide specialized microenvironmental niches for the development and control of immune responses. Particular mesenchymal stromal cells known as fibroblastic reticular cells (FRCs) generate distinc...
Fundamental Research - Sep 1, 2015 - Aug 31, 2018
Automatically Closed
Project leader: Ludewig Burkhard
Members: Cheng Hung-Wei
Impact of intestinal stromal cells on the function of innate lymphoid cells in an animal model for inflammatory bowel disease
Jan 1, 2015Intestinal homeostasis requires codependent interactions between the intestinal epithelium, the microbiota and the immune system. Innate lymphoid cells (ILCs) play critical roles in intestinal homeostasis, the regulation of intestinal epithelial cell...
Fundamental Research - Jan 1, 2015 - Dec 31, 2015
Automatically Closed
Project leader: Scandella Elke
Clinical evaluation of a polyvalent vaccine against Salmonella enterica in a phase I/II Study
Jun 1, 2013Salmonella enterica infections are an important global health problem with more than 20 million individuals suffering from enteric fever annually and more than 200’000 lethal cases per year. Although enteric fever can be treated appropriately with an...
Fundamental Research - Jun 1, 2013 - Dec 31, 2016
Automatically Closed
Project leader: Ludewig Burkhard, Vernazza Pietro
Members: Carreño Juan-Manuel
Selection and education of heart-specific Th cells by thymic and lymph node stromal cells
Apr 1, 2013Myocarditis is a frequent disease in children and young adults that can precipitate lethal dilated cardiomyopathy (DCM). Since some heart antigens, such as the cardiac myosin heavy chain alpha (myhca) are not represented in the thymus, heart-specific...
Fundamental Research - Apr 1, 2013 - Mar 31, 2016
Completed
Project leader: Ludewig Burkhard
Members: Pérez Shibayama Christian Ivan, Bösch Maximilian, Gil Cruz Cristina
Systems biology approach to molecularly characterize the lung cancer microenvironment
Jan 1, 2013Lung cancer is the most frequent cause of death in cancer patients in industrialized countries. Most patients with advanced nonsmall cell lung cancer (NSCLC) do not respond to the current treatment schemes indicating that the basic mechanisms of tumo...
Fundamental Research - Jan 1, 2013 - Dec 31, 2014
Completed
Project leader: Ludewig Burkhard, Brutsche Martin
Members: Baty Florent, Novkovic Mario, Onder Lucas
Role CCR7-ligands in virus-induced chronic CNS inflammation and demyelination
Jan 1, 2013Background: Epidemiological studies indicate that onset and progression of multiple sclerosis (MS) critically depends on environmental factors, including infectious agents. Experimental infections with neurotropic viruses can precipitate MS-like path...
Fundamental Research - Jan 1, 2013 - Dec 31, 2013
Completed
Project leader: Ludewig Burkhard
Members: Gil Cruz Cristina, Cupovic Jovana
Secretome analysis of the human airway epithelium following human respiratory virus infection
Jan 1, 2013The human airway epithelium represents the entry port of many human respiratory viruses, such as respiratory syncytial virus (RSV), influenza A viruses (IAV), and human coronaviruses (HCoV). It represents the interface between the external world and...
Fundamental Research - Jan 1, 2013 - Dec 31, 2013
Completed
Project leader: Thiel Volker
Members: Dijkman Ronald, Jonsdottir Hulda
Imaging-based Systems Biology Analysis of Lymph Node Structure and Function in Viral Infection
Aug 1, 2012Our research plan includes three complementary subprojects, which are carried-out in a highly synergistic manner by the partners Dr. Stein (UBERN), Prof. Ludewig (KSSG) and Dr. Sharpe (CRG), respectively. The three subprojects address the following a...
Fundamental Research - Aug 1, 2012 - Jul 31, 2016
Automatically Closed
Project leader: Ludewig Burkhard
Members: Chai Qian, Gil Cruz Cristina
Systems immunological analysis of lymph node structure and function in viral infection
Aug 1, 2012Peripheral lymph nodes (PLNs) perform three central functions as a structural interface between the innate and adaptive immune systems: first, sentinel PLNs retain microbial‐derived antigen (Ag) from the periphery arriving via afferent lymphatic ves...
Fundamental Research - Aug 1, 2012 - Jul 31, 2016
Completed
Project leader: Ludewig Burkhard
Members: Chai Qian, Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Novkovic Mario
Systembiologische Untersuchungen zur molekularen Charakterisierung der Mikroumgebung in Lungentumoren
Jul 1, 2012Das Thema des geplanten Forschungsprojekts sind systembiologische Untersuchungen zur molekularen Charakterisierung der Mikroumgebung in Lungentumoren. Lungenkrebs ist eine der häufigsten Todesursachen in den industrialisierten Ländern. Die meisten Pa...
Fundamental Research - Jul 1, 2012 - Jun 30, 2014
Completed
Project leader: Ludewig Burkhard, Brutsche Martin
Members: Franzini Anca, Tarantino Ignazio
Systems biology approach to moleculary characterize the lung cancer microenvironment
Jul 1, 2012Tumor cells display distinct genetic alterations that permit their unrestricted growth. In contrast, stromal cells that provide the growth scaffold and nutrients for the tumor, most likely exhibit universal signatures that determine their function. T...
Fundamental Research - Jul 1, 2012 - Jun 30, 2014
Completed
Project leader: Ludewig Burkhard
Members: Franzini Anca, Bocharov Gennady
Genetic modification of the human airway epthelium - a paradigmatic system to study host responses to human respiratory viruses
Jul 1, 2012Das menschliche Atemwegsepithelium ist die Haupteintrittspforte für viele respiratorische Viren. Obwohl primäre humane Epithelzellen in Form eines Atemwegsepitheliums, das in vieler Hinsicht den in vivo Verhältnissen entspricht, kultiviert werden kön...
Fundamental Research - Jul 1, 2012 - Dec 31, 2013
Completed
Project leader: Thiel Volker
Members: Jonsdottir Hulda, Dijkman Ronald