Prof. Dr. med. Lukas Flatz
Principal Investigator and Senior Consultant
attending physician
Dermatologie | Venerologie | Allergologie · Dept. IV
Innate and adaptive immune control of genetically engineered live-attenuated arenavirus vaccine prototypes
Pinschewer D, Flatz L, Steinborn R, Horvath E, Fernandez M, Lutz H, Suter M, Bergthaler A. Innate and adaptive immune control of genetically engineered live-attenuated arenavirus vaccine prototypes. Int Immunol 2010; 22:749-56.
Jun 28, 2010Innate and adaptive immune control of genetically engineered live-attenuated arenavirus vaccine prototypes
Jun 28, 2010Int Immunol 2010; 22:749-56
Pinschewer Daniel D, Flatz Lukas, Steinborn Ralf, Horvath Edit, Fernandez Marylise, Lutz Hans, Suter Mark, Bergthaler Andreas
T cell-dependence of Lassa fever pathogenesis
Flatz L, Günther S, Hanisch U, Brück W, Kreutzfeldt M, Verschoor A, Bestmann L, Schedensack M, Regen T, Bergthaler A, Merkler D, Rieger T, Pinschewer D. T cell-dependence of Lassa fever pathogenesis. PLoS Pathog 2010; 6:e1000836.
Mar 26, 2010T cell-dependence of Lassa fever pathogenesis
Mar 26, 2010PLoS Pathog 2010; 6:e1000836
Flatz Lukas, Günther Stephan, Hanisch Uwe-Karsten, Brück Wolfgang, Kreutzfeldt Mario, Verschoor Admar, Bestmann Lukas, Schedensack Mariann, Regen Tommy, Bergthaler Andreas, Merkler Doron, Rieger Toni, Pinschewer Daniel D
Development of replication-defective lymphocytic choriomeningitis virus vectors for the induction of potent CD8+ T cell immunity
Flatz L, Radbruch A, Levy F, Lambert P, Siegrist C, Restifo N, Löhning M, Ochsenbein A, Nabel G, Broek M, Kochanek S, Hegazy A, Bergthaler A, Verschoor A, Claus C, Fernandez M, Gattinoni L, Johnson S, Kreppel F, Pinschewer D. Development of replication-defective lymphocytic choriomeningitis virus vectors for the induction of potent CD8+ T cell immunity. Nat Med 2010; 16:339-45.
Feb 7, 2010Development of replication-defective lymphocytic choriomeningitis virus vectors for the induction of potent CD8+ T cell immunity
Feb 7, 2010Nat Med 2010; 16:339-45
Flatz Lukas, Radbruch Andreas, Levy Frederic, Lambert Paul-Henri, Siegrist Claire-Anne, Restifo Nicholas P, Löhning Max, Ochsenbein Adrian F, Nabel Gary J, Broek Maries van den, Kochanek Stefan, Hegazy Ahmed N, Bergthaler Andreas, Verschoor Admar, Claus Christina, Fernandez Marylise, Gattinoni Luca, Johnson Susan, Kreppel Florian, Pinschewer Daniel D
Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions
Hegazy A, Radbruch A, Pinschewer D, Flatz L, Bergthaler A, Fröhlich A, Panse I, Helmstetter C, Peine M, Löhning M. Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions. Immunity 2010; 32:116-28.
Jan 14, 2010Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions
Jan 14, 2010Immunity 2010; 32:116-28
Hegazy Ahmed N, Radbruch Andreas, Pinschewer Daniel D, Flatz Lukas, Bergthaler Andreas, Fröhlich Anja, Panse Isabel, Helmstetter Caroline, Peine Michael, Löhning Max
Impaired antibody response causes persistence of prototypic T cell-contained virus
Bergthaler A, Siegrist C, Odermatt B, Verbeek J, Senn B, Fitsche A, Fernandez M, Horvath E, Sommerstein R, Merkler D, Eschli B, Fink K, Holdener M, Hegazy A, Verschoor A, Flatz L, Pinschewer D. Impaired antibody response causes persistence of prototypic T cell-contained virus. PLoS Biol 2009; 7:e1000080.
Apr 7, 2009Impaired antibody response causes persistence of prototypic T cell-contained virus
Apr 7, 2009PLoS Biol 2009; 7:e1000080
Bergthaler Andreas, Siegrist Claire-Anne, Odermatt Bernhard, Verbeek J Sjef, Senn Beatrice M, Fitsche André, Fernandez Marylise, Horvath Edit, Sommerstein Rami, Merkler Doron, Eschli Bruno, Fink Katja, Holdener Martin, Hegazy Ahmed N, Verschoor Admar, Flatz Lukas, Pinschewer Daniel D
Hematopoietic cell-derived interferon controls viral replication and virus-induced disease
Lang P, Ohashi P, Ludewig B, Honda K, Bergthaler A, Flatz L, Pellegrini M, Recher M, Navarini A, Verschoor A, Cervantes-Barragan L, Lang K. Hematopoietic cell-derived interferon controls viral replication and virus-induced disease. Blood 2009; 113:1045-52.
Jan 29, 2009Hematopoietic cell-derived interferon controls viral replication and virus-induced disease
Jan 29, 2009Blood 2009; 113:1045-52
Lang Philipp A, Ohashi Pamela S, Ludewig Burkhard, Honda Kenya, Bergthaler Andreas, Flatz Lukas, Pellegrini Marc, Recher Mike, Navarini Alexander A, Verschoor Admar, Cervantes-Barragan Luisa, Lang Karl S
Overexpression of lymphotoxin in T cells induces fulminant thymic involution
Heikenwalder M, Nedospasov S, Holländer G, Macpherson A, Rülicke T, Flatz L, Priller J, Schmidt H, Tumanov A, Rossi S, Junt T, Lang K, Zeller N, Prinz M, Aguzzi A. Overexpression of lymphotoxin in T cells induces fulminant thymic involution. Am J Pathol 2008; 172:1555-70.
May 15, 2008Overexpression of lymphotoxin in T cells induces fulminant thymic involution
May 15, 2008Am J Pathol 2008; 172:1555-70
Heikenwalder Mathias, Nedospasov Sergei A, Holländer Georg A, Macpherson Andrew J, Rülicke Thomas, Flatz Lukas, Priller Josef, Schmidt Hauke, Tumanov Alexei, Rossi Simona, Junt Tobias, Lang Karl S, Zeller Nicolas, Prinz Marco, Aguzzi Adriano
Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses
Navarini A, Hengartner H, Odermatt B, Landmann R, Bille J, Flatz L, Bergthaler A, Meury S, Georgiev P, Lang K, Recher M, Zinkernagel R. Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses. Proc Natl Acad Sci USA 2006; 103:15535-9.
Oct 9, 2006Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses
Oct 9, 2006Proc Natl Acad Sci USA 2006; 103:15535-9
Navarini Alexander A, Hengartner Hans, Odermatt Bernhard, Landmann Regine, Bille Jacques, Flatz Lukas, Bergthaler Andreas, Meury Susanne, Georgiev Panco, Lang Karl S, Recher Mike, Zinkernagel Rolf M
Recovery of an arenavirus entirely from RNA polymerase I/II-driven cDNA
Flatz L, Bergthaler A, de la Torre J, Pinschewer D. Recovery of an arenavirus entirely from RNA polymerase I/II-driven cDNA. Proc Natl Acad Sci USA 2006; 103:4663-8.
Mar 13, 2006Recovery of an arenavirus entirely from RNA polymerase I/II-driven cDNA
Mar 13, 2006Proc Natl Acad Sci USA 2006; 103:4663-8
Flatz Lukas, Bergthaler Andreas, de la Torre Juan Carlos, Pinschewer Daniel D
Daptomycin is highly efficacious against penicillin-resistant and penicillin- and quinolone-resistant pneumococci in experimental meningitis
Cottagnoud P, Pfister M, Acosta F, Cottagnoud M, Flatz L, Kühn F, Müller H, Stucki A. Daptomycin is highly efficacious against penicillin-resistant and penicillin- and quinolone-resistant pneumococci in experimental meningitis. Antimicrob Agents Chemother 2004; 48:3928-33.
Oct 1, 2004Daptomycin is highly efficacious against penicillin-resistant and penicillin- and quinolone-resistant pneumococci in experimental meningitis
Oct 1, 2004Antimicrob Agents Chemother 2004; 48:3928-33
Cottagnoud Philippe, Pfister Marc, Acosta Fernando, Cottagnoud Marianne, Flatz Lukas, Kühn Felix, Müller Hans-Peter, Stucki Armin
Ceftriaxone acts synergistically with levofloxacin in experimental meningitis and reduces levofloxacin-induced resistance in penicillin-resistant pneumococci
Flatz L, Cottagnoud M, Kühn F, Entenza J, Stucki A, Cottagnoud P. Ceftriaxone acts synergistically with levofloxacin in experimental meningitis and reduces levofloxacin-induced resistance in penicillin-resistant pneumococci. J Antimicrob Chemother 2004; 53:305-10.
Jan 16, 2004Ceftriaxone acts synergistically with levofloxacin in experimental meningitis and reduces levofloxacin-induced resistance in penicillin-resistant pneumococci
Jan 16, 2004J Antimicrob Chemother 2004; 53:305-10
Flatz Lukas, Cottagnoud M, Kühn F, Entenza J, Stucki A, Cottagnoud P
Meropenem prevents levofloxacin-induced resistance in penicillin-resistant pneumococci and acts synergistically with levofloxacin in experimental meningitis
Cottagnoud P, Cottagnoud M, Acosta F, Flatz L, Kühn F, Stucki A, Entenza J. Meropenem prevents levofloxacin-induced resistance in penicillin-resistant pneumococci and acts synergistically with levofloxacin in experimental meningitis. Eur J Clin Microbiol Infect Dis 2003; 22:656-62.
Oct 14, 2003Meropenem prevents levofloxacin-induced resistance in penicillin-resistant pneumococci and acts synergistically with levofloxacin in experimental meningitis
Oct 14, 2003Eur J Clin Microbiol Infect Dis 2003; 22:656-62
Cottagnoud P, Cottagnoud M, Acosta F, Flatz Lukas, Kühn F, Stucki A, Entenza J
Cefotaxime acts synergistically with levofloxacin in experimental meningitis due to penicillin-resistant pneumococci and prevents selection of levofloxacin-resistant mutants in vitro
Kühn F, Cottagnoud M, Acosta F, Flatz L, Entenza J, Cottagnoud P. Cefotaxime acts synergistically with levofloxacin in experimental meningitis due to penicillin-resistant pneumococci and prevents selection of levofloxacin-resistant mutants in vitro. Antimicrob Agents Chemother 2003; 47:2487-91.
Aug 1, 2003Cefotaxime acts synergistically with levofloxacin in experimental meningitis due to penicillin-resistant pneumococci and prevents selection of levofloxacin-resistant mutants in vitro
Aug 1, 2003Antimicrob Agents Chemother 2003; 47:2487-91
Kühn F, Cottagnoud M, Acosta F, Flatz Lukas, Entenza J, Cottagnoud P