Prof. Dr. med. Lukas Flatz
Principal Investigator and Senior Consultant
attending physician
Dermatologie | Venerologie | Allergologie · Dept. IV
Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8 T cells
Cupovic J, Klenerman P, Engeler D, Krebs P, Scandella E, Oxenius A, Flatz L, Provine N, De Martin A, Cheng H, Lütge M, Colston J, Onder L, Ring S, Ludewig B. Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8 T cells. Nat Immunol 2021; 22:1042-1051.
Jul 15, 2021Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8 T cells
Jul 15, 2021Nat Immunol 2021; 22:1042-1051
Cupovic Jovana, Klenerman Paul, Engeler Daniel, Krebs Philippe, Scandella Elke, Oxenius Annette, Flatz Lukas, Provine Nicholas M, De Martin Angelina, Cheng Hung-Wei, Lütge Mechthild, Colston Julia M, Onder Lucas, Ring Sandra, Ludewig Burkhard
Epidemiology of cutaneous melanoma and keratinocyte cancer in white populations 1943-2036
Garbe C, Leiter U, Flatz L, Martus P, Hollezcek B, Katalinic A, Amaral T, Gandini S, Keim U, Whiteman D. Epidemiology of cutaneous melanoma and keratinocyte cancer in white populations 1943-2036. Eur J Cancer 2021; 152:18-25.
May 29, 2021Epidemiology of cutaneous melanoma and keratinocyte cancer in white populations 1943-2036
May 29, 2021Eur J Cancer 2021; 152:18-25
Garbe Claus, Leiter Ulrike, Flatz Lukas, Martus Peter, Hollezcek Bernd, Katalinic Alexander, Amaral Teresa, Gandini Sara, Keim Ulrike, Whiteman David
Preexisting and Post-COVID-19 Immune Responses to SARS-CoV-2 in Patients with Cancer
Bilich T, Flatz L, Held S, Brossart P, Märklin M, Wagner P, Erne E, Klein R, Rammensee H, Salih H, Berner F, Wacker M, Roerden M, Maringer Y, Nelde A, Heitmann J, Dubbelaar M, Peter A, Hörber S, Bauer J, Rieth J, Walz J. Preexisting and Post-COVID-19 Immune Responses to SARS-CoV-2 in Patients with Cancer. Cancer Discov 2021; 11:1982-1995.
May 19, 2021Preexisting and Post-COVID-19 Immune Responses to SARS-CoV-2 in Patients with Cancer
May 19, 2021Cancer Discov 2021; 11:1982-1995
Bilich Tatjana, Flatz Lukas, Held Stefanie, Brossart Peter, Märklin Melanie, Wagner Philipp, Erne Eva, Klein Reinhild, Rammensee Hans-Georg, Salih Helmut R, Berner Fiamma, Wacker Marcel, Roerden Malte, Maringer Yacine, Nelde Annika, Heitmann Jonas S, Dubbelaar Marissa L, Peter Andreas, Hörber Sebastian, Bauer Jens, Rieth Jonas, Walz Juliane S
Pembrolizumab-Associated CD8 Vasculitic Mononeuritis Multiplex in a Patient With Mesothelioma
Baldauf M, Jörger M, Flatz L, Rodriguez R, Frank S, Felbecker A, Hundsberger T. Pembrolizumab-Associated CD8 Vasculitic Mononeuritis Multiplex in a Patient With Mesothelioma. Neurol Neuroimmunol Neuroinflamm 2021; 8
Apr 6, 2021Pembrolizumab-Associated CD8 Vasculitic Mononeuritis Multiplex in a Patient With Mesothelioma
Apr 6, 2021Neurol Neuroimmunol Neuroinflamm 2021; 8
Baldauf Michaela, Jörger Markus, Flatz Lukas, Rodriguez Regulo, Frank Stephan, Felbecker Ansgar, Hundsberger Thomas
Recombinant lymphocytic choriomeningitis virus-based vaccine vector protects type I interferon receptor deficient mice from viral challenge
Królik M, Csepregi L, Hartmann F, Engetschwiler C, Flatz L. Recombinant lymphocytic choriomeningitis virus-based vaccine vector protects type I interferon receptor deficient mice from viral challenge. Vaccine 2021; 39:1257-1264.
Jan 29, 2021Recombinant lymphocytic choriomeningitis virus-based vaccine vector protects type I interferon receptor deficient mice from viral challenge
Jan 29, 2021Vaccine 2021; 39:1257-1264
Królik Michał Wojciech, Csepregi Lucia, Hartmann Fabienne, Engetschwiler Céline, Flatz Lukas
Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies
Hasan Ali O, Penninger J, Bergthaler A, Popa A, Gómez-Mejia A, Schüpbach R, Bühler P, Vernazza P, Kahlert C, Kohler P, Albrich W, Kern L, Thiel S, Weber M, Paprotny M, Brugger S, Risch L, Bomze D, Flatz L. Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies. Clin Infect Dis 2021; 73:e2869-e2874.
Jan 2, 2021Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies
Jan 2, 2021Clin Infect Dis 2021; 73:e2869-e2874
Hasan Ali Omar, Penninger Josef M, Bergthaler Andreas, Popa Alexandra M, Gómez-Mejia Alejandro, Schüpbach Reto A, Bühler Philipp K, Vernazza Pietro, Kahlert Christian, Kohler Philipp, Albrich Werner, Kern Lukas, Thiel Sarah, Weber Myriam, Paprotny Matthias, Brugger Silvio D, Risch Lorenz, Bomze David, Flatz Lukas
Pretreatment metastatic growth rate determines clinical outcome of advanced melanoma patients treated with anti-PD-1 antibodies: a multicenter cohort study
Wagner N, Schraag A, Klumpp B, Hoetzenecker W, Berking C, Richtig E, Ziemer M, Mangana J, Terheyden P, Loquai C, Nguyen V, Gebhardt C, Meier F, Diem S, Cozzio A, Flatz L, Röcken M, Garbe C, Gassenmaier M, Weide B, Leiter U, Lenders M, Kühl K, Reinhardt L, André F, Dudda M, Ring N, Ebel C, Stäger R, Zellweger C, Lang R, Paar M, Gussek P, Richtig G, Stürmer S, Kimeswenger S, Oellinger A, Forschner A, Eigentler T. Pretreatment metastatic growth rate determines clinical outcome of advanced melanoma patients treated with anti-PD-1 antibodies: a multicenter cohort study. J Immunother Cancer 2021; 9
Jan 1, 2021Pretreatment metastatic growth rate determines clinical outcome of advanced melanoma patients treated with anti-PD-1 antibodies: a multicenter cohort study
Jan 1, 2021J Immunother Cancer 2021; 9
Wagner Nikolaus, Schraag Amadeus, Klumpp Bernhard, Hoetzenecker Wolfram, Berking Carola, Richtig Erika, Ziemer Mirjana, Mangana Johanna, Terheyden Patrick, Loquai Carmen, Nguyen Van Anh, Gebhardt Christoffer, Meier Friedegund, Diem Stefan, Cozzio Antonio, Flatz Lukas, Röcken Martin, Garbe Claus, Gassenmaier Maximilian, Weide Benjamin, Leiter Ulrike, Lenders Max M, Kühl Kathrin, Reinhardt Lydia, André Fiona, Dudda Milena, Ring Natalie, Ebel Chiara, Stäger Ramon, Zellweger Caroline, Lang Roland, Paar Michael, Gussek Philipp, Richtig Georg, Stürmer Suzan H, Kimeswenger Susanne, Oellinger Angela, Forschner Andrea, Eigentler Thomas K
First-line treatment of NRAS-mutated metastatic melanoma with a MEK inhibitor
Bickel A, Diem S, Flatz L, Stinn B, Siano M. First-line treatment of NRAS-mutated metastatic melanoma with a MEK inhibitor. J Cancer Res Ther 2021; 17:276-278.
Jan 1, 2021First-line treatment of NRAS-mutated metastatic melanoma with a MEK inhibitor
Jan 1, 2021J Cancer Res Ther 2021; 17:276-278
Bickel Angelika, Diem Stefan, Flatz Lukas, Stinn Björn, Siano Marco
Early disappearance of tumor antigen-reactive T cells from peripheral blood correlates with superior clinical outcomes in melanoma under anti-PD-1 therapy
Bochem J, Meier F, Terheyden P, Königsrainer A, Garbe C, Flatz L, Pawelec G, Eigentler T, Löffler M, Weide B, Niessner H, Sinnberg T, Zelba H, Spreuer J, Amaral T, Gaissler A, Pop O, Thiel K, Yurttas C, Soffel D, Forchhammer S, Wistuba-Hamprecht K. Early disappearance of tumor antigen-reactive T cells from peripheral blood correlates with superior clinical outcomes in melanoma under anti-PD-1 therapy. J Immunother Cancer 2021; 9
Jan 1, 2021Early disappearance of tumor antigen-reactive T cells from peripheral blood correlates with superior clinical outcomes in melanoma under anti-PD-1 therapy
Jan 1, 2021J Immunother Cancer 2021; 9
Bochem Jonas, Meier Friedegund, Terheyden Patrick, Königsrainer Alfred, Garbe Claus, Flatz Lukas, Pawelec Graham, Eigentler Thomas K, Löffler Markus W, Weide Benjamin, Niessner Heike, Sinnberg Tobias, Zelba Henning, Spreuer Janine, Amaral Teresa, Gaissler Andrea, Pop Oltin, Thiel Karolin, Yurttas Can, Soffel Daniel, Forchhammer Stephan, Wistuba-Hamprecht Kilian
Prognostic role of gamma-glutamyl transferase in metastatic melanoma patients treated with immune checkpoint inhibitors
Winter J, Eigentler T, Garbe C, Röcken M, Cozzio A, Flatz L, Purde M, Weide B, Leiter U, Forschner A, Gassenmaier M, Lenders M, Wagner N. Prognostic role of gamma-glutamyl transferase in metastatic melanoma patients treated with immune checkpoint inhibitors. Cancer Immunol Immunother 2020; 70:1089-1099.
Oct 28, 2020Prognostic role of gamma-glutamyl transferase in metastatic melanoma patients treated with immune checkpoint inhibitors
Oct 28, 2020Cancer Immunol Immunother 2020; 70:1089-1099
Winter Johanna, Eigentler Thomas K, Garbe Claus, Röcken Martin, Cozzio Antonio, Flatz Lukas, Purde Mette-Triin, Weide Benjamin, Leiter Ulrike, Forschner Andrea, Gassenmaier Maximilian, Lenders Max M, Wagner Nikolaus
CD155 on Tumor Cells Drives Resistance to Immunotherapy by Inducing the Degradation of the Activating Receptor CD226 in CD8 T Cells
Bald T, Scolyer R, Long G, Wilmott J, Hughes B, Ahern E, Taheri T, Kristiansen G, Geyer M, Hölzel M, Seo E, Batstone M, Landsberg J, Smyth M, Martinet L, Johnston R, Möller A, Nicholson S, Veillette A, Dougall W, Flatz L, Pop O, Dietrich D, Nakamura K, Casey M, Koufariotis L, Li R, Li K, Meza Guzman L, Lima L, Das I, Krumeich S, Stannard K, Corvino D, Sundarrajan A, Aguilera A, Salim N, Jorge M, Quine B, Effern M, Jacquelin S, Madore J, Pearson S, Raghavendra A, Lepletier A, Vari F, Kelly G, Ham S, Braun M. CD155 on Tumor Cells Drives Resistance to Immunotherapy by Inducing the Degradation of the Activating Receptor CD226 in CD8 T Cells. Immunity 2020; 53:805-823.e15.
Oct 13, 2020CD155 on Tumor Cells Drives Resistance to Immunotherapy by Inducing the Degradation of the Activating Receptor CD226 in CD8 T Cells
Oct 13, 2020Immunity 2020; 53:805-823.e15
Bald Tobias, Scolyer Richard A, Long Georgina V, Wilmott James S, Hughes Brett G M, Ahern Elizabeth, Taheri Touraj, Kristiansen Glen, Geyer Matthias, Hölzel Michael, Seo Eun Y, Batstone Martin D, Landsberg Jennifer, Smyth Mark J, Martinet Ludovic, Johnston Robert J, Möller Andreas, Nicholson Sandra E, Veillette André, Dougall William C, Flatz Lukas, Pop Oltin, Dietrich Dimo, Nakamura Kyohei, Casey Mika, Koufariotis Lambros T, Li Rui, Li Kunlun, Meza Guzman Lizeth G, Lima Luize G, Das Indrajit, Krumeich Sophie, Stannard Kimberley, Corvino Dillon, Sundarrajan Ashmitha, Aguilera Amelia Roman, Salim Nazhifah, Jorge Maria Villancanas, Quine Brodie, Effern Maike, Jacquelin Sebastien, Madore Jason, Pearson Sally, Raghavendra Ashwini, Lepletier Ailin, Vari Frank, Kelly Gabrielle, Ham Sunyoung, Braun Matthias
Heterologous Prime Boost Vaccination Induces Protective Melanoma-Specific CD8 T Cell Responses
Ring S, Królik M, Hartmann F, Schmidt E, Ali O, Ludewig B, Kochanek S, Flatz L. Heterologous Prime Boost Vaccination Induces Protective Melanoma-Specific CD8 T Cell Responses. Mol Ther Oncolytics 2020; 19:179-187.
Oct 10, 2020Heterologous Prime Boost Vaccination Induces Protective Melanoma-Specific CD8 T Cell Responses
Oct 10, 2020Mol Ther Oncolytics 2020; 19:179-187
Ring Sandra, Królik Michał Wojciech, Hartmann Fabienne, Schmidt Erika, Ali Omar Hasan, Ludewig Burkhard, Kochanek Stefan, Flatz Lukas
Survival-Inferred Fragility Index of Phase 3 Clinical Trials Evaluating Immune Checkpoint Inhibitors
Bomze D, Asher N, Hasan A, Flatz L, Azoulay D, Markel G, Meirson T. Survival-Inferred Fragility Index of Phase 3 Clinical Trials Evaluating Immune Checkpoint Inhibitors. JAMA Netw Open 2020; 3:e2017675.
Oct 1, 2020Survival-Inferred Fragility Index of Phase 3 Clinical Trials Evaluating Immune Checkpoint Inhibitors
Oct 1, 2020JAMA Netw Open 2020; 3:e2017675
Bomze David, Asher Nethanel, Hasan Ali, Flatz Lukas, Azoulay Daniel, Markel Gal, Meirson Tomer
Frequency of serological non-responders and false-negative RT-PCR results in SARS-CoV-2 testing: a population-based study
Baron R, Bodmer T, Imperiali M, Heer S, Renz H, Flatz L, Kohler P, Vernazza P, Kahlert C, Paprotny M, Ferrara F, Egli K, Risch L, Weber M, Thiel S, Grossmann K, Wohlwend N, Lung T, Hillmann D, Ritzler M, Bigler S, Risch M. Frequency of serological non-responders and false-negative RT-PCR results in SARS-CoV-2 testing: a population-based study. Clin Chem Lab Med 2020; 58:2131-2140.
Aug 31, 2020Frequency of serological non-responders and false-negative RT-PCR results in SARS-CoV-2 testing: a population-based study
Aug 31, 2020Clin Chem Lab Med 2020; 58:2131-2140
Baron Rita Christiane, Bodmer Thomas, Imperiali Mauro, Heer Sonja, Renz Harald, Flatz Lukas, Kohler Philipp, Vernazza Pietro, Kahlert Christian, Paprotny Matthias, Ferrara Francesca, Egli Konrad, Risch Lorenz, Weber Myriam, Thiel Sarah, Grossmann Kirsten, Wohlwend Nadia, Lung Thomas, Hillmann Dorothea, Ritzler Michael, Bigler Susanna, Risch Martin
Molecular, clinicopathological, and immune correlates of LAG3 promoter DNA methylation in melanoma
Fröhlich A, Ring S, Golletz C, Pietsch T, Strieth S, Brossart P, Gielen G, Kristiansen G, Bootz F, Landsberg J, Flatz L, Hoffmann F, Sirokay J, Fietz S, Vogt T, Dietrich J, Zarbl R, Florin M, Kuster P, Saavedra G, Valladolid S, Dietrich D. Molecular, clinicopathological, and immune correlates of LAG3 promoter DNA methylation in melanoma. EBioMedicine 2020; 59:102962.
Aug 30, 2020Molecular, clinicopathological, and immune correlates of LAG3 promoter DNA methylation in melanoma
Aug 30, 2020EBioMedicine 2020; 59:102962
Fröhlich Anne, Ring Sandra, Golletz Carsten, Pietsch Torsten, Strieth Sebastian, Brossart Peter, Gielen Gerrit H, Kristiansen Glen, Bootz Friedrich, Landsberg Jennifer, Flatz Lukas, Hoffmann Friederike, Sirokay Judith, Fietz Simon, Vogt Timo J, Dietrich Jörn, Zarbl Romina, Florin Mike, Kuster Pia, Saavedra Gonzalo, Valladolid Susana Ramírez, Dietrich Dimo
Fingolimod and tumor-infiltrating lymphocytes in checkpoint-inhibitor treated cancer patients
Hasan Ali O, Hundsberger T, Diem S, Müller S, Pop O, Markert E, Müller J, Moulin A, Ring S, Ackermann C, Berner F, Flatz L. Fingolimod and tumor-infiltrating lymphocytes in checkpoint-inhibitor treated cancer patients. Cancer Immunol Immunother 2020; 70:563-568.
Aug 17, 2020Fingolimod and tumor-infiltrating lymphocytes in checkpoint-inhibitor treated cancer patients
Aug 17, 2020Cancer Immunol Immunother 2020; 70:563-568
Hasan Ali Omar, Hundsberger Thomas, Diem Stefan, Müller Stefanie, Pop Oltin, Markert Eva, Müller Joachim, Moulin Alexandre, Ring Sandra, Ackermann Christoph Jakob, Berner Fiamma, Flatz Lukas
Ocular Adverse Events Induced by Immune Checkpoint Inhibitors: A Comprehensive Pharmacovigilance Analysis
Bomze D, Meirson T, Hasan A, Goldman A, Flatz L, Habot-Wilner Z. Ocular Adverse Events Induced by Immune Checkpoint Inhibitors: A Comprehensive Pharmacovigilance Analysis. Ocul Immunol Inflamm 2020:1-7.
Aug 4, 2020Ocular Adverse Events Induced by Immune Checkpoint Inhibitors: A Comprehensive Pharmacovigilance Analysis
Aug 4, 2020Ocul Immunol Inflamm 2020:1-7
Bomze David, Meirson Tomer, Hasan Ali, Goldman Adam, Flatz Lukas, Habot-Wilner Zohar
Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma
Effern M, Gebhardt T, Bald T, Tüting T, Flatz L, Smyth M, Landsberg J, Aymans P, Daoud M, van den Boorn-Konijnenberg D, Hinze D, Bawden E, Yong M, Boll H, Liebing J, Braun M, Glodde N, Hölzel M. Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma. Immunity 2020; 53:564-580.e9.
Aug 3, 2020Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma
Aug 3, 2020Immunity 2020; 53:564-580.e9
Effern Maike, Gebhardt Thomas, Bald Tobias, Tüting Thomas, Flatz Lukas, Smyth Mark J, Landsberg Jennifer, Aymans Pia, Daoud Mila, van den Boorn-Konijnenberg Debby, Hinze Daniel, Bawden Emma, Yong Michelle, Boll Helena N, Liebing Jana, Braun Matthias, Glodde Nicole, Hölzel Michael
Prognostic and predictive value of PD-L2 DNA methylation and mRNA expression in melanoma
Hoffmann F, Landsberg J, Kristiansen G, Flatz L, Pietsch T, Dietrich J, Ring S, Gielen G, Strieth S, Kuster P, Saavedra G, Brossart P, Holderried T, Posch C, Fröhlich A, Sirokay J, Niebel D, Zarbl R, Dietrich D. Prognostic and predictive value of PD-L2 DNA methylation and mRNA expression in melanoma. Clin Epigenetics 2020; 12:94.
Jun 26, 2020Prognostic and predictive value of PD-L2 DNA methylation and mRNA expression in melanoma
Jun 26, 2020Clin Epigenetics 2020; 12:94
Hoffmann Friederike, Landsberg Jennifer, Kristiansen Glen, Flatz Lukas, Pietsch Torsten, Dietrich Jörn, Ring Sandra, Gielen Gerrit H, Strieth Sebastian, Kuster Pia, Saavedra Gonzalo, Brossart Peter, Holderried Tobias A W, Posch Christian, Fröhlich Anne, Sirokay Judith, Niebel Dennis, Zarbl Romina, Dietrich Dimo
Genomic profiling of late-onset basal cell carcinomas from two brothers with nevoid basal cell carcinoma syndrome
Hasan Ali O, Navarini A, Kim A, French L, Dermitzakis E, Christiano A, Hohl D, Bickers D, Nikolaev S, Jochum W, Fritzsche F, Yurchenko A, Pavlova O, Sartori A, Bomze D, Higgins R, Ring S, Hartmann F, Bühler D, Flatz L. Genomic profiling of late-onset basal cell carcinomas from two brothers with nevoid basal cell carcinoma syndrome. J Eur Acad Dermatol Venereol 2020
Jun 21, 2020Genomic profiling of late-onset basal cell carcinomas from two brothers with nevoid basal cell carcinoma syndrome
Jun 21, 2020J Eur Acad Dermatol Venereol 2020
Hasan Ali O, Navarini A A, Kim A, French L E, Dermitzakis E, Christiano A M, Hohl D, Bickers D R, Nikolaev S I, Jochum Wolfram, Fritzsche F R, Yurchenko A A, Pavlova O, Sartori A, Bomze D, Higgins R, Ring Sandra, Hartmann F, Bühler D, Flatz Lukas