Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses

Publication

Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses

Journal Paper/Review - Oct 9, 2006

Navarini Alexander A, Hengartner Hans, Odermatt Bernhard, Landmann Regine, Bille Jacques, Flatz Lukas, Bergthaler Andreas, Meury Susanne, Georgiev Panco, Lang Karl S, Recher Mike, Zinkernagel Rolf M

Citation

Navarini A, Hengartner H, Odermatt B, Landmann R, Bille J, Flatz L, Bergthaler A, Meury S, Georgiev P, Lang K, Recher M, Zinkernagel R. Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses. Proc Natl Acad Sci USA 2006; 103:15535-9.

Type

Journal Paper/Review (English)

Journal

Proc Natl Acad Sci USA 2006; 103

Publication Date

Oct 9, 2006

Issn Print

0027-8424

Pages

15535-9

Brief description/objective

The reason why severe localized or systemic virus infections enhance and aggravate bacterial superinfection is poorly understood. Here we show that virus-induced IFN type I caused apoptosis in bone marrow granulocytes, drastically reduced granulocyte infiltrates at the site of bacterial superinfection, caused up to 1,000-fold higher bacterial titers in solid organs, and increased disease susceptibility. The finding that the innate antiviral immune response reduces the antibacterial granulocyte defense offers an explanation for enhanced susceptibility to bacterial superinfection during viral disease.