Prof. Dr. Burkhard Ludewig
Head, Institute of Immunobiology
Head, Medical Research Center
Head of clinic/institute/center
Medizinisches Forschungszentrum, Institute of Immunobiology · Management
Regulation of lymphoid organ fibroblast differentiation and function by bone morphogenic proteins
Jan 1, 2023
Fundamental Research - Jan 1, 2023 - Dec 31, 2026
Ongoing
Project leader: Ludewig Burkhard
Deciphering the molecular landscape of the stromal cells in human lymph nodes at the single-cell level
Mar 1, 2019Secondary lymphoid organs are strategically positioned at routes of pathogen invasion and thereby increase the likelihood of lymphocytes to encounter their cognate antigens at a particular location and during a certain time window. Lymph nodes are fo...
Fundamental Research - Mar 1, 2019 - Dec 31, 2019
Automatically Closed
Project leader: Ludewig Burkhard
Stromal Cell Niches at the Nexus of the Innate Lymphoid Cell Interactome
Jan 1, 2019Innate lymphoid cells (ILCs) critically impact a diverse array of diseases. While the main cell-intrinsic molecular pathways and some of the soluble mediators that regulate ILC development and their functional activity have been characterized, the ce...
Fundamental Research - Jan 1, 2019 - Dec 31, 2022
Automatically Closed
Project leader: Ludewig Burkhard
Members: Lütge Mechthild
Identification and manipulation of immune-stimulating fibroblastic stromal cell niches in the
Jan 1, 2019The unique anatomy of the central nervous system (CNS) necessitates that inflammation in this organ is limited. However, emerging studies reveal that focal inflammation may be more prominent than previously appreciated. Avenues for immune surveillanc...
Fundamental Research - Jan 1, 2019 - Dec 31, 2022
Automatically Closed
Project leader: Pikor Natalia, Ludewig Burkhard
Transcriptomic analysis of the B and T cell repertoire in Multiple Sclerosis – an exploratory study
Jan 1, 2019Multiple Sclerosis (MS) is an immune-mediated disease of the central nervous system (CNS). While T cells dominate the immune response, both B and T cells contribute to the demyelination and neuronal injury that underlies clinical disease manifestatio...
Fundamental Research - Jan 1, 2019 - Jan 31, 2019
Automatically Closed
Project leader: Pikor Natalia, Ludewig Burkhard
Deciphering the transcriptomic landscape of cancer-associated fibroblasts in pancreatic cancer / Oncological Research
Jan 1, 2019Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancer types with a 5-year survival of only 7% and strongly limited treatment options. A major obstacle for successful treatment is the immunosuppressive nature of the tumor microe...
Fundamental Research - Jan 1, 2019 - Dec 31, 2021
Automatically Closed
Project leader: Ludewig Burkhard, Lütge Mechthild
Inorganic Nanoparticles with Anti-inflammatory and Antimicrobial Activity: New Prospects for Long-term Local Immunoimodulation?
Jan 1, 2019Control and eventual attenuation of inflammation is important in the management of a plethora of diseases. However, suppression of inflammatory responses, e.g. by corticosteroids or systemic blockade of immune effector pathways, is associated with se...
Fundamental Research - Jan 1, 2019 - Dec 31, 2019
Automatically Closed
Project leader: Ludewig Burkhard, Herrmann Inge
Identification and manipulation of immune-stimulating fibroblastic stromal cell niches in the inflamed CNS
Jan 1, 2019The unique anatomy of the central nervous system (CNS) necessitates that inflammation in this organ is limited. However, emerging studies reveal that focal inflammation may be more prominent than previously appreciated. Avenues for immune surveill...
Fundamental Research - Jan 1, 2019 - Jun 30, 2023
Ongoing
Project leader: Pikor Natalia, Ludewig Burkhard
Deciphering the transcriptomic landscape of cancer-associated fibroblasts in pancreatic cancer – an exploratory clinical study
Jul 1, 2018Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancer types with a 5-year survival of only 7% 1. While surgical resection of localized disease offers a moderate increase in survival, patients with metastatic pancreas cancer are...
Fundamental Research - Jul 1, 2018 - Dec 31, 2018
Completed
Project leader: Ludewig Burkhard
Members: Lütge Mechthild
Dissecting the association of anti-microbiota antibodies and auto-reactive T-cells in cardiomyopathy– an exploratory research Project
Jan 25, 2018Prospective research project in which biological material is sampled from humans and health-related personal data is collected (HFV Art 6). To generate further scientific evidence for a potential role of crossreactive antimicrobial T and B cell respo...
Clinical Studies - Jan 25, 2018 - Aug 25, 2021
Completed
Project leader: Ludewig Burkhard
Members: Maeder Micha, Vetsch Susanne
Defining the identity and differentiation pathways of the immune-stimulating fibroblastic tumor stroma
Jan 1, 2018Lung cancer is the most frequent cause of death in cancer patients in industrialized countries. A particular property of non-small cell lung cancer is the composition of the tumor microenvironment (TME) with a very high proportion of stromal cells. W...
Fundamental Research - Jan 1, 2018 - Dec 31, 2021
Automatically Closed
Project leader: Ludewig Burkhard
Members: De Martin Angelina
Dissecting the association of the human palatine tonsil microbiome and HPV-driven oropharyngeal squamous cell carcinoma
Jan 1, 2017Oropharyngeal squamous cell carcinoma (OPSCC) can be caused by viral transformation of epithelial cells in the oropharynx such as high risk-human papilloma virus (HR-HPV). Importantly, the incidence of OPSCC has been increasing during the last decade...
Fundamental Research - Jan 1, 2017 - Dec 31, 2018
Automatically Closed
Project leader: Ludewig Burkhard
Members: Broglie Däppen Martina, Stöckli Sandro, Cupovic Jovana
Constructing accessory lymph nodes in situ for control of mammary carcinoma
Jul 1, 2016Lymph nodes (LNs) are situated at junctures of the blood vascular and the lymphatic system where antigens drain from peripheral tissues via afferent lymphatics. The decision whether and how immune responses against tumors are initiated and maintained...
Fundamental Research - Jul 1, 2016 - Jun 30, 2019
Automatically Closed
Project leader: Ludewig Burkhard
Members: Cupovic Jovana
Defining the origin of lymph node and Peyer's patch fibroblastic reticular cells at single cell resolution
Apr 1, 2016Secondary lymphoid organs such as lymph nodes (LNs) and Peyer’s patches (PPs) sample antigens from the body’s inner and outer surfaces and mediate optimal interaction of immune cells. These functions rely on the presence of specialized microenvironme...
Fundamental Research - Apr 1, 2016 - Mar 31, 2019
Automatically Closed
Project leader: Ludewig Burkhard
Members: Mörbe Urs, Perez Shibayama Christian
Targeting breast cancer through manipulation of IL-7 producing tumor fibroblasts
Jan 1, 2016Breast cancer is by far the most frequent gynaecological cancer. Despite considerable advances in antitumor therapies during the last 15 years, metastatic and recurrent breast cancer is still incurable, indicating that the underlying pathogenesis of...
Fundamental Research - Jan 1, 2016 - Dec 31, 2017
Automatically Closed
Project leader: Ludewig Burkhard
Members: Bösch Maximilian
Role of activated fibroblastic stromal cells in relapsing-remitting experimental autoimmune encephalomyelitis
Oct 1, 2015Multiple Sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) resulting in demyelination, axonal loss and consequential clinical impairment. In addition, the presence of meningeal inflammatory infiltrates in the progressive M...
Fundamental Research - Oct 1, 2015 - Nov 1, 2016
Automatically Closed
Project leader: Ludewig Burkhard
Members: Pikor Natalia
Blockade der Fibroblastenreifung zum Schutz vor autoimmuner Sehnerventzündung
Oct 1, 2015Optikusneuritis (Neuritis nervi optici, NNO) ist eine akute Entzündung des Sehnervs, die mit Symptomen wie Augenschmerzen und partiellem oder komplettem Sehverlust einhergeht. Die meisten Fälle der NNO sind auf multiple Sklerose (MS) als Grunderkrank...
Fundamental Research - Oct 1, 2015 - Sep 30, 2016
Automatically Closed
Project leader: Ludewig Burkhard
Members: Cupovic Jovana
Impact of omental fibroblastic stromal cells on the induction of anti-bacterial immunity
Oct 1, 2015Adaptive immune responses are induced within secondary lymphoid organs (SLOs) such as lymph nodes, spleen and Peyer’s patches. Structure and compartmentalization of SLOs is determined by fibroblastic stromal cells which built and maintain specialized...
Fundamental Research - Oct 1, 2015 - Sep 30, 2016
Automatically Closed
Project leader: Ludewig Burkhard
Members: Perez Shibayama Christian, Mörbe Urs
Ontogeny and functional characterization of splenic fibroblastic reticular cells (FRCs) and their mesenchymal precursors during homeostasis, immune-activation and infection
Sep 1, 2015Secondary lymphatic organs (SLOs) such as the spleen provide specialized microenvironmental niches for the development and control of immune responses. Particular mesenchymal stromal cells known as fibroblastic reticular cells (FRCs) generate distinc...
Fundamental Research - Sep 1, 2015 - Aug 31, 2018
Automatically Closed
Project leader: Ludewig Burkhard
Members: Cheng Hung-Wei
Clinical evaluation of a polyvalent vaccine against Salmonella enterica in a phase I/II Study
Jun 1, 2013Salmonella enterica infections are an important global health problem with more than 20 million individuals suffering from enteric fever annually and more than 200’000 lethal cases per year. Although enteric fever can be treated appropriately with an...
Fundamental Research - Jun 1, 2013 - Dec 31, 2016
Automatically Closed
Project leader: Ludewig Burkhard, Vernazza Pietro
Members: Carreño Juan-Manuel