Prof. Dr. Burkhard Ludewig
Head, Institute of Immunobiology
Head, Medical Research Center
Head of clinic/institute/center
Medizinisches Forschungszentrum, Institute of Immunobiology · Management
Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function
Cheng H, Scandella E, Hehlgans T, Pérez Shibayama C, Gil Cruz C, Novkovic M, Onder L, Engetschwiler C, Lütge M, Mörbe U, Ludewig B. Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function. Nat Commun 2022; 13:2027.
Apr 19, 2022Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function
Apr 19, 2022Nat Commun 2022; 13:2027
Cheng Hung-Wei, Scandella Elke, Hehlgans T, Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Novkovic M, Onder Lucas, Engetschwiler Céline, Lütge Mechthild, Mörbe Urs, Ludewig Burkhard
Neonatal LTβR signaling is required for the accumulation of eosinophils in the inflamed adult mesenteric lymph node.
Li C, Ward L, Nguyen A, Lam E, Dasoveanu D, Ahmed M, Haniuda K, Buechler M, He H, Ludewig B, McNagny K, Gommerman J. Neonatal LTβR signaling is required for the accumulation of eosinophils in the inflamed adult mesenteric lymph node. Mucosal Immunol 2022; 15:418-427.
Feb 18, 2022Neonatal LTβR signaling is required for the accumulation of eosinophils in the inflamed adult mesenteric lymph node.
Feb 18, 2022Mucosal Immunol 2022; 15:418-427
Li Conglei, Ward Lesley A, Nguyen Albert, Lam Evelyn, Dasoveanu Dragos C, Ahmed Musaddeque, Haniuda Kei, Buechler Matthew B, He Housheng Hansen, Ludewig Burkhard, McNagny Kelly Marshall, Gommerman Jennifer L
A diverse fibroblastic stromal cell landscape in the spleen directs tissue homeostasis and immunity
Alexandre Y, Belz G, Ludewig B, Haque A, Mackay L, D'Costa R, Starkey G, Gordon C, Christo S, Cao W, Groom J, Pal B, Devi S, Williams C, Gandolfo L, Lee H, Schienstock D, Mueller S. A diverse fibroblastic stromal cell landscape in the spleen directs tissue homeostasis and immunity. Sci Immunol 2022; 7:eabj0641.
Jan 7, 2022A diverse fibroblastic stromal cell landscape in the spleen directs tissue homeostasis and immunity
Jan 7, 2022Sci Immunol 2022; 7:eabj0641
Alexandre Yannick O, Belz Gabrielle T, Ludewig Burkhard, Haque Ashraful, Mackay Laura K, D'Costa Rohit, Starkey Graham, Gordon Claire L, Christo Susan N, Cao Wang, Groom Joanna R, Pal Bhupinder, Devi Sapna, Williams Cameron G, Gandolfo Luke C, Lee Hyun Jae, Schienstock Dominik, Mueller Scott N
Postvaccination anti-S IgG levels predict anti-SARS-CoV-2 neutralising activity over 24 weeks in patients with RA.
Schmiedeberg K, Abela I, Pikor N, Vuilleumier N, Schwarzmueller M, Epp S, Pagano S, Grabherr S, Patterson A, Nussberger M, Trkola A, Ludewig B, von Kempis J, Rubbert-Roth A. Postvaccination anti-S IgG levels predict anti-SARS-CoV-2 neutralising activity over 24 weeks in patients with RA. RMD Open 2022; 8
Jan 1, 2022Postvaccination anti-S IgG levels predict anti-SARS-CoV-2 neutralising activity over 24 weeks in patients with RA.
Jan 1, 2022RMD Open 2022; 8
Schmiedeberg Kristin, Abela Irene A, Pikor Natalia, Vuilleumier Nicolas, Schwarzmueller Magdalena, Epp Selina, Pagano Sabrina, Grabherr Sarah, Patterson Angelica Brooke, Nussberger Madalina, Trkola Alexandra, Ludewig Burkhard, von Kempis Johannes, Rubbert-Roth Andrea
Anti-S1 Antibodies After Vaccination with Anti SARS-CoV-2 mRNA Vaccines in Patients with Rheumatoid Arthritis Differ in Magnitude and Kinetics from Healthy Controls: Results from a Prospective, Observational Controlled Study
Rubbert-Roth A, Vuilleumier N, Ludewig B, Schmiedeberg K, Rottländer Y, Pirker I, von Kempis J (2022). Anti-S1 Antibodies After Vaccination with Anti SARS-CoV-2 mRNA Vaccines in Patients with Rheumatoid Arthritis Differ in Magnitude and Kinetics from Healthy Controls: Results from a Prospective, Observational Controlled Study.
Dec 28, 2021Anti-S1 Antibodies After Vaccination with Anti SARS-CoV-2 mRNA Vaccines in Patients with Rheumatoid Arthritis Differ in Magnitude and Kinetics from Healthy Controls: Results from a Prospective, Observational Controlled Study
Dec 28, 2021ACR Converence 2021
Rubbert-Roth Andrea, Vuilleumier Nicolas, Ludewig Burkhard, Schmiedeberg Kristin, Rottländer Yella, Pirker Ian, von Kempis Johannes
Visualization and functional characterization of lymphoid organ fibroblasts
Onder L, Cheng H, Ludewig B. Visualization and functional characterization of lymphoid organ fibroblasts. Immunol Rev 2021
Dec 5, 2021Visualization and functional characterization of lymphoid organ fibroblasts
Dec 5, 2021Immunol Rev 2021
Onder Lucas, Cheng Hung-Wei, Ludewig Burkhard
Anti-SARS-CoV-2 mRNA vaccines as inducers of humoral response against apolipoprotein A-1?
Vuilleumier N, Pagano S, Ludewig B, Schmiedeberg K, Haller C, von Kempis J, Rubbert-Roth A. Anti-SARS-CoV-2 mRNA vaccines as inducers of humoral response against apolipoprotein A-1?. Eur J Clin Invest 2021; 52:e13713.
Nov 29, 2021Anti-SARS-CoV-2 mRNA vaccines as inducers of humoral response against apolipoprotein A-1?
Nov 29, 2021Eur J Clin Invest 2021; 52:e13713
Vuilleumier Nicolas, Pagano Sabrina, Ludewig Burkhard, Schmiedeberg Kristin, Haller Christoph, von Kempis Johannes, Rubbert-Roth Andrea
Keratinocyte differentiation antigen-specific T cells in immune checkpoint inhibitor-treated NSCLC patients are associated with improved survival.
Berner F, Niederer R, Luimstra J, Pop O, Jochum A, Purde M, Hasan Ali O, Bomze D, Bauer J, Freudenmann L, Marcu A, Wolfschmitt E, Haen S, Gross T, Dubbelaar M, Abdou M, Baumgaertner P, Appenzeller C, Cicin-Sain C, Lenz T, Speiser D, Ludewig B, Driessen C, Jörger M, Früh M, Jochum W, Cozzio A, Rammensee H, Walz J, Neefjes J, Flatz L. Keratinocyte differentiation antigen-specific T cells in immune checkpoint inhibitor-treated NSCLC patients are associated with improved survival. Oncoimmunology 2021; 10:2006893.
Nov 27, 2021Keratinocyte differentiation antigen-specific T cells in immune checkpoint inhibitor-treated NSCLC patients are associated with improved survival.
Nov 27, 2021Oncoimmunology 2021; 10:2006893
Berner Fiamma, Niederer Rebekka, Luimstra Jolien J, Pop Oltin Tiberiu, Jochum Ann-Kristin, Purde Mette-Triin, Hasan Ali Omar, Bomze David, Bauer Jens, Freudenmann Lena Katharina, Marcu Ana, Wolfschmitt Eva-Maria, Haen Sebastian, Gross Thorben, Dubbelaar MariLisa, Abdou Marie-Therese, Baumgaertner Petra, Appenzeller Christina, Cicin-Sain Caroline, Lenz Tobias, Speiser Daniel E, Ludewig Burkhard, Driessen Christoph, Jörger Markus, Früh Martin, Jochum Wolfram, Cozzio Antonio, Rammensee Hans-Georg, Walz Juliane, Neefjes Jacques, Flatz Lukas
Efficacy and tolerability of a third dose of an mRNA anti-SARS-CoV-2 vaccine in patients with rheumatoid arthritis with absent or minimal serological response to two previous doses
Schmiedeberg K, Vuilleumier N, Pagano S, Albrich W, Ludewig B, von Kempis J, Rubbert-Roth A. Efficacy and tolerability of a third dose of an mRNA anti-SARS-CoV-2 vaccine in patients with rheumatoid arthritis with absent or minimal serological response to two previous doses. Lancet Rheumatol 2021; 4:e11-e13.
Oct 26, 2021Efficacy and tolerability of a third dose of an mRNA anti-SARS-CoV-2 vaccine in patients with rheumatoid arthritis with absent or minimal serological response to two previous doses
Oct 26, 2021Lancet Rheumatol 2021; 4:e11-e13
Schmiedeberg Kristin, Vuilleumier Nicolas, Pagano Sabrina, Albrich Werner, Ludewig Burkhard, von Kempis Johannes, Rubbert-Roth Andrea
Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment
Ring S, Spiegl M, Besse A, Bonilla W, Stemeseder F, Schmidt S, Orlinger K, Krebs P, Ludewig B, Wenger R, Hartmann F, Cupovic J, Onder L, Lütge M, Pérez Shibayama C, Gil Cruz C, Scandella E, De Martin A, Mörbe U, Flatz L. Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment. Nat Commun 2021; 12:4734.
Aug 5, 2021Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment
Aug 5, 2021Nat Commun 2021; 12:4734
Ring Sandra, Spiegl Matthias, Besse Andrej, Bonilla Weldy V, Stemeseder Felix, Schmidt Sarah, Orlinger Klaus K, Krebs Philippe, Ludewig Burkhard, Wenger Robert, Hartmann Fabienne, Cupovic Jovana, Onder Lucas, Lütge Mechthild, Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Scandella Elke, De Martin Angelina, Mörbe Urs, Flatz Lukas
Communication, construction, and fluid control: lymphoid organ fibroblastic reticular cell and conduit networks
Acton S, Onder L, Novkovic M, Martinez V, Ludewig B. Communication, construction, and fluid control: lymphoid organ fibroblastic reticular cell and conduit networks. Trends Immunol 2021; 42:782-794.
Aug 3, 2021Communication, construction, and fluid control: lymphoid organ fibroblastic reticular cell and conduit networks
Aug 3, 2021Trends Immunol 2021; 42:782-794
Acton Sophie E, Onder Lucas, Novkovic Mario, Martinez Victor G, Ludewig Burkhard
Distinct microbial communities colonize tonsillar squamous cell carcinoma.
De Martin A, Lütge M, Stanossek Y, Engetschwiler C, Cupovic J, Brown K, Demmer I, Broglie M, Geuking M, Jochum W, McCoy K, Stöckli S, Ludewig B. Distinct microbial communities colonize tonsillar squamous cell carcinoma. Oncoimmunology 2021; 10:1945202.
Jul 25, 2021Distinct microbial communities colonize tonsillar squamous cell carcinoma.
Jul 25, 2021Oncoimmunology 2021; 10:1945202
De Martin Angelina, Lütge Mechthild, Stanossek Yves, Engetschwiler Céline, Cupovic Jovana, Brown Kirsty, Demmer Izadora, Broglie Martina Anja, Geuking Markus B, Jochum Wolfram, McCoy Kathy D, Stöckli Sandro, Ludewig Burkhard
Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8 T cells
Cupovic J, Klenerman P, Engeler D, Krebs P, Scandella E, Oxenius A, Flatz L, Provine N, De Martin A, Cheng H, Lütge M, Colston J, Onder L, Ring S, Ludewig B. Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8 T cells. Nat Immunol 2021; 22:1042-1051.
Jul 15, 2021Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8 T cells
Jul 15, 2021Nat Immunol 2021; 22:1042-1051
Cupovic Jovana, Klenerman Paul, Engeler Daniel, Krebs Philippe, Scandella Elke, Oxenius Annette, Flatz Lukas, Provine Nicholas M, De Martin Angelina, Cheng Hung-Wei, Lütge Mechthild, Colston Julia M, Onder Lucas, Ring Sandra, Ludewig Burkhard
Anti-SARS-CoV-2 mRNA vaccine in patients with rheumatoid arthritis
Rubbert-Roth A, Vuilleumier N, Ludewig B, Schmiedeberg K, Haller C, von Kempis J. Anti-SARS-CoV-2 mRNA vaccine in patients with rheumatoid arthritis. Lancet Rheumatol 2021; 3:e470-e472.
Jun 8, 2021Anti-SARS-CoV-2 mRNA vaccine in patients with rheumatoid arthritis
Jun 8, 2021Lancet Rheumatol 2021; 3:e470-e472
Rubbert-Roth Andrea, Vuilleumier Nicolas, Ludewig Burkhard, Schmiedeberg Kristin, Haller Christoph, von Kempis Johannes
Differentiation and activation of fibroblastic reticular cells
Lütge M, Pikor N, Ludewig B. Differentiation and activation of fibroblastic reticular cells. Immunol Rev 2021; 302:32-46.
May 27, 2021Differentiation and activation of fibroblastic reticular cells
May 27, 2021Immunol Rev 2021; 302:32-46
Lütge Mechthild, Pikor Natalia, Ludewig Burkhard
Fibroblasts as immune regulators in infection, inflammation and cancer
Davidson S, Coles M, Thomas T, Kollias G, Ludewig B, Turley S, Brenner M, Buckley C. Fibroblasts as immune regulators in infection, inflammation and cancer. Nat Rev Immunol 2021; 21:704-717.
Apr 28, 2021Fibroblasts as immune regulators in infection, inflammation and cancer
Apr 28, 2021Nat Rev Immunol 2021; 21:704-717
Davidson Sarah, Coles Mark, Thomas Tom, Kollias George, Ludewig Burkhard, Turley Shannon, Brenner Michael, Buckley Christopher D
Insights into coronavirus immunity taught by the murine coronavirus
Grabherr S, Ludewig B, Pikor N. Insights into coronavirus immunity taught by the murine coronavirus. Eur J Immunol 2021; 51:1062-1070.
Mar 22, 2021Insights into coronavirus immunity taught by the murine coronavirus
Mar 22, 2021Eur J Immunol 2021; 51:1062-1070
Grabherr Sarah, Ludewig Burkhard, Pikor Natalia
Fibroblastic reticular cell lineage convergence in Peyer's patches governs intestinal immunity
Prados A, Ludewig B, Koliaraki V, Pérez Shibayama C, Gil Cruz C, Lütge M, Mörbe U, Cheng H, Onder L, Kollias G. Fibroblastic reticular cell lineage convergence in Peyer's patches governs intestinal immunity. Nat Immunol 2021; 22:510-519.
Mar 11, 2021Fibroblastic reticular cell lineage convergence in Peyer's patches governs intestinal immunity
Mar 11, 2021Nat Immunol 2021; 22:510-519
Prados Alejandro, Ludewig Burkhard, Koliaraki Vasiliki, Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Lütge Mechthild, Mörbe Urs, Cheng Hung-Wei, Onder Lucas, Kollias George
The AP-1 Transcription Factor Fosl-2 Regulates Autophagy in Cardiac Fibroblasts during Myocardial Fibrogenesis
Seidenberg J, Stellato M, Hukara A, Ludewig B, Klingel K, Distler O, Błyszczuk P, Kania G. The AP-1 Transcription Factor Fosl-2 Regulates Autophagy in Cardiac Fibroblasts during Myocardial Fibrogenesis. Int J Mol Sci 2021; 22
Feb 13, 2021The AP-1 Transcription Factor Fosl-2 Regulates Autophagy in Cardiac Fibroblasts during Myocardial Fibrogenesis
Feb 13, 2021Int J Mol Sci 2021; 22
Seidenberg Jemima, Stellato Mara, Hukara Amela, Ludewig Burkhard, Klingel Karin, Distler Oliver, Błyszczuk Przemysław, Kania Gabriela
Development and Immunological Function of Lymph Node Stromal Cells
Pikor N, Cheng H, Onder L, Ludewig B. Development and Immunological Function of Lymph Node Stromal Cells. J Immunol 2021; 206:257-263.
Jan 15, 2021Development and Immunological Function of Lymph Node Stromal Cells
Jan 15, 2021J Immunol 2021; 206:257-263
Pikor Natalia, Cheng Hung-Wei, Onder Lucas, Ludewig Burkhard