Prof. Dr. med. Lukas Flatz
Principal Investigator and Senior Consultant
attending physician
Dermatologie | Venerologie | Allergologie · Interdisciplinary Medical Services
Immune signatures predict development of autoimmune toxicity in patients with cancer treated with immune checkpoint inhibitors.
Núñez N, Berner F, Friebel E, Unger S, Wyss N, Gomez J, Purde M, Niederer R, Porsch M, Lichtensteiger C, Kramer R, Erdmann M, Schmitt C, Heinzerling L, Abdou M, Karbach J, Schadendorf D, Zimmer L, Ugurel S, Klümper N, Hölzel M, Power L, Kreutmair S, Capone M, Madonna G, Cevhertas L, Heider A, Amaral T, Hasan Ali O, Bomze D, Dimitriou F, Diem S, Ascierto P, Dummer R, Jäger E, Driessen C, Levesque M, van de Veen W, Joerger M, Früh M, Becher B, Flatz L. Immune signatures predict development of autoimmune toxicity in patients with cancer treated with immune checkpoint inhibitors. Med (N Y) 2023
Jan 13, 2023Immune signatures predict development of autoimmune toxicity in patients with cancer treated with immune checkpoint inhibitors.
Jan 13, 2023Med (N Y) 2023
Núñez Nicolás Gonzalo, Berner Fiamma, Friebel Ekaterina, Unger Susanne, Wyss Nina, Gomez Julia Martinez, Purde Mette-Triin, Niederer Rebekka, Porsch Maximilian, Lichtensteiger Christa, Kramer Rafaela, Erdmann Michael, Schmitt Christina, Heinzerling Lucie, Abdou Marie-Therese, Karbach Julia, Schadendorf Dirk, Zimmer Lisa, Ugurel Selma, Klümper Niklas, Hölzel Michael, Power Laura, Kreutmair Stefanie, Capone Mariaelena, Madonna Gabriele, Cevhertas Lacin, Heider Anja, Amaral Teresa, Hasan Ali Omar, Bomze David, Dimitriou Florentia, Diem Stefan, Ascierto Paolo Antonio, Dummer Reinhard, Jäger Elke, Driessen Christoph, Levesque Mitchell Paul, van de Veen Willem, Joerger Markus, Früh Martin, Becher Burkhard, Flatz Lukas
Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19.
Sinnberg T, Lichtensteiger C, Ali O, Pop O, Risch L, Brugger S, Velic A, Bomze D, Kohler P, Vernazza P, Albrich W, Kahlert C, Abdou M, Wyss N, Hofmeister K, Niessner H, Zinner C, Gilardi M, Tzankov A, Röcken M, Dulovic A, Shambat S, Ruetalo N, Buehler P, Scheier T, Jochum W, Kern L, Henz S, Schneider T, Kuster G, Lampart M, Siegemund M, Bingisser R, Schindler M, Schneiderhan-Marra N, Kalbacher H, McCoy K, Spengler W, Brutsche M, Macek B, Twerenbold R, Penninger J, Matter M, Flatz L, Jochum A. Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19. Am J Respir Crit Care Med 2023; 207:38-49.
Jan 1, 2023Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19.
Jan 1, 2023Am J Respir Crit Care Med 2023; 207:38-49
Sinnberg Tobias, Lichtensteiger Christa, Ali Omar Hasan, Pop Oltin T, Risch Lorenz, Brugger Silvio D, Velic Ana, Bomze David, Kohler Philipp, Vernazza Pietro, Albrich Werner C, Kahlert Christian R, Abdou Marie-Therese, Wyss Nina, Hofmeister Kathrin, Niessner Heike, Zinner Carl, Gilardi Mara, Tzankov Alexandar, Röcken Martin, Dulovic Alex, Shambat Srikanth Mairpady, Ruetalo Natalia, Buehler Philipp K, Scheier Thomas C, Jochum Wolfram, Kern Lukas, Henz Samuel, Schneider Tino, Kuster Gabriela M, Lampart Maurin, Siegemund Martin, Bingisser Roland, Schindler Michael, Schneiderhan-Marra Nicole, Kalbacher Hubert, McCoy Kathy D, Spengler Werner, Brutsche Martin H, Macek Boris, Twerenbold Raphael, Penninger Josef M, Matter Matthias S, Flatz Lukas, Jochum Ann-Kristin
Autoreactive napsin A-specific T cells are enriched in lung tumors and inflammatory lung lesions during immune checkpoint blockade.
Berner F, Bomze D, Lichtensteiger C, Walter V, Niederer R, Hasan Ali O, Wyss N, Bauer J, Freudenmann L, Marcu A, Wolfschmitt E, Haen S, Gross T, Abdou M, Diem S, Knöpfli S, Sinnberg T, Hofmeister K, Cheng H, Toma M, Klümper N, Purde M, Pop O, Jochum A, Pascolo S, Jörger M, Früh M, Jochum W, Rammensee H, Läubli H, Hölzel M, Neefjes J, Walz J, Flatz L. Autoreactive napsin A-specific T cells are enriched in lung tumors and inflammatory lung lesions during immune checkpoint blockade. Sci Immunol 2022; 7:eabn9644.
Sep 2, 2022Autoreactive napsin A-specific T cells are enriched in lung tumors and inflammatory lung lesions during immune checkpoint blockade.
Sep 2, 2022Sci Immunol 2022; 7:eabn9644
Berner Fiamma, Bomze David, Lichtensteiger Christa, Walter Vincent, Niederer Rebekka, Hasan Ali Omar, Wyss Nina, Bauer Jens, Freudenmann Lena Katharina, Marcu Ana, Wolfschmitt Eva-Maria, Haen Sebastian, Gross Thorben, Abdou Marie-Therese, Diem Stefan, Knöpfli Stella, Sinnberg Tobias, Hofmeister Kathrin, Cheng Hung-Wei, Toma Marieta, Klümper Niklas, Purde Mette-Triin, Pop Oltin Tiberiu, Jochum Ann-Kristin, Pascolo Steve, Jörger Markus, Früh Martin, Jochum Wolfram, Rammensee Hans-Georg, Läubli Heinz, Hölzel Michael, Neefjes Jacques, Walz Juliane, Flatz Lukas
Vitamin C Deficiency in Blood Samples of COVID-19 Patients.
Sinnberg T, Lichtensteiger C, Hill-Mündel K, Leischner C, Niessner H, Busch C, Renner O, Wyss N, Flatz L, Lauer U, Hoelzle L, Nohr D, Burkard M, Marongiu L, Venturelli S. Vitamin C Deficiency in Blood Samples of COVID-19 Patients. Antioxidants (Basel) 2022; 11
Aug 15, 2022Vitamin C Deficiency in Blood Samples of COVID-19 Patients.
Aug 15, 2022Antioxidants (Basel) 2022; 11
Sinnberg Tobias, Lichtensteiger Christa, Hill-Mündel Katharina, Leischner Christian, Niessner Heike, Busch Christian, Renner Olga, Wyss Nina, Flatz Lukas, Lauer Ulrich M, Hoelzle Ludwig E, Nohr Donatus, Burkard Markus, Marongiu Luigi, Venturelli Sascha
Frequency and Genomic Aspects of Intrinsic Resistance to Vismodegib in Locally Advanced Basal Cell Carcinoma.
Yurchenko A, Pop O, Ighilahriz M, Padioleau I, Rajabi F, Sharpe H, Poulalhon N, Dreno B, Khammari A, Delord M, Alberti A, Soufir N, Battistella M, Mourah S, Bouquet F, Savina A, Besse A, Mendez-Lopez M, Grange F, Monestier S, Mortier L, Meyer N, Dutriaux C, Robert C, Saiag P, Herms F, Lambert J, de Sauvage F, Dumaz N, Flatz L, Basset-Seguin N, Nikolaev S. Frequency and Genomic Aspects of Intrinsic Resistance to Vismodegib in Locally Advanced Basal Cell Carcinoma. Clin Cancer Res 2022; 28:1422-1432.
Apr 1, 2022Frequency and Genomic Aspects of Intrinsic Resistance to Vismodegib in Locally Advanced Basal Cell Carcinoma.
Apr 1, 2022Clin Cancer Res 2022; 28:1422-1432
Yurchenko Andrey A, Pop Oltin T, Ighilahriz Meriem, Padioleau Ismael, Rajabi Fatemeh, Sharpe Hayley J, Poulalhon Nicolas, Dreno Brigitte, Khammari Amir, Delord Marc, Alberti Antonio, Soufir Nadem, Battistella Maxime, Mourah Samia, Bouquet Fanny, Savina Ariel, Besse Andrej, Mendez-Lopez Max, Grange Florent, Monestier Sandrine, Mortier Laurent, Meyer Nicolas, Dutriaux Caroline, Robert Caroline, Saiag Philippe, Herms Florian, Lambert Jerome, de Sauvage Frederic J, Dumaz Nicolas, Flatz Lukas, Basset-Seguin Nicole, Nikolaev Sergey
C reactive protein flare predicts response to checkpoint inhibitor treatment in non-small cell lung cancer.
Klümper N, Saal J, Berner F, Lichtensteiger C, Wyss N, Heine A, Bauernfeind F, Ellinger J, Brossart P, Diem S, Schmid S, Jörger M, Frueh M, Ritter M, Hölzel M, Flatz L, Bald T. C reactive protein flare predicts response to checkpoint inhibitor treatment in non-small cell lung cancer. J Immunother Cancer 2022; 10
Mar 1, 2022C reactive protein flare predicts response to checkpoint inhibitor treatment in non-small cell lung cancer.
Mar 1, 2022J Immunother Cancer 2022; 10
Klümper Niklas, Saal Jonas, Berner Fiamma, Lichtensteiger Christa, Wyss Nina, Heine Annkristin, Bauernfeind Franz Georg, Ellinger Jörg, Brossart Peter, Diem Stefan, Schmid Sabine, Jörger Markus, Frueh Martin, Ritter Manuel, Hölzel Michael, Flatz Lukas, Bald Tobias
Local tumor microbial signatures and response to checkpoint blockade in non-small cell lung cancer.
Bösch M, Baty F, Albrich W, Flatz L, Rodriguez R, Rothschild S, Jörger M, Früh M, Brutsche M. Local tumor microbial signatures and response to checkpoint blockade in non-small cell lung cancer. Oncoimmunology 2021; 10:1988403.
Dec 10, 2021Local tumor microbial signatures and response to checkpoint blockade in non-small cell lung cancer.
Dec 10, 2021Oncoimmunology 2021; 10:1988403
Bösch Maximilian, Baty Florent, Albrich Werner C, Flatz Lukas, Rodriguez Regulo, Rothschild Sacha I, Jörger Markus, Früh Martin, Brutsche Martin H
Presence of autoantibodies in serum does not impact the occurrence of immune checkpoint inhibitor-induced hepatitis in a prospective cohort of cancer patients.
Purde M, Niederer R, Wagner N, Diem S, Berner F, Hasan Ali O, Hillmann D, Bergamin I, Jörger M, Risch M, Niederhauser C, Lenz T, Früh M, Risch L, Semela D, Flatz L. Presence of autoantibodies in serum does not impact the occurrence of immune checkpoint inhibitor-induced hepatitis in a prospective cohort of cancer patients. J Cancer Res Clin Oncol 2021; 148:647-656.
Dec 7, 2021Presence of autoantibodies in serum does not impact the occurrence of immune checkpoint inhibitor-induced hepatitis in a prospective cohort of cancer patients.
Dec 7, 2021J Cancer Res Clin Oncol 2021; 148:647-656
Purde Mette-Triin, Niederer Rebekka, Wagner Nikolaus B, Diem Stefan, Berner Fiamma, Hasan Ali Omar, Hillmann Dorothea, Bergamin Irina, Jörger Markus, Risch Martin, Niederhauser Christoph, Lenz Tobias L, Früh Martin, Risch Lorenz, Semela David, Flatz Lukas
Association between Immune-Related Adverse Events and Survival in 319 Stage IV Melanoma Patients Treated with PD-1-Based Immunotherapy: An Approach Based on Clinical Chemistry
Serna-Higuita L, Eigentler T, Garbe C, Thomas I, Seeber O, Flatz L, Leiter U, Forschner A, Amaral T, Martus P. Association between Immune-Related Adverse Events and Survival in 319 Stage IV Melanoma Patients Treated with PD-1-Based Immunotherapy: An Approach Based on Clinical Chemistry. Cancers (Basel) 2021; 13
Dec 6, 2021Association between Immune-Related Adverse Events and Survival in 319 Stage IV Melanoma Patients Treated with PD-1-Based Immunotherapy: An Approach Based on Clinical Chemistry
Dec 6, 2021Cancers (Basel) 2021; 13
Serna-Higuita Lina María, Eigentler Thomas Kurt, Garbe Claus, Thomas Ioannis, Seeber Olivia, Flatz Lukas, Leiter Ulrike, Forschner Andrea, Amaral Teresa, Martus Peter
Keratinocyte differentiation antigen-specific T cells in immune checkpoint inhibitor-treated NSCLC patients are associated with improved survival.
Berner F, Niederer R, Luimstra J, Pop O, Jochum A, Purde M, Hasan Ali O, Bomze D, Bauer J, Freudenmann L, Marcu A, Wolfschmitt E, Haen S, Gross T, Dubbelaar M, Abdou M, Baumgaertner P, Appenzeller C, Cicin-Sain C, Lenz T, Speiser D, Ludewig B, Driessen C, Jörger M, Früh M, Jochum W, Cozzio A, Rammensee H, Walz J, Neefjes J, Flatz L. Keratinocyte differentiation antigen-specific T cells in immune checkpoint inhibitor-treated NSCLC patients are associated with improved survival. Oncoimmunology 2021; 10:2006893.
Nov 27, 2021Keratinocyte differentiation antigen-specific T cells in immune checkpoint inhibitor-treated NSCLC patients are associated with improved survival.
Nov 27, 2021Oncoimmunology 2021; 10:2006893
Berner Fiamma, Niederer Rebekka, Luimstra Jolien J, Pop Oltin Tiberiu, Jochum Ann-Kristin, Purde Mette-Triin, Hasan Ali Omar, Bomze David, Bauer Jens, Freudenmann Lena Katharina, Marcu Ana, Wolfschmitt Eva-Maria, Haen Sebastian, Gross Thorben, Dubbelaar MariLisa, Abdou Marie-Therese, Baumgaertner Petra, Appenzeller Christina, Cicin-Sain Caroline, Lenz Tobias, Speiser Daniel E, Ludewig Burkhard, Driessen Christoph, Jörger Markus, Früh Martin, Jochum Wolfram, Cozzio Antonio, Rammensee Hans-Georg, Walz Juliane, Neefjes Jacques, Flatz Lukas
Cutaneous melanoma attributable to UVR exposure in Denmark and Germany
Keim U, Gandini S, Amaral T, Katalinic A, Holleczek B, Flatz L, Leiter U, Whiteman D, Garbe C. Cutaneous melanoma attributable to UVR exposure in Denmark and Germany. Eur J Cancer 2021; 159:98-104.
Nov 3, 2021Cutaneous melanoma attributable to UVR exposure in Denmark and Germany
Nov 3, 2021Eur J Cancer 2021; 159:98-104
Keim Ulrike, Gandini Sara, Amaral Teresa, Katalinic Alexander, Holleczek Bernd, Flatz Lukas, Leiter Ulrike, Whiteman David, Garbe Claus
Large Hemorrhagic Extrascleral Ciliary Body Melanoma Recurrence Treated With Transarterial Embolization and Coiling Followed by Exenteration
Weber J, Flatz L, Sommacal A, Varde M. Large Hemorrhagic Extrascleral Ciliary Body Melanoma Recurrence Treated With Transarterial Embolization and Coiling Followed by Exenteration. Ophthalmic Plast Reconstr Surg. 2021; 37:e184-e187.
Oct 1, 2021Large Hemorrhagic Extrascleral Ciliary Body Melanoma Recurrence Treated With Transarterial Embolization and Coiling Followed by Exenteration
Oct 1, 2021Ophthalmic Plast Reconstr Surg. 2021; 37:e184-e187
Weber Johannes, Flatz Lukas, Sommacal Andreas, Varde Meghana
Large Hemorrhagic Extrascleral Ciliary Body Melanoma Recurrence Treated With Transarterial Embolization and Coiling Followed by Exenteration
Weber J, Flatz L, Sommacal A, Varde M. Large Hemorrhagic Extrascleral Ciliary Body Melanoma Recurrence Treated With Transarterial Embolization and Coiling Followed by Exenteration. Ophthalmic Plast Reconstr Surg. 2021; 37:e184-e187.
Sep 1, 2021Large Hemorrhagic Extrascleral Ciliary Body Melanoma Recurrence Treated With Transarterial Embolization and Coiling Followed by Exenteration
Sep 1, 2021Ophthalmic Plast Reconstr Surg. 2021; 37:e184-e187
Weber Johannes, Flatz Lukas, Sommacal Andreas, Varde Meghana
Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment
Ring S, Spiegl M, Besse A, Bonilla W, Stemeseder F, Schmidt S, Orlinger K, Krebs P, Ludewig B, Wenger R, Hartmann F, Cupovic J, Onder L, Lütge M, Perez Shibayama C, Gil Cruz C, Scandella E, De Martin A, Mörbe U, Flatz L. Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment. Nat Commun 2021; 12:4734.
Aug 5, 2021Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment
Aug 5, 2021Nat Commun 2021; 12:4734
Ring Sandra, Spiegl Matthias, Besse Andrej, Bonilla Weldy V, Stemeseder Felix, Schmidt Sarah, Orlinger Klaus K, Krebs Philippe, Ludewig Burkhard, Wenger Robert, Hartmann Fabienne, Cupovic Jovana, Onder Lucas, Lütge Mechthild, Perez Shibayama Christian, Gil Cruz Cristina, Scandella Elke, De Martin Angelina, Mörbe Urs, Flatz Lukas
Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8 T cells
Cupovic J, Klenerman P, Engeler D, Krebs P, Scandella E, Oxenius A, Flatz L, Provine N, De Martin A, Cheng H, Lütge M, Colston J, Onder L, Ring S, Ludewig B. Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8 T cells. Nat Immunol 2021; 22:1042-1051.
Jul 15, 2021Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8 T cells
Jul 15, 2021Nat Immunol 2021; 22:1042-1051
Cupovic Jovana, Klenerman Paul, Engeler Daniel, Krebs Philippe, Scandella Elke, Oxenius Annette, Flatz Lukas, Provine Nicholas M, De Martin Angelina, Cheng Hung-Wei, Lütge Mechthild, Colston Julia M, Onder Lucas, Ring Sandra, Ludewig Burkhard
Epidemiology of cutaneous melanoma and keratinocyte cancer in white populations 1943-2036
Garbe C, Leiter U, Flatz L, Martus P, Hollezcek B, Katalinic A, Amaral T, Gandini S, Keim U, Whiteman D. Epidemiology of cutaneous melanoma and keratinocyte cancer in white populations 1943-2036. Eur J Cancer 2021; 152:18-25.
May 29, 2021Epidemiology of cutaneous melanoma and keratinocyte cancer in white populations 1943-2036
May 29, 2021Eur J Cancer 2021; 152:18-25
Garbe Claus, Leiter Ulrike, Flatz Lukas, Martus Peter, Hollezcek Bernd, Katalinic Alexander, Amaral Teresa, Gandini Sara, Keim Ulrike, Whiteman David
Preexisting and Post-COVID-19 Immune Responses to SARS-CoV-2 in Patients with Cancer
Bilich T, Flatz L, Held S, Brossart P, Märklin M, Wagner P, Erne E, Klein R, Rammensee H, Salih H, Berner F, Wacker M, Roerden M, Maringer Y, Nelde A, Heitmann J, Dubbelaar M, Peter A, Hörber S, Bauer J, Rieth J, Walz J. Preexisting and Post-COVID-19 Immune Responses to SARS-CoV-2 in Patients with Cancer. Cancer Discov 2021; 11:1982-1995.
May 19, 2021Preexisting and Post-COVID-19 Immune Responses to SARS-CoV-2 in Patients with Cancer
May 19, 2021Cancer Discov 2021; 11:1982-1995
Bilich Tatjana, Flatz Lukas, Held Stefanie, Brossart Peter, Märklin Melanie, Wagner Philipp, Erne Eva, Klein Reinhild, Rammensee Hans-Georg, Salih Helmut R, Berner Fiamma, Wacker Marcel, Roerden Malte, Maringer Yacine, Nelde Annika, Heitmann Jonas S, Dubbelaar Marissa L, Peter Andreas, Hörber Sebastian, Bauer Jens, Rieth Jonas, Walz Juliane S
Pembrolizumab-Associated CD8 Vasculitic Mononeuritis Multiplex in a Patient With Mesothelioma
Baldauf M, Kapauer M, Jörger M, Flatz L, Rodriguez R, Frank S, Felbecker A, Hundsberger T. Pembrolizumab-Associated CD8 Vasculitic Mononeuritis Multiplex in a Patient With Mesothelioma. Neurol Neuroimmunol Neuroinflamm 2021; 8
Apr 6, 2021Pembrolizumab-Associated CD8 Vasculitic Mononeuritis Multiplex in a Patient With Mesothelioma
Apr 6, 2021Neurol Neuroimmunol Neuroinflamm 2021; 8
Baldauf Michaela, Kapauer Monika, Jörger Markus, Flatz Lukas, Rodriguez Regulo, Frank Stephan, Felbecker Ansgar, Hundsberger Thomas
Recombinant lymphocytic choriomeningitis virus-based vaccine vector protects type I interferon receptor deficient mice from viral challenge
Królik M, Csepregi L, Hartmann F, Engetschwiler C, Flatz L. Recombinant lymphocytic choriomeningitis virus-based vaccine vector protects type I interferon receptor deficient mice from viral challenge. Vaccine 2021; 39:1257-1264.
Jan 29, 2021Recombinant lymphocytic choriomeningitis virus-based vaccine vector protects type I interferon receptor deficient mice from viral challenge
Jan 29, 2021Vaccine 2021; 39:1257-1264
Królik Michał Wojciech, Csepregi Lucia, Hartmann Fabienne, Engetschwiler Céline, Flatz Lukas
Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies
Hasan Ali O, Penninger J, Bergthaler A, Popa A, Gómez-Mejia A, Schüpbach R, Bühler P, Vernazza P, Kahlert C, Kohler P, Albrich W, Kern L, Thiel S, Weber M, Paprotny M, Brugger S, Risch L, Bomze D, Flatz L. Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies. Clin Infect Dis 2021; 73:e2869-e2874.
Jan 2, 2021Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies
Jan 2, 2021Clin Infect Dis 2021; 73:e2869-e2874
Hasan Ali Omar, Penninger Josef M, Bergthaler Andreas, Popa Alexandra M, Gómez-Mejia Alejandro, Schüpbach Reto A, Bühler Philipp K, Vernazza Pietro, Kahlert Christian, Kohler Philipp, Albrich Werner, Kern Lukas, Thiel Sarah, Weber Myriam, Paprotny Matthias, Brugger Silvio D, Risch Lorenz, Bomze David, Flatz Lukas