Autoreactive T cells targeting type II pneumocyte antigens in COVID-19 convalescent patients.

Publication

Autoreactive T cells targeting type II pneumocyte antigens in COVID-19 convalescent patients.

Journal Paper/Review - Oct 10, 2023

Lichtensteiger Christa, Koblischke Maximilian, Berner Fiamma, Jochum Ann-Kristin, Sinnberg Tobias, Balciunaite Beatrice, Purde Mette-Triin, Walter Vincent, Abdou Marie-Therese, Hofmeister Kathrin, Kohler Philipp, Vernazza Pietro L, Albrich Werner, Kahlert Christian, Zoufaly Alexander, Traugott Marianna T, Kern Lukas, Pietsch Urs, Kleger Gian-Reto, Filipovic Miodrag, Kneilling Manfred, Cozzio Antonio, Pop Oltin, Bomze David, Bergthaler Andreas, Hasan Ali, Aberle Judith, Flatz Lukas

Citation

Lichtensteiger C, Koblischke M, Berner F, Jochum A, Sinnberg T, Balciunaite B, Purde M, Walter V, Abdou M, Hofmeister K, Kohler P, Vernazza P, Albrich W, Kahlert C, Zoufaly A, Traugott M, Kern L, Pietsch U, Kleger G, Filipovic M, Kneilling M, Cozzio A, Pop O, Bomze D, Bergthaler A, Hasan A, Aberle J, Flatz L. Autoreactive T cells targeting type II pneumocyte antigens in COVID-19 convalescent patients. J Autoimmun 2023; 140:103118.

Type

Journal Paper/Review (English)

Journal

J Autoimmun 2023; 140

Publication Date

Oct 10, 2023

Issn Electronic

1095-9157

Pages

103118

Brief description/objective

The role of autoreactive T cells on the course of Coronavirus disease-19 (COVID-19) remains elusive. Type II pneumocytes represent the main target cells of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Autoimmune responses against antigens highly expressed in type II pneumocytes may influence the severity of COVID-19 disease.