Dr. Lucas Onder
Senior Scientist/Post-Doc at Institute of Immunobiology, Medical Research Center, Kantonsspital St. Gallen, Switzerland
wissenschaftliche(r) Mitarbeiter/in
Institut für Immunbiologie · Dept. Direktion
Bone morphogenic protein-4 availability in the cardiac microenviroment controls inflammation and fibrosis in autoimmune myocarditis
Pérez Shibayama C, Gil Cruz C, Cadosch N, Lütge M, Cheng H, De Martin A, Frischmann K, Joachimbauer A, Onder L, Papadopoulou I, Papadopoulou C, Ring S, Krebs P, P. Vu V, P. Nägele M, Rosi V, Parianos D, Zsilavecz V, Cooper L, Flammer A, Ruschitzka F, Reiner P, Schmidt D, Ludewig B. Bone morphogenic protein-4 availability in the cardiac microenviroment controls inflammation and fibrosis in autoimmune myocarditis. Nature Cardiovascular Research 2024; volume 3:301-316.
19.04.2024Bone morphogenic protein-4 availability in the cardiac microenviroment controls inflammation and fibrosis in autoimmune myocarditis
19.04.2024Nature Cardiovascular Research 2024; volume 3:301-316
Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Cadosch Nadine, Lütge Mechthild, Cheng Hung-Wei, De Martin Angelina, Frischmann Kira, Joachimbauer Anna, Onder Lucas, Papadopoulou Iliana, Papadopoulou Chrysa, Ring Sandra, Krebs Philippe, P. Vu Vivian, P. Nägele Matthias, Rosi Valentina, Parianos Danae, Zsilavecz Valentin W, Cooper Leslie T., Flammer Andreas, Ruschitzka Frank, Reiner Peter P, Schmidt Dörthe, Ludewig Burkhard
Conserved stromal-immune cell circuits secure B cell homeostasis and function.
Lütge M, De Martin A, Gil Cruz C, Pérez Shibayama C, Stanossek Y, Onder L, Cheng H, Kurz L, Cadosch N, Soneson C, Robinson M, Stöckli S, Ludewig B, Pikor N. Conserved stromal-immune cell circuits secure B cell homeostasis and function. Nat Immunol 2023
18.05.2023Conserved stromal-immune cell circuits secure B cell homeostasis and function.
18.05.2023Nat Immunol 2023
Lütge Mechthild, De Martin Angelina, Gil Cruz Cristina, Pérez Shibayama Christian Ivan, Stanossek Yves, Onder Lucas, Cheng Hung-Wei, Kurz Lisa, Cadosch Nadine, Soneson Charlotte, Robinson Mark D, Stöckli Sandro, Ludewig Burkhard, Pikor Natalia
PI16 reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches.
De Martin A, Stanossek Y, Lütge M, Cadosch N, Onder L, Cheng H, Brandstadter J, Maillard I, Stöckli S, Pikor N, Ludewig B. PI16 reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches. Nat Immunol 2023; 24:1138-1148.
18.05.2023PI16 reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches.
18.05.2023Nat Immunol 2023; 24:1138-1148
De Martin Angelina, Stanossek Yves, Lütge Mechthild, Cadosch Nadine, Onder Lucas, Cheng Hung-Wei, Brandstadter Joshua D, Maillard Ivan, Stöckli Sandro, Pikor Natalia, Ludewig Burkhard
The quorum sensing com system regulates pneumococcal colonisation and invasive disease in a pseudo-stratified airway tissue model.
Kahlert C, Nigg S, Onder L, Dijkman R, Diener L, Vidal A, Rodriguez R, Vernazza P, Thiel V, Vidal J, Albrich W. The quorum sensing com system regulates pneumococcal colonisation and invasive disease in a pseudo-stratified airway tissue model. Microbiol Res 2022; 268:127297.
31.12.2022The quorum sensing com system regulates pneumococcal colonisation and invasive disease in a pseudo-stratified airway tissue model.
31.12.2022Microbiol Res 2022; 268:127297
Kahlert Christian, Nigg Susanne, Onder Lucas, Dijkman Ronald, Diener Liliane, Vidal Ana G Jop, Rodriguez Regulo, Vernazza Pietro, Thiel Volker, Vidal Jorge E, Albrich Werner
Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function
Cheng H, Scandella E, Hehlgans T, Pérez Shibayama C, Gil Cruz C, Novkovic M, Onder L, Engetschwiler C, Lütge M, Mörbe U, Ludewig B. Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function. Nat Commun 2022; 13:2027.
19.04.2022Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function
19.04.2022Nat Commun 2022; 13:2027
Cheng Hung-Wei, Scandella Elke, Hehlgans T, Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Novkovic M, Onder Lucas, Engetschwiler Céline, Lütge Mechthild, Mörbe Urs, Ludewig Burkhard
Visualization and functional characterization of lymphoid organ fibroblasts
Onder L, Cheng H, Ludewig B. Visualization and functional characterization of lymphoid organ fibroblasts. Immunol Rev 2021
05.12.2021Visualization and functional characterization of lymphoid organ fibroblasts
05.12.2021Immunol Rev 2021
Onder Lucas, Cheng Hung-Wei, Ludewig Burkhard
Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment
Ring S, Spiegl M, Besse A, Bonilla W, Stemeseder F, Schmidt S, Orlinger K, Krebs P, Ludewig B, Wenger R, Hartmann F, Cupovic J, Onder L, Lütge M, Pérez Shibayama C, Gil Cruz C, Scandella E, De Martin A, Mörbe U, Flatz L. Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment. Nat Commun 2021; 12:4734.
05.08.2021Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment
05.08.2021Nat Commun 2021; 12:4734
Ring Sandra, Spiegl Matthias, Besse Andrej, Bonilla Weldy V, Stemeseder Felix, Schmidt Sarah, Orlinger Klaus K, Krebs Philippe, Ludewig Burkhard, Wenger Robert, Hartmann Fabienne, Cupovic Jovana, Onder Lucas, Lütge Mechthild, Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Scandella Elke, De Martin Angelina, Mörbe Urs, Flatz Lukas
Communication, construction, and fluid control: lymphoid organ fibroblastic reticular cell and conduit networks
Acton S, Onder L, Novkovic M, Martinez V, Ludewig B. Communication, construction, and fluid control: lymphoid organ fibroblastic reticular cell and conduit networks. Trends Immunol 2021; 42:782-794.
03.08.2021Communication, construction, and fluid control: lymphoid organ fibroblastic reticular cell and conduit networks
03.08.2021Trends Immunol 2021; 42:782-794
Acton Sophie E, Onder Lucas, Novkovic Mario, Martinez Victor G, Ludewig Burkhard
Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8 T cells
Cupovic J, Klenerman P, Engeler D, Krebs P, Scandella E, Oxenius A, Flatz L, Provine N, De Martin A, Cheng H, Lütge M, Colston J, Onder L, Ring S, Ludewig B. Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8 T cells. Nat Immunol 2021; 22:1042-1051.
15.07.2021Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8 T cells
15.07.2021Nat Immunol 2021; 22:1042-1051
Cupovic Jovana, Klenerman Paul, Engeler Daniel, Krebs Philippe, Scandella Elke, Oxenius Annette, Flatz Lukas, Provine Nicholas M, De Martin Angelina, Cheng Hung-Wei, Lütge Mechthild, Colston Julia M, Onder Lucas, Ring Sandra, Ludewig Burkhard
Fibroblastic reticular cell lineage convergence in Peyer's patches governs intestinal immunity
Prados A, Ludewig B, Koliaraki V, Pérez Shibayama C, Gil Cruz C, Lütge M, Mörbe U, Cheng H, Onder L, Kollias G. Fibroblastic reticular cell lineage convergence in Peyer's patches governs intestinal immunity. Nat Immunol 2021; 22:510-519.
11.03.2021Fibroblastic reticular cell lineage convergence in Peyer's patches governs intestinal immunity
11.03.2021Nat Immunol 2021; 22:510-519
Prados Alejandro, Ludewig Burkhard, Koliaraki Vasiliki, Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Lütge Mechthild, Mörbe Urs, Cheng Hung-Wei, Onder Lucas, Kollias George
Development and Immunological Function of Lymph Node Stromal Cells
Pikor N, Cheng H, Onder L, Ludewig B. Development and Immunological Function of Lymph Node Stromal Cells. J Immunol 2021; 206:257-263.
15.01.2021Development and Immunological Function of Lymph Node Stromal Cells
15.01.2021J Immunol 2021; 206:257-263
Pikor Natalia, Cheng Hung-Wei, Onder Lucas, Ludewig Burkhard
PPARγ is essential for the development of bone marrow erythroblastic island macrophages and splenic red pulp macrophages
Okreglicka K, Schneider C, Nielsen P, Ludewig B, Kurrer M, Feng Q, Onder L, Pohlmeier L, Iten I, Kopf M. PPARγ is essential for the development of bone marrow erythroblastic island macrophages and splenic red pulp macrophages. J Exp Med 2021; 218
03.01.2021PPARγ is essential for the development of bone marrow erythroblastic island macrophages and splenic red pulp macrophages
03.01.2021J Exp Med 2021; 218
Okreglicka Katarzyna, Schneider Christoph, Nielsen Peter, Ludewig Burkhard, Kurrer Michael, Feng Qian, Onder Lucas, Pohlmeier Lea, Iten Irina, Kopf Manfred
Type I interferon signaling in fibroblastic reticular cells prevents exhaustive activation of antiviral CD8 T cells
Pérez Shibayama C, Gil Cruz C, Colston J, Novkovic M, De Martin A, Ring S, Onder L, Cheng H, Lütge M, Islander U, Ludewig B. Type I interferon signaling in fibroblastic reticular cells prevents exhaustive activation of antiviral CD8 T cells. Sci Immunol 2020; 5
11.09.2020Type I interferon signaling in fibroblastic reticular cells prevents exhaustive activation of antiviral CD8 T cells
11.09.2020Sci Immunol 2020; 5
Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Colston Julia, Novkovic Mario, De Martin Angelina, Ring Sandra, Onder Lucas, Cheng Hung-Wei, Lütge Mechthild, Islander Ulrika, Ludewig Burkhard
B cell zone reticular cell microenvironments shape CXCL13 gradient formation
Cosgrove J, Uguccioni M, Legler D, Lacey C, Coatesworth A, Polak W, Cupedo T, Manoury B, Thelen M, Stein J, Wolf M, Leake M, Timmis J, Ludewig B, Heller M, Venetz D, Taylor E, Novkovic M, Albrecht S, Pikor N, Zhou Z, Onder L, Mörbe U, Cupovic J, Miller H, Alden K, Thuery A, O'Toole P, Pinter R, Jarrett S, Coles M. B cell zone reticular cell microenvironments shape CXCL13 gradient formation. Nat Commun 2020; 11:3677.
22.07.2020B cell zone reticular cell microenvironments shape CXCL13 gradient formation
22.07.2020Nat Commun 2020; 11:3677
Cosgrove Jason, Uguccioni Mariagrazia, Legler Daniel F, Lacey Charles J, Coatesworth Andrew, Polak Wojciech G, Cupedo Tom, Manoury Bénedicte, Thelen Marcus, Stein Jens V, Wolf Marlene, Leake Mark C, Timmis Jon, Ludewig Burkhard, Heller Manfred, Venetz Daniel, Taylor Emily, Novkovic Mario, Albrecht Stefan, Pikor Natalia, Zhou Zhaoukun, Onder Lucas, Mörbe Urs, Cupovic Jovana, Miller Helen, Alden Kieran, Thuery Anne, O'Toole Peter, Pinter Rita, Jarrett Simon, Coles Mark C
Remodeling of light and dark zone follicular dendritic cells governs germinal center responses
Pikor N, Onder L, Linterman M, Nagasawa T, Nombela-Arrieta C, Cheng H, Novkovic M, Pérez Shibayama C, Gil Cruz C, Lütge M, Mörbe U, Ludewig B. Remodeling of light and dark zone follicular dendritic cells governs germinal center responses. Nat Immunol 2020; 21:649-659.
18.05.2020Remodeling of light and dark zone follicular dendritic cells governs germinal center responses
18.05.2020Nat Immunol 2020; 21:649-659
Pikor Natalia, Onder Lucas, Linterman Michelle A, Nagasawa Takashi, Nombela-Arrieta César, Cheng Hung-Wei, Novkovic Mario, Pérez Shibayama Christian Ivan, Gil Cruz Cristina, Lütge Mechthild, Mörbe Urs, Ludewig Burkhard
YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells
Choi S, Jang J, Onder L, Moon J, Jeong H, Adams R, Kim J, Ludewig B, Song J, Lim D, Yang M, Choi J, Bae H, Jeong S, Park I, Cho H, Hong S, Lee D, Lee C, Park J, Suh S, Koh G. YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells. Nat Commun 2020; 11:519.
24.01.2020YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells
24.01.2020Nat Commun 2020; 11:519
Choi Sung Yong, Jang Jeon Yeob, Onder Lucas, Moon Jeong Hwan, Jeong Han-Sin, Adams Ralf H, Kim Jin-Man, Ludewig Burkhard, Song Joo-Hye, Lim Dae-Sik, Yang Myung Jin, Choi Jeongwoon, Bae Hosung, Jeong Sun-Hye, Park Intae, Cho Hyunsoo, Hong Seon Pyo, Lee Da-Hye, Lee Choong-Kun, Park Jin-Sung, Suh Sang Heon, Koh Gou Young
Topological Structure and Robustness of the Lymph Node Conduit System
Novkovic M, Onder L, Bocharov G, Ludewig B. Topological Structure and Robustness of the Lymph Node Conduit System. Cell Rep 2020; 30:893-904.e6.
21.01.2020Topological Structure and Robustness of the Lymph Node Conduit System
21.01.2020Cell Rep 2020; 30:893-904.e6
Novkovic Mario, Onder Lucas, Bocharov Gennady, Ludewig Burkhard
Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy
Gil Cruz C, Jahns R, Wyss M, Mooser C, Lambrecht B, Maeder M, Rickli H, Flatz L, Eriksson U, Geuking M, McCoy K, Boivin-Jahns V, Slack E, Arnoldini M, Pérez Shibayama C, De Martin A, Ronchi F, Van der Borght K, Niederer R, Onder L, Lütge M, Novkovic M, Nindl V, Ramos G, Ludewig B. Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy. Science 2019; 366:881-886.
15.11.2019Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy
15.11.2019Science 2019; 366:881-886
Gil Cruz Cristina, Jahns Roland, Wyss Madeleine, Mooser Catherine, Lambrecht Bart N, Maeder Micha, Rickli Hans, Flatz Lukas, Eriksson Urs, Geuking Markus B, McCoy Kathy D, Boivin-Jahns Valérie, Slack Emma M C, Arnoldini Markus, Pérez Shibayama Christian Ivan, De Martin Angelina, Ronchi Francesca, Van der Borght Katrien, Niederer Rebekka, Onder Lucas, Lütge Mechthild, Novkovic Mario, Nindl Veronika, Ramos Gustavo, Ludewig Burkhard
Lymph Node Mesenchymal and Endothelial Stromal Cells Cooperate via the RANK-RANKL Cytokine Axis to Shape the Sinusoidal Macrophage Niche
Camara A, Flacher V, Ludewig B, Yagita H, Tanaka M, Asano K, Onder L, Chypre M, Sponsel J, Alloush F, Cordeiro O, Mueller C. Lymph Node Mesenchymal and Endothelial Stromal Cells Cooperate via the RANK-RANKL Cytokine Axis to Shape the Sinusoidal Macrophage Niche. Immunity 2019; 50:1467-1481.e6.
11.06.2019Lymph Node Mesenchymal and Endothelial Stromal Cells Cooperate via the RANK-RANKL Cytokine Axis to Shape the Sinusoidal Macrophage Niche
11.06.2019Immunity 2019; 50:1467-1481.e6
Camara Abdouramane, Flacher Vincent, Ludewig Burkhard, Yagita Hideo, Tanaka Masato, Asano Kenichi, Onder Lucas, Chypre Mélanie, Sponsel Janina, Alloush Farouk, Cordeiro Olga G, Mueller Christopher G
Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp
Cheng H, Hehlgans T, Rülicke T, Pfeffer K, Sorg U, Tersteegen A, Miyazaki J, Robinson M, Scandella E, Pikor N, Lütge M, Soneson C, Novkovic M, Onder L, Ludewig B. Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp. Nat Commun 2019; 10:1739.
15.04.2019Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp
15.04.2019Nat Commun 2019; 10:1739
Cheng Hung-Wei, Hehlgans Thomas, Rülicke Thomas, Pfeffer Klaus, Sorg Ursula, Tersteegen Anne, Miyazaki Jun-Ichi, Robinson Mark D, Scandella Elke, Pikor Natalia, Lütge Mechthild, Soneson Charlotte, Novkovic Mario, Onder Lucas, Ludewig Burkhard