Prof. Dr. Burkhard Ludewig
Head, Institute of Immunobiology
Head, Medical Research Center
Head of clinic/institute/center
Medizinisches Forschungszentrum, Institute of Immunobiology · Management
Impact of immune regulation on virus-induced chronic CNS inflammation and demyelination
Aug 1, 2009Background: Multiple sclerosis (MS) is an important disease affecting young adults. Epidemiological studies indicate that this disease critically depends on environmental factors, including infectious agents. It appears that infections with a variety...
Fundamental Research - Aug 1, 2009 - Sep 30, 2009
Completed
Project leader: Ludewig Burkhard, Thiel Volker
Members: Cervantes-Barragan Luisa, Cupovic Jovana
Examining the function of lymphoid organ structure during antiviral immune responses using microscopic and mesoscopic imaging
Jun 1, 2009The adaptive immune system protects us from infectious viruses and other microbes. Cells of the adaptive immune system ‐ lymphocytes and antigen‐presenting cells (APC) ‐ are highly organized in strategic tissue locations throughout...
Fundamental Research - Jun 1, 2009 - Jul 31, 2012
Completed
Project leader: Ludewig Burkhard
Members: Scandella Elke, Onder Lucas
TOLERAGE: Normalisation of immune reactivity in old age – from basic mechanisms to clinical application
Apr 1, 2008Reconstitution of normal immune function in old age is generally based on boosting the response against foreign antigens, e.g. infectious microorganisms. Our focus, however, will be to normalise immune reactivity by correcting the immune dysregulati...
Fundamental Research - Apr 1, 2008 - Sep 30, 2012
Completed
Project leader: Ludewig Burkhard, Thiel Volker
Members: Cervantes-Barragan Luisa, Eugster Karin
Entwicklung einer Coronavirus basierten Multigenvakzine zum Schutz gegen Tumorerkrankungen
Jan 1, 2008Krebszellen produzieren antigenetische Zielstrukturen, die sie für einen Angriff durch spezifische Immunzellen sensibilisieren. Die effektivste Waffe des Immunsystems gegen Tumorzellen sind zytotoxische T-Zellen. Die effiziente Aktivierung dieser Kil...
Fundamental Research - Jan 1, 2008 - Dec 31, 2009
Completed
Project leader: Ludewig Burkhard, Thiel Volker
Members: Makia Divine, Nussbacher Monika
Impact of immune regulation on virus-induced chronic CNS inflammation and demyelination
Jan 1, 2008Background: Multiple sclerosis (MS) is an important disease affecting young adults. Epidemiological studies indicate that this disease critically depends on environmental factors, including infectious agents. It appears that infections with a variety...
Fundamental Research - Jan 1, 2008 - Dec 31, 2008
Completed
Project leader: Ludewig Burkhard
Members: Cervantes-Barragan Luisa, Eugster Karin
Role of professional and non-professional antigen presenting cells in cardiovascular immunopathological disease
Apr 1, 2007The importance of chronic inflammatory processes in the pathogenesis of cardiovascular diseases is now widely recognized. Atherosclerosis and autoimmune myocarditis are prototypical diseases illustrating the detrimental effects of constant immune act...
Fundamental Research - Apr 1, 2007 - Mar 31, 2010
Completed
Project leader: Ludewig Burkhard
Members: Eugster Karin, Nindl Veronika
Multiepitop Imfpung von Grad III/IV Melanompatienten mit dendritischen Zellen: Bedeutung von Peptidaffinität und -dichte für die optimale Generierung von tumorspezifischen zytotoxischen T-Lymphozyten
Jan 1, 2007Die immunologische Forschung der letzten Jahre hat deutlich gemacht, dass Krebszellen Zielstrukturen, sogenannte Antigene, produzieren, die sie für einen Angriff durch spezifische Immunzellen sensibilisieren. Die effektivste Waffe des Immunsystems ge...
Clinical Studies - Jan 1, 2007 - Dec 31, 2009
Completed
Project leader: Ludewig Burkhard, Gillessen Sommer Silke, Cerny Thomas
Members: Maier Reinhard, Templeton Arnoud
Immunpathologie der Virus induzierten Chorioretinitis
Jan 1, 2007Die Chorioretinitis ist eine häufig zu visuellen Wahrnehmungsstörungen (Sehbehinderung oder gar Erblindung) führende Erkrankung. Ursache der sich flächenhaft ausdehnenden und rasch progredienten Erkrankung der Netzhaut sind oftmals virale Infektionen...
Fundamental Research - Jan 1, 2007 - Dec 31, 2009
Completed
Project leader: Ludewig Burkhard
Preventing autoimmune myocarditis through cardiac myosin-specific tolerance
Jan 1, 2007The exact pathological basis of human myocarditis has not yet been sufficiently clarified and therefore, the appropriate treatment has remained a major clinical problem. Assuming that immunopathological damage contributes to the inflammatory nature o...
Fundamental Research - Jan 1, 2007 - Dec 31, 2009
Completed
Project leader: Ludewig Burkhard
Members: Nindl Veronika, Maier Reinhard
AIDS-CoVAC: Generation of a coronavirus-based multigene AIDS vaccine and evaluation in a preclinical SIV model
Dec 1, 2006Coronaviruses spread via mucosal surfaces and can infect dendritic cells. These features and their exceptional transcription strategy make them extremely promising candidate vaccine vectors to overcome known problems of current HIV vaccine approaches...
Fundamental Research - Dec 1, 2006 - May 31, 2009
Completed
Project leader: Ludewig Burkhard, Thiel Volker
Members: Eugster Karin, Cervantes-Barragan Luisa, Makia Divine
Coronavirus-based multigene HIV vaccine vectors
Jul 1, 2005The specific aim of this application is to provide the proof-of-principle that coronavirus vectors can indeed induce protective antiviral humoral and cellular immune responses in vivo. To this end, we will generate mouse hepatitis virus (MHV) vectors...
Fundamental Research - Jul 1, 2005 - Jun 30, 2007
Completed
Project leader: Thiel Volker
Members: Ludewig Burkhard