Prof. Dr. med. Lukas Flatz
Principal Investigator and Senior Consultant
attending physician
Dermatologie | Venerologie | Allergologie · Dept. IV
GLUT1-positive recurrent basal cell carcinoma of basosquamous subtype detected by positron emission tomography
Hasan Ali O, Diem S, Aschwanden J, Markert E, Tasman A, Müller J, Flatz L. GLUT1-positive recurrent basal cell carcinoma of basosquamous subtype detected by positron emission tomography. JAAD Case Rep 2016; 2:415-417.
Oct 13, 2016GLUT1-positive recurrent basal cell carcinoma of basosquamous subtype detected by positron emission tomography
Oct 13, 2016JAAD Case Rep 2016; 2:415-417
Hasan Ali Omar, Diem Stefan, Aschwanden Josef, Markert Eva, Tasman Abel-Jan, Müller Joachim, Flatz Lukas
Characterization of nivolumab-associated skin reactions in patients with metastatic non-small cell lung cancer
Hasan Ali O, Diem S, Markert E, Jochum W, Kerl K, French L, Speiser D, Früh M, Flatz L. Characterization of nivolumab-associated skin reactions in patients with metastatic non-small cell lung cancer. Oncoimmunology 2016; 5:e1231292.
Sep 19, 2016Characterization of nivolumab-associated skin reactions in patients with metastatic non-small cell lung cancer
Sep 19, 2016Oncoimmunology 2016; 5:e1231292
Hasan Ali Omar, Diem Stefan, Markert Eva, Jochum Wolfram, Kerl Katrin, French Lars E, Speiser Daniel E, Früh Martin, Flatz Lukas
Pembrolizumab-associated minimal change disease in a patient with malignant pleural mesothelioma
Bickel A, Koneth I, Enzler-Tschudy A, Neuweiler J, Flatz L, Früh M. Pembrolizumab-associated minimal change disease in a patient with malignant pleural mesothelioma. BMC cancer 2016; 16:656.
Aug 19, 2016Pembrolizumab-associated minimal change disease in a patient with malignant pleural mesothelioma
Aug 19, 2016BMC cancer 2016; 16:656
Bickel Angelika, Koneth Irene, Enzler-Tschudy Annette, Neuweiler Jörg, Flatz Lukas, Früh Martin
Pembrolizumab-triggered Uveitis: An Additional Surrogate Marker for Responders in Melanoma Immunotherapy?
Diem S, Goldinger S, Urner-Bloch U, Siano M, Dummer R, Speiser D, Maillard S, Rüesch R, Keller F, Flatz L. Pembrolizumab-triggered Uveitis: An Additional Surrogate Marker for Responders in Melanoma Immunotherapy?. J Immunother 2016; 39:379-382.
Jan 1, 2016Pembrolizumab-triggered Uveitis: An Additional Surrogate Marker for Responders in Melanoma Immunotherapy?
Jan 1, 2016J Immunother 2016; 39:379-382
Diem Stefan, Goldinger Simone M, Urner-Bloch Ursula, Siano Marco, Dummer Reinhard, Speiser Daniel E, Maillard Samia A, Rüesch Reinhard, Keller Fabienne, Flatz Lukas
Generation of Lymphocytic Choriomeningitis Virus Based Vaccine Vectors
Ring S, Flatz L. Generation of Lymphocytic Choriomeningitis Virus Based Vaccine Vectors. Methods Mol Biol 2016; 1404:351-64.
Jan 1, 2016Generation of Lymphocytic Choriomeningitis Virus Based Vaccine Vectors
Jan 1, 2016Methods Mol Biol 2016; 1404:351-64
Ring Sandra, Flatz Lukas
STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity
Demaria O, Speiser D, Modlin R, Martinon F, Petrova T, Hwu P, Michielin O, Gaide O, Flatz L, Di Domizio J, Gestermann N, Coso S, De Gassart A, Gilliet M. STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity. Proc Natl Acad Sci USA 2015; 112:15408-13.
Nov 25, 2015STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity
Nov 25, 2015Proc Natl Acad Sci USA 2015; 112:15408-13
Demaria Olivier, Speiser Daniel E, Modlin Robert L, Martinon Fabio, Petrova Tatiana V, Hwu Patrick, Michielin Olivier, Gaide Olivier, Flatz Lukas, Di Domizio Jeremy, Gestermann Nicolas, Coso Sanja, De Gassart Aude, Gilliet Michel
Arenavirus Glycan Shield Promotes Neutralizing Antibody Evasion and Protracted Infection
Sommerstein R, Siegrist C, Lambert P, Bowden T, Coutard B, Rabah N, Meda P, Rigo D, Ter Meulen J, Igonet S, Bergthaler A, Sahin M, Fischer N, Magistrelli G, Malinge P, Remy M, Flatz L, Pinschewer D. Arenavirus Glycan Shield Promotes Neutralizing Antibody Evasion and Protracted Infection. PLoS Pathog 2015; 11:e1005276.
Nov 20, 2015Arenavirus Glycan Shield Promotes Neutralizing Antibody Evasion and Protracted Infection
Nov 20, 2015PLoS Pathog 2015; 11:e1005276
Sommerstein Rami, Siegrist Claire-Anne, Lambert Paul-Henri, Bowden Thomas A, Coutard Bruno, Rabah Nadia, Meda Paolo, Rigo Dorothée, Ter Meulen Jan, Igonet Sebastien, Bergthaler Andreas, Sahin Mehmet, Fischer Nicolas, Magistrelli Giovanni, Malinge Pauline, Remy Melissa M, Flatz Lukas, Pinschewer Daniel D
Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage
Bhattacharya A, Arnold I, Flatz L, Xu H, Lang P, Aderem A, Takaoka A, Superti-Furga G, Colinge J, Ludewig B, Löhning M, Baazim H, Khamina K, Panse I, Hegazy A, Deigendesch N, Kosack L, Cupovic J, Kandasamy R, Hildebrandt A, Merkler D, Kühl A, Vilagos B, Schliehe C, Bergthaler A. Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage. Immunity 2015; 43:974-86.
Nov 17, 2015Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage
Nov 17, 2015Immunity 2015; 43:974-86
Bhattacharya Anannya, Arnold Isabelle, Flatz Lukas, Xu Haifeng C, Lang Philipp A, Aderem Alan, Takaoka Akinori, Superti-Furga Giulio, Colinge Jacques, Ludewig Burkhard, Löhning Max, Baazim Hatoon, Khamina Kseniya, Panse Isabel, Hegazy Ahmed N, Deigendesch Nikolaus, Kosack Lindsay, Cupovic Jovana, Kandasamy Richard K, Hildebrandt Andrea, Merkler Doron, Kühl Anja A, Vilagos Bojan, Schliehe Christopher, Bergthaler Andreas
Protective efficacy of individual CD8+ T cell specificities in chronic viral infection
Johnson S, Bergthaler A, Graw F, Flatz L, Bonilla W, Siegrist C, Lambert P, Regoes R, Pinschewer D. Protective efficacy of individual CD8+ T cell specificities in chronic viral infection. J Immunol 2015; 194:1755-62.
Jan 7, 2015Protective efficacy of individual CD8+ T cell specificities in chronic viral infection
Jan 7, 2015J Immunol 2015; 194:1755-62
Johnson Susan, Bergthaler Andreas, Graw Frederik, Flatz Lukas, Bonilla Weldy V, Siegrist Claire-Anne, Lambert Paul-Henri, Regoes Roland R, Pinschewer Daniel D
Transcriptional profiles reveal a stepwise developmental program of memory CD8(+) T cell differentiation
Roychoudhuri R, Sékaly R, Restifo N, Cameron M, Gilliet M, Nabel G, Gattinoni L, Goulet J, Hegazy A, Fourati S, Nichols C, Klebanoff C, Ji Y, Pan L, Honda M, Lefebvre F, Flatz L. Transcriptional profiles reveal a stepwise developmental program of memory CD8(+) T cell differentiation. Vaccine 2014; 33:914-23.
Nov 1, 2014Transcriptional profiles reveal a stepwise developmental program of memory CD8(+) T cell differentiation
Nov 1, 2014Vaccine 2014; 33:914-23
Roychoudhuri Rahul, Sékaly Rafick P, Restifo Nicholas P, Cameron Mark, Gilliet Michel, Nabel Gary J, Gattinoni Luca, Goulet Jean-Philippe, Hegazy Ahmed N, Fourati Slim, Nichols Carmen N, Klebanoff Christopher A, Ji Yun, Pan Li, Honda Mitsuo, Lefebvre Francois, Flatz Lukas
Evolution of Recombinant Lymphocytic Choriomeningitis Virus/Lassa Virus In Vivo Highlights the Importance of the GPC Cytosolic Tail in Viral Fitness
Sommerstein R, Ramos da Palma J, Olschläger S, Bergthaler A, Barba L, Lee B, Pasquato A, Flatz L. Evolution of Recombinant Lymphocytic Choriomeningitis Virus/Lassa Virus In Vivo Highlights the Importance of the GPC Cytosolic Tail in Viral Fitness. J Virol 2014; 88:8340-8348.
May 14, 2014Evolution of Recombinant Lymphocytic Choriomeningitis Virus/Lassa Virus In Vivo Highlights the Importance of the GPC Cytosolic Tail in Viral Fitness
May 14, 2014J Virol 2014; 88:8340-8348
Sommerstein Rami, Ramos da Palma Joel, Olschläger Stephan, Bergthaler Andreas, Barba Leticia, Lee Boris P-L, Pasquato Antonella, Flatz Lukas
Cancer immunotherapy drives implementation science in oncology
Speiser D, Flatz L. Cancer immunotherapy drives implementation science in oncology. Hum Vaccin Immunother 2014; 10:3107-10.
Jan 1, 2014Cancer immunotherapy drives implementation science in oncology
Jan 1, 2014Hum Vaccin Immunother 2014; 10:3107-10
Speiser Daniel E, Flatz Lukas
Anti-TNF therapy in the treatment of psoriasis in a patient with acute-on-chronic pancreatitis
Clayton H, Flatz L, Vollenweider-Roten S, Schoepfer A, Gilliet M, Conrad C. Anti-TNF therapy in the treatment of psoriasis in a patient with acute-on-chronic pancreatitis. Dermatology (Basel) 2013; 227:193-6.
Oct 31, 2013Anti-TNF therapy in the treatment of psoriasis in a patient with acute-on-chronic pancreatitis
Oct 31, 2013Dermatology (Basel) 2013; 227:193-6
Clayton Helena, Flatz Lukas, Vollenweider-Roten Sonia, Schoepfer Alain, Gilliet Michel, Conrad Curdin
Vaccination strategies against highly pathogenic arenaviruses: the next steps toward clinical trials
Olschläger S, Flatz L. Vaccination strategies against highly pathogenic arenaviruses: the next steps toward clinical trials. PLoS Pathog 2013; 9:e1003212.
Apr 11, 2013Vaccination strategies against highly pathogenic arenaviruses: the next steps toward clinical trials
Apr 11, 2013PLoS Pathog 2013; 9:e1003212
Olschläger Stephan, Flatz Lukas
Role of T-cell-mediated inflammation in psoriasis: pathogenesis and targeted therapy
Flatz L, Conrad C. Role of T-cell-mediated inflammation in psoriasis: pathogenesis and targeted therapy. Psoriasis: Targets & Therapy 2013
Feb 27, 2013Role of T-cell-mediated inflammation in psoriasis: pathogenesis and targeted therapy
Feb 27, 2013Psoriasis: Targets & Therapy 2013
Flatz Lukas, Conrad Curdin
Sensitive and rapid detection of ganciclovir resistance by PCR based MALDI-TOF analysis
Zürcher S, Schaller A, Gorgievski-Hrisoho M, Garzoni C, Mohacsi P, Barbani M, Mühlemann K, Lüthi A, Mooser C, Flatz L. Sensitive and rapid detection of ganciclovir resistance by PCR based MALDI-TOF analysis. J Clin Virol 2012; 54:359-63.
May 24, 2012Sensitive and rapid detection of ganciclovir resistance by PCR based MALDI-TOF analysis
May 24, 2012J Clin Virol 2012; 54:359-63
Zürcher Samuel, Schaller André, Gorgievski-Hrisoho Meri, Garzoni Christian, Mohacsi Paul, Barbani Maria Teresa, Mühlemann Kathrin, Lüthi Alexander Urs, Mooser Catherine, Flatz Lukas
Gene-based vaccination with a mismatched envelope protects against simian immunodeficiency virus infection in nonhuman primates
Flatz L, Donaldson M, Schmidt S, Gall J, Pinschewer D, Letvin N, Rao S, Mascola J, Roederer M, Shen L, Asmal M, Todd J, Cheng C, Wang L, Foulds K, Ko S, Kong W, Roychoudhuri R, Shi W, Bao S, Nabel G. Gene-based vaccination with a mismatched envelope protects against simian immunodeficiency virus infection in nonhuman primates. J Virol 2012; 86:7760-70.
May 16, 2012Gene-based vaccination with a mismatched envelope protects against simian immunodeficiency virus infection in nonhuman primates
May 16, 2012J Virol 2012; 86:7760-70
Flatz Lukas, Donaldson Mitzi, Schmidt Stephen D, Gall Jason G D, Pinschewer Daniel D, Letvin Norman L, Rao Srinivas, Mascola John R, Roederer Mario, Shen Ling, Asmal Mohammed, Todd John-Paul, Cheng Cheng, Wang Lingshu, Foulds Kathryn E, Ko Sung-Youl, Kong Wing-Pui, Roychoudhuri Rahul, Shi Wei, Bao Saran, Nabel Gary J
Cross-species analysis of the replication complex of Old World arenaviruses reveals two nucleoprotein sites involved in L protein function
Kerber R, Rieger T, Busch C, Flatz L, Pinschewer D, Kümmerer B, Günther S. Cross-species analysis of the replication complex of Old World arenaviruses reveals two nucleoprotein sites involved in L protein function. J Virol 2011; 85:12518-28.
Sep 14, 2011Cross-species analysis of the replication complex of Old World arenaviruses reveals two nucleoprotein sites involved in L protein function
Sep 14, 2011J Virol 2011; 85:12518-28
Kerber Romy, Rieger Toni, Busch Carola, Flatz Lukas, Pinschewer Daniel D, Kümmerer Beate M, Günther Stephan
Single-cell gene-expression profiling reveals qualitatively distinct CD8 T cells elicited by different gene-based vaccines
Flatz L, Sékaly R, Haddad E, Roederer M, Lin M, Kettaf N, Goulet J, Filali-Mouhim A, Honda M, Roychoudhuri R, Nabel G. Single-cell gene-expression profiling reveals qualitatively distinct CD8 T cells elicited by different gene-based vaccines. Proc Natl Acad Sci USA 2011; 108:5724-9.
Mar 21, 2011Single-cell gene-expression profiling reveals qualitatively distinct CD8 T cells elicited by different gene-based vaccines
Mar 21, 2011Proc Natl Acad Sci USA 2011; 108:5724-9
Flatz Lukas, Sékaly Rafick P, Haddad Elias K, Roederer Mario, Lin Min, Kettaf Nadia, Goulet Jean-Philippe, Filali-Mouhim Abdelali, Honda Mitsuo, Roychoudhuri Rahul, Nabel Gary J
Viral replicative capacity is the primary determinant of lymphocytic choriomeningitis virus persistence and immunosuppression
Bergthaler A, Flatz L, Hegazy A, Johnson S, Horvath E, Löhning M, Pinschewer D. Viral replicative capacity is the primary determinant of lymphocytic choriomeningitis virus persistence and immunosuppression. Proc Natl Acad Sci USA 2010; 107:21641-6.
Nov 22, 2010Viral replicative capacity is the primary determinant of lymphocytic choriomeningitis virus persistence and immunosuppression
Nov 22, 2010Proc Natl Acad Sci USA 2010; 107:21641-6
Bergthaler Andreas, Flatz Lukas, Hegazy Ahmed N, Johnson Susan, Horvath Edit, Löhning Max, Pinschewer Daniel D